Advances in artificially intelligent robots have enabled pioneering scientists to endow them with human-like capabilities. A new study by Cornell University researchers published in Science Advances introduces an autonomous, self-healing soft robot that is not only able to identify injuries but also heal itself. The scientists plan to integrate these soft robots with artificial intelligence (AI) machine learning in the future. "We introduce an autonomous self-healing optical sensing mechanism, networks of self-healing light guides for dynamic sensing (SHeaLDS), which exploit the damage-resilient properties intrinsic to light propagation, in combination with an intrinsic self-healing material, to achieve an optomechanical sensor that both autonomously self-heals and provides reliable dynamic sensing performance," wrote Rob Shepherd, associate professor of mechanical and aerospace engineering at Cornell, in collaboration with Young Seong Kim and Hedan Bai. The soft robot consists of a flexible material called poly elastomer (polyurethane urea).

NAS has been explosively studied to automate the discovery of top-performer neural networks, but suffers from heavy resource consumption and often incurs search bias due to truncated training or approximations. Recent NAS works [1], [2], [3] start to explore indicators that can predict a network's performance without training. However, they either leveraged limited properties of deep networks, or the benefits of their training-free indicators are not applied to more extensive search methods. By rigorous correlation analysis, we present a unified framework to understand and accelerate NAS, by disentangling "TEG" characteristics of searched networks - Trainability, Expressivity, Generalization - all assessed in a training-free manner. The TEG indicators could be scaled up and integrated with various NAS search methods, including both supernet and single-path NAS approaches. Extensive studies validate the effective and efficient guidance from our TEG-NAS framework, leading to both improved search accuracy and over 56% reduction in search time cost. Moreover, we visualize search trajectories on three landscapes of "TEG" characteristics, observing that a good local minimum is easier to find on NAS-Bench-201 given its simple topology, whereas balancing "TEG" characteristics is much harder on the DARTS space due to its complex landscape geometry.

From a pig heart being successfully transplanted into a human, to being able to redirect an asteroid on a collision course with Earth, there have been all manner of weird and wonderful scientific discoveries in 2022. They include the human genome finally been mapped after two decades, the unearthing of Africa's oldest known dinosaur, and the release of the first ever image of a supermassive black hole at the heart of our Milky Way galaxy. There was also the alarming discovery that microplastics are everywhere – including in us – and the hugely-anticipated first images from the world's most powerful space telescope James Webb, which will peer back to the dawn of the universe. Here, MailOnline looks at 10 of the most interesting advances this year. The year began with a bang scientifically when just a week into it a dying man became the first patient in the world to get a heart transplant from a genetically-modified pig.

Using Structural Health Monitoring (SHM) systems with extensive sensing arrangements on every civil structure can be costly and impractical. Various concepts have been introduced to alleviate such difficulties, such as Population-based SHM (PBSHM). Nevertheless, the studies presented in the literature do not adequately address the challenge of accessing the information on different structural states (conditions) of dissimilar civil structures. The study herein introduces a novel framework named Structural State Translation (SST), which aims to estimate the response data of different civil structures based on the information obtained from a dissimilar structure. SST can be defined as Translating a state of one civil structure to another state after discovering and learning the domain-invariant representation in the source domains of a dissimilar civil structure. SST employs a Domain-Generalized Cycle-Generative (DGCG) model to learn the domain-invariant representation in the acceleration datasets obtained from a numeric bridge structure that is in two different structural conditions. In other words, the model is tested on three dissimilar numeric bridge models to translate their structural conditions. The evaluation results of SST via Mean Magnitude-Squared Coherence (MMSC) and modal identifiers showed that the translated bridge states (synthetic states) are significantly similar to the real ones. As such, the minimum and maximum average MMSC values of real and translated bridge states are 91.2% and 97.1%, the minimum and the maximum difference in natural frequencies are 5.71% and 0%, and the minimum and maximum Modal Assurance Criterion (MAC) values are 0.998 and 0.870. This study is critical for data scarcity and PBSHM, as it demonstrates that it is possible to obtain data from structures while the structure is actually in a different condition or state.

Machine learning methods have revolutionized the discovery process of new molecules and materials. However, the intensive training process of neural networks for molecules with ever-increasing complexity has resulted in exponential growth in computation cost, leading to long simulation time and high energy consumption. Photonic chip technology offers an alternative platform for implementing neural networks with faster data processing and lower energy usage compared to digital computers. Photonics technology is naturally capable of implementing complex-valued neural networks at no additional hardware cost. Here, we demonstrate the capability of photonic neural networks for predicting the quantum mechanical properties of molecules. To the best of our knowledge, this work is the first to harness photonic technology for machine learning applications in computational chemistry and molecular sciences, such as drug discovery and materials design. We further show that multiple properties can be learned simultaneously in a photonic chip via a multi-task regression learning algorithm, which is also the first of its kind as well, as most previous works focus on implementing a network in the classification task.

As a common appearance defect of concrete bridges, cracks are important indices for bridge structure health assessment. Although there has been much research on crack identification, research on the evolution mechanism of bridge cracks is still far from practical applications. In this paper, the state-of-the-art research on intelligent theories and methodologies for intelligent feature extraction, data fusion and crack detection based on data-driven approaches is comprehensively reviewed. The research is discussed from three aspects: the feature extraction level of the multimodal parameters of bridge cracks, the description level and the diagnosis level of the bridge crack damage states. We focus on previous research concerning the quantitative characterization problems of multimodal parameters of bridge cracks and their implementation in crack identification, while highlighting some of their major drawbacks. In addition, the current challenges and potential future research directions are discussed.

Synthesis planning programs trained on chemical reaction data can design efficient routes to new molecules of interest, but are limited in their ability to leverage rare chemical transformations. This challenge is acute for enzymatic reactions, which are valuable due to their selectivity and sustainability but are few in number. We report a retrosynthetic search algorithm using two neural network models for retrosynthesis–one covering 7984 enzymatic transformations and one 163,723 synthetic transformations–that balances the exploration of enzymatic and synthetic reactions to identify hybrid synthesis plans. This approach extends the space of retrosynthetic moves by thousands of uniquely enzymatic one-step transformations, discovers routes to molecules for which synthetic or enzymatic searches find none, and designs shorter routes for others. Application to (-)-Δ9 tetrahydrocannabinol (THC) (dronabinol) and R,R-formoterol (arformoterol) illustrates how our strategy facilitates the replacement of metal catalysis, high step counts, or costly enantiomeric resolution with more elegant hybrid proposals. The identification of synthetic routes combining enzymatic and non-enzymatic reactions has been challenging and requiring expert knowledge. Here, the authors describe a computational retrosynthetic approach relying on neural network models for planning synthetic routes using both strategies.

National Association of Securities Dealers Automated Quotations(NASDAQ) is an American stock exchange based. It is one of the most valuable stock economic indices in the world and is located in New York City \cite{pagano2008quality}. The volatility of the stock market and the influence of economic indicators such as crude oil, gold, and the dollar in the stock market, and NASDAQ shares are also affected and have a volatile and chaotic nature \cite{firouzjaee2022lstm}.In this article, we have examined the effect of oil, dollar, gold, and the volatility of the stock market in the economic market, and then we have also examined the effect of these indicators on NASDAQ stocks. Then we started to analyze the impact of the feedback on the past prices of NASDAQ stocks and its impact on the current price. Using PCA and Linear Regression algorithm, we have designed an optimal dynamic learning experience for modeling these stocks. The results obtained from the quantitative analysis are consistent with the results of the qualitative analysis of economic studies, and the modeling done with the optimal dynamic experience of machine learning justifies the current price of NASDAQ shares.

Due to the subtle balance of intermolecular interactions that govern structure-property relations, predicting the stability of crystal structures formed from molecular building blocks is a highly non-trivial scientific problem. A particularly active and fruitful approach involves classifying the different combinations of interacting chemical moieties, as understanding the relative energetics of different interactions enables the design of molecular crystals and fine-tuning their stabilities. While this is usually performed based on the empirical observation of the most commonly encountered motifs in known crystal structures, we propose to apply a combination of supervised and unsupervised machine-learning techniques to automate the construction of an extensive library of molecular building blocks. We introduce a structural descriptor tailored to the prediction of the binding (lattice) energy and apply it to a curated dataset of organic crystals and exploit its atom-centered nature to obtain a data-driven assessment of the contribution of different chemical groups to the lattice energy of the crystal. We then interpret this library using a low-dimensional representation of the structure-energy landscape and discuss selected examples of the insights into crystal engineering that can be extracted from this analysis, providing a complete database to guide the design of molecular materials.

Artificial Intelligence (AI) and Machine Learning (ML) are weaving their way into the fabric of society, where they are playing a crucial role in numerous facets of our lives. As we witness the increased deployment of AI and ML in various types of devices, we benefit from their use into energy-efficient algorithms for low powered devices. In this paper, we investigate a scale and medium that is far smaller than conventional devices as we move towards molecular systems that can be utilized to perform machine learning functions, i.e., Molecular Machine Learning (MML). Fundamental to the operation of MML is the transport, processing, and interpretation of information propagated by molecules through chemical reactions. We begin by reviewing the current approaches that have been developed for MML, before we move towards potential new directions that rely on gene regulatory networks inside biological organisms as well as their population interactions to create neural networks. We then investigate mechanisms for training machine learning structures in biological cells based on calcium signaling and demonstrate their application to build an Analog to Digital Converter (ADC). Lastly, we look at potential future directions as well as challenges that this area could solve.