Generative models of observations under interventions have been a vibrant topic of interest across machine learning and the sciences in recent years. For example, in drug discovery, there is a need to model the effects of diverse interventions on cells in order to characterize unknown biological mechanisms of action. We propose the Sparse Additive Mechanism Shift Variational Autoencoder, SAMS-VAE, to combine compositionality, disentanglement, and interpretability for perturbation models. SAMS-VAE models the latent state of a perturbed sample as the sum of a local latent variable capturing sample-specific variation and sparse global variables of latent intervention effects. Crucially, SAMS-VAE sparsifies these global latent variables for individual perturbations to identify disentangled, perturbation-specific latent subspaces that are flexibly composable. We evaluate SAMS-VAE both quantitatively and qualitatively on a range of tasks using two popular single cell sequencing datasets.In order to measure perturbation-specific model-properties, we also introduce a framework for evaluation of perturbation models based on average treatment effects with links to posterior predictive checks. SAMS-VAE outperforms comparable models in terms of generalization across in-distribution and out-of-distribution tasks, including a combinatorial reasoning task under resource paucity, and yields interpretable latent structures which correlate strongly to known biological mechanisms. Our results suggest SAMS-VAE is an interesting addition to the modeling toolkit for machine learning-driven scientific discovery.

Breakthroughs, discoveries, and DIY tips sent every weekday. The United States Consumer Product Safety Commission (CPSC) is well known for getting their point across on social media. A seven-minute montage of mannequins succumbing to 4th of July firework injuries may be an unconventional way to warn about the dangers of recreational explosives--but try forgetting those images when lighting your next bottle rocket. In similar pyrotechnic fashion, the CPSC is warning everyone to take extra care during the holidays when it comes to all kinds of combustible, seasonally appropriate objects. On December 22, the commission illustrated how some gifts are far more flammable than others with its 30-minute Escooter Lithium-Ion Battery Yule Log video.

Switch 2 games are on sale through Jan. 5 Carreyrou is perhaps for exposing the Theranos fraudulent blood test scandal. According to, the lawsuit was filed alongside five other writers who all claim big tech companies have been violating their intellectual property rights in the name of building large language models. This comes after a banner year for IP lawsuits against AI companies brought by rights holders. Just about every type of entity that deals in protected content has gone to court against AI companies this year, from movie studios like to papers like the . Some of these cases have led to settlements in the form of partnerships, such as the between Disney and OpenAI.

When you purchase through links in our articles, we may earn a small commission. At the same time, IDC predicts that the PC market could also shrink by 8.9 per cent during the year. Research firm IDC predicts that the average price of computers could rise by up to 8% in 2026 due to a global shortage of memory chips (RAM and NAND). The background is the sharp increase in demand for HBM memory for AI data centers, which is prioritized over the production of consumer memory, which is less profitable for manufacturers. Meanwhile, IDC predicts that the PC market could also shrink by between 2.4 and 8.9 percent in 2026 as a result of the shortage.

When you purchase through links in our articles, we may earn a small commission. For today's professionals, video editing is no longer a specialist craft reserved for post-production teams. It's a daily tool--used by marketers shaping campaigns, educators building courses, founders pitching ideas, and creators publishing across platforms at speed. It's finding software that delivers that power without slowing everything down. Wondershare Filmora V15 is built for professionals who want the best of both worlds: serious capability and frictionless usability. It doesn't ask users to compromise.

You still need to wash your hands with soap and warm water though. Breakthroughs, discoveries, and DIY tips sent every weekday. The most dreaded time of year rolls around every winter like clockwork: cold and flu season. The time when hand washing increases, sanitizing surfaces intensifies, and old and young schedule regular seasonal vaccines in an attempt to prevent sickness from descending on their households. But there's one piece of ammunition you should absolutely skip this season--and all year-round--because it does more harm than good: antibacterial hand soap.

ChatGPT's annual summary shows, among other things, how many long lines of thought your chats generated during the year.

Three killed after Russia launches'massive' attack across Ukraine Russia carried out a massive overnight attack on several Ukrainian cities, President Volodymyr Zelensky has said, a day after he warned of strikes over the Christmas period. At least three people were killed, according to Ukrainian officials, including a four-year-old child, while energy infrastructure was also targeted, leaving several regions without power. Russia launched 635 drones and 38 missiles, Ukraine's air force said, adding that 621 of them were downed. Zelensky said people simply want to be with their families, at home, and safe in the run-up to Christmas, and said the strikes sent an extremely clear signal about Russia's priorities despite ongoing peace talks. He added that Russian President Vladimir Putin still cannot accept that he must stop killing.

Why do we have five fingers and toes? It all goes back to our fishy ancestors. The answer to why we have five fingers and toes is surprisingly difficult to suss out. Breakthroughs, discoveries, and DIY tips sent every weekday. The popular nursery rhyme is an early childhood memory for many of us.

Pope Leo XIV made his first address to the College of Cardinals on May 10, 2025 in Vatican City, and touched upon the rise of artificial intelligence. Pope Leo XIV made his first address to the College of Cardinals on May 10, 2025 in Vatican City, and touched upon the rise of artificial intelligence. As technologists race to accelerate AI's progress with minimal guardrails, they are being met with increasing resistance from a powerful global contingent: Christian leaders and their congregations. Christians are not a monolith by any means. But this year, Christian leaders across sects--including Catholics, Evangelicals, and Baptists--sounded the alarm on AI's potential impact on family, human relationships, labor, and the church itself.