Time-series forecasting increasingly demands not only accurate observational predictions but also causal forecasting under interventional and counterfactual queries in multivariate systems. We present DoFlow, a flow based generative model defined over a causal DAG that delivers coherent observational and interventional predictions, as well as counterfactuals through the natural encoding and decoding mechanism of continuous normalizing flows (CNFs). We also provide a supporting counterfactual recovery result under certain assumptions. Beyond forecasting, DoFlow provides explicit likelihoods of future trajectories, enabling principled anomaly detection. Experiments on synthetic datasets with various causal DAG and real world hydropower and cancer treatment time series show that DoFlow achieves accurate system-wide observational forecasting, enables causal forecasting over interventional and counterfactual queries, and effectively detects anomalies. This work contributes to the broader goal of unifying causal reasoning and generative modeling for complex dynamical systems.

Objectives: Unsupervised learning with electronic health record (EHR) data has shown promise for phenotype discovery, but approaches typically disregard existing clinical information, limiting interpretability. We operationalize a Bayesian latent class framework for phenotyping that incorporates domain-specific knowledge to improve clinical meaningfulness of EHR-derived phenotypes and illustrate its utility by identifying an asthma sub-phenotype informed by features of Type 2 (T2) inflammation. Materials and methods: We illustrate a framework for incorporating clinical knowledge into a Bayesian latent class model via informative priors to guide unsupervised clustering toward clinically relevant subgroups. This approach models missingness, accounting for potential missing-not-at-random patterns, and provides patient-level probabilities for phenotype assignment with uncertainty. Using reusable and flexible code, we applied the model to a large asthma EHR cohort, specifying informative priors for T2 inflammation-related features and weakly informative priors for other clinical variables, allowing the data to inform posterior distributions. Results and Conclusion: Using encounter data from January 2017 to February 2024 for 44,642 adult asthma patients, we found a bimodal posterior distribution of phenotype assignment, indicating clear class separation. The T2 inflammation-informed class (38.7%) was characterized by elevated eosinophil levels and allergy markers, plus high healthcare utilization and medication use, despite weakly informative priors on the latter variables. These patterns suggest an "uncontrolled T2-high" sub-phenotype. This demonstrates how our Bayesian latent class modeling approach supports hypothesis generation and cohort identification in EHR-based studies of heterogeneous diseases without well-established phenotype definitions.

Children will be taught how to budget and how mortgages work as the government seeks to modernise the national curriculum in England's schools. They will also be taught how to spot fake news and disinformation, including AI-generated content, following the first review of what is taught in schools in over a decade. Education Secretary Bridget Phillipson said the government wanted to revitalise the curriculum but keep a firm foundation in basics like English, maths and reading. Head teachers said the review's recommendations were sensible but would require sufficient funding and teachers. The government commissioned a review of the national curriculum and assessments in England last year, in the hope of developing a cutting edge curriculum that would narrow attainment gaps between the most disadvantaged students and their classmates.

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AMANDA PLATELL: Fergie's delusions have reached a new low. I can't believe Beatrice and Eugenie are egging her on. Wake up and see he's the master of the dark arts: MEGYN KELLY blows the lid on the REAL Mamdani... how are they missing this? 'Screaming' Sydney Sweeney'hates' that she was caught hiding in ex-fiancé's car: Now insiders spill truth about backseat rendezvous and lingering'frustrations' Karoline Leavitt warns'short of planes falling out of the sky' Democrats won't reopen government Donald Trump's adopted hometown is set to name its airport after the president Now he's dead, here's the full story of what happened that day... and the ghastly aftermath no one knows about Bella Thorne continues swimsuit season as she works sexy bikini for Los Cabo trip with her'love' Mark Emms Why Tuesday's races aren't as close as you think: White House analyst CRAIG KESHISHIAN reveals what the polls always miss She took my son... now I'm exposing the secrets she's hidden from the world Big Short star Michael Burry's $1BILLION bet against tech giants shakes markets: 'We've seen this movie before' The murder that haunts the Kennedys: Martha Moxley's loved ones reveal their truth in the FREE The Crime Desk newsletter... as accused cousin cleared in killing breaks cover Boy George's vile attack on lesbian banned by LA gym for confronting'transgender patron who stared at her while she was naked in locker room' Diddy's male prison protector unmasked: How disgraced mogul has repaid him... and turned to God for repentance US spy jet spotted patrolling cartel stronghold off Mexico's coast for hours The US Navy's P-8 Poseidon, an aircraft designed for anti-submarine warfare, surveillance, and reconnaissance, was spotted circling a drug-smuggling hub off Mexico's coast. On Tuesday, flight trackers recorded the jet performing multiple loops miles offshore from Tijuana, a city long plagued by violent organized crime and considered a major corridor for cartel operations. The P-8 took off from the Naval Air Station Whidbey Island in Washington, flew through Oregon and through California .

A supermassive black hole's star snack lit up the cosmos like never before. This artist's concept depicts a supermassive black hole in the process of shredding a massive star--at least 30 times the mass of our Sun--to pieces. Scientists propose this is what happened around the distant black hole referred to as J2245+3743, which in 2018, brightened dramatically to create the brightest black hole flare ever recorded, shining with the light of 10 trillion suns. Breakthroughs, discoveries, and DIY tips sent every weekday. It's hard to wrap your head around the fundamentals of a black hole .

The US company says putting AI processors in space would ease pressure on the Earth's resources. The US company says putting AI processors in space would ease pressure on the Earth's resources. US technology company's engineers want to exploit solar power and the falling cost of rocket launches Google is hatching plans to put artificial intelligence datacentres into space, with its first trial equipment sent into orbit in early 2027. Its scientists and engineers believe tightly packed constellations of about 80 solar-powered satellites could be arranged in orbit about 400 miles above the Earth's surface equipped with the powerful processors required to meet rising demand for AI. Prices of space launches are falling so quickly that by the middle of the 2030s the running costs of a space-based datacentre could be comparable to one on Earth, according to Google research released on Tuesday.

Ukrainian President Volodymyr Zelensky says he has visited troops near the town of Pokrovsk, where the fiercest front line battle between Russia and Ukraine is currently taking place. Zelensky posted photos showing him meeting personnel at a command post in the Dobropillya sector, some 20km (12 miles) north of Pokrovsk in the Donetsk region. Kyiv's top military commander, Oleksandr Syrskiy, said on Monday that Ukraine was increasing pressure on the Dobropillya front to force the enemy to disperse its forces and make it impossible to concentrate their main efforts in the Pokrovsk area. Russia has been trying to seize Pokrovsk - a strategic frontline town and logistic hub - for over a year. Although it has taken them months to approach the town's borders, Russian soldiers have now infiltrated it and on Friday, Zelensky said Russia had amassed 170,000 troops on its outskirts.

Poachers kill over 20,000 African elephants every year for their ivory. Breakthroughs, discoveries, and DIY tips sent every weekday. The California Department of Fish and Wildlife (CDFW) recently broke up an alleged illegal poaching front in Los Angeles County. According to the department, thousands of elephant ivory pieces along with multiple "large, intricately carved tusks," a sea turtle shell, and at least nine rhinoceros horns were confiscated from an unnamed business. "The global demand for ivory and rhino horn fuels poaching and organized crime," CDFW Deputy Director and Chief of Law Enforcement Nathaniel Arnold said in a statement, adding that these and other operations "send a clear message" to black market vendors.

A new ghost-tapping scam has caused victims to lose up to $1,000 as scammers use handheld card readers to steal from contactless payment systems nationwide.