This paper presents Generalized Correspondence-LDA (GC-LDA), a generalization of the Correspondence-LDA model that allows for variable spatial representations to be associated with topics, and increased flexibility in terms of the strength of the correspondence between data types induced by the model. We present three variants of GC-LDA, each of which associates topics with a different spatial representation, and apply them to a corpus of neuroimaging data. In the context of this dataset, each topic corresponds to a functional brain region, where the region's spatial extent is captured by a probability distribution over neural activity, and the region's cognitive function is captured by a probability distribution over linguistic terms. We illustrate the qualitative improvements offered by GC-LDA in terms of the types of topics extracted with alternative spatial representations, as well as the model's ability to incorporate a-priori knowledge from the neuroimaging literature. We furthermore demonstrate that the novel features of GC-LDA improve predictions for missing data.

We introduce the framework of {\em blind regression} motivated by {\em matrix completion} for recommendation systems: given $m$ users, $n$ movies, and a subset of user-movie ratings, the goal is to predict the unobserved user-movie ratings given the data, i.e., to complete the partially observed matrix. Following the framework of non-parametric statistics, we posit that user $u$ and movie $i$ have features $x_1(u)$ and $x_2(i)$ respectively, and their corresponding rating $y(u,i)$ is a noisy measurement of $f(x_1(u), x_2(i))$ for some unknown function $f$. In contrast with classical regression, the features $x = (x_1(u), x_2(i))$ are not observed, making it challenging to apply standard regression methods to predict the unobserved ratings. Inspired by the classical Taylor's expansion for differentiable functions, we provide a prediction algorithm that is consistent for all Lipschitz functions. In fact, the analysis through our framework naturally leads to a variant of collaborative filtering, shedding insight into the widespread success of collaborative filtering in practice. Assuming each entry is sampled independently with probability at least $\max(m^{-1+\delta},n^{-1/2+\delta})$ with $\delta > 0$, we prove that the expected fraction of our estimates with error greater than $\epsilon$ is less than $\gamma^2 / \epsilon^2$ plus a polynomially decaying term, where $\gamma^2$ is the variance of the additive entry-wise noise term. Experiments with the MovieLens and Netflix datasets suggest that our algorithm provides principled improvements over basic collaborative filtering and is competitive with matrix factorization methods.

Ukrainian President Volodymyr Zelensky is set to visit Prime Minister Sir Keir Starmer in the UK on Tuesday to agree a new defence partnership aimed at tackling cheap attack drones. Downing Street said the deal would bring together Ukrainian expertise and the UK's industrial base to manufacture and supply drones and other capabilities. The two leaders are also expected to discuss further support Ukraine against Russia's full-scale invasion, now in its fourth year. Their meeting comes as the US-Israeli war with Iran enters a third week, during which US President Donald Trump has criticised the UK and other countries over the extent of their response to the conflict. Under the partnership between the UK and Ukraine, closer co-operation in the defence industries will also be sought with third countries as part of efforts to bolster international security.

How does our motor system solve the problem of anticipatory control in spite of a wide spectrum of response dynamics from different musculo-skeletal systems, transport delays as well as response latencies throughout the central nervous system? To a great extent, our highly-skilled motor responses are a result of a reactive feedback system, originating in the brain-stem and spinal cord, combined with a feed-forward anticipatory system, that is adaptively fine-tuned by sensory experience and originates in the cerebellum. Based on that interaction we design the counterfactual predictive control (CFPC) architecture, an anticipatory adaptive motor control scheme in which a feed-forward module, based on the cerebellum, steers an error feedback controller with counterfactual error signals. Those are signals that trigger reactions as actual errors would, but that do not code for any current of forthcoming errors. In order to determine the optimal learning strategy, we derive a novel learning rule for the feed-forward module that involves an eligibility trace and operates at the synaptic level. In particular, our eligibility trace provides a mechanism beyond co-incidence detection in that it convolves a history of prior synaptic inputs with error signals. In the context of cerebellar physiology, this solution implies that Purkinje cell synapses should generate eligibility traces using a forward model of the system being controlled. From an engineering perspective, CFPC provides a general-purpose anticipatory control architecture equipped with a learning rule that exploits the full dynamics of the closed-loop system.

Most learning algorithms are not invariant to the scale of the signal that is being approximated. We propose to adaptively normalize the targets used in the learning updates. This is important in value-based reinforcement learning, where the magnitude of appropriate value approximations can change over time when we update the policy of behavior. Our main motivation is prior work on learning to play Atari games, where the rewards were clipped to a predetermined range. This clipping facilitates learning across many different games with a single learning algorithm, but a clipped reward function can result in qualitatively different behavior. Using adaptive normalization we can remove this domain-specific heuristic without diminishing overall performance.

US President Donald Trump has renewed his criticism of the UK government over its response to the Iran conflict, after Prime Minister Sir Keir Starmer said the country would not be drawn into the wider war. Trump told reporters on Monday he was not happy with the UK, adding it should be involved enthusiastically in efforts to reopen the Strait of Hormuz - a vital oil shipping channel . He later told a press conference there were some countries that greatly disappointed me before he singled out the UK, which he said had been considered the Rolls-Royce of allies. Trump's remarks came after Sir Keir said the UK was working with allies on a viable, collective plan to reopen the strait. Sir Keir also said the UK already had minehunters in the region but there was no decision yet on what action would be taken.

We study a general adversarial online learning problem, in which we are given a decision set X' in a reflexive Banach space X and a sequence of reward vectors in the dual space of X. At each iteration, we choose an action from X', based on the observed sequence of previous rewards. Our goal is to minimize regret, defined as the gap between the realized reward and the reward of the best fixed action in hindsight. Using results from infinite dimensional convex analysis, we generalize the method of Dual Averaging (or Follow the Regularized Leader) to our setting and obtain upper bounds on the worst-case regret that generalize many previous results. Under the assumption of uniformly continuous rewards, we obtain explicit regret bounds in a setting where the decision set is the set of probability distributions on a compact metric space S. Importantly, we make no convexity assumptions on either the set S or the reward functions. We also prove a general lower bound on the worst-case regret for any online algorithm. We then apply these results to the problem of learning in repeated two-player zero-sum games on compact metric spaces. In doing so, we first prove that if both players play a Hannan-consistent strategy, then with probability 1 the empirical distributions of play weakly converge to the set of Nash equilibria of the game. We then show that, under mild assumptions, Dual Averaging on the (infinite-dimensional) space of probability distributions indeed achieves Hannan-consistency.

Online optimization covers problems such as online resource allocation, online bipartite matching, adwords (a central problem in e-commerce and advertising), and adwords with separable concave returns. We analyze the worst case competitive ratio of two primal-dual algorithms for a class of online convex (conic) optimization problems that contains the previous examples as special cases defined on the positive orthant. We derive a sufficient condition on the objective function that guarantees a constant worst case competitive ratio (greater than or equal to $\frac{1}{2}$) for monotone objective functions. We provide new examples of online problems on the positive orthant % and the positive semidefinite cone that satisfy the sufficient condition. We show how smoothing can improve the competitive ratio of these algorithms, and in particular for separable functions, we show that the optimal smoothing can be derived by solving a convex optimization problem. This result allows us to directly optimize the competitive ratio bound over a class of smoothing functions, and hence design effective smoothing customized for a given cost function.

Medical researchers are coming to appreciate that many diseases are in fact complex, heterogeneous syndromes composed of subpopulations that express different variants of a related complication. Longitudinal data extracted from individual electronic health records (EHR) offer an exciting new way to study subtle differences in the way these diseases progress over time. In this paper, we focus on answering two questions that can be asked using these databases of longitudinal EHR data. First, we want to understand whether there are individuals with similar disease trajectories and whether there are a small number of degrees of freedom that account for differences in trajectories across the population. Second, we want to understand how important clinical outcomes are associated with disease trajectories. To answer these questions, we propose the Disease Trajectory Map (DTM), a novel probabilistic model that learns low-dimensional representations of sparse and irregularly sampled longitudinal data. We propose a stochastic variational inference algorithm for learning the DTM that allows the model to scale to large modern medical datasets. To demonstrate the DTM, we analyze data collected on patients with the complex autoimmune disease, scleroderma. We find that DTM learns meaningful representations of disease trajectories and that the representations are significantly associated with important clinical outcomes.

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