TGPT is designed to understand and generate transaction trajectories while simultaneously supporting a variety of downstream prediction and classification tasks. We introduce a novel 3D-Transformer architecture specifically tailored for capturing the complex dynamics in payment transaction data. This architecture incorporates design innovations that enhance modality fusion and computational efficiency, while seamlessly enabling joint optimization with downstream objectives. Trained on billion-scale real-world transactions, TGPT significantly improves downstream classification performance against a competitive production model and exhibits advantages over baselines in generating future transactions. We conduct extensive empirical evaluations utilizing a diverse collection of company transaction datasets spanning multiple downstream tasks, thereby enabling a thorough assessment of TGPT's effectiveness and efficiency in comparison to established methodologies. Furthermore, we examine the incorporation of LLM-derived embeddings within TGPT and benchmark its performance against fine-tuned LLMs, demonstrating that TGPT achieves superior predictive accuracy as well as faster training and inference. We anticipate that the architectural innovations and practical guidelines from this work will advance foundation models for transaction-like data and catalyze future research in this emerging field.

With the deepening of digital transformation, business process optimisation has become the key to improve the competitiveness of enterprises. This study constructs a business process optimisation model integrating artificial intelligence and big data to achieve intelligent management of the whole life cycle of processes. The model adopts a three-layer architecture incorporating data processing, AI algorithms, and business logic to enable real-time process monitoring and optimization. Through distributed computing and deep learning techniques, the system can handle complex business scenarios while maintaining high performance and reliability. Experimental validation across multiple enterprise scenarios shows that the model shortens process processing time by 42%, improves resource utilisation by 28%, and reduces operating costs by 35%. The system maintained 99.9% availability under high concurrent loads. The research results have important theoretical and practical value for promoting the digital transformation of enterprises, and provide new ideas for improving the operational efficiency of enterprises.

The inference latency of diffusion models remains a critical barrier to their real-time application. While trajectory-based and distribution-based step distillation methods offer solutions, they present a fundamental trade-off. Trajectory-based methods preserve global structure but act as a "lossy compressor", sacrificing high-frequency details. Conversely, distribution-based methods can achieve higher fidelity but often suffer from mode collapse and unstable training. This paper recasts them from independent paradigms into synergistic components within our novel Hierarchical Distillation (HD) framework. We leverage trajectory distillation not as a final generator, but to establish a structural ``sketch", providing a near-optimal initialization for the subsequent distribution-based refinement stage. This strategy yields an ideal initial distribution that enhances the ceiling of overall performance. To further improve quality, we introduce and refine the adversarial training process. We find standard discriminator structures are ineffective at refining an already high-quality generator. To overcome this, we introduce the Adaptive Weighted Discriminator (AWD), tailored for the HD pipeline. By dynamically allocating token weights, AWD focuses on local imperfections, enabling efficient detail refinement. Our approach demonstrates state-of-the-art performance across diverse tasks. On ImageNet $256\times256$, our single-step model achieves an FID of 2.26, rivaling its 250-step teacher. It also achieves promising results on the high-resolution text-to-image MJHQ benchmark, proving its generalizability. Our method establishes a robust new paradigm for high-fidelity, single-step diffusion models.

Multi-agent multi-objective systems (MAMOS) have emerged as powerful frameworks for modelling complex decision-making problems across various real-world domains, such as robotic exploration, autonomous traffic management, and sensor network optimisation. MAMOS offers enhanced scalability and robustness through decentralised control and more accurately reflects inherent trade-offs between conflicting objectives. In MAMOS, each agent uses utility functions that map return vectors to scalar values. Existing MAMOS optimisation methods face challenges in handling heterogeneous objective and utility function settings, where training non-stationarity is intensified due to private utility functions and the associated policies. In this paper, we first theoretically prove that direct access to, or structured modeling of, global utility functions is necessary for the Bayesian Nash Equilibrium under decentralised execution constraints. To access the global utility functions while preserving the decentralised execution, we propose an Agent-Attention Multi-Agent Multi-Objective Reinforcement Learning (AA-MAMORL) framework. Our approach implicitly learns a joint belief over other agents' utility functions and their associated policies during centralised training, effectively mapping global states and utilities to each agent's policy. In execution, each agent independently selects actions based on local observations and its private utility function to approximate a BNE, without relying on inter-agent communication. We conduct comprehensive experiments in both a custom-designed MAMO Particle environment and the standard MOMALand benchmark. The results demonstrate that access to global preferences and our proposed AA-MAMORL significantly improve performance and consistently outperform state-of-the-art methods.

In offline reinforcement learning, value overestimation caused by out-of-distribution (OOD) actions significantly limits policy performance. Recently, diffusion models have been leveraged for their strong distribution-matching capabilities, enforcing conservatism through behavior policy constraints. However, existing methods often apply indiscriminate regularization to redundant actions in low-quality datasets, resulting in excessive conservatism and an imbalance between the expressiveness and efficiency of diffusion modeling. To address these issues, we propose DIffusion policies with Value-conditional Optimization (DIVO), a novel approach that leverages diffusion models to generate high-quality, broadly covered in-distribution state-action samples while facilitating efficient policy improvement. Specifically, DIVO introduces a binary-weighted mechanism that utilizes the advantage values of actions in the offline dataset to guide diffusion model training. This enables a more precise alignment with the dataset's distribution while selectively expanding the boundaries of high-advantage actions. During policy improvement, DIVO dynamically filters high-return-potential actions from the diffusion model, effectively guiding the learned policy toward better performance. This approach achieves a critical balance between conservatism and explorability in offline RL. We evaluate DIVO on the D4RL benchmark and compare it against state-of-the-art baselines. Empirical results demonstrate that DIVO achieves superior performance, delivering significant improvements in average returns across locomotion tasks and outperforming existing methods in the challenging AntMaze domain, where sparse rewards pose a major difficulty.

Background: Identifying new indications for approved drugs is a complex and time-consuming process that requires extensive knowledge of pharmacology, clinical data, and advanced computational methods. Recently, deep learning (DL) methods have shown their capability for the accurate prediction of drug repositioning. However, implementing DL-based modeling requires in-depth domain knowledge and proficient programming skills. Results: In this application, we introduce DeepDR, the first integrated platform that combines a variety of established DL-based models for disease- and target-specific drug repositioning tasks. DeepDR leverages invaluable experience to recommend candidate drugs, which covers more than 15 networks and a comprehensive knowledge graph that includes 5.9 million edges across 107 types of relationships connecting drugs, diseases, proteins/genes, pathways, and expression from six existing databases and a large scientific corpus of 24 million PubMed publications. Additionally, the recommended results include detailed descriptions of the recommended drugs and visualize key patterns with interpretability through a knowledge graph. Conclusion: DeepDR is free and open to all users without the requirement of registration. We believe it can provide an easy-to-use, systematic, highly accurate, and computationally automated platform for both experimental and computational scientists.

Unsupervised remote sensing change detection aims to monitor and analyze changes from multi-temporal remote sensing images in the same geometric region at different times, without the need for labeled training data. Previous unsupervised methods attempt to achieve style transfer across multi-temporal remote sensing images through reconstruction by a generator network, and then capture the unreconstructable areas as the changed regions. However, it often leads to poor performance due to generator overfitting. In this paper, we propose a novel Consistency Change Detection Framework (CCDF) to address this challenge. Specifically, we introduce a Cycle Consistency (CC) module to reduce the overfitting issues in the generator-based reconstruction. Additionally, we propose a Semantic Consistency (SC) module to enable detail reconstruction. Extensive experiments demonstrate that our method outperforms other state-of-the-art approaches.

Glioblastoma (GBM) is the most common aggressive, fast-growing brain tumor, with a grim prognosis. Despite clinical diagnostic advancements, there have not been any substantial improvements to patient prognosis. Histopathological assessment of excised tumors is the first line of clinical diagnostic routine. We hypothesize that automated, robust, and accurate identification of distinct histological sub-regions within GBM could contribute to morphologically understanding this disease at scale. In this study, we designed a four-step deep learning approach to classify six (6) histopathological regions and quantitatively evaluated it on the BraTS-Path 2024 challenge dataset, which includes digitized Hematoxylin \& Eosin (H\&E) stained GBM tissue sections annotated for six distinct regions. We used the challenge's publicly available training dataset to develop and evaluate the effectiveness of several variants of EfficientNet architectures (i.e., B0, B1, B2, B3, B4). EfficientNet-B1 and EfficientNet-B4 achieved the best performance, achieving an F1 score of 0.98 in a 5-fold cross-validation configuration using the BraTS-Path training set. The quantitative performance evaluation of our proposed approach with EfficientNet-B1 on the BraTS-Path hold-out validation data and the final hidden testing data yielded F1 scores of 0.546 and 0.517, respectively, for the associated 6-class classification task. The difference in the performance on training, validation, and testing data highlights the challenge of developing models that generalize well to new data, which is crucial for clinical applications. The source code of the proposed approach can be found at the GitHub repository of Indiana University Division of Computational Pathology: https://github.com/IUCompPath/brats-path-2024-enet.

We introduce Lumine, the first open recipe for developing generalist agents capable of completing hours-long complex missions in real time within challenging 3D open-world environments. Lumine adopts a human-like interaction paradigm that unifies perception, reasoning, and action in an end-to-end manner, powered by a vision-language model. It processes raw pixels at 5 Hz to produce precise 30 Hz keyboard-mouse actions and adaptively invokes reasoning only when necessary. Trained in Genshin Impact, Lumine successfully completes the entire five-hour Mondstadt main storyline on par with human-level efficiency and follows natural language instructions to perform a broad spectrum of tasks in both 3D open-world exploration and 2D GUI manipulation across collection, combat, puzzle-solving, and NPC interaction. In addition to its in-domain performance, Lumine demonstrates strong zero-shot cross-game generalization. Without any fine-tuning, it accomplishes 100-minute missions in Wuthering Waves and the full five-hour first chapter of Honkai: Star Rail. These promising results highlight Lumine's effectiveness across distinct worlds and interaction dynamics, marking a concrete step toward generalist agents in open-ended environments.

Hypothesis generation in biomedical research has traditionally centered on uncovering hidden relationships within vast scientific literature, often using methods like Literature-Based Discovery (LBD). Despite progress, current approaches typically depend on single data types or predefined extraction patterns, which restricts the discovery of novel and complex connections. Recent advances in Large Language Model (LLM) agents show significant potential, with capabilities in information retrieval, reasoning, and generation. However, their application to biomedical hypothesis generation has been limited by the absence of standardized datasets and execution environments. To address this, we introduce BioVerge, a comprehensive benchmark, and BioVerge Agent, an LLM-based agent framework, to create a standardized environment for exploring biomedical hypothesis generation at the frontier of existing scientific knowledge. Our dataset includes structured and textual data derived from historical biomedical hypotheses and PubMed literature, organized to support exploration by LLM agents. BioVerge Agent utilizes a ReAct-based approach with distinct Generation and Evaluation modules that iteratively produce and self-assess hypothesis proposals. Through extensive experimentation, we uncover key insights: 1) different architectures of BioVerge Agent influence exploration diversity and reasoning strategies; 2) structured and textual information sources each provide unique, critical contexts that enhance hypothesis generation; and 3) self-evaluation significantly improves the novelty and relevance of proposed hypotheses.