This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by FCT (INESC-ID multiannual funding) through the PIDDAC Program funds and under project PEst-OE/EEI/LA0021/2011 and the FP7 Cooperation Work Programme: Food, Agriculture and Fisheries, and Biotechnologies, KBBE-227258 (BIOHYPO project). Quotient Bioresearch received part-funding from the European Union in the scope of BIOHYPO project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: During the elaboration of this manuscript, Ian Morrissey and Daniel Knight were employed by Quotient Bioresearch and belonged to the BIOHYPO European project.