Since its 2009 genesis block, the Bitcoin network has processed >1.08 billion (B) transactions representing >8.72B BTC, offering rich potential for machine learning (ML); yet, its pseudonymity and obscured flow of funds inherent in its UTxO-based design, have rendered this data largely inaccessible for ML research. Addressing this gap, we present an ML-compatible graph modeling the Bitcoin's economic topology by reconstructing the flow of funds. This temporal, heterogeneous graph encompasses complete transaction history up to block 863000, consisting of >2.4B nodes and >39.72B edges. Additionally, we provide custom sampling methods yielding node and edge feature vectors of sampled communities, tools to load and analyze the Bitcoin graph data within specialized graph databases, and ready-to-use database snapshots. This comprehensive dataset and toolkit empower the ML community to tackle Bitcoin's intricate ecosystem at scale, driving progress in applications such as anomaly detection, address classification, market analysis, and large-scale graph ML benchmarking. Dataset and code available at https://github.com/B1AAB/EBA

As large language models (LLMs) are increasingly integrated into real-world applications, ensuring their safety, robustness, and privacy compliance has become critical. We present OpenGuardrails, the first fully open-source platform that unifies large-model-based safety detection, manipulation defense, and deployable guardrail infrastructure. OpenGuardrails protects against three major classes of risks: (1) content-safety violations such as harmful or explicit text generation, (2) model-manipulation attacks including prompt injection, jailbreaks, and code-interpreter abuse, and (3) data leakage involving sensitive or private information. Unlike prior modular or rule-based frameworks, OpenGuardrails introduces three core innovations: (1) a Configurable Policy Adaptation mechanism that allows per-request customization of unsafe categories and sensitivity thresholds; (2) a Unified LLM-based Guard Architecture that performs both content-safety and manipulation detection within a single model; and (3) a Quantized, Scalable Model Design that compresses a 14B dense base model to 3.3B via GPTQ while preserving over 98 of benchmark accuracy. The system supports 119 languages, achieves state-of-the-art performance across multilingual safety benchmarks, and can be deployed as a secure gateway or API-based service for enterprise use. All models, datasets, and deployment scripts are released under the Apache 2.0 license.

Glioblastoma (GBM) is an aggressive primary brain tumor with a median survival of approximately 15 months. In clinical practice, the Stupp protocol serves as the standard first-line treatment. However, patients exhibit highly heterogeneous therapeutic responses which required at least two months before first visual impact can be observed, typically with MRI. Early prediction treatment response is crucial for advancing personalized medicine. Disease Progression Modeling (DPM) aims to capture the trajectory of disease evolution, while Treatment Response Prediction (TRP) focuses on assessing the impact of therapeutic interventions. Whereas most TRP approaches primarly rely on time-series data, we consider the problem of early visual TRP as a slice-to-slice translation model generating post-treatment MRI from a pre-treatment MRI, thus reflecting the tumor evolution. To address this problem we propose a Latent Diffusion Model with a concatenation-based conditioning from the pre-treatment MRI and the tumor localization, and a classifier-free guidance to enhance generation quality using survival information, in particular post-treatment tumor evolution. Our model were trained and tested on a local dataset consisting of 140 GBM patients collected at Centre François Baclesse. For each patient we collected pre and post T1-Gd MRI, tumor localization manually delineated in the pre-treatment MRI by medical experts, and survival information.

The emerging large language model role-playing agents (LLM RPAs) aim to simulate individual human behaviors, but the persona fidelity is often undermined by manually-created profiles (e.g., cherry-picked information and personality characteristics) without validating the alignment with the target individuals. To address this limitation, our work introduces the Dynamic Persona Refinement Framework (DPRF). DPRF aims to optimize the alignment of LLM RPAs' behaviors with those of target individuals by iteratively identifying the cognitive divergence, either through free-form or theory-grounded, structured analysis, between generated behaviors and human ground truth, and refining the persona profile to mitigate these divergences. We evaluate DPRF with five LLMs on four diverse behavior-prediction scenarios: formal debates, social media posts with mental health issues, public interviews, and movie reviews. DPRF can consistently improve behavioral alignment considerably over baseline personas and generalizes across models and scenarios. Our work provides a robust methodology for creating high-fidelity persona profiles and enhancing the validity of downstream applications, such as user simulation, social studies, and personalized AI.

Language is, as commonly theorized, largely arbitrary. Yet, systematic relationships between phonetics and semantics have been observed in many specific cases. To what degree could those systematic relationships manifest themselves in large scale, quantitative investigations--both in previously identified and unidentified phenomena? This work undertakes a distributional approach to quantifying phonosemantic iconicity at scale across 6 diverse languages (English, Spanish, Hindi, Finnish, Turkish, and Tamil). In each language, we analyze the alignment of morphemes' phonetic and semantic similarity spaces with a suite of statistical measures, and discover an array of interpretable phonosemantic alignments not previously identified in the literature, along with crosslinguistic patterns. We also analyze 5 previously hypothesized phonosemantic alignments, finding support for some such alignments and mixed results for others.

Is an LLM telling you different facts than it's telling me? This paper introduces ConsistencyAI, an independent benchmark for measuring the factual consistency of large language models (LLMs) for different personas. ConsistencyAI tests whether, when users of different demographics ask identical questions, the model responds with factually inconsistent answers. Designed without involvement from LLM providers, this benchmark offers impartial evaluation and accountability. In our experiment, we queried 19 LLMs with prompts that requested 5 facts for each of 15 topics. We repeated this query 100 times for each LLM, each time adding prompt context from a different persona selected from a subset of personas modeling the general population. We processed the responses into sentence embeddings, computed cross-persona cosine similarity, and computed the weighted average of cross-persona cosine similarity to calculate factual consistency scores. In 100-persona experiments, scores ranged from 0.9065 to 0.7896, and the mean was 0.8656, which we adopt as a benchmark threshold. xAI's Grok-3 is most consistent, while several lightweight models rank lowest. Consistency varies by topic: the job market is least consistent, G7 world leaders most consistent, and issues like vaccines or the Israeli-Palestinian conflict diverge by provider. These results show that both the provider and the topic shape the factual consistency. We release our code and interactive demo to support reproducible evaluation and encourage persona-invariant prompting strategies.

While Large Language Models (LLMs) have made agentic AI, chatbots, and other intelligent applications possible, they have also enabled the affordable creation of highly convincing AI-generated disinformation (Bontcheva et al., 2024), which poses a systemic risk to democratic stability and global security (VIGINUM, 2025; Bengio, 2025). Initially, AI-generated texts suffered from linguistic mistakes and thus were more easily detectable by humans. However, modern LLMs, particularly instruction-tuned models, have significantly improved in producing outputs which are indistinguishable from human-written text (Spitale et al., 2023; Heppell et al., 2024). These advances have resulted in their misuse in generating persuasive disinformation narratives, including political manipulation, health disinformation, conspiracy propagation, and Foreign Information Manipulation and Interference (FIMI) (Vykopal et al., 2024; Chen and Shu, 2024a; Barman et al., 2024; Chen and Shu, 2024b; Heppell et al., 2024; VIGINUM, 2025). While there is a growing body of research on the generation and detection of LLM-produced disinformation (Chen and Shu, 2024a; Lucas et al., 2023; Vykopal et al., 2024; Heppell et al., 2024), a critical aspect remains largely unstudied - namely, whether LLMs are capable of generating fluent and convincing personalised disinformation (i.e., disinformation narratives tailored to specific audiences) in multiple languages and at scale. The few prior studies on AIgenerated personalised disinformation are limited to English and address a very narrow set of personas (e.g., students, parents) (Zugecova et al., 2024). Crucially, prior work has not yet examined whether LLMs can adapt disinformation to country-specific linguistic and cultural contexts in multiple languages.

Knowledge of the medical decision process, which can be modeled as medical decision trees (MDTs), is critical to building clinical decision support systems. However, current MDT construction methods rely heavily on time-consuming and laborious manual annotation. To address this challenge, we propose PI-LoRA (Path-Integrated LoRA), a novel low-rank adaptation method for automatically extracting MDTs from clinical guidelines and textbooks. We integrate gradient path information to capture synergistic effects between different modules, enabling more effective and reliable rank allocation. This framework ensures that the most critical modules receive appropriate rank allocations while less important ones are pruned, resulting in a more efficient and accurate model for extracting medical decision trees from clinical texts. Extensive experiments on medical guideline datasets demonstrate that our PI-LoRA method significantly outperforms existing parameter-efficient fine-tuning approaches for the Text2MDT task, achieving better accuracy with substantially reduced model complexity. The proposed method achieves state-of-the-art results while maintaining a lightweight architecture, making it particularly suitable for clinical decision support systems where computational resources may be limited.

To effectively process impulse noise for narrowband powerline communications (NB-PLCs) transceivers, capturing comprehensive statistics of nonperiodic asynchronous impulsive noise (APIN) is a critical task. However, existing mathematical noise generative models only capture part of the characteristics of noise. In this study, we propose a novel generative adversarial network (GAN) called noise generation GAN (NGGAN) that learns the complicated characteristics of practically measured noise samples for data synthesis. To closely match the statistics of complicated noise over the NB-PLC systems, we measured the NB-PLC noise via the analog coupling and bandpass filtering circuits of a commercial NB-PLC modem to build a realistic dataset. To train NGGAN, we adhere to the following principles: 1) we design the length of input signals that the NGGAN model can fit to facilitate cyclostationary noise generation; 2) the Wasserstein distance is used as a loss function to enhance the similarity between the generated noise and training data; and 3) to measure the similarity performances of GAN-based models based on the mathematical and practically measured datasets, we conduct both quantitative and qualitative analyses. The training datasets include: 1) a piecewise spectral cyclostationary Gaussian model (PSCGM); 2) a frequency-shift (FRESH) filter; and 3) practical measurements from NB-PLC systems. Simulation results demonstrate that the generated noise samples from the proposed NGGAN are highly close to the real noise samples. The principal component analysis (PCA) scatter plots and Fréchet inception distance (FID) analysis have shown that NGGAN outperforms other GAN-based models by generating noise samples with superior fidelity and higher diversity.

Although large language models (LLMs) have revolutionized natural language processing capabilities, their practical implementation as autonomous multi-agent systems (MAS) for industrial problem-solving encounters persistent barriers. Conventional MAS architectures are fundamentally restricted by inflexible, hand-crafted graph topologies that lack contextual responsiveness, resulting in diminished efficacy across varied academic and commercial workloads. To surmount these constraints, we introduce AMAS, a paradigm-shifting framework that redefines LLM-based MAS through a novel dynamic graph designer. This component autonomously identifies task-specific optimal graph configurations via lightweight LLM adaptation, eliminating the reliance on monolithic, universally applied structural templates. Instead, AMAS exploits the intrinsic properties of individual inputs to intelligently direct query trajectories through task-optimized agent pathways. Rigorous validation across question answering, mathematical deduction, and code generation benchmarks confirms that AMAS systematically exceeds state-of-the-art single-agent and multi-agent approaches across diverse LLM architectures. Our investigation establishes that context-sensitive structural adaptability constitutes a foundational requirement for high-performance LLM MAS deployments.