Multi-omics data offer unprecedented insights into complex biological systems, yet their high dimensionality, sparsity, and intricate interactions pose significant analytical challenges. Network-based approaches have advanced multi-omics research by effectively capturing biologically relevant relationships among molecular entities. While these methods are powerful for representing molecular interactions, there remains a need for tools specifically designed to effectively utilize these network representations across diverse downstream analyses. To fulfill this need, we introduce BioNeuralNet, a flexible and modular Python framework tailored for end-to-end network-based multi-omics data analysis. BioNeuralNet leverages Graph Neural Networks (GNNs) to learn biologically meaningful low-dimensional representations from multi-omics networks, converting these complex molecular networks into versatile embeddings. BioNeuralNet supports all major stages of multi-omics network analysis, including several network construction techniques, generation of low-dimensional representations, and a broad range of downstream analytical tasks. Its extensive utilities, including diverse GNN architectures, and compatibility with established Python packages (e.g., scikit-learn, PyTorch, NetworkX), enhance usability and facilitate quick adoption. BioNeuralNet is an open-source, user-friendly, and extensively documented framework designed to support flexible and reproducible multi-omics network analysis in precision medicine.

We propose the Wasserstein Black Hole Transformer (WBHT) framework for detecting black hole (BH) anomalies in communication networks. These anomalies cause packet loss without failure notifications, disrupting connectivity and leading to financial losses. WBHT combines generative modeling, sequential learning, and attention mechanisms to improve BH anomaly detection. It integrates a Wasserstein generative adversarial network with attention mechanisms for stable training and accurate anomaly identification. The model uses long-short-term memory layers to capture long-term dependencies and convolutional layers for local temporal patterns. A latent space encoding mechanism helps distinguish abnormal network behavior. Tested on real-world network data, WBHT outperforms existing models, achieving significant improvements in F1 score (ranging from 1.65% to 58.76%). Its efficiency and ability to detect previously undetected anomalies make it a valuable tool for proactive network monitoring and security, especially in mission-critical networks.

Accurate spatiotemporal traffic forecasting is vital for intelligent resource management in 5G and beyond. However, conventional AI approaches often fail to capture the intricate spatial and temporal patterns that exist, due to e.g., the mobility of users. We introduce a lightweight, dual-path Spatiotemporal Network that leverages a Scalar LSTM (sLSTM) for efficient temporal modeling and a three-layer Conv3D module for spatial feature extraction. A fusion layer integrates both streams into a cohesive representation, enabling robust forecasting. Our design improves gradient stability and convergence speed while reducing prediction error. Evaluations on real-world datasets show superior forecast performance over ConvLSTM baselines and strong generalization to unseen regions, making it well-suited for large-scale, next-generation network deployments. Experimental evaluation shows a 23% MAE reduction over ConvLSTM, with a 30% improvement in model generalization.

--Artificial intelligence (AI) and machine learning (ML) models are rapidly permeating the 5G Radio Access Network (RAN), powering beam management, channel state information (CSI) feedback, positioning, and mobility prediction. However, without a standardized life-cycle management (LCM) framework, challenges, such as model drift, vendor lock-in, and limited transparency, hinder large-scale adoption. Beginning with the Network Data Analytics Function (NWDAF) in Rel-16, subsequent releases introduced standardized interfaces for model transfer, execution, performance monitoring, and closed-loop control, culminating in Rel-20's two-sided CSI-compression Work Item and vendor-agnostic LCM profile. This article reviews the resulting five-block LCM architecture, KPI-driven monitoring mechanisms, and inter-vendor collaboration schemes, while identifying open challenges in resource-efficient monitoring, environment drift detection, intelligent decision-making, and flexible model training. These developments lay the foundation for AI-native transceivers as a key enabler for 6G. C.-H. Huang is with the Department of Electrical Engineering, National Taiwan University National Taiwan University, Taipei 10617, Taiwan, Email: chuhsianh@ntu.edu.tw. C.-K. Wen is with the Institute of Communications Engineering, National Sun Y at-sen University, Kaohsiung 80424, Taiwan, Email: chaokai.wen@mail.nsysu.edu.tw. Li is with the Department of Electrical and Electronic Engineering, Imperial College London, SW7 2AZ London, U.K., Email: geoffrey.li@imperial.ac.uk. This work has been submitted to the IEEE for possible publication. RTIFICIAL intelligence (AI) and machine learning (ML) have demonstrated significant potential in enhancing radio access network (RAN) performance, particularly for nonlinear and analytically complex tasks, such as beam management [1], channel state information (CSI) feedback [2], [3], positioning [4], and mobility prediction [5].

Resource allocation (RA) is critical to efficient service deployment in Network Function Virtualization (NFV), a transformative networking paradigm. Recently, deep Reinforcement Learning (RL)-based methods have been showing promising potential to address this complexity. However, the lack of a systematic benchmarking framework and thorough analysis hinders the exploration of emerging networks and the development of more robust algorithms while causing inconsistent evaluation. In this paper, we introduce Virne, a comprehensive benchmarking framework for the NFV-RA problem, with a focus on supporting deep RL-based methods. Virne provides customizable simulations for diverse network scenarios, including cloud, edge, and 5G environments. It also features a modular and extensible implementation pipeline that supports over 30 methods of various types, and includes practical evaluation perspectives beyond effectiveness, such as scalability, generalization, and scalability. Furthermore, we conduct in-depth analysis through extensive experiments to provide valuable insights into performance trade-offs for efficient implementation and offer actionable guidance for future research directions. Overall, with its diverse simulations, rich implementations, and extensive evaluation capabilities, Virne could serve as a comprehensive benchmark for advancing NFV-RA methods and deep RL applications. The code is publicly available at https://github.com/GeminiLight/virne.

Pioneered by the foundational information theory by Claude Shannon and the visionary framework of machine intelligence by Alan Turing, the convergent evolution of information and communication technologies (IT/CT) has created an unbroken wave of connectivity and computation. This synergy has sparked a technological revolution, now reaching its peak with large artificial intelligence (AI) models that are reshaping industries and redefining human-machine collaboration. However, the realization of ubiquitous intelligence faces considerable challenges due to substantial resource consumption in large models and high communication bandwidth demands. To address these challenges, AI Flow has been introduced as a multidisciplinary framework that integrates cutting-edge IT and CT advancements, with a particular emphasis on the following three key points. First, device-edge-cloud framework serves as the foundation, which integrates end devices, edge servers, and cloud clusters to optimize scalability and efficiency for low-latency model inference. Second, we introduce the concept of familial models, which refers to a series of different-sized models with aligned hidden features, enabling effective collaboration and the flexibility to adapt to varying resource constraints and dynamic scenarios. Third, connectivity- and interaction-based intelligence emergence is a novel paradigm of AI Flow. By leveraging communication networks to enhance connectivity, the collaboration among AI models across heterogeneous nodes achieves emergent intelligence that surpasses the capability of any single model. The innovations of AI Flow provide enhanced intelligence, timely responsiveness, and ubiquitous accessibility to AI services, paving the way for the tighter fusion of AI techniques and communication systems.

Utilizing CPUs to serve large language models (LLMs) is a resource-friendly alternative to GPU serving. Existing CPU-based solutions ignore workload differences between the prefill and the decode phases of LLM inference, applying a static per-NUMA (Non-Uniform Memory Access) node model partition and utilizing vendor libraries for operator-level execution, which is suboptimal. We propose Sandwich, a hardware-centric CPU-based LLM serving engine that uses different execution plans for the prefill and decode phases and optimizes them separately. We evaluate Sandwich across diverse baselines and datasets on five CPU platforms, including x86 with AVX-2 and AVX-512, as well as ARM with NEON. Sandwich achieves an average 2.01x throughput improvement and 90% satisfactory time-to-first-token (TTFT) and time-per-output-token (TPOT) latencies with up to 3.40x lower requirements in single sequence serving, and significant improvement in Goodput in continuous-batching serving. The GEMM kernels generated by Sandwich outperform representative vendor kernels and other dynamic shape solutions, achieving performance comparable to static compilers with three orders of magnitude less kernel tuning costs.

In this paper, we tackle the challenge of radio access network (RAN) slicing within an open RAN (O-RAN) architecture. Our focus centers on a network that includes multiple mobile virtual network operators (MVNOs) competing for physical resource blocks (PRBs) with the goal of meeting probabilistic delay upper bound constraints for their clients while minimizing PRB utilization. Initially, we derive a reward function based on the law of large numbers (LLN), then implement practical modifications to adapt it for real-world experimental scenarios. We then propose our solution, the Percentile-based Delay-Aware Deep Reinforcement Learning (PDA-DRL), which demonstrates its superiority over several baselines, including DRL models optimized for average delay constraints, by achieving a 38\% reduction in resultant average delay. Furthermore, we delve into the issue of model weight sharing among multiple MVNOs to develop a robust personalized model. We introduce a reward-based personalization method where each agent prioritizes other agents' model weights based on their performance. This technique surpasses traditional aggregation methods, such as federated averaging, and strategies reliant on traffic patterns and model weight distance similarities.

Service-level mobile traffic prediction for individual users is essential for network efficiency and quality of service enhancement. However, current prediction methods are limited in their adaptability across different urban environments and produce inaccurate results due to the high uncertainty in personal traffic patterns, the lack of detailed environmental context, and the complex dependencies among different network services. These challenges demand advanced modeling techniques that can capture dynamic traffic distributions and rich environmental features. Inspired by the recent success of diffusion models in distribution modeling and Large Language Models (LLMs) in contextual understanding, we propose an LLM-Enhanced Spatio-temporal Diffusion Model (LSDM). LSDM integrates the generative power of diffusion models with the adaptive learning capabilities of transformers, augmented by the ability to capture multimodal environmental information for modeling service-level patterns and dynamics. Extensive evaluations on real-world service-level datasets demonstrate that the model excels in traffic usage predictions, showing outstanding generalization and adaptability. After incorporating contextual information via LLM, the performance improves by at least 2.83% in terms of the coefficient of determination. Compared to models of a similar type, such as CSDI, the root mean squared error can be reduced by at least 8.29%. The code and dataset will be available at: https://github.com/SoftYuaneR/LSDM.

This paper investigates a joint beamforming and resource allocation problem in downlink reconfigurable intelligent surface (RIS)-assisted orthogonal frequency division multiplexing (OFDM) systems to minimize the average delay, where data packets for each user arrive at the base station (BS) stochastically. The sequential optimization problem is inherently a Markov decision process (MDP), thus falling within the remit of reinforcement learning. To effectively handle the mixed action space and reduce the state space dimensionality, a hybrid deep reinforcement learning (DRL) approach is proposed. Specifically, proximal policy optimization (PPO)-Theta is employed to optimize the RIS phase shift design, while PPO-N is responsible for subcarrier allocation decisions. The active beamforming at the BS is then derived from the jointly optimized RIS phase shifts and subcarrier allocation decisions. To further mitigate the curse of dimensionality associated with subcarrier allocation, a multi-agent strategy is introduced to optimize the subcarrier allocation indicators more efficiently. Moreover, to achieve more adaptive resource allocation and accurately capture the network dynamics, key factors closely related to average delay, such as the number of backlogged packets in buffers and current packet arrivals, are incorporated into the state space. Furthermore, a transfer learning framework is introduced to enhance the training efficiency and accelerate convergence. Simulation results demonstrate that the proposed algorithm significantly reduces the average delay, enhances resource allocation efficiency, and achieves superior system robustness and fairness compared to baseline methods.