A novel approach is presented for the development of expert systems for structural design problems. This approach differs from the conventional expert systems in two fundamental respects. First, mathematical optimization is introduced into the design process. Second, a computer is used to obtain parts of the knowledge necessary in the expert systems in addition to heuristics and experiential knowledge obtained from documented materials and human experts. As an example of this approach, a prototype coupled expert system, the bridge truss expert (BTExpert), is presented for optimum design of bridge trusses subjected to moving loads. BTExpert was developed by interfacing an interactive optimization program developed in Fortran 77 to an expert system shell developed in Pascal. This new generation of expert systems-embracing various advanced technologies such as AI (machine intelligence), the numeric optimization technique, and interactive computer graphics -- should find enormous practical implications.

Artificial intelligence, or AI, is largely an experimental science—at least as much progress has been made by building and analyzing programs as by examining theoretical questions. MYCIN is one of several well-known programs that embody some intelligence and provide data on the extent to which intelligent behavior can be programmed. As with other AI programs, its development was slow and not always in a forward direction. But we feel we learned some useful lessons in the course of nearly a decade of work on MYCIN and related programs. In this book we share the results of many experiments performed in that time, and we try to paint a coherent picture of the work. The book is intended to be a critical analysis of several pieces of related research, performed by a large number of scientists. We believe that the whole field of AI will benefit from such attempts to take a detailed retrospective look at experiments, for in this way the scientific foundations of the field will gradually be defined. It is for all these reasons that we have prepared this analysis of the MYCIN experiments.

The complete book in a single file.

A practical criterion for the success of a knowledge-based problem-solving system is its usefulness as a tool to those working in its specialized domain of expertise. This paper describes an evaluation and several applications of a knowledge-based system, the PROSPECTOR consultant for mineral exploration. PROSPECTOR is a rule-based judgmental reasoning system that evaluates the mineral potential of a site or region with respect to inference network models of specific classes of ore deposits. Knowledge about a particular type of ore deposit is encoded in a computational model representing observable geological features and the relative significance thereof.In Hayes, J. E., Michie, D., and Pao, Y.-H. (Eds.), Machine Intelligence 10. Ellis Horwood.

D.Michie (Ed.), Expert systems in the micro- electronic age.Edinburgh: Edinburgh University Press, 153-167

Retrospective on lessons learned from the Dendral project."The DENDRAL and Meta-DENDRAL programs are products of a large, interdisciplinary group of Stanford University scientists concerned with many and highly varied aspects of the mechanization of scientific reasoning and the formalization of scientific knowledge for this purpose. An early motivation for our wok was to explore the power of existing Al methods, such as heuristic search, for reasoning in difficult scientific problems. Another concern has been to exploit the AI methodology to understand better some fundamental questions in the philosophy of science, for example the processes by which explanatory hypotheses are discovered or judged adequate. From the start, the project has had an applications dimension. It has sought to develop "expert level" agents to assist in the solution of problems in their discipline that require complex symbolic reasoning. The applications dimension is the focus of this paper."Artificial Intelligence 11 (1-2): 5-24

The design of application of artificia l intelli­gence to a scientific task such as Organic Chemical Synthesis was the topic of a Doctoral Thesis completed in the summer of 197I. Chemical synthesis in practice involves i) the choice of molecule to be synthesized; i i) the formulation and specification of a plan for synthesis (involving a valid reaction pathway leading from commercial or readily available compounds to the target compounds with consideration of feasibility regarding the purposes of synthesis);iii ) the selection of specific individual steps of reaction and their temporal ordering for execution; iv) the exper­imental execution of the synthesis and v) the redesign of syntheses, if necessary, depending upon the exper­imental results. In IJCAI-73: THIRD INTERNATIONAL JOINT CONFERENCE ON ARTIFICIAL INTELLIGENCE, 20-23 August 1973, Stanford University Stanford, California.

"A computer program has been written which can formulate hypotheses from a given set of scientific data. The data consist of the mass spectrum and the empirical formula of an organic chemical compound. The hypotheses which are produced describe molecular structures which are plausible explanations of the data. The hypotheses are generated systematically within the program's theory of chemical stability and within limiting constraints which are inferred from the data by heuristic rules. The program excludes hypotheses inconsistent with the data and lists its candidate explanatory hypotheses in order of decreasing plausibility. The computer program is heuristic in that it searches for plausible hypotheses in a small subset of the total hypothesis space according to heuristic rules learned from chemists."In Meltzer, B., Michie, D., and Swann, M. (Eds.), Machine Intelligence 4, pp. 209-254. Edinburgh University Press