This research focuses on rational pesticide design, using graph machine learning to accelerate the development of safer, eco-friendly agrochemicals, inspired by in silico methods in drug discovery. With an emphasis on ecotoxicology, the initial contributions include the creation of ApisTox, the largest curated dataset on pesticide toxicity to honey bees. We conducted a broad evaluation of machine learning (ML) models for molecular graph classification, including molecular fingerprints, graph kernels, GNNs, and pretrained transformers. The results show that methods successful in medicinal chemistry often fail to generalize to agrochemicals, underscoring the need for domain-specific models and benchmarks. Future work will focus on developing a comprehensive benchmarking suite and designing ML models tailored to the unique challenges of pesticide discovery.

Porous materials exhibit vast structural diversity and support critical applications in gas storage, separations, and catalysis. However, predictive modeling remains challenging due to the multiscale nature of structure-property relationships, where performance is governed by both local chemical environments and global pore-network topology. These complexities, combined with sparse and unevenly distributed labeled data, hinder generalization across material families. We propose the Interaction Topological Transformer (ITT), a unified data-efficient framework that leverages novel interaction topology to capture materials information across multiple scales and multiple levels, including structural, elemental, atomic, and pairwise-elemental organization. ITT extracts scale-aware features that reflect both compositional and relational structure within complex porous frameworks, and integrates them through a built-in Transformer architecture that supports joint reasoning across scales. Trained using a two-stage strategy, i.e., self-supervised pretraining on 0.6 million unlabeled structures followed by supervised fine-tuning, ITT achieves state-of-the-art, accurate, and transferable predictions for adsorption, transport, and stability properties. This framework provides a principled and scalable path for learning-guided discovery in structurally and chemically diverse porous materials.

We present Speech Vecalign, a parallel speech document alignment method that monotonically aligns speech segment embeddings and does not depend on text transcriptions. Compared to the baseline method Global Mining, a variant of speech mining, Speech Vecalign produces longer speech-to-speech alignments. It also demonstrates greater robustness than Local Mining, another speech mining variant, as it produces less noise. We applied Speech Vecalign to 3,000 hours of unlabeled parallel English-German (En-De) speech documents from VoxPopuli, yielding about 1,000 hours of high-quality alignments. We then trained En-De speech-to-speech translation models on the aligned data. Speech Vecalign improves the En-to-De and De-to-En performance over Global Mining by 0.37 and 0.18 ASR-BLEU, respectively. Moreover, our models match or outperform SpeechMatrix model performance, despite using 8 times fewer raw speech documents.

The growing global demand for critical raw materials (CRMs) has highlighted the need to access difficult and hazardous environments such as abandoned underground mines. These sites pose significant challenges for conventional machinery and human operators due to confined spaces, structural instability, and lack of infrastructure. To address this, we propose a modular multi-robot system designed for autonomous operation in such environments, enabling sequential mineral extraction tasks. Unlike existing work that focuses primarily on mapping and inspection through global behavior or central control, our approach incorporates physical interaction capabilities using specialized robots coordinated through local high-level behavior control. Our proposed system utilizes Hierarchical Finite State Machine (HFSM) behaviors to structure complex task execution across heterogeneous robotic platforms. Each robot has its own HFSM behavior to perform sequential autonomy while maintaining overall system coordination, achieved by triggering behavior execution through inter-robot communication. This architecture effectively integrates software and hardware components to support collaborative, task-driven multi-robot operation in confined underground environments.

Cable-driven serpentine manipulators hold great potential in unstructured environments, offering obstacle avoidance, multi-directional force application, and a lightweight design. By placing all motors and sensors at the base and employing plastic links, we can further reduce the arm's weight. To demonstrate this concept, we developed a 9-degree-of-freedom cable-driven serpentine manipulator with an arm length of 545 mm and a total mass of only 308 g. However, this design introduces flexibility-induced variations, such as cable slack, elongation, and link deformation. These variations result in discrepancies between analytical predictions and actual link positions, making pose estimation more challenging. To address this challenge, we propose a physical reservoir computing based pose estimation method that exploits the manipulator's intrinsic nonlinear dynamics as a high-dimensional reservoir. Experimental results show a mean pose error of 4.3 mm using our method, compared to 4.4 mm with a baseline long short-term memory network and 39.5 mm with an analytical approach. This work provides a new direction for control and perception strategies in lightweight cable-driven serpentine manipulators leveraging their intrinsic dynamics.

Empowering large language models (LLMs) with chemical intelligence remains a challenge due to the scarcity of high-quality, domain-specific instruction-response datasets and the misalignment of existing synthetic data generation pipelines with the inherently hierarchical and rule-governed structure of chemical information. To address this, we propose ChemOrch, a framework that synthesizes chemically grounded instruction-response pairs through a two-stage process: task-controlled instruction generation and tool-aware response construction. ChemOrch enables controllable diversity and levels of difficulty for the generated tasks, and ensures response precision through tool planning and distillation, and tool-based self-repair mechanisms. The effectiveness of ChemOrch is evaluated based on: 1) the high quality of generated instruction data, demonstrating superior diversity and strong alignment with chemical constraints; 2) the reliable generation of evaluation tasks that more effectively reveal LLM weaknesses in chemistry; and 3) the significant improvement of LLM chemistry capabilities when the generated instruction data are used for fine-tuning. Our work thus represents a critical step toward scalable and verifiable chemical intelligence in LLMs.

Miniature robots are untethered actuators, which have significant potential to make existing minimally invasive surgery considerably safer and painless, and enable unprecedented treatments because they are much smaller and dexterous than existing surgical robots. Of the miniature robots, the magnetically actuated ones are the most functional and dexterous. However, existing magnetic miniature robots are currently impractical for surgery because they are either restricted to possessing at most two on-board functionalities or having limited five degrees-of-freedom (DOF) locomotion. Some of these actuators are also only operational under specialized environments where actuation from strong external magnets must be at very close proximity (< 4 cm away). Here we present a millimeter-scale soft robot where its magnetization profile can be reprogrammed upon command to perform five surgical functionalities: drug-dispensing, cutting through biological tissues (simulated with gelatin), gripping, storing (biological) samples and remote heating. By possessing full six-DOF motions, including the sixth-DOF rotation about its net magnetic moment, our soft robot can also roll and two-anchor crawl across challenging unstructured environments, which are impassable by its five-DOF counterparts. Because our actuating magnetic fields are relatively uniform and weak (at most 65 mT and 1.5 T/m), such fields can theoretically penetrate through biological tissues harmlessly and allow our soft robot to remain controllable within the depths of the human body. We envision that this work marks a major milestone for the advancement of soft actuators, and towards revolutionizing minimally invasive treatments with untethered miniature robots that have unprecedented functionalities.

Reinforcement Learning from Verifiable Rewards (RLVR) has recently shown that large language models (LLMs) can develop their own reasoning without direct supervision. However, applications in the medical domain, specifically for question answering, are susceptible to significant reward hacking during the reasoning phase. Our work addresses two primary forms of this behavior: i) providing a final answer without preceding reasoning, and ii) employing non-standard reasoning formats to exploit the reward mechanism. To mitigate these, we introduce a composite reward function with specific penalties for these behaviors. Our experiments show that extending RLVR with our proposed reward model leads to better-formatted reasoning with less reward hacking and good accuracy compared to the baselines. This approach marks a step toward reducing reward hacking and enhancing the reliability of models utilizing RLVR.

How is Russia replenishing its military? What is a'coalition of the willing'? How China forgot promises and'debts' to Ukraine How are Europe, the US pulling apart on Ukraine? Ukrainian drones hit a key oil-processing and petrochemical complex in Russia's Bashkortostan region, as well as an oil refinery in the Volgograd region, as Ukraine escalates its campaign against Russia's extensive oil and gas sector. Russian military units claim to have breached Ukraine's western village of Yampol and secured new positions near five residential areas in the same area, according to Russia's state TASS news agency.

Artificial Intelligence (AI) has transitioned from a futuristic concept reserved for large corporations to a present-day, accessible, and essential growth lever for Small and Medium-sized Enterprises (SMEs). For entrepreneurs and business leaders, strategic AI adoption is no longer an option but an imperative for competitiveness, operational efficiency, and long-term survival. This report provides a comprehensive framework for SME leaders to navigate this technological shift, offering the foundational knowledge, business case, practical applications, and strategic guidance necessary to harness the power of AI. The quantitative evidence supporting AI adoption is compelling; 91% of SMEs using AI report that it directly boosts their revenue. Beyond top-line growth, AI drives profound operational efficiencies, with studies showing it can reduce operational costs by up to 30% and save businesses more than 20 hours of valuable time each month. This transformation is occurring within the context of a seismic economic shift; the global AI market is projected to surge from $233.46 Billion in 2024 to an astonishing $1.77 Trillion by 2032. This paper demystifies the core concepts of AI, presents a business case based on market data, details practical applications, and lays out a phased, actionable adoption strategy.