We may earn revenue from the products available on this page and participate in affiliate programs. Deep down, we want to be cyborgs. We spend huge chunks of time interacting with technology every day, but the friction created by devices and interfaces persists. This year, we got closer than we have been to tech that truly augments reality. Meta took its smart glasses beyond its beginning as a simple content creation tool.

Multiple instance learning (MIL) is a powerful tool to solve the weakly supervised classification in whole slide image (WSI) based pathology diagnosis. However, the current MIL methods are usually based on independent and identical distribution hypothesis, thus neglect the correlation among different instances. To address this problem, we proposed a new framework, called correlated MIL, and provided a proof for convergence. Based on this framework, we devised a Transformer based MIL (TransMIL), which explored both morphological and spatial information. The proposed TransMIL can effectively deal with unbalanced/balanced and binary/multiple classification with great visualization and interpretability. We conducted various experiments for three different computational pathology problems and achieved better performance and faster convergence compared with state-of-the-art methods. The test AUC for the binary tumor classification can be up to 93.09% over CAMELYON16 dataset. And the AUC over the cancer subtypes classification can be up to 96.03% and 98.82% over TCGA-NSCLC dataset and TCGA-RCC dataset, respectively.

As autonomous systems rapidly become ubiquitous, there is a growing need for a legal and regulatory framework toaddress when and how such a system harms someone. There have been several attempts within the philosophy literature to define harm, but none of them has proven capable of dealing with with the many examples that have been presented, leading some to suggest that the notion of harm should be abandoned and ``replaced by more well-behaved notions''. As harm is generally something that is caused, most of these definitions have involved causality at some level. Yet surprisingly, none of them makes use of causal models and the definitions of actual causality that they can express. In this paper we formally define a qualitative notion of harm that uses causal models and is based on a well-known definition of actual causality (Halpern, 2016). The key novelty of our definition is that it is based on contrastive causation and uses a default utility to which the utility of actual outcomes is compared. We show that our definition is able to handle the examples from the literature, and illustrate its importance for reasoning about situations involving autonomous systems.

We study online convex optimization in the random order model, recently proposed by Garber et al. (2020), where the loss functions may be chosen by an adversary, but are then presented to the online algorithm in a uniformly random order. Focusing on the scenario where the cumulative loss function is (strongly) convex, yet individual loss functions are smooth but might be non-convex, we give algorithms that achieve the optimal bounds and significantly outperform the results of Garber et al. (2020), completely removing the dimension dependence and improve their scaling with respect to the strong convexity parameter. Our analysis relies on novel connections between algorithmic stability and generalization for sampling without-replacement analogous to those studied in the with-replacement i.i.d.

Detecting where and when brain regions activate in a cognitive task or in a given clinical condition is the promise of non-invasive techniques like magnetoencephalography (MEG) or electroencephalography (EEG). This problem, referred to as source localization, or source imaging, poses however a high-dimensional statistical inference challenge. While sparsity promoting regularizations have been proposed to address the regression problem, it remains unclear how to ensure statistical control of false detections in this setting. Moreover, MEG/EEG source imaging requires to work with spatio-temporal data and autocorrelated noise. To deal with this, we adapt the desparsified Lasso estimator ---an estimator tailored for high dimensional linear model that asymptotically follows a Gaussian distribution under sparsity and moderate feature correlation assumptions--- to temporal data corrupted with autocorrelated noise. We call it the desparsified multi-task Lasso (d-MTLasso). We combine d-MTLasso with spatially constrained clustering to reduce data dimension and with ensembling to mitigate the arbitrary choice of clustering; the resulting estimator is called ensemble of clustered desparsified multi-task Lasso (ecd-MTLasso). With respect to the current procedures, the two advantages of ecd-MTLasso are that i)it offers statistical guarantees and ii)it allows to trade spatial specificity for sensitivity, leading to a powerful adaptive method. Extensive simulations on realistic head geometries, as well as empirical results on various MEG datasets, demonstrate the high recovery performance of ecd-MTLasso and its primary practical benefit: offer a statistically principled way to threshold MEG/EEG source maps.

When compared to the image classification models, black-box adversarial attacks against video classification models have been largely understudied. This could be possible because, with video, the temporal dimension poses significant additional challenges in gradient estimation. Query-efficient black-box attacks rely on effectively estimated gradients towards maximizing the probability of misclassifying the target video. In this work, we demonstrate that such effective gradients can be searched for by parameterizing the temporal structure of the search space with geometric transformations.

Individual's opinions are fundamentally shaped and evolved by their interactions with other people, and social phenomena such as disagreement and polarization are now tightly woven into daily life. The quantification and optimization of these concepts have been the subject of much recent research behind a wealth of high-impact data mining applications. In particular, researchers have addressed the question of how such concepts can be optimized by influencing the opinion of a small number of individuals or by designing the network from scratch.Here, rather than a "design-from-scratch" approach or altering the initial opinion, we study the optimization problem of recommending $k$ new links to minimize the sum of polarization and disagreement in a social network with $n$ nodes and $m$ edges. We show that our objective function of this combinatorial optimization problem is not submodular, although it is monotone. We propose a simple greedy algorithm with a constant-factor approximation that solves the problem in cubic running time, and we provide theoretical analysis of the approximation guarantee for the algorithm. To overcome the computation challenge for large networks, we also provide a fast algorithm with computation complexity $\Otil (mk\eps^{-2})$ for any $\eps> 0$, where the $\Otil (\cdot)$ notation suppresses the ${\rm poly} (\log n)$ factors. Extensive experiments on real datasets demonstrate both the efficiency and effectiveness of our algorithms.

We study the problem of Safe Policy Improvement (SPI) under constraints in the offline Reinforcement Learning (RL) setting. We consider the scenario where: (i) we have a dataset collected under a known baseline policy, (ii) multiple reward signals are received from the environment inducing as many objectives to optimize. We present an SPI formulation for this RL setting that takes into account the preferences of the algorithm's user for handling the trade-offs for different reward signals while ensuring that the new policy performs at least as well as the baseline policy along each individual objective. We build on traditional SPI algorithms and propose a novel method based on Safe Policy Iteration with Baseline Bootstrapping (SPIBB, Laroche et al., 2019) that provides high probability guarantees on the performance of the agent in the true environment. We show the effectiveness of our method on a synthetic grid-world safety task as well as in a real-world critical care context to learn a policy for the administration of IV fluids and vasopressors to treat sepsis.

One of the main strengths of online algorithms is their ability to adapt to arbitrary data sequences. This is especially important in nonparametric settings, where performance is measured against rich classes of comparator functions that are able to fit complex environments. Although such hard comparators and complex environments may exhibit local regularities, efficient algorithms, which can provably take advantage of these local patterns, are hardly known. We fill this gap by introducing efficient online algorithms (based on a single versatile master algorithm) each adapting to one of the following regularities: (i) local Lipschitzness of the competitor function, (ii) local metric dimension of the instance sequence, (iii) local performance of the predictor across different regions of the instance space. Extending previous approaches, we design algorithms that dynamically grow hierarchical ε-nets on the instance space whose prunings correspond to different "locality profiles" for the problem at hand. Using a technique based on tree experts, we simultaneously and efficiently compete against all such prunings, and prove regret bounds each scaling with a quantity associated with a different type of local regularity. When competing against "simple" locality profiles, our technique delivers regret bounds that are significantly better than those proven using the previous approach. On the other hand, the time dependence of our bounds is not worse than that obtained by ignoring any local regularities.

Supervised Pix2Pix and unsupervised Cycle-consistency are two modes that dominate the field of medical image-to-image translation. However, neither modes are ideal. The Pix2Pix mode has excellent performance. But it requires paired and well pixel-wise aligned images, which may not always be achievable due to respiratory motion or anatomy change between times that paired images are acquired. The Cycle-consistency mode is less stringent with training data and works well on unpaired or misaligned images.