We revisit the contextual cascading bandit, where a learning agent recommends an ordered list (cascade) of items, and a user scans the list sequentially, stopping at the first attractive item. Although cascading bandits underpin various applications including recommender systems and search engines, the role of the cascade length K in shaping regret has remained unclear. Contrary to prior results that regret grows with K, we prove that regret actually decreases once K is large enough. Leveraging this insight, we design a new upper-confidence-bound algorithm built on online mirror descent that attains the sharpest known regret upper bound, O min{K pK 1,1}d Tfor contextual cascading bandits. To complement this new regret upper bound, we provide a nearly matching lower bound of Ω min{KpK 1,1}d T, where 0 p p < 1. Together, these results fully characterize how regret truly scales with K, thereby closing the theoretical gap for contextual cascading bandits. Finally, comprehensive experiments validate our theoretical results and show the effectiveness of our proposed method.

Anthropic still can't distribute Claude Mythos or Fable 5 after running afoul of the Trump administration. But no one can say exactly what the company did wrong. It's been nearly a week since the Trump administration sent an export control directive to Anthropic, forcing one of the world's leading AI labs to pull its most advanced models offline. After days of negotiations between Anthropic and the White House, the two still remain at odds about how to bring Claude Mythos and Fable 5 back. Well, it depends whom you ask.

Recent advances in diffusion models have dramatically improved image fidelity and diversity. However, aligning these models with nuanced human preferences -such as aesthetics, engagement, and subjective appeal remains a key challenge due to the scarcity of large-scale human annotations. Collecting such data is both expensive and limited in diversity. To address this, we leverage the reasoning capabilities of vision-language models (VLMs) and propose Self-Play Reward Optimization (SPRO), a scalable, annotation-free training framework based on multimodal self-play. SPRO learns to jointly align prompt and image generation with human preferences by iteratively generating, evaluating, and learning to refine outputs using synthetic reward signals such as aesthetics and human engagement.

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice. Diagnosis remains complex and error prone, especially in high-pressure or resource-limited settings, underscoring the need for frameworks that help clinicians make timely and cost-effective decisions. We propose ACTMED(Adaptive Clinical Test selection via Model-based Experimental Design), a diagnostic framework that integrates Bayesian Experimental Design (BED) with large language models (LLMs) to better emulate real-world diagnostic reasoning. At each step, ACTMED selects the test expected to yield the greatest reduction in diagnostic uncertainty for a given patient. LLMs act as flexible simulators, generating plausible patient state distributions and supporting belief updates without requiring structured, task-specific training data. Clinicians can remain in the loop; reviewing test suggestions, interpreting intermediate outputs, and applying clinical judgment throughout. We evaluate ACTMEDon real-world datasets and show it can optimize test selection to improve diagnostic accuracy, interpretability, and resource use. This represents a step toward transparent, adaptive, and clinician-aligned diagnostic systems that generalize across settings with reduced reliance on domain-specific data.

Understanding complex systems by inferring trajectories from sparse sample snapshots is a fundamental challenge in a wide range of domains, e.g., single-cell biology, meteorology, and economics. Despite advancements in Bridge and Flow matching frameworks, current methodologies rely on pairwise interpolation between adjacent snapshots. This hinders their ability to capture long-range temporal dependencies and potentially affects the coherence of the inferred trajectories. To address these issues, we introduce Momentum Multi-Marginal Schrödinger Bridge Matching (3MSBM), a novel matching framework that learns smooth measure-valued splines for stochastic systems that satisfy multiple positional constraints. This is achieved by lifting the dynamics to phase space and generalizing stochastic bridges to be conditioned on several points, forming a multi-marginal conditional stochastic optimal control problem. The underlying dynamics are then learned by minimizing a variational objective, having fixed the path induced by the multi-marginal conditional bridge. As a matching approach, 3MSBM learns transport maps that preserve intermediate marginals throughout training, significantly improving convergence and scalability. Extensive experimentation in a series of real-world applications validates the superior performance of 3MSBM compared to existing methods in capturing complex dynamics with temporal dependencies, opening new avenues for training matching frameworks in multi-marginal settings.

Learning with relational and network-structured data is increasingly vital in sensitive domains where protecting the privacy of individual entities is paramount. Differential Privacy (DP) offers a principled approach for quantifying privacy risks, with DP-SGD emerging as a standard mechanism for private model training. However, directly applying DP-SGD to relational learning is challenging due to two key factors: (i) entities often participate in multiple relations, resulting in high and difficult-to-control sensitivity; and (ii) relational learning typically involves multistage, potentially coupled (interdependent) sampling procedures that make standard privacy amplification analyses inapplicable. This work presents a principled framework for relational learning with formal entity-level DP guarantees. We provide a rigorous sensitivity analysis and introduce an adaptive gradient clipping scheme that modulates clipping thresholds based on entity occurrence frequency. We also extend the privacy amplification results to a tractable subclass of coupled sampling, where the dependence arises only through sample sizes. These contributions lead to a tailored DP-SGD variant for relational data with provable privacy guarantees. Experiments on fine-tuning text encoders over text-attributed network-structured relational data demonstrate the strong utility-privacy trade-offs of our approach.

Flexible docking, which predicts the binding conformations of both proteins and small molecules by modeling their structural flexibility, plays a vital role in structure-based drug design. Although recent generative approaches, particularly diffusion-based models, have shown promising results, they require iterative sampling to generate candidate structures and depend on separate scoring functions for pose selection. This leads to an inefficient pipeline that is difficult to scale in real-world drug discovery workflows. To overcome these challenges, we introduce FIGRDock, a fast and accurate flexible docking framework that understands complicated interactions between molecules and proteins with a regression-based approach. FIGRDock leverages initial docking poses from conventional tools to distill interaction-aware distance patterns, which serve as explicit structural conditions to directly guide the prediction of the final protein-ligand complex via a regression model. This one-shot inference paradigm enables rapid and precise pose prediction without reliance on multi-step sampling or external scoring stages. Experimental results show that FIGRDock achieves up to 100 faster inference than diffusion-based docking methods, while consistently surpassing them in accuracy across standard benchmarks. These results suggest that FIGRDock has the potential to offer a scalable and efficient solution for flexible docking, advancing the pace of structure-based drug discovery.4

Deep ensembles deliver state-of-the-art, reliable uncertainty quantification, but their heavy computational and memory requirements hinder their practical deployments to real applications such as on-device AI. Knowledge distillation compresses an ensemble into small student models, but existing techniques struggle to preserve uncertainty partly because reducing the size of DNNs typically results in variation reduction. To resolve this limitation, we introduce a new method of distribution distillation (i.e.

While Large Language Models (LLMs) demonstrate strong performance across domains, their long-context capabilities are limited by transient neural activations causing information decay and unstructured feed-forward network (FFN) weights leading to semantic fragmentation. Inspired by the brain's working memory and cortical modularity, we propose PaceLLM, featuring two innovations: (1) a Persistent Activity (PA) Mechanism that mimics prefrontal cortex (PFC) neurons' persistent firing by introducing an activation-level memory bank to dynamically retrieve, reuse, and update critical FFN states, addressing contextual decay; and (2) Cortical Expert (CE) Clustering that emulates task-adaptive neural specialization to reorganize FFN weights into semantic modules, establishing cross-token dependencies and mitigating fragmentation.

Google just introduced a new smart home speaker yesterday, but the arrival of a new product heralds the end of others. The company has confirmed that it will end production of the Nest Home Mini and Nest Audio. These Nest devices have been on the market for around five years (or longer, if you count 2017's Google Home Mini) and it seems logical for Google to prioritize the newer generation given the current strategy of putting its Gemini chatbot everywhere it possibly can. Although the pair of speakers has been discontinued, any of the two smart home products in the wild will remain operational. Existing Nest Mini and Nest Audio devices will continue to be fully supported with regular software updates, security patches and customer care, a rep from Google told Engadget.