Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA. In addition, these methods rely on tokenizers or fixed k-mers to aggregate meaningful DNA units, losing single nucleotide resolution (i.e. DNA "characters") where subtle genetic variations can completely alter protein function via single nucleotide polymorphisms (SNPs). Recently, Hyena, a large language model based on implicit convolutions was shown to match attention in quality while allowing longer context lengths and lower time complexity.

In this supplementary material, we provide the proofs of convergence analysis in Section 1, 1-vs-1 transformation employed in the classification and semantic segmentation tasks in Section 2, the coordinate-wise and the preprocessing method of the LSTM teacher in Section 3, the loss functions of YOLO-v3 in Section 4, more experiments of image classification in Section 5, and the inferences of semantic segmentation in Section 6. A differentiable function e()is L-smooth with gradient Lipschitz constant C (uniformly Lipschitz continuous), if e(x) e(y) C x y, x,y. The function is called block-wise smooth with gradient Lipschitz Ci, if i e(x i,xi) ie(x i,x i) Ci xi x i, x,x (1) or with gradient Lipschitz constants { Ci}, if i e(x i,xi) ie(x i,xi) Ci x i x i, x,x (2) Further, Let Gmax max{Ci, Ci, k} C. Definition 2. For a differentiable function e(), if e(x) = 0, then x is a first-order stationary solution (SS1). For a differentiable function e(), if x is a SS1, and there exists ϵ > 0 so that for any y in the ϵ-neighborhood of x, we have e(x) e(y), then xis a local minimum. A saddle point xis an SS1 that is not a local minimum. If λmin( 2e(x)) < 0, x is a strict (non-degenerate) saddle point.

With the concept of teaching being introduced to the machine learning community, a teacher model start using dynamic loss functions to teach the training of a student model. The dynamic intends to set adaptive loss functions to different phases of student model learning. In existing works, the teacher model 1) merely determines the loss function based on the present states of the student model, i.e., disregards the experience of the teacher; 2) only utilizes the states of the student model, e.g., training iteration number and loss/accuracy from training/validation sets, while ignoring the states of the loss function. In this paper, we first formulate the loss adjustment as a temporal task by designing a teacher model with memory units, and, therefore, enables the student learning to be guided by the experience of the teacher model. Then, with a dynamic loss network, we can additionally use the states of the loss to assist the teacher learning in enhancing the interactions between the teacher and the student model. Extensive experiments demonstrate our approach can enhance student learning and improve the performance of various deep models on real-world tasks, including classification, objective detection, and semantic segmentation scenarios.

Elon Musk Testifies That He Started OpenAI to Prevent a'Terminator Outcome' The judge also warned Musk and Sam Altman to curb their "propensity to use social media to make things worse outside the courtroom" after both sides traded attacks online. Elon Musk and Sam Altman appeared in a federal courtroom together for the first time on Tuesday as they fight over OpenAI's decade-long evolution and what it means for the company's future. The trial in Musk's lawsuit against Altman could result in financial damages and, more significantly, governance changes at OpenAI that may complicate its plans for an initial public offering as soon as this year. As the first witness on the stand, Musk immediately sought to frame his case as more than just about OpenAI. Siding with Altman "will give license to looting every charity in America" and shake the "entire foundation of charitable giving," Musk told a panel of nine jurors advising US District Judge Yvonne Gonzalez Rogers on how to rule.

US lawmakers gave King Charles III a standing ovation upon mentioning the importance of "checks and balances" on executive power during his historic speech to Congress. Ukrainian drones strike Russia's Tuapse refinery for third time

Runway-to-Space Spaceplane Challenge lets teams fly payloads on Dawn Aerospace's reusable Aurora spaceplane from Oklahoma, with flights expected to begin in 2027.

We study the consistency of surrogate risks for robust binary classification. It is common to learn robust classifiers by adversarial training, which seeks to minimize the expected 0-1 loss when each example can be maliciously corrupted within a small ball. We give a simple and complete characterization of the set of surrogate loss functions that are consistent, i.e., that can replace the 0-1loss without affecting the minimizing sequences of the original adversarial risk, for any data distribution. We also prove a quantitative version of adversarial consistency for the ρ-margin loss. Our results reveal that the class of adversarially consistent surrogates is substantially smaller than in the standard setting, where many common surrogates are known to be consistent.

Generating controllable and photorealistic digital human avatars is a long-standing and important problem in Vision and Graphics. Recent methods have shown great progress in terms of either photorealism or inference speed while the combination of the two desired properties still remains unsolved. To this end, we propose a novel method, called DELIFFAS, which parameterizes the appearance of the human as a surface light field that is attached to a controllable and deforming human mesh model. At the core, we represent the light field around the human with a deformable two-surface parameterization, which enables fast and accurate inference of the human appearance. This allows perceptual supervision on the full image compared to previous approaches that could only supervise individual pixels or small patches due to their slow runtime. Our carefully designed human representation and supervision strategy leads to state-of-the-art synthesis results and inference time. The video results and code are available at https://vcai.