This paper proposes Co-TAP (T: Triple, A: Agent, P: Protocol), a three-layer agent interaction protocol designed to address the challenges faced by multi-agent systems across the three core dimensions of Interoperability, Interaction and Collaboration, and Knowledge Sharing. We have designed and proposed a layered solution composed of three core protocols: the Human-Agent Interaction Protocol (HAI), the Unified Agent Protocol (UAP), and the Memory-Extraction-Knowledge Protocol (MEK). HAI focuses on the interaction layer, standardizing the flow of information between users, interfaces, and agents by defining a standardized, event-driven communication paradigm. This ensures the real-time performance, reliability, and synergy of interactions. As the core of the infrastructure layer, UAP is designed to break down communication barriers among heterogeneous agents through unified service discovery and protocol conversion mechanisms, thereby enabling seamless interconnection and interoperability of the underlying network. MEK, in turn, operates at the cognitive layer. By establishing a standardized ''Memory (M) - Extraction (E) - Knowledge (K)'' cognitive chain, it empowers agents with the ability to learn from individual experiences and form shareable knowledge, thereby laying the foundation for the realization of true collective intelligence. We believe this protocol framework will provide a solid engineering foundation and theoretical guidance for building the next generation of efficient, scalable, and intelligent multi-agent applications.

We introduce the SEER (Span-based Emotion Evidence Retrieval) Benchmark to test Large Language Models' (LLMs) ability to identify the specific spans of text that express emotion. Unlike traditional emotion recognition tasks that assign a single label to an entire sentence, SEER targets the underexplored task of emotion evidence detection: pinpointing which exact phrases convey emotion. This span-level approach is crucial for applications like empathetic dialogue and clinical support, which need to know how emotion is expressed, not just what the emotion is. SEER includes two tasks: identifying emotion evidence within a single sentence, and identifying evidence across a short passage of five consecutive sentences. It contains new annotations for both emotion and emotion evidence on 1200 real-world sentences. We evaluate 14 open-source LLMs and find that, while some models approach average human performance on single-sentence inputs, their accuracy degrades in longer passages. Our error analysis reveals key failure modes, including overreliance on emotion keywords and false positives in neutral text.

Large Language Models (LLMs) are being increasingly used as synthetic agents in social science, in applications ranging from augmenting survey responses to powering multi-agent simulations. This paper outlines cautions that should be taken when interpreting LLM outputs and proposes a pragmatic reframing for the social sciences in which LLMs are used as high-capacity pattern matchers for quasi-predictive interpolation under explicit scope conditions and not as substitutes for probabilistic inference. Practical guardrails such as independent draws, preregistered human baselines, reliability-aware validation, and subgroup calibration, are introduced so that researchers may engage in useful prototyping and forecasting while avoiding category errors.

An effective physician should possess a combination of empathy, expertise, patience, and clear communication when treating a patient. Recent advances have successfully endowed AI doctors with expert diagnostic skills, particularly the ability to actively seek information through inquiry. However, other essential qualities of a good doctor remain overlooked. It features 3,000 realistically simulated patient agents that exhibit diverse linguistic patterns, cognitive limitations, emotional responses, and tendencies for passive disclosure. We also introduce a multi-faceted evaluation framework, covering task success, inquiry proficiency, dialogue competence, inquiry efficiency, and patient experience. Experiments on different LLMs reveal substantial challenges across the evaluation aspects. Even state-of-the-art models show significant room for improvement in their inquiry capabilities. These models are highly sensitive to variations in realistic patient behavior, which considerably impacts diagnostic accuracy. Furthermore, our fine-grained metrics expose trade-offs between different evaluation perspectives, highlighting the challenge of balancing performance and practicality in real-world clinical settings.Figure 1: Comparison between MAQ E enables more realistic patient simulation by integrating diverse behaviors and evaluates doctor inquiries from more comprehensive and fine-grained perspectives. A medical career is among the most demanding professions to master. A physician's role extends far beyond treating diseases; it also involves employing nuanced conversational skills to understand a patient's condition and guide them through moments of vulnerability. Current Large Language Models (LLMs) have reached the initial stage of this journey by grasping extensive medical knowledge and expertise in clinical examinations (Nori et al., 2023; Wang et al., 2023; Saab et al., 2024; Singhal et al., 2025; Dou et al., 2025). However, their passive, response-driven nature (Li et al., 2024)--an inherent tendency to answer user queries directly rather than to engage in goal-oriented dialogue--limits their practical utility. This shortcoming is particularly critical in clinical consultation, the focus of this work, where an LLM must proactively converse with patients to gather information through thoughtful and compassionate inquiry. Existing studies (Liao et al., 2023; Li et al., 2024; Schmidgall et al., 2024; Nori et al., 2025) have proposed several benchmarks to evaluate the inquiry capabilities of LLMs. A prevalent method is to develop a virtual interaction environment in which a patient is simulated by an LLM based on a synthesized profile.

We present PEARL (Peer-Enhanced Adaptive Radio via On-Device LLM), a framework for cooperative cross-layer optimization in device-to-device (D2D) communication. Building on our previous work on single-device on-device LLMs, PEARL extends the paradigm by leveraging both publisher and subscriber states to guide Wi-Fi Aware (WA) parameter selection. A context-aware reward, which normalizes latency by application tolerances and modulates energy by device battery states, provides richer supervision for KL-based finetuning. We study two lightweight variants: PEARL (Head + Low-Rank Adaptation (LoRA)) achieves the best overall performance, while PEARL-Lite (Head-only) delivers sub-20 ms inference at near-identical objective scores. Across synthetic scenarios grounded in real measurements, PEARL improves objective scores over heuristic and compact model baselines and reduces energy by up to 16% in cooperative low-battery cases. These results demonstrate that peer-aware context, reward-aligned training, and head-based efficiency make LLMs practical for always-on, on-device cross-layer control. Code, real-world demo, and dataset are available at https://github.com/abman23/pearl

Cascade systems route computational requests to smaller models when possible and defer to larger models only when necessary, offering a promising approach to balance cost and quality in LLM deployment. However, they face a fundamental challenge in open-ended text generation: determining output reliability when generation quality lies on a continuous spectrum, often with multiple valid responses. To address this, we propose semantic agreement -- meaning-level consensus between ensemble outputs -- as a training-free signal for reliable deferral. We show that when diverse model outputs agree semantically, their consensus is a stronger reliability signal than token-level confidence. Evaluated from 500M to 70B-parameter models, we find that semantic cascades match or surpass target-model quality at 40% of the cost and reduce latency by up to 60%. Our method requires no model internals, works across black-box APIs, and remains robust to model updates, making it a practical baseline for real-world LLM deployment.

To enable robots to comprehend high-level human instructions and perform complex tasks, a key challenge lies in achieving comprehensive scene understanding: interpreting and interacting with the 3D environment in a meaningful way. This requires a smart map that fuses accurate geometric structure with rich, human-understandable semantics. To address this, we introduce the 3D Queryable Scene Representation (3D QSR), a novel framework built on multimedia data that unifies three complementary 3D representations: (1) 3D-consistent novel view rendering and segmentation from panoptic reconstruction, (2) precise geometry from 3D point clouds, and (3) structured, scalable organization via 3D scene graphs. Built on an object-centric design, the framework integrates with large vision-language models to enable semantic queryability by linking multimodal object embeddings, and supporting object-level retrieval of geometric, visual, and semantic information. The retrieved data are then loaded into a robotic task planner for downstream execution. We evaluate our approach through simulated robotic task planning scenarios in Unity, guided by abstract language instructions and using the indoor public dataset Replica. Furthermore, we apply it in a digital duplicate of a real wet lab environment to test QSR-supported robotic task planning for emergency response. The results demonstrate the framework's ability to facilitate scene understanding and integrate spatial and semantic reasoning, effectively translating high-level human instructions into precise robotic task planning in complex 3D environments.

As generative models are advancing in quality and quantity for creating synthetic content, deepfakes begin to cause online mistrust. Deepfake detectors are proposed to counter this effect, however, misuse of detectors claiming fake content as real or vice versa further fuels this misinformation problem. We present the first comprehensive uncertainty analysis of deepfake detectors, systematically investigating how generative artifacts influence prediction confidence. As reflected in detectors' responses, deepfake generators also contribute to this uncertainty as their generative residues vary, so we cross the uncertainty analysis of deepfake detectors and generators. Based on our observations, the uncertainty manifold holds enough consistent information to leverage uncertainty for deepfake source detection. Our approach leverages Bayesian Neural Networks and Monte Carlo dropout to quantify both aleatoric and epistemic uncertainties across diverse detector architectures. We evaluate uncertainty on two datasets with nine generators, with four blind and two biological detectors, compare different uncertainty methods, explore region- and pixel-based uncertainty, and conduct ablation studies. We conduct and analyze binary real/fake, multi-class real/fake, source detection, and leave-one-out experiments between the generator/detector combinations to share their generalization capability, model calibration, uncertainty, and robustness against adversarial attacks. We further introduce uncertainty maps that localize prediction confidence at the pixel level, revealing distinct patterns correlated with generator-specific artifacts. Our analysis provides critical insights for deploying reliable deepfake detection systems and establishes uncertainty quantification as a fundamental requirement for trustworthy synthetic media detection.

Online artificial intelligence (AI) algorithms are an important component of digital health interventions. These online algorithms are designed to continually learn and improve their performance as streaming data is collected on individuals. Deploying online AI presents a key challenge: balancing adaptability of online AI with reproducibility. Online AI in digital interventions is a rapidly evolving area, driven by advances in algorithms, sensors, software, and devices. Digital health intervention development and deployment is a continuous process, where implementation - including the AI decision-making algorithm - is interspersed with cycles of re-development and optimization. Each deployment informs the next, making iterative deployment a defining characteristic of this field. This iterative nature underscores the importance of reproducibility: data collected across deployments must be accurately stored to have scientific utility, algorithm behavior must be auditable, and results must be comparable over time to facilitate scientific discovery and trustworthy refinement. This paper proposes a reproducible scientific workflow for developing, deploying, and analyzing online AI decision-making algorithms in digital health interventions. Grounded in practical experience from multiple real-world deployments, this workflow addresses key challenges to reproducibility across all phases of the online AI algorithm development life-cycle.

Federated Learning (FL) presents significant potential for collaborative optimization without data sharing. Since synthetic data is sent to the server, leveraging the popular concept of dataset distillation, this FL framework protects real data privacy while alleviating data heterogeneity. However, such methods are still challenged by the redundant information and noise in entire spatial-domain designs, which inevitably increases the communication burden. In this paper, we propose a novel Frequency-Domain aware FL method with high-energy concentration (FedFD) to address this problem. Our FedFD is inspired by the discovery that the discrete cosine transform predominantly distributes energy to specific regions, referred to as high-energy concentration. The principle behind FedFD is that low-energy like high-frequency components usually contain redundant information and noise, thus filtering them helps reduce communication costs and optimize performance. Our FedFD is mathematically formulated to preserve the low-frequency components using a binary mask, facilitating an optimal solution through frequency-domain distribution alignment. In particular, real data-driven synthetic classification is imposed into the loss to enhance the quality of the low-frequency components. On five image and speech datasets, FedFD achieves superior performance than state-of-the-art methods while reducing communication costs. For example, on the CIFAR-10 dataset with Dirichlet coefficient $α= 0.01$, FedFD achieves a minimum reduction of 37.78\% in the communication cost, while attaining a 10.88\% performance gain.