Complex biological networks are fundamental to biomedical science, capturing interactions among molecules, cells, genes, and tissues. Deciphering these networks is critical for understanding health and disease, yet their scale and complexity represent a daunting challenge for current computational methods. Traditional biological network analysis methods, including deep learning approaches, while powerful, face inherent challenges such as limited scalability, oversmoothing long-range dependencies, difficulty in multimodal integration, expressivity bounds, and poor interpretability. We present Graph2Image, a framework that transforms large biological networks into sets of two-dimensional images by spatially arranging representative network nodes on a 2D grid. This transformation decouples the nodes as images, enabling the use of convolutional neural networks (CNNs) with global receptive fields and multi-scale pyramids, thus overcoming limitations of existing biological network analysis methods in scalability, memory efficiency, and long-range context capture. Graph2Image also facilitates seamless integration with other imaging and omics modalities and enhances interpretability through direct visualization of node-associated images. When applied to several large-scale biological network datasets, Graph2Image improved classification accuracy by up to 67.2% over existing methods and provided interpretable visualizations that revealed biologically coherent patterns. It also allows analysis of very large biological networks (nodes > 1 billion) on a personal computer. Graph2Image thus provides a scalable, interpretable, and multimodal-ready approach for biological network analysis, offering new opportunities for disease diagnosis and the study of complex biological systems.

Among the various types of cyberattacks, identifying zero-day attacks is problematic because they are unknown to security systems as their pattern and characteristics do not match known blacklisted attacks. There are many Machine Learning (ML) models designed to analyze and detect network attacks, especially using supervised models. However, these models are designed to classify samples (normal and attacks) based on the patterns they learn during the training phase, so they perform inefficiently on unseen attacks. This research addresses this issue by evaluating five different supervised models to assess their performance and execution time in predicting zero-day attacks and find out which model performs accurately and quickly. The goal is to improve the performance of these supervised models by not only proposing a framework that applies grid search, dimensionality reduction and oversampling methods to overcome the imbalance problem, but also comparing the effectiveness of oversampling on ml model metrics, in particular the accuracy. To emulate attack detection in real life, this research applies a highly imbalanced data set and only exposes the classifiers to zero-day attacks during the testing phase, so the models are not trained to flag the zero-day attacks. Our results show that Random Forest (RF) performs best under both oversampling and non-oversampling conditions, this increased effectiveness comes at the cost of longer processing times. Therefore, we selected XG Boost (XGB) as the top model due to its fast and highly accurate performance in detecting zero-day attacks.

Deep learning models have shown high accuracy in classifying electrocardiograms (ECGs), but their black box nature hinders clinical adoption due to a lack of trust and interpretability. To address this, we propose a novel three-stage training paradigm that transfers knowledge from multimodal clinical data (laboratory exams, vitals, biometrics) into a powerful, yet unimodal, ECG encoder. We employ a self-supervised, joint-embedding pre-training stage to create an ECG representation that is enriched with contextual clinical information, while only requiring the ECG signal at inference time. Furthermore, as an indirect way to explain the model's output we train it to also predict associated laboratory abnormalities directly from the ECG embedding. Evaluated on the MIMIC-IV-ECG dataset, our model outperforms a standard signal-only baseline in multi-label diagnosis classification and successfully bridges a substantial portion of the performance gap to a fully multimodal model that requires all data at inference. Our work demonstrates a practical and effective method for creating more accurate and trustworthy ECG classification models. By converting abstract predictions into physiologically grounded \emph{explanations}, our approach offers a promising path toward the safer integration of AI into clinical workflows.

Cost-effective and scalable video analytics are essential for precision livestock monitoring, where high-resolution footage and near-real-time monitoring needs from commercial farms generates substantial computational workloads. This paper presents a comprehensive case study on optimizing a poultry welfare monitoring system through system-level improvements across detection, tracking, clustering, and behavioral analysis modules. We introduce a set of optimizations, including multi-level parallelization, Optimizing code with substituting CPU code with GPU-accelerated code, vectorized clustering, and memory-efficient post-processing. Evaluated on real-world farm video footage, these changes deliver up to a 2x speedup across pipelines without compromising model accuracy. Our findings highlight practical strategies for building high-throughput, low-latency video inference systems that reduce infrastructure demands in agricultural and smart sensing deployments as well as other large-scale video analytics applications.

Singing accent research is underexplored compared to speech accent studies, primarily due to the scarcity of suitable datasets. Existing singing datasets often suffer from detail loss, frequently resulting from the vocal-instrumental separation process. Additionally, they often lack regional accent annotations. To address this, we introduce the Multi-Accent Mandarin Dry-Vocal Singing Dataset (MADVSD). MADVSD comprises over 670 hours of dry vocal recordings from 4,206 native Mandarin speakers across nine distinct Chinese regions. In addition to each participant recording audio of three popular songs in their native accent, they also recorded phonetic exercises covering all Mandarin vowels and a full octave range. We validated MADVSD through benchmark experiments in singing accent recognition, demonstrating its utility for evaluating state-of-the-art speech models in singing contexts. Furthermore, we explored dialectal influences on singing accent and analyzed the role of vowels in accentual variations, leveraging MADVSD's unique phonetic exercises.

Automated singing assessment is crucial for education and entertainment. However, existing systems face two fundamental limitations: reliance on reference tracks, which stifles creative expression, and the simplification of complex performances into non-diagnostic scores based solely on pitch and rhythm. We advocate for a shift from discriminative to descriptive evaluation, creating a complete ecosystem for reference-free, multi-dimensional assessment. First, we introduce Sing-MD, a large-scale dataset annotated by experts across four dimensions: breath control, timbre quality, emotional expression, and vocal technique. Our analysis reveals significant annotation inconsistencies among experts, challenging the validity of traditional accuracy-based metrics. Second, addressing the memory limitations of Multimodal Large Language Models (MLLMs) in analyzing full-length songs, we propose VocalVerse. This efficient hybrid architecture leverages a lightweight acoustic encoder to model global performance features and long-term dependencies. Third, to address automated metric shortcomings, we establish the H-TPR (Human-in-the-loop Tiered Perceptual Ranking) benchmark, which evaluates a model's ability to generate perceptually valid rankings rather than predicting noisy ground-truth scores.

Haptic interfaces play a critical role in medical teleoperation by enabling surgeons to interact with remote environments through realistic force and motion feedback. Achieving high fidelity in such systems requires balancing performance trade-off among workspace, dexterity, stiffness, inertia, and bandwidth, particularly in applications demanding pure rotational motion. This paper presents the design methodology and kinematic analysis of a Cable-Driven Coaxial Spherical Parallel Mechanism (CDC-SPM) developed to address these challenges. The proposed cable-driven interface design allows for reducing the mass placed at the robot arm end-effector, thereby minimizing inertial loads, enhancing stiffness, and improving dynamic responsiveness. Through parallel and coaxial actuation, the mechanism achieves decoupled rotational degrees of freedom with isotropic force and torque transmission. Simulation and analysis demonstrate that the CDC-SPM provides accurate, responsive, and safe motion characteristics suitable for high-precision haptic applications. These results highlight the mechanism's potential for medical teleoperation tasks such as ultrasound imaging, where precise and intuitive manipulation is essential.

We propose new methodologies for both unlearning random set of samples and class unlearning and show that they outperform existing methods. The main driver of our unlearning methods is the similarity of predictions to a retrained model on both the forget and remain samples. We introduce Adversarial Machine UNlearning (AMUN), which surpasses prior state-of-the-art methods for image classification based on SOTA MIA scores. AMUN lowers the model's confidence on forget samples by fine-tuning on their corresponding adversarial examples. Through theoretical analysis, we identify factors governing AMUN's performance, including smoothness. To facilitate training of smooth models with a controlled Lipschitz constant, we propose FastClip, a scalable method that performs layer-wise spectral-norm clipping of affine layers. In a separate study, we show that increased smoothness naturally improves adversarial example transfer, thereby supporting the second factor above. Following the same principles for class unlearning, we show that existing methods fail in replicating a retrained model's behavior by introducing a nearest-neighbor membership inference attack (MIA-NN) that uses the probabilities assigned to neighboring classes to detect unlearned samples and demonstrate the vulnerability of such methods. We then propose a fine-tuning objective that mitigates this leakage by approximating, for forget-class inputs, the distribution over remaining classes that a model retrained from scratch would produce. To construct this approximation, we estimate inter-class similarity and tilt the target model's distribution accordingly. The resulting Tilted ReWeighting(TRW) distribution serves as the desired target during fine-tuning. Across multiple benchmarks, TRW matches or surpasses existing unlearning methods on prior metrics.

Currently, there is a noticeable lack of AI in the medical field to support doctors in treating heterogenous brain tumors such as Glioblastoma Multiforme (GBM), the deadliest human cancer in the world with a five-year survival rate of just 5.1%. This project develops an AI system offering the only end-to-end solution by aiding doctors with both diagnosis and treatment planning. In the diagnosis phase, a sequential decision-making framework consisting of 4 classification models (Convolutional Neural Networks and Support Vector Machine) are used. Each model progressively classifies the patient's brain into increasingly specific categories, with the final step being named diagnosis. For treatment planning, an RL system consisting of 3 generative models is used. First, the resection model (diffusion model) analyzes the diagnosed GBM MRI and predicts a possible resection outcome. Second, the radiotherapy model (Spatio-Temporal Vision Transformer) generates an MRI of the brain's progression after a user-defined number of weeks. Third, the chemotherapy model (Diffusion Model) produces the post-treatment MRI. A survival rate calculator (Convolutional Neural Network) then checks if the generated post treatment MRI has a survival rate within 15% of the user defined target. If not, a feedback loop using proximal policy optimization iterates over this system until an optimal resection location is identified. When compared to existing solutions, this project found 3 key findings: (1) Using a sequential decision-making framework consisting of 4 small diagnostic models reduced computing costs by 22.28x, (2) Transformers regression capabilities decreased tumor progression inference time by 113 hours, and (3) Applying Augmentations resembling Real-life situations improved overall DICE scores by 2.9%. These results project to increase survival rates by 0.9%, potentially saving approximately 2,250 lives.

Accurately predicting experimentally-realizable 3D molecular crystal structures from their 2D chemical graphs is a long-standing open challenge in computational chemistry called crystal structure prediction (CSP). Efficiently solving this problem has implications ranging from pharmaceuticals to organic semiconductors, as crystal packing directly governs the physical and chemical properties of organic solids. In this paper, we introduce OXtal, a large-scale 100M parameter all-atom diffusion model that directly learns the conditional joint distribution over intramolecular conformations and periodic packing. To efficiently scale OXtal, we abandon explicit equivariant architectures imposing inductive bias arising from crystal symmetries in favor of data augmentation strategies. We further propose a novel crystallization-inspired lattice-free training scheme, Stoichiometric Stochastic Shell Sampling ($S^4$), that efficiently captures long-range interactions while sidestepping explicit lattice parametrization -- thus enabling more scalable architectural choices at all-atom resolution. By leveraging a large dataset of 600K experimentally validated crystal structures (including rigid and flexible molecules, co-crystals, and solvates), OXtal achieves orders-of-magnitude improvements over prior ab initio machine learning CSP methods, while remaining orders of magnitude cheaper than traditional quantum-chemical approaches. Specifically, OXtal recovers experimental structures with conformer $\text{RMSD}_1<0.5$ Å and attains over 80\% packing similarity rate, demonstrating its ability to model both thermodynamic and kinetic regularities of molecular crystallization.