An Immigration and Customs Enforcement (ICE) officer has shot a man in the leg in the US city of Minneapolis, where an ICE agent shot dead a woman last week. In a statement, the Department of Homeland Security (DHS) said federal officers initially pursued the man in a car chase because he was illegally in the US from Venezuela. The City of Minneapolis confirmed a man was shot and taken to hospital for non-life threatening injuries. An ICE officer was also taken to hospital to be treated for injuries, the DHS said. Minneapolis city officials said on X: We understand there is anger.

A labour rights organisation claims it has found evidence of worker exploitation in a Chinese factory that makes the viral Labubu dolls. China Labor Watch (CLW), a US-based non-governmental organisation, alleges that its investigation found that one of Pop Mart's suppliers made employees work excessive overtime shifts, sign blank or incomplete contracts and did not give them paid leave. The furry Labubu dolls have surged in popularity around the world in recent years and are best known for selling toys in blind boxes, which hide its content from buyers until it is opened. Pop Mart told the BBC that it is investigating the claims. The Beijing-based toy retailer said it appreciated the details from the review and that it will firmly require companies making its toys to correct their practices if the allegations are found to be true.

Deforestation might lead to more deadly mosquito bites. The Atlantic Forest on the eastern coast of South America is home to about 40 different mosquito species. Breakthroughs, discoveries, and DIY tips sent six days a week. If you're someone who mosquitoes just, we feel your pain. Unfortunately, new data indicates the number of mosquito species that feed on humans is increasing--and it's likely to get worse.

Elon Musk said he was'not aware of any naked underage images generated by Grok. Elon Musk said he was'not aware of any naked underage images generated by Grok. Musk's X to block Grok AI tool from creating sexualised images of real people UK government claims vindication after Keir Starmer criticised earlier decision to keep functionality as'horrific' The UK government has claimed "vindication" after Elon Musk's X announced it had stopped its AI-powered Grok feature from editing pictures of real people to show them in revealing clothes such as bikinis, including for premium subscribers. Following a fortnight of public outcry at the tool embedded into X being used to create sexualised images of women and children, the company said it would "geoblock" the ability of users "to generate images of real people in bikinis, underwear, and similar attire via the Grok account and in Grok in X", in countries where it was illegal. It said it would do this in the UK in line with law changes ministers have pledged to introduce.

Could Ukraine hold a presidential election right now? Will Europe use frozen Russian assets to fund war? How can Ukraine rebuild China ties? 'Ukraine is running out of men, money and time' Ukrainian President Volodymyr Zelenskyy said that a state of emergency was being declared for Ukraine's energy sector, after repeated Russian attacks destroyed electricity and heat infrastructure. Zelenskyy said he asked the government to review curfew restrictions during "this extremely cold weather".

President Trump signed a proclamation on Wednesday to impose a 25 percent tariff on a narrow list of foreign semiconductors, providing a way for the government to earn revenue off the sale of lucrative chips used in artificial intelligence. The tariff, which would take effect Thursday, is far more limited than what the president initially threatened. Last year, the administration began an investigation aimed at encouraging tech companies and chip makers to buy semiconductors made in America. But instead of approving sweeping tariffs that would affect the industry, Wednesday's announcement showed the administration has settled for narrower levies that allow it to take a cut of artificial intelligence chips sold to China. A document released by the White House said a 25 percent tariff would be put on A.I. chips made by companies like Nvidia and AMD that are imported into the United States and then re-exported to other countries. The tariff would not apply to semiconductors that are brought into the country to be used domestically in data centers or in products for American consumers, industry or the government.

The news is a blow for Thinking Machines Lab. Two narratives are already emerging about what happened. Thinking Machines cofounders Barret Zoph and Luke Metz are leaving the fledgling AI lab and rejoining OpenAI, the ChatGPT-maker announced on Thursday. OpenAI's CEO of applications, Fidji Simo, shared the news in a memo to staff Thursday afternoon. The news was first reported on X by technology reporter Kylie Robison, who wrote that Zoph was fired for "unethical conduct."

Elon Musk's AI model Grok will no longer be able to edit photos of real people to show them in revealing clothing, after widespread concern over sexualised AI deepfakes in countries including the UK and US. We have implemented technological measures to prevent the Grok account from allowing the editing of images of real people in revealing clothing such as bikinis. This restriction applies to all users, including paid subscribers, reads an announcement on X, which operates the Grok AI tool. The change was announced hours after California's top prosecutor said the state was probing the spread of sexualised AI deepfakes, including of children, generated by the AI model. The update expands measures that stop all users, including paid subscribers, editing images of real people in revealing outfits.

Zelensky declares state of emergency in Ukraine's energy sector Ukraine has declared a state of emergency in the country's energy sector, with particular focus on Kyiv, as ongoing Russian strikes continue to leave thousands of residents without power. The nation is in the midst of a particularly cold winter, with overnight temperatures in Kyiv dropping to around -20C. After a special cabinet meeting, President Volodymyr Zelensky said a round-the-clock task force would be set up to deal with the damaging consequences of Russian airstrikes and worsening weather conditions. He accused Moscow of deliberately exploiting the harsh, sub-zero temperatures to target critical infrastructure, including energy distribution facilities. In recent weeks, Kyiv has been particularly affected by Russian attacks, leaving thousands of homes without regular power, heating or running water.

Structure-based and ligand-based computational drug design have traditionally relied on disjoint data sources and modeling assumptions, limiting their joint use at scale. In this work, we introduce Contrastive Geometric Learning for Unified Computational Drug Design (ConGLUDe), a single contrastive geometric model that unifies structure- and ligand-based training. ConGLUDe couples a geometric protein encoder that produces whole-protein representations and implicit embeddings of predicted binding sites with a fast ligand encoder, removing the need for pre-defined pockets. By aligning ligands with both global protein representations and multiple candidate binding sites through contrastive learning, ConGLUDe supports ligand-conditioned pocket prediction in addition to virtual screening and target fishing, while being trained jointly on protein-ligand complexes and large-scale bioactivity data. Across diverse benchmarks, ConGLUDe achieves state-of-the-art zero-shot virtual screening performance in settings where no binding pocket information is provided as input, substantially outperforms existing methods on a challenging target fishing task, and demonstrates competitive ligand-conditioned pocket selection. These results highlight the advantages of unified structure-ligand training and position ConGLUDe as a step toward general-purpose foundation models for drug discovery.