Before deploying an AI system to replace an existing process, it must be compared with the incumbent to ensure improvement without added risk. Traditional evaluation relies on ground truth for both systems, but this is often unavailable due to delayed or unknowable outcomes, high costs, or incomplete data, especially for long-standing systems deemed safe by convention. The more practical solution is not to compute absolute risk but the difference between systems. We therefore propose a marginal risk assessment framework, that avoids dependence on ground truth or absolute risk. It emphasizes three kinds of relative evaluation methodology, including predictability, capability and interaction dominance. By shifting focus from absolute to relative evaluation, our approach equips software teams with actionable guidance: identifying where AI enhances outcomes, where it introduces new risks, and how to adopt such systems responsibly.

While most recent 3DGS-based SLAM works focus on small-scale indoor scenes, developing 3DGS-based SLAM methods for large-scale forest scenes holds great potential for many real-world applications, especially for wildfire emergency response and forest management. However, this line of research is impeded by the absence of a comprehensive and high-quality dataset, and collecting such a dataset over real-world scenes is costly and technically infeasible. To this end, we have built a large-scale, comprehensive, and high-quality synthetic dataset for SLAM in wildfire and forest environments. Leveraging the Unreal Engine 5 Electric Dreams Environment Sample Project, we developed a pipeline to easily collect aerial and ground views, including ground-truth camera poses and a range of additional data modalities from unmanned aerial vehicle. Our pipeline also provides flexible controls on environmental factors such as light, weather, and types and conditions of wildfire, supporting the need for various tasks covering forest mapping, wildfire emergency response, and beyond. The resulting pilot dataset, WildfireX-SLAM, contains 5.5k low-altitude RGB-D aerial images from a large-scale forest map with a total size of 16 km . On top of WildfireX-SLAM, a thorough benchmark is also conducted, which not only reveals the unique challenges of 3DGS-based SLAM in the forest but also highlights potential improvements for future works. The dataset and code will be publicly available.

Exploring the Utilities of the Rationales from Large Language Models to Enhance Automated Essay Scoring Hong Jiao University of Maryland, College Park Hanna Choi University of Maryland, College Park Haowei Hua Princeton University Abstract This study explored the utilities of rationales generated by GPT-4.1 and GPT -5 in automated scoring using Prompt 6 essays from the 2012 Kaggle ASAP data . Essay-based scoring was compared with rationale-based scoring. The study found in general essay -based scoring performed better than rationale -based scoring with higher Quadratic Weighted Kappa (QWK). However, rationale-based scoring led to higher scoring accuracy in terms of F1 scores for score 0 which had less representation due to class imbalance issues . The ensemble modeling of essay-based scoring models increased the scoring accuracy at both specific score levels and across all score levels. The ensemble modeling of essay -based scoring and each of the rationale-based scoring performed about the same. Further ensemble of essay -based scoring and both rationale-based scoring yielded the best scoring accuracy with QWK of 0.870 compared with 0.848 reported in literature. Introduction Automated essay scoring methodology develops along with the advances in AI technology. Starting from the early supervised machine learning models based on engineered features ( e.g., Mahana et al., 2012) to recent use of large language models (LLMs), the methods for automated essay scoring as demonstrated in Appendix A evolved with the advances in machine learning, deep learning, language models, and LLMs. Using automated scoring of Prompt 6 in the Automated Student Assessment Prize (ASAP) dataset from Kaggle, this study intends to explore the utility of rationales generated by LLMs in enhancing automated essay scoring. For the ASAP Prompt 6, automated scoring models have been developed since 2012 after the Kaggle competition.

Artificial intelligence (AI) agents are emerging as transformative tools in drug discovery, with the ability to autonomously reason, act, and learn through complicated research workflows. Building on large language models (LLMs) coupled with perception, computation, action, and memory tools, these agentic AI systems could integrate diverse biomedical data, execute tasks, carry out experiments via robotic platforms, and iteratively refine hypotheses in closed loops. We provide a conceptual and technical overview of agentic AI architectures, ranging from ReAct and Reflection to Supervisor and Swarm systems, and illustrate their applications across key stages of drug discovery, including literature synthesis, toxicity prediction, automated protocol generation, small-molecule synthesis, drug repurposing, and end-to-end decision-making. To our knowledge, this represents the first comprehensive work to present real-world implementations and quantifiable impacts of agentic AI systems deployed in operational drug discovery settings. Early implementations demonstrate substantial gains in speed, reproducibility, and scalability, compressing workflows that once took months into hours while maintaining scientific traceability. We discuss the current challenges related to data heterogeneity, system reliability, privacy, and benchmarking, and outline future directions towards technology in support of science and translation.

Recent advances in neural decoding have enabled the reconstruction of visual experiences from brain activity, positioning fMRI-to-image reconstruction as a promising bridge between neuroscience and computer vision. However, current methods predominantly rely on subject-specific models or require subject-specific fine-tuning, limiting their scalability and real-world applicability. In this work, we introduce ZEBRA, the first zero-shot brain visual decoding framework that eliminates the need for subject-specific adaptation. ZEBRA is built on the key insight that fMRI representations can be decomposed into subject-related and semantic-related components. By leveraging adversarial training, our method explicitly disentangles these components to isolate subject-invariant, semantic-specific representations. This disentanglement allows ZEBRA to generalize to unseen subjects without any additional fMRI data or retraining. Extensive experiments show that ZEBRA significantly outperforms zero-shot baselines and achieves performance comparable to fully finetuned models on several metrics. Our work represents a scalable and practical step toward universal neural decoding. Code and model weights are available at: https://github.com/xmed-lab/ZEBRA.

As Natural Language Generation (NLG) continues to be widely adopted, properly assessing it has become quite difficult. Lately, using large language models (LLMs) for evaluating these generations has gained traction, as they tend to align more closely with human preferences than conventional n-gram or embedding-based metrics. In our experiments, we show that LLM judges have low intra-rater reliability in their assigned scores across different runs. This variance makes their ratings inconsistent, almost arbitrary in the worst case, making it difficult to measure how good their judgments actually are. We quantify this inconsistency across different NLG tasks and benchmarks and see if judicious use of LLM judges can still be useful following proper guidelines.

Aggregating intracranial recordings across subjects is challenging since electrode count, placement, and covered regions vary widely. Spatial normalization methods like MNI coordinates offer a shared anatomical reference, but often fail to capture true functional similarity, particularly when localization is imprecise; even at matched anatomical coordinates, the targeted brain region and underlying neural dynamics can differ substantially between individuals. We propose a scalable representation-learning framework that (i) learns a subject-agnostic functional identity for each electrode from multi-region local field potentials using a Siamese encoder with contrastive objectives, inducing an embedding geometry that is locality-sensitive to region-specific neural signatures, and (ii) tokenizes these embeddings for a transformer that models inter-regional relationships with a variable number of channels. We evaluate this framework on a 20-subject dataset spanning basal ganglia-thalamic regions collected during flexible rest/movement recording sessions with heterogeneous electrode layouts. The learned functional space supports accurate within-subject discrimination and forms clear, region-consistent clusters; it transfers zero-shot to unseen channels. The transformer, operating on functional tokens without subject-specific heads or supervision, captures cross-region dependencies and enables reconstruction of masked channels, providing a subject-agnostic backbone for downstream decoding. Together, these results indicate a path toward large-scale, cross-subject aggregation and pretrain-ing for intracranial neural data where strict task structure and uniform sensor placement are unavailable. Building models that generalize across subjects in neuroscience requires representations that remain stable despite variability in data acquisition. Intracranial neural recordings lack this stability: electrode locations, counts, sampling, and coverage differ across individuals, reflecting clinical needs rather than standardized layouts. Without a shared representational system, cross-subject aggregation is unreliable, limiting scalable modeling and clinical translation. Such recordings are uniquely valuable for studying inter-regional communication, yet their heterogeneity makes them especially challenging to align. In practice, two obstacles dominate: Anatomical variability and inconsistent electrode coverage.

Safety guardrails in large language models(LLMs) are developed to prevent malicious users from generating toxic content at a large scale. However, these measures can inadvertently introduce or reflect new biases, as LLMs may refuse to generate harmful content targeting some demographic groups and not others. We explore this selective refusal bias in LLM guardrails through the lens of refusal rates of targeted individual and intersectional demographic groups, types of LLM responses, and length of generated refusals. Our results show evidence of selective refusal bias across gender, sexual orientation, nationality, and religion attributes. This leads us to investigate additional safety implications via an indirect attack, where we target previously refused groups. Our findings emphasize the need for more equitable and robust performance in safety guardrails across demographic groups.

Security applications are increasingly relying on large language models (LLMs) for cyber threat detection; however, their opaque reasoning often limits trust, particularly in decisions that require domain-specific cybersecurity knowledge. Because security threats evolve rapidly, LLMs must not only recall historical incidents but also adapt to emerging vulnerabilities and attack patterns. Retrieval-Augmented Generation (RAG) has demonstrated effectiveness in general LLM applications, but its potential for cybersecurity remains underexplored. In this work, we introduce a RAG-based framework designed to contextualize cybersecurity data and enhance LLM accuracy in knowledge retention and temporal reasoning. Using external datasets and the Llama-3-8B-Instruct model, we evaluate baseline RAG, an optimized hybrid retrieval approach, and conduct a comparative analysis across multiple performance metrics. Our findings highlight the promise of hybrid retrieval in strengthening the adaptability and reliability of LLMs for cybersecurity tasks.

This paper addresses the limitations of large-scale language models in safety alignment and robustness by proposing a fine-tuning method that combines contrastive distillation with noise-robust training. The method freezes the backbone model and transfers the knowledge boundaries of the teacher model to the student model through distillation, thereby improving semantic consistency and alignment accuracy. At the same time, noise perturbations and robust optimization constraints are introduced during training to ensure that the model maintains stable predictive outputs under noisy and uncertain inputs. The overall framework consists of distillation loss, robustness loss, and a regularization term, forming a unified optimization objective that balances alignment ability with resistance to interference. To systematically validate its effectiveness, the study designs experiments from multiple perspectives, including distillation weight sensitivity, stability analysis under computation budgets and mixed-precision environments, and the impact of data noise and distribution shifts on model performance. Results show that the method significantly outperforms existing baselines in knowledge transfer, robustness, and overall safety, achieving the best performance across several key metrics. This work not only enriches the theoretical system of parameter-efficient fine-tuning but also provides a new solution for building safer and more trustworthy alignment mechanisms.