12-lead ECGs with high sampling frequency are the clinical gold standard for arrhythmia detection, but their short-term, spot-check nature often misses intermittent events. Wearable ECGs enable long-term monitoring but suffer from irregular, lower sampling frequencies due to battery constraints, making morphology analysis challenging. We present an end-to-end classification pipeline to address these issues. We train a latent ODE to model continuous ECG waveforms and create robust feature vectors from high-frequency single-channel signals. We construct three latent vectors per waveform via downsampling the initial 360 Hz ECG to 90 Hz and 45 Hz. We then use a gradient boosted tree to classify these vectors and test robustness across frequencies. Performance shows minimal degradation, with macro-averaged AUC-ROC values of 0.984, 0.978, and 0.976 at 360 Hz, 90 Hz, and 45 Hz, respectively, suggesting a way to sidestep the trade-off between signal fidelity and battery life. This enables smaller wearables, promoting long-term monitoring of cardiac health.

Detecting trajectory anomalies is a vital task in modern Intelligent Transportation Systems (ITS), enabling the identification of unsafe, inefficient, or irregular travel behaviours. While deep learning has emerged as the dominant approach, several key challenges remain unresolved. First, sub-trajectory anomaly detection, capable of pinpointing the precise segments where anomalies occur, remains underexplored compared to whole-trajectory analysis. Second, many existing methods depend on carefully tuned thresholds, limiting their adaptability in real-world applications. Moreover, the irregular sampling of trajectory data and the presence of noise in training sets further degrade model performance, making it difficult to learn reliable representations of normal routes. To address these challenges, we propose a contrastive reinforcement learning framework for online trajectory anomaly detection, CroTad. Our method is threshold-free and robust to noisy, irregularly sampled data. By incorporating contrastive learning, CroTad learns to extract diverse normal travel patterns for different itineraries and effectively distinguish anomalous behaviours at both sub-trajectory and point levels. The detection module leverages deep reinforcement learning to perform online, real-time anomaly scoring, enabling timely and fine-grained identification of abnormal segments. Extensive experiments on two real-world datasets demonstrate the effectiveness and robustness of our framework across various evaluation scenarios.

Single-cell RNA sequencing (scRNA-seq) enables transcrip-tomic profiling at cellular resolution but suffers from pervasive dropout events that obscure biological signals. We present SCR-MF, a modular two-stage workflow that combines principled dropout detection using scRecover with robust non-parametric imputation via missForest. Across public and simulated datasets, SCR-MF achieves robust and interpretable performance comparable to or exceeding existing imputation methods in most cases, while preserving biological fidelity and transparency. Runtime analysis demonstrates that SCR-MF provides a competitive balance between accuracy and computational efficiency, making it suitable for mid-scale single-cell datasets.

In multi-vehicle cooperative driving tasks involving high-frequency continuous control, traditional state-based reward functions suffer from the issue of vanishing reward differences. This phenomenon results in a low signal-to-noise ratio (SNR) for policy gradients, significantly hindering algorithm convergence and performance improvement. To address this challenge, this paper proposes a novel Hybrid Differential Reward (HDR) mechanism. We first theoretically elucidate how the temporal quasi-steady nature of traffic states and the physical proximity of actions lead to the failure of traditional reward signals. Building on this analysis, the HDR framework innovatively integrates two complementary components: (1) a Temporal Difference Reward (TRD) based on a global potential function, which utilizes the evolutionary trend of potential energy to ensure optimal policy invariance and consistency with long-term objectives; and (2) an Action Gradient Reward (ARG), which directly measures the marginal utility of actions to provide a local guidance signal with a high SNR. Furthermore, we formulate the cooperative driving problem as a Multi-Agent Partially Observable Markov Game (POMDPG) with a time-varying agent set and provide a complete instantiation scheme for HDR within this framework. Extensive experiments conducted using both online planning (MCTS) and Multi-Agent Reinforcement Learning (QMIX, MAPPO, MADDPG) algorithms demonstrate that the HDR mechanism significantly improves convergence speed and policy stability. The results confirm that HDR guides agents to learn high-quality cooperative policies that effectively balance traffic efficiency and safety.

Macrocyclic peptides are an emerging modality that combines biologics-like affinity with small-molecule-like developability, but their vast combinatorial space and multi-parameter objectives make lead optimization slow and challenging. Prior generative approaches such as PepINVENT require chemists to pre-specify mutable positions for optimization, choices that are not always known a priori, and rely on static pretraining and optimization algorithms that limit the model's ability to generalize and effectively optimize peptide sequences. We introduce PepEVOLVE, a position-aware, dynamic framework that learns both where to edit and how to dynamically optimize peptides for multi-objective improvement. PepEVOLVE (i) augments pretraining with dynamic masking and CHUCKLES shifting to improve generalization, (ii) uses a context-free multi-armed bandit router that discovers high-reward residues, and (iii) couples a novel evolving optimization algorithm with group-relative advantage to stabilize reinforcement updates. During in silico evaluations, the router policy reliably learns and concentrates probability on chemically meaningful sites that influence the peptide's properties. On a therapeutically motivated Rev-binding macrocycle benchmark, PepEVOLVE outperformed PepINVENT by reaching higher mean scores (approximately 0.8 vs. 0.6), achieving best candidates with a score of 0.95 (vs. 0.87), and converging in fewer steps under the task of optimizing permeability and lipophilicity with structural constraints. Overall, PepEVOLVE offers a practical, reproducible path to peptide lead optimization when optimal edit sites are unknown, enabling more efficient exploration and improving design quality across multiple objectives.

In multi UAV scenarios,the traditional Artificial Potential Field (APF) method often leads to redundant flight paths and frequent abrupt heading changes due to unreasonable obstacle avoidance path planning,and is highly prone to inter UAV collisions during the obstacle avoidance process.To address these issues,this study proposes a novel hybrid algorithm that combines the improved Multi-Robot Formation Obstacle Avoidance (MRF IAPF) algorithm with an enhanced APF optimized for single UAV path planning.Its core ideas are as follows:first,integrating three types of interaction forces from MRF IAPF obstacle repulsion force,inter UAV interaction force,and target attraction force;second,incorporating a refined single UAV path optimization mechanism,including collision risk assessment and an auxiliary sub goal strategy.When a UAV faces a high collision threat,temporary waypoints are generated to guide obstacle avoidance,ensuring eventual precise arrival at the actual target.Simulation results demonstrate that compared with traditional APF based formation algorithms,the proposed algorithm achieves significant improvements in path length optimization and heading stability,can effectively avoid obstacles and quickly restore the formation configuration,thus verifying its applicability and effectiveness in static environments with unknown obstacles.

Early detection of rising talents is of paramount importance in the field of advertising. In this paper, we define a concept of talent breakout and propose a method to detect Japanese talents before their rise to stardom. The main focus of the study is to determine the effectiveness of combining Twitter and TV data on predicting time-dependent changes in social data. Although traditional time-series models are known to be robust in many applications, the success of neural network models in various fields (e.g.\ Natural Language Processing, Computer Vision, Reinforcement Learning) continues to spark an interest in the time-series community to apply new techniques in practice. Therefore, in order to find the best modeling approach, we have experimented with traditional, neural network and ensemble learning methods. We observe that ensemble learning methods outperform traditional and neural network models based on standard regression metrics. However, by utilizing the concept of talent breakout, we are able to assess the true forecasting ability of the models, where neural networks outperform traditional and ensemble learning methods in terms of precision and recall.

Development of large-area, high-speed electronic skins is a grand challenge for robotics, prosthetics, and human-machine interfaces, but is fundamentally limited by wiring complexity and data bottlenecks. Here, we introduce Single-Pixel Tactile Skin (SPTS), a paradigm that uses compressive sampling to reconstruct rich tactile information from an entire sensor array via a single output channel. This is achieved through a direct circuit-level implementation where each sensing element, equipped with a miniature microcontroller, contributes a dynamically weighted analog signal to a global sum, performing distributed compressed sensing in hardware. Our flexible, daisy-chainable design simplifies wiring to a few input lines and one output, and significantly reduces measurement requirements compared to raster scanning methods. We demonstrate the system's performance by achieving object classification at an effective 3500 FPS and by capturing transient dynamics, resolving an 8 ms projectile impact into 23 frames. A key feature is the support for adaptive reconstruction, where sensing fidelity scales with measurement time. This allows for rapid contact localization using as little as 7% of total data, followed by progressive refinement to a high-fidelity image - a capability critical for responsive robotic systems. This work offers an efficient pathway towards large-scale tactile intelligence for robotics and human-machine interfaces.

The growing number of Large Language Models (LLMs) with diverse capabilities and response styles provides users with a wider range of choices, which presents challenges in selecting appropriate LLMs, as user preferences vary in terms of performance, cost, and response style. Current LLM selection methods typically optimize for a single fixed objective, such as performance, cost, or a trade-off between them, and fail to learn individual user preferences from interaction data. To address these limitations, we propose PersonalizedRouter, a graph-based framework that models diverse user profiles and performs personalized LLM selection by leveraging interaction data that includes task context, queries, candidate LLMs, and user decisions. To capture contextual information between user queries and optimal LLMs, PersonalizedRouter converts the interaction data into a heterogeneous graph, where the relationships between different types of nodes are represented by edges. To evaluate adaptability across users, we design two strategies: the multi-cost-efficiency simulation strategy and the LLM-as-a-Judge strategy. In addition, we construct PersonaRoute-Bench, a large-scale benchmark with 1,000 simulated users and 10 LLMs. Experimental results show that PersonalizedRouter significantly outperforms existing LLM selection methods and surpasses the strongest methods by a large margin of 15.38% and 9.83% under two simulation strategies. On the PersonaRoute-Bench with 1,000 users, it further surpasses the best methods by 16.19% and 59.69% while maintaining higher efficiency. Moreover, PersonalizedRouter demonstrates strong few-shot generalization, achieving 64.81% and 85.80% of the fully trained model's performance when adapting to new users and new LLMs.

Parkinson's disease (PD) is a progressive neurodegenerative disorder that, in addition to directly impairing functional mobility, is frequently associated with vocal impairments such as hypophonia and dysarthria, which typically manifest in the early stages. The use of vocal biomarkers to support the early diagnosis of PD presents a non-invasive, low-cost, and accessible alternative in clinical settings. Thus, the objective of this cross-sectional study was to consistently evaluate the effectiveness of a Deep Neural Network (DNN) in distinguishing individuals with Parkinson's disease from healthy controls, in comparison with traditional Machine Learning (ML) methods, using vocal biomarkers. Two publicly available voice datasets were used. Mel-frequency cepstral coefficients (MFCCs) were extracted from the samples, and model robustness was assessed using a validation strategy with 1000 independent random executions. Performance was evaluated using classification statistics. Since normality assumptions were not satisfied, non-parametric tests (Kruskal-Wallis and Bonferroni post-hoc tests) were applied to verify whether the tested classification models were similar or different in the classification of PD. With an average accuracy of $98.65\%$ and $92.11\%$ on the Italian Voice dataset and Parkinson's Telemonitoring dataset, respectively, the DNN demonstrated superior performance and efficiency compared to traditional ML models, while also achieving competitive results when benchmarked against relevant studies. Overall, this study confirms the efficiency of DNNs and emphasizes their potential to provide greater accuracy and reliability for the early detection of neurodegenerative diseases using voice-based biomarkers.