Chronic diseases often progress differently across patients. Rather than randomly varying, there are typically a small number of subtypes for how a disease progresses across patients. To capture this structured heterogeneity, the Subtype and Stage Inference Event-Based Model (SuStaIn) estimates the number of subtypes, the order of disease progression for each subtype, and assigns each patient to a subtype from primarily cross-sectional data. It has been widely applied to uncover the subtypes of many diseases and inform our understanding of them. But how robust is its performance? In this paper, we develop a principled Bayesian subtype variant of the event-based model (BEBMS) and compare its performance to SuStaIn in a variety of synthetic data experiments with varied levels of model misspecification. BEBMS substantially outperforms SuStaIn across ordering, staging, and subtype assignment tasks. Further, we apply BEBMS and SuStaIn to a real-world Alzheimer's data set. We find BEBMS has results that are more consistent with the scientific consensus of Alzheimer's disease progression than SuStaIn.

In recent years, financial sentiment analysis of public opinion has become increasingly important for market forecasting and risk assessment. However, existing methods often struggle to effectively integrate diverse opinion modalities and capture fine-grained interactions across them. This paper proposes an end-to-end deep learning framework that integrates two distinct modalities of financial opinions: recency modality (timely opinions) and popularity modality (trending opinions), through a novel cross-modal attention mechanism specifically designed for financial sentiment analysis. While both modalities consist of textual data, they represent fundamentally different information channels: recency-driven market updates versus popularity-driven collective sentiment. Our model first uses BERT (Chinese-wwm-ext) for feature embedding and then employs our proposed Financial Multi-Head Cross-Attention (FMHCA) structure to facilitate information exchange between these distinct opinion modalities. The processed features are optimized through a transformer layer and fused using multimodal factored bilinear pooling for classification into negative, neutral, and positive sentiment. Extensive experiments on a comprehensive dataset covering 837 companies demonstrate that our approach achieves an accuracy of 83.5%, significantly outperforming baselines including BERT+Transformer by 21 percent. These results highlight the potential of our framework to support more accurate financial decision-making and risk management.

Recent large vision-language models (LVLMs) have been applied to diverse VQA tasks. However, achieving practical performance typically requires task-specific fine-tuning with large numbers of image-text pairs, which are costly to collect. In this work, we study text-centric training, a setting where only textual descriptions are available and no real images are provided, as a paradigm for low-cost data scaling. Unlike images, whose collection is often restricted by privacy constraints and scarcity in niche domains, text is widely available. Moreover, text is easily editable, enabling automatic diversification and expansion with LLMs at minimal human effort. While this offers clear advantages over image collection in terms of scalability and cost, training on raw text without images still yields limited gains on VQA tasks because of the image-text modality gap. To address this issue, we propose a Text-Printed Image (TPI), which generates synthetic images by directly rendering the given textual description on a plain white canvas. This simple rendering projects text into the image modality and can be integrated into arbitrary existing LVLM training pipelines at low cost. Moreover, TPI preserves the semantics of the text, whereas text-to-image models often fail to do. Across four models and seven benchmarks, our systematic experiments show that TPI enables more effective text-centric training than synthetic images generated by a diffusion model. We further explore TPI as a low-cost data-augmentation strategy and demonstrate its practical utility. Overall, our findings highlight the significant potential of text-centric training and, more broadly, chart a path toward fully automated data generation for LVLMs.

The number and sophistication of cyberthreats have increased along with the internet's exponential expansion, especially those that are spread by bad URLs. A variety of assaults, such as phishing, drive-by downloads, command-and-control communications, and data exfiltration, are launched using malicious websites. Because attackers are constantly changing URLs to avoid detection, traditional blacklisting techniques are unable to keep up with the dynamic and hostile character of contemporary threats. As a result, intelligent algorithms that can recognize intricate patterns in URLs and instantly identify malicious ones have become crucial components of contemporary cybersecurity protection designs [1, 13]. Because machine learning (ML) and deep learning (DL) approaches can identify non-linear relationships in input data and generalize from observed patterns, they have shown considerable promise in the field of malicious URL detection [2, 3]. But there are still a number of obstacles to overcome: class imbalance (lack of labeled malicious data compared to benign URLs); attackers' adversarial techniques that produce highly obfuscated or anomalous URLs that undermine the effectiveness of traditional classifiers; and the majority of detection systems are restricted to monolingual user interfaces and lack real-time usability features.

In cell culture bioprocessing, real-time batch process monitoring (BPM) refers to the continuous tracking and analysis of key process variables such as viable cell density, nutrient levels, metabolite concentrations, and product titer throughout the duration of a batch run. This enables early detection of deviations and supports timely control actions to ensure optimal cell growth and product quality. BPM plays a critical role in ensuring the quality and regulatory compliance of biopharmaceutical manufacturing processes. However, the development of accurate soft sensors for BPM is hindered by key challenges, including limited historical data, infrequent feedback, heterogeneous process conditions, and high-dimensional sensory inputs. This study presents a comprehensive benchmarking analysis of machine learning (ML) methods designed to address these challenges, with a focus on learning from historical data with limited volume and relevance in the context of bioprocess monitoring. We evaluate multiple ML approaches including feature dimensionality reduction, online learning, and just-in-time learning across three datasets, one in silico dataset and two real-world experimental datasets. Our findings highlight the importance of training strategies in handling limited data and feedback, with batch learning proving effective in homogeneous settings, while just-in-time learning and online learning demonstrate superior adaptability in cold-start scenarios. Additionally, we identify key meta-features, such as feed media composition and process control strategies, that significantly impact model transferability. The results also suggest that integrating Raman-based predictions with lagged offline measurements enhances monitoring accuracy, offering a promising direction for future bioprocess soft sensor development.

Human motor control remains agile and robust despite limited sensory information for feedback, a property attributed to the body's ability to perform morphological computation through muscle coordination with variable impedance. However, it remains unclear how such low-level mechanical computation reduces the control requirements of the high-level controller. In this study, we implement a hierarchical controller consisting of a high-level neural network trained by reinforcement learning and a low-level variable-impedance muscle coor dination model with mono- and biarticular muscles in monoped locomotion task. We systematically restrict the high-level controller by varying the control frequency and by introducing biologically inspired observation conditions: delayed, partial, and substituted observation. Under these conditions, we evaluate how the low-level variable-impedance muscle coordination contributes to learning process of high-level neural network. The results show that variable-impedance muscle coordination enables stable locomotion even under slow-rate control frequency and limited observation conditions. These findings demonstrate that the morphological computation of muscle coordination effectively offloads high-frequency feedback of the high-level controller and provide a design principle for the controller in motor control.

Decoding imagined speech engages complex neural processes that are difficult to interpret due to uncertainty in timing and the limited availability of imagined-response datasets. In this study, we present a Magnetoencephalography (MEG) dataset collected from trained musicians as they imagined and listened to musical and poetic stimuli. We show that both imagined and perceived brain responses contain consistent, condition-specific information. Using a sliding-window ridge regression model, we first mapped imagined responses to listened responses at the single-subject level, but found limited generalization across subjects. At the group level, we developed an encoder-decoder convolutional neural network with a subject-specific calibration layer that produced stable and generalizable mappings. The CNN consistently outperformed the null model, yielding significantly higher correlations between predicted and true listened responses for nearly all held-out subjects. Our findings demonstrate that imagined neural activity can be transformed into perception-like responses, providing a foundation for future brain-computer interface applications involving imagined speech and music.

Vision-language pretraining (VLP) has emerged as a powerful paradigm in medical image analysis, enabling representation learning from large-scale image-text pairs without relying on expensive manual annotations. However, existing methods often struggle with the noise inherent in web-collected data and the complexity of unstructured long medical texts. To address these challenges, we propose a novel VLP framework integrating a Multi-Agent data GENeration (MAGEN) system and Ontology-based Multi-Aspect Knowledge-Enhanced (O-MAKE) pretraining. First, MAGEN enhances data quality by synthesizing knowledge-enriched descriptions via a foundation model-assisted captioning and retrieval-based verification pipeline. Second, O-MAKE addresses the difficulty of learning from long, unstructured texts by decomposing them into distinct knowledge aspects. This facilitates fine-grained alignment at both global and patch levels, while explicitly modeling medical concept relationships through ontology-guided mechanisms. We validate our framework in the field of dermatology, where comprehensive experiments demonstrate the effectiveness of each component. Our approach achieves state-of-the-art zero-shot performance on disease classification and cross-modal retrieval tasks across eight datasets. Our code and the augmented dataset Derm1M-AgentAug, comprising over 400k skin-image-text pairs, will be released at https://github.com/SiyuanYan1/Derm1M.

As an effective method to boost the performance of Large Language Models (LLMs) on the question answering (QA) task, Retrieval-Augmented Generation (RAG), which queries highly relevant information from external complex documents, has attracted tremendous attention from both industry and academia. Existing RAG approaches often focus on general documents, and they overlook the fact that many real-world documents (such as books, booklets, handbooks, etc.) have a hierarchical structure, which organizes their content from different granularity levels, leading to poor performance for the QA task. To address these limitations, we introduce BookRAG, a novel RAG approach targeted for documents with a hierarchical structure, which exploits logical hierarchies and traces entity relations to query the highly relevant information. Specifically, we build a novel index structure, called BookIndex, by extracting a hierarchical tree from the document, which serves as the role of its table of contents, using a graph to capture the intricate relationships between entities, and mapping entities to tree nodes. Leveraging the BookIndex, we then propose an agent-based query method inspired by the Information Foraging Theory, which dynamically classifies queries and employs a tailored retrieval workflow. Extensive experiments on three widely adopted benchmarks demonstrate that BookRAG achieves state-of-the-art performance, significantly outperforming baselines in both retrieval recall and QA accuracy while maintaining competitive efficiency.

In this work we study how explicit world-modeling objectives affect the internal representations and downstream capability of Transformers across different training stages. We use a controlled 2x2x2 Rubik's Cube and ask: (1) how does explicitly pretraining a world model affect the model's latent representations, and (2) how does world-model quality affect the model's performance after reinforcement learning post-training? We compare standard next-token prediction to two explicit world-modeling strategies -- (i) state-prediction pretraining and (ii) a joint state-prediction + next-token objective -- and assess task performance after Group Relative Policy Optimization (GRPO) is applied as post-training. We evaluate the representation quality with linear probes and causal interventions. We find that explicit world-modeling yields more linearly decodable and causally steerable state representations. More importantly, we find that improved state representations lead to higher gains for GRPO, especially on harder cube states. Our results indicate that sharpening state representations can improve the effectiveness of post-training for sequence-planning tasks.