Deep generative models have demonstrated remarkable success in medical image synthesis. However, ensuring conditioning faithfulness and high-quality synthetic images for direct or counterfactual generation remains a challenge. In this work, we introduce a cycle training framework to fine-tune diffusion models for improved conditioning adherence and enhanced synthetic image realism. Our approach, Cycle Diffusion Model (CDM), enforces consistency between generated and original images by incorporating cycle constraints, enabling more reliable direct and counterfactual generation. Experiments on a combined 3D brain MRI dataset (from ABCD, HCP aging & young adults, ADNI, and PPMI) show that our method improves conditioning accuracy and enhances image quality as measured by FID and SSIM. The results suggest that the cycle strategy used in CDM can be an effective method for refining diffusion-based medical image generation, with applications in data augmentation, counterfactual, and disease progression modeling.

Recommender systems (RS) greatly influence users' consumption decisions, making them attractive targets for malicious shilling attacks that inject fake user profiles to manipulate recommendations. Existing shilling methods can generate effective and stealthy fake profiles when training data only contain rating matrix, but they lack comprehensive solutions for scenarios where side features are present and utilized by the recommender. To address this gap, we extend the Leg-UP framework by enhancing the generator architecture to incorporate side features, enabling the generation of side-feature-aware fake user profiles. Experiments on benchmarks show that our method achieves strong attack performance while maintaining stealthiness.

Uncovering cause-and-effect mechanisms from data is fundamental to scientific progress. While large language models (LLMs) show promise for enhancing causal discovery (CD) from unstructured data, their application to the increasingly prevalent multimodal setting remains a critical challenge. Even with the advent of multimodal LLMs (MLLMs), their efficacy in multimodal CD is hindered by two primary limitations: (1) difficulty in exploring intra- and inter-modal interactions for comprehensive causal variable identification; and (2) insufficiency to handle structural ambiguities with purely observational data. To address these challenges, we propose MLLM-CD, a novel framework for multimodal causal discovery from unstructured data. It consists of three key components: (1) a novel contrastive factor discovery module to identify genuine multimodal factors based on the interactions explored from contrastive sample pairs; (2) a statistical causal structure discovery module to infer causal relationships among discovered factors; and (3) an iterative multimodal counterfactual reasoning module to refine the discovery outcomes iteratively by incorporating the world knowledge and reasoning capabilities of MLLMs. Extensive experiments on both synthetic and real-world datasets demonstrate the effectiveness of the proposed MLLM-CD in revealing genuine factors and causal relationships among them from multimodal unstructured data.

Unfolding networks are interpretable networks emerging from iterative algorithms, incorporate prior knowledge of data structure, and are designed to solve inverse problems like compressed sensing, which deals with recovering data from noisy, missing observations. Compressed sensing finds applications in critical domains, from medical imaging to cryptography, where adversarial robustness is crucial to prevent catastrophic failures. However, a solid theoretical understanding of the performance of unfolding networks in the presence of adversarial attacks is still in its infancy. In this paper, we study the adversarial generalization of unfolding networks when perturbed with $l_2$-norm constrained attacks, generated by the fast gradient sign method. Particularly, we choose a family of state-of-the-art overaparameterized unfolding networks and deploy a new framework to estimate their adversarial Rademacher complexity. Given this estimate, we provide adversarial generalization error bounds for the networks under study, which are tight with respect to the attack level. To our knowledge, this is the first theoretical analysis on the adversarial generalization of unfolding networks. We further present a series of experiments on real-world data, with results corroborating our derived theory, consistently for all data. Finally, we observe that the family's overparameterization can be exploited to promote adversarial robustness, shedding light on how to efficiently robustify neural networks.

The growing popularity of robotic minimally invasive surgeries has made deep learning-based surgical training a key area of research. A thorough understanding of the surgical scene components is crucial, which semantic segmentation models can help achieve. However, most existing work focuses on surgical tools and overlooks anatomical objects. Additionally, current state-of-the-art (SOT A) models struggle to balance capturing high-level contextual features and low-level edge features. We propose a Feature-Adaptive Spatial Localization model (FASL-Seg), designed to capture features at multiple levels of detail through two distinct processing streams, namely a Low-Level Feature Projection (LLFP) and a High-Level Feature Projection (HLFP) stream, for varying feature resolutions - enabling precise segmentation of anatomy and surgical instruments. We evaluated FASL-Seg on surgical segmentation benchmark datasets EndoVis18 and EndoVis17 on three use cases. The FASL-Seg model achieves a mean Intersection over Union (mIoU) of 72.71% on parts and anatomy segmentation in EndoVis18, improving on SOT A by 5%. It further achieves a mIoU of 85.61% and 72.78% in EndoVis18 and EndoVis17 tool type segmentation, respectively, outperforming SOT A overall performance, with comparable per-class SOT A results in both datasets and consistent performance in various classes for anatomy and instruments, demonstrating the effectiveness of distinct processing streams for varying feature resolutions.

Context: Predicting human trajectories is crucial for the safety and reliability of autonomous systems, such as automated vehicles and mobile robots. However, rigorously testing the underlying multimodal Human Trajectory Prediction (HTP) models, which typically use multiple input sources (e.g., trajectory history and environment maps) and produce stochastic outputs (multiple possible future paths), presents significant challenges. The primary difficulty lies in the absence of a definitive test oracle, as numerous future trajectories might be plausible for any given scenario. Objectives: This research presents the application of Metamorphic Testing (MT) as a systematic methodology for testing multimodal HTP systems. We address the oracle problem through metamorphic relations (MRs) adapted for the complexities and stochastic nature of HTP. Methods: We present five MRs, targeting transformations of both historical trajectory data and semantic segmentation maps used as an environmental context. These MRs encompass: 1) label-preserving geometric transformations (mirroring, rotation, rescaling) applied to both trajectory and map inputs, where outputs are expected to transform correspondingly. 2) Map-altering transformations (changing semantic class labels, introducing obstacles) with predictable changes in trajectory distributions. We propose probabilistic violation criteria based on distance metrics between probability distributions, such as the Wasserstein or Hellinger distance. Conclusion: This study introduces tool, a MT framework for the oracle-less testing of multimodal, stochastic HTP systems. It allows for assessment of model robustness against input transformations and contextual changes without reliance on ground-truth trajectories.

We study how prompt-level inductive biases influence the cognitive behavior of large language models (LLMs) in instructional dialogue. We introduce a symbolic scaffolding method paired with a short-term memory schema designed to promote adaptive, structured reasoning in Socratic tutoring. Using controlled ablation across five system variants, we evaluate model outputs via expert-designed rubrics covering scaffolding, responsiveness, symbolic reasoning, and conversational memory. We present preliminary results using an LLM-based evaluation framework aligned to a cognitively grounded rubric. This enables scalable, systematic comparisons across architectural variants in early-stage experimentation. The preliminary results show that our full system consistently outperforms baseline variants. Analysis reveals that removing memory or symbolic structure degrades key cognitive behaviors, including abstraction, adaptive probing, and conceptual continuity. These findings support a processing-level account in which prompt-level cognitive scaffolds can reliably shape emergent instructional strategies in LLMs.

We propose Collab-REC, a multi-agent framework designed to counteract popularity bias and enhance diversity in tourism recommendations. In our setting, three LLM-based agents -- Personalization, Popularity, and Sustainability generate city suggestions from complementary perspectives. A non-LLM moderator then merges and refines these proposals via multi-round negotiation, ensuring each agent's viewpoint is incorporated while penalizing spurious or repeated responses. Experiments on European city queries show that Collab-REC improves diversity and overall relevance compared to a single-agent baseline, surfacing lesser-visited locales that often remain overlooked. This balanced, context-aware approach addresses over-tourism and better aligns with constraints provided by the user, highlighting the promise of multi-stakeholder collaboration in LLM-driven recommender systems.

Drug-drug interactions pose a significant challenge in clinical pharmacology, with severe class imbalance among interaction types limiting the effectiveness of predictive models. Common interactions dominate datasets, while rare but critical interactions remain underrepre-sented, leading to poor model performance on infrequent cases. Existing methods often treat DDI prediction as a binary problem, ignoring class-specific nuances and exacerbating bias toward frequent interactions. To address this, we propose a framework combining Generative Flow Networks (GFlowNet) with Variational Graph Autoencoders (VGAE) to generate synthetic samples for rare classes, improving model balance and generate effective and novel DDI pairs. Our approach enhances predictive performance across interaction types, ensuring better clinical reliability.

Accurate and robust indoor localization is critical for smart building applications, yet existing Wi-Fi-based systems are often vulnerable to environmental conditions. This work presents a novel indoor localization system, called LiGen, that leverages the spectral intensity patterns of ambient light as fingerprints, offering a more stable and infrastructure-free alternative to radio signals. To address the limited spectral data, we design a data augmentation framework based on generative adversarial networks (GANs), featuring two variants: PointGAN, which generates fingerprints conditioned on coordinates, and FreeGAN, which uses a weak localization model to label unconditioned samples. Our positioning model, leveraging a Multi-Layer Perceptron (MLP) architecture to train on synthesized data, achieves submeter-level accuracy, outperforming Wi-Fi-based baselines by over 50\%. LiGen also demonstrates strong robustness in cluttered environments. To the best of our knowledge, this is the first system to combine spectral fingerprints with GAN-based data augmentation for indoor localization.