Single unit activity in the striatum of awake monkeys shows a marked dependence on the expected reward that a behavior will elicit. We present a computational model of spiny neurons, the principal neurons of the striatum, to assess the hypothesis that direct neuromodulatory effects of dopamine through the activation of D 1 receptors mediate the reward dependency of spiny neuron activity. Dopamine release results in the amplification of key ion currents, leading to the emergence of bistability, which not only modulates the peak firing rate but also introduces a temporal and state dependence of the model's response, thus improving the detectability of temporally correlated inputs. 1 Introduction The classic notion of the basal ganglia as being involved in purely motor processing has expanded over the years to include sensory and cognitive functions. A surprising new finding is that much of this activity shows a motivational component. For instance, striatal activity related to visual stimuli is dependent on the type of reinforcement (primary vs secondary) that a behavior will elicit [1].

We present a novel, flexible statistical approach for modelling music and text jointly. The approach is based on multi-modal mixture models and maximum a posteriori estimation using EM. The learned models can be used to browse databases with documents containing music and text, to search for music using queries consisting of music and text (lyrics and other contextual information), to annotate text documents with music, and to automatically recommend or identify similar songs.

Recently, interest is growing to develop an effective communication interface connecting the human brain to a computer, the'Brain-Computer Interface' (BCI). One motivation of BCI research is to provide a new communication channel substituting normal motor output in patients with severe neuromuscular disabilities. In the last decade, various neurophysiological cortical processes, such as slow potential shifts, movement related potentials (MRPs) or event-related desynchronization (ERD) of spontaneous EEG rhythms, were shown to be suitable for BCI, and, consequently, different independent approaches of extracting BCI-relevant EEGfeatures for single-trial analysis are under investigation. Here, we present and systematically compare several concepts for combining such EEGfeatures to improve the single-trial classification. Feature combinations are evaluated on movement imagination experiments with 3 subjects where EEGfeatures are based on either MRPs or ERD, or both. Those combination methods that incorporate the assumption that the single EEGfeatures are physiologically mutually independent outperform the plain method of'adding' evidence where the single-feature vectors are simply concatenated. These results strengthen the hypothesis that MRP and ERD reflect at least partially independent aspects of cortical processes and open a new perspective to boost BCI effectiveness.

A standard view of memory consolidation is that episodes are stored temporarily in the hippocampus, and are transferred to the neocortex through replay. Various recent experimental challenges to the idea of transfer, particularly for human memory, are forcing its reevaluation. However, although there is independent neurophysiological evidence for replay, short of transfer, there are few theoretical ideas for what it might be doing. We suggest and demonstrate two important computational roles associated with neocortical indices.

Well-known applications include part-of-speech (POS) tagging, named entity classification, information extraction, text segmentation and phoneme classification in text and speech processing [7] as well as problems like protein homology detection, secondary structure prediction or gene classification in computational biology [3]. Up to now, the predominant formalism for modeling and predicting label sequences has been based on Hidden Markov Models (HMMs) and variations thereof. Yet, despite its success, generative probabilistic models - of which HMMs are a special case - have two major shortcomings, which this paper is not the first one to point out. First, generative probabilistic models are typically trained using maximum likelihood estimation (MLE) for a joint sampling model of observation and label sequences. As has been emphasized frequently, MLE based on the joint probability model is inherently non-discriminative and thus may lead to suboptimal prediction accuracy. Secondly, efficient inference and learning in this setting often requires to make questionable conditional independence assumptions.

We show that two important properties of the primary visual cortex emerge when the principle of temporal coherence is applied to natural image sequences. The properties are simple-cell-like receptive fields and complex-cell-like pooling of simple cell outputs, which emerge when we apply two different approaches to temporal coherence. In the first approach we extract receptive fields whose outputs are as temporally coherent as possible. This approach yields simple-cell-like receptive fields (oriented, localized, multiscale). Thus, temporal coherence is an alternative to sparse coding in modeling the emergence of simple cell receptive fields. The second approach is based on a two-layer statistical generative model of natural image sequences. In addition to modeling the temporal coherence of individual simple cells, this model includes inter-cell temporal dependencies.

Address-event representation (AER), originally proposed as a means to communicate sparse neural events between neuromorphic chips, has proven efficient in implementing large-scale networks with arbitrary, configurable synaptic connectivity. In this work, we further extend the functionality of AER to implement arbitrary, configurable synaptic plasticity in the address domain. As proof of concept, we implement a biologically inspired form of spike timing-dependent plasticity (STDP) based on relative timing of events in an AER framework. Experimental results from an analog VLSI integrate-and-fire network demonstrate address domain learning in a task that requires neurons to group correlated inputs.

A population of neurons typically exhibits a broad diversity of responses to sensory inputs. The intuitive notion of functional classification is that cells can be clustered so that most of the diversity is captured by the identity of the clusters rather than by individuals within clusters. We show how this intuition can be made precise using information theory, without any need to introduce a metric on the space of stimuli or responses. Applied to the retinal ganglion cells of the salamander, this approach recovers classical results, but also provides clear evidence for subclasses beyond those identified previously. Further, we find that each of the ganglion cells is functionally unique, and that even within the same subclass only a few spikes are needed to reliably distinguish between cells.

In this paper, we study a special kind of learning problem in which each training instance is given a set of (or distribution over) candidate class labels and only one of the candidate labels is the correct one. Such a problem can occur, e.g., in an information retrieval setting where a set of words is associated with an image, or if classes labels are organized hierarchically. We propose a novel discriminative approach for handling the ambiguity of class labels in the training examples. The experiments with the proposed approach over five different UCI datasets show that our approach is able to find the correct label among the set of candidate labels and actually achieve performance close to the case when each training instance is given a single correct label. In contrast, naIve methods degrade rapidly as more ambiguity is introduced into the labels. 1 Introduction Supervised and unsupervised learning problems have been extensively studied in the machine learning literature. In supervised classification each training instance is associated with a single class label, while in unsupervised classification (i.e.

Accurate representation of articulated motion is a challenging problem for machine perception. Several successful tracking algorithms have been developed that model human body as an articulated tree. We propose a learning-based method for creating such articulated models from observations of multiple rigid motions. This paper is concerned with recovering topology of the articulated model, when the rigid motion of constituent segments is known. Our approach is based on finding the Maximum Likelihood tree shaped factorization of the joint probability density function (PDF) of rigid segment motions. The topology of graphical model formed from this factorization corresponds to topology of the underlying articulated body. We demonstrate the performance of our algorithm on both synthetic and real motion capture data.