We introduce MusclePose as an end-to-end learnable physics-infused 3D human pose estimator that incorporates muscle-dynamics modeling to infer human dynamics from monocular video. Current physics pose estimators aim to predict physically plausible poses by enforcing the underlying dynamics equations that govern motion. Since this is an underconstrained problem without force-annotated data, methods often estimate kinetics with external physics optimizers that may not be compatible with existing learning frameworks, or are too slow for real-time inference. While more recent methods use a regression-based approach to overcome these issues, the estimated kinetics can be seen as auxiliary predictions, and may not be physically plausible. To this end, we build on existing regressionbased approaches, and aim to improve the biofidelity of kinetic inference with a multihypothesis approach -- by inferring joint torques via Lagrange's equations and via muscle dynamics modeling with muscle torque generators. Furthermore, MusclePose predicts detailed human anthropometrics based on values from biomechanics studies, in contrast to existing physics pose estimators that construct their human models with shape primitives. We show that MusclePose is competitive with existing 3D pose estimators in positional accuracy, while also able to infer plausible human kinetics and muscle signals consistent with values from biomechanics studies, without requiring an external physics engine.

The growing adoption of machine learning models for biological sequences has intensified the need for interpretable predictions, with Shapley values emerging as a theoretically grounded standard for model explanation. While effective for local explanations of individual input sequences, scaling Shapley-based interpretability to extract global biological insights requires evaluating thousands of sequences--incurring exponential computational cost per query. We introduce SHAP zero, a novel algorithm that amortizes the cost of Shapley value computation across large-scale biological datasets. After a one-time model sketching step, SHAP zero enables near-zero marginal cost for future queries by uncovering an underexplored connection between Shapley values, high-order feature interactions, and the sparse Fourier transform of the model. Applied to models of guide RNA efficacy, DNA repair outcomes, and protein fitness, SHAP zero explains predictions orders of magnitude faster than existing methods, recovering rich combinatorial interactions previously inaccessible at scale. This work opens the door to principled, efficient, and scalable interpretability for black-box sequence models in biology.

This paper proposes X2-DFD, an eXplainable and eXtendable framework based on multimodal large-language models (MLLMs) for deepfake detection, consisting of three key stages (see Figure 1). The first stage, Model Feature Assessment, systematically evaluates the detectability of forgery-related features for the MLLM, generating a prioritized ranking of features based on their intrinsic importance to the model. The second stage, Explainable Dataset Construction, consists of two key modules: Strong Feature Strengthening, which is designed to enhance the model's existing detection and explanation capabilities by reinforcing its well-learned features, and Weak Feature Supplementing, which addresses gaps by integrating specific feature detectors (e.g., low-level artifact analyzers) to compensate for the MLLM's limitations. The third stage, Fine-tuning and Inference, involves finetuning the MLLM on the constructed dataset and deploying it for final detection and explanation. By integrating these three stages, our approach enhances the MLLM's strengths while supplementing its weaknesses, ultimately improving both the detectability and explainability. Extensive experiments and ablations, followed by a comprehensive human study, validate the improved performance of our approach compared to the original MLLMs. More encouragingly, our framework is designed to be plug-and-play, allowing it to seamlessly integrate with future more advanced MLLMs and specific feature detectors, leading to continual improvement and extension to face the challenges of rapidly evolving deepfakes.

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Time Series Forecasting (TSF) is a crucial task in various domains, yet existing TSF models rely heavily on high-quality data and insufficiently exploit all available data. This paper explores a novel self-supervised approach to re-label time series datasets by inherently constructing candidate datasets. During the optimization of a simple reconstruction network, intermediates are used as pseudo labels in a self-supervised paradigm, improving generalization for any predictor. We introduce the SelfCorrection with Adaptive Mask (SCAM), which discards overfitted components and selectively replaces them with pseudo labels generated from reconstructions. Additionally, we incorporate Spectral Norm Regularization (SNR) to further suppress overfitting from a loss landscape perspective. Our experiments on eleven real-world datasets demonstrate that SCAM consistently improves the performance of various backbone models. This work offers a new perspective on constructing datasets and enhancing the generalization of TSF models through self-supervised learning. The code is available at https://github.com/SuDIS-ZJU/SCAM.

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Weekly quiz: How many SpaceX employees just became millionaires? This week, the White House hosted a UFC fight on its South Lawn, Royal Marines boarded a Russian shadow fleet oil tanker, and a schoolgirl said she would be left staring at a wall if social media was banned for under-16s. But how much attention did you pay to what else happened in the world over the past seven days? Try last week's quiz, or have a go at something from the archives . Musk's SpaceX overtakes Amazon to become world's fifth most valuable firm For the first time, individual investors can take a stake in Elon Musk's rockets-to-AI company.

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Human-like agents have long been one of the goals in pursuing artificial intelligence. Although reinforcement learning (RL) has achieved superhuman performance in many domains, relatively little attention has been focused on designing human-like RL agents. As a result, many reward-driven RL agents often exhibit unnatural behaviors compared to humans, raising concerns for both interpretability and trustworthiness. To achieve human-like behavior in RL, this paper first formulates human-likeness as trajectory optimization, where the objective is to find an action sequence that closely aligns with human behavior while also maximizing rewards, and adapts the classic receding-horizon control to human-like learning as a tractable and efficient implementation. To achieve this, we introduce Macro Action Quantization (MAQ), a human-like RL framework that distills human demonstrations into macro actions via Vector-Quantized VAE. Experiments on D4RL Adroit benchmarks show that MAQ significantly improves human-likeness, increasing trajectory similarity scores, and achieving the highest human-likeness rankings among all RL agents in the human evaluation study. Our results also demonstrate that MAQ can be easily integrated into various off-the-shelf RL algorithms, opening a promising direction for learning human-like RL agents.

The brain is made up of a vast set of heterogeneous regions that dynamically organize into pathways as a function of task demands. Examples of such pathways can be found in the interactions between cortical and subcortical networks during learning, or in sub-networks specializing for task characteristics such as difficulty or modality. Despite the large role these pathways play in cognition, the mechanisms through which brain regions organize into pathways remain unclear. In this work, we use an extension of the Heterogeneous Mixture-of-Experts architecture to show that heterogeneous regions do not form processing pathways by themselves, implying that the brain likely implements specific constraints which result in the reliable formation of pathways. We identify three biologically relevant inductive biases that encourage pathway formation: a routing cost imposed on the use of more complex regions, a scaling factor that reduces this cost when task performance is low, and randomized expert dropout. When comparing our resulting Mixtureof-Pathways model with the brain, we observe that the artificial pathways in our model match how the brain uses cortical and subcortical systems to learn and solve tasks of varying difficulty. In summary, we introduce a novel framework for investigating how the brain forms task-specific pathways through inductive biases, and the effects these biases have on the behavior of Mixture-of-Experts models.