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CPathAgent: An Agent-based Foundation Model for Interpretable High-Resolution Pathology Image Analysis Mimicking Pathologists' Diagnostic Logic
Recent advances in computational pathology have led to the emergence of numerous foundation models. These models typically rely on general-purpose encoders with multi-instance learning for whole slide image (WSI) classification or apply multimodal approaches to generate reports directly from images. However, these models cannot emulate the diagnostic approach of pathologists, who systematically examine slides at low magnification to obtain an overview before progressively zooming in on suspicious regions to formulate comprehensive diagnoses.
Bipolar Self-attention for Spiking Transformers
Harnessing the event-driven characteristic, Spiking Neural Networks (SNNs) present a promising avenue toward energy-efficient Transformer architectures. However, existing Spiking Transformers still suffer significant performance gaps compared to their Artificial Neural Network counterparts. Through comprehensive analysis, we attribute this gap to these two factors. First, the binary nature of spike trains limits Spiking Self-attention (SSA)'s capacity to capture negative-negative and positive-negative membrane potential interactions on Querys and Keys. Second, SSA typically omits Softmax functions to avoid energy-intensive multiplyaccumulate operations, thereby failing to maintain row-stochasticity constraints on attention scores.
Personalized Federated Conformal Prediction with Localization
Personalized federated learning addresses data heterogeneity across distributed agents but lacks uncertainty quantification that is both agent-specific and instancespecific, which is a critical requirement for risk-sensitive applications. We propose personalized federated conformal prediction (PFCP), a novel framework that combines personalized federated learning with conformal prediction to provide statistically valid agent-personalized prediction sets with instance-localization. By leveraging privacy-preserving knowledge transfer from other source agents, PFCP ensures marginal coverage guarantees for target agents while significantly improving conditional coverage performance on individual test instances, which has been validated by extensive experiments.
Conservative classifiers do consistently well with improving agents: characterizing statistical and online learning
Machine learning is now ubiquitous in societal decision-making, for example in evaluating job candidates or loan applications, and it is increasingly important to take into account how classified agents will react to the learning algorithms. The majority of recent literature on strategic classification has focused on reducing and countering deceptive behaviors by the classified agents, but recent work of Attias et al. [5] identifies surprising properties of learnability when the agents genuinely improve in order to attain the desirable classification, such as smaller generalization error than standard PAC-learning. In this paper we characterize so-called learnability with improvements across multiple new axes. We introduce an asymmetric variant of minimally consistent concept classes and use it to provide an exact characterization of proper learning with improvements in the realizable setting. While prior work studies learnability only under general, arbitrary agent improvement regions, we give positive results for more natural Euclidean ball improvement sets. In particular, we characterize improper learning under a generative assumption on the data distribution. We further show how to learn in more challenging settings, achieving lower generalization error under well-studied bounded noise models and obtaining mistake bounds in realizable and agnostic online learning. We resolve open questions posed by Attias et al. [5] for both proper and improper learning.
Policy Optimized Text-to-Image Pipeline Design
Text-to-image generation has evolved beyond single monolithic models to complex multi-component pipelines. These combine fine-tuned generators, adapters, upscaling blocks and even editing steps, leading to significant improvements in image quality. However, their effective design requires substantial expertise. Recent approaches have shown promise in automating this process through large language models (LLMs), but they suffer from two critical limitations: extensive computational requirements from generating images with hundreds of predefined pipelines, and poor generalization beyond memorized training examples. We introduce a novel reinforcement learning-based framework that addresses these inefficiencies.
Flow World Benchmark for Flying on a Word Learning
Unmanned Aerial Vehicles (UAVs) are evolving into language-interactive platforms, enabling more intuitive forms of human-drone interaction. While prior works have primarily focused on high-level planning and long-horizon navigation, we shift attention to language-guided fine-grained trajectory control, where UAVs execute short-range, reactive flight behaviors in response to language instructions. We formalize this problem as the Flying-on-a-Word (Flow) task and introduce UAV imitation learning as an effective approach. In this framework, UAVs learn fine-grained control policies by mimicking eUAxpert pilotVtrajectoriesFlopaired withwatomic Fly around the tree ahead Land on the left side of carlanguage instructions. To support this paradigm, we present UAV-Flow, the firstreal-world benchmark for language-conditioned, fine-grained UAV control.
Reverse Engineering Human Preferences with Reinforcement Learning
The capabilities of Large Language Models (LLMs) are routinely evaluated by other LLMs trained to predict human preferences. This framework--known as LLM-as-a-judge--is highly scalable and relatively low cost. However, it is also vulnerable to malicious exploitation, as LLM responses can be tuned to overfit the preferences of the judge. Previous work shows that the answers generated by a candidate-LLM can be edited post hoc to maximise the score assigned to them by a judge-LLM. In this study, we adopt a different approach and use the signal provided by judge-LLMs as a reward to adversarially tune models that generate text preambles designed to boost downstream performance.
Risk Management for Mitigating Benchmark Failure Modes: BenchRisk
Large language model (LLM) benchmarks inform LLM use decisions (e.g., "is this LLM safe to deploy for my use case and context?"). However, benchmarks may be rendered unreliable by various failure modes that impact benchmark bias, variance, coverage, or people's capacity to understand benchmark evidence. Using the National Institute of Standards and Technology's risk management process as a foundation, this research iteratively analyzed 26 popular benchmarks, identifying 57 potential failure modes and 196 corresponding mitigation strategies. The mitigations reduce failure likelihood and/or severity, providing a frame for evaluating "benchmark risk," which is scored to provide a metaevaluation benchmark: BenchRisk. Higher scores indicate that benchmark users are less likely to reach an incorrect or unsupported conclusion about an LLM. All 26 scored benchmarks present significant risk within one or more of the five scored dimensions (comprehensiveness, intelligibility, consistency, correctness, and longevity), which points to important open research directions for the field of LLM benchmarking. The BenchRisk workflow allows for comparison between benchmarks; as an open-source tool, it also facilitates the identification and sharing of risks and their mitigations.
Efficient Representativeness-Aware Coreset Selection
Dynamic coreset selection is a promising approach for improving the training efficiency of deep neural networks by periodically selecting a small subset of the most representative or informative samples, thereby avoiding the need to train on the entire dataset. However, it remains inherently challenging due not only to the complex interdependencies among samples and the evolving nature of model training, but also to a critical coreset representativeness degradation issue identified and explored in-depth in this paper, that is, the representativeness or information content of the coreset degrades over time as training progresses. Therefore, we argue that, in addition to designing accurate selection rules, it is equally important to endow the algorithms with the ability to assess the quality of the current coreset. Such awareness enables timely re-selection, mitigating the risk of overfitting to stale subsets-a limitation often overlooked by existing methods. To this end, this paper proposes an Efficient Representativeness-Aware Coreset Selection (ERACS) method for deep neural networks, a lightweight framework that enables dynamic tracking and maintenance of coreset quality during training.
Multi-Expert Distributionally Robust Optimization for Out-of-Distribution Generalization
Distribution shifts between training and test data undermine the reliability of deep neural networks, challenging real-world applications across domains and subpopulations. While distributionally robust optimization (DRO) methods like GroupDRO aim to improve robustness by optimizing worst-case performance over predefined groups, their use of a single global classifier can be restrictive when facing substantial inter-environment variability. We propose Multi-Expert Distributionally Robust Optimization (MEDRO), a novel extension of GroupDRO designed to address such complex shifts. MEDRO employs a shared feature extractor with m environment-specific expert classifier heads, and introduces a min-max objective over all m2 expert-environment pairings, explicitly modeling cross-environment risks. This expanded uncertainty set captures fine-grained distributional variations that a single classifier might overlook. Empirical evaluations on a range of standard distribution shift benchmarks demonstrate that MEDRO often achieves robust predictive performance compared to existing methods. Furthermore, MEDRO offers practical inference strategies, such as ensembling or gating mechanisms, for typical scenarios where environment labels are unavailable at test time. Our findings suggest MEDRO as a promising step toward resilient and generalizable machine learning under real-world distribution shifts.