Metastructured auxetic patches, characterized by negative Poisson's ratios, offer unique mechanical properties that closely resemble the behavior of human tissues and organs. As a result, these patches have gained significant attention for their potential applications in organ repair and tissue regeneration. This study focuses on neural networks-based computational modeling of auxetic patches with a sinusoidal metastructure fabricated from silk fibroin, a bio-inspired material known for its biocompatibility and strength. The primary objective of this research is to introduce a novel, data-driven framework for patch design. To achieve this, we conducted experimental fabrication and mechanical testing to determine material properties and validate the corresponding finite element models. Finite element simulations were then employed to generate the necessary data, while greedy sampling, an active learning technique, was utilized to reduce the computational cost associated with data labeling. Two neural networks were trained to accurately predict Poisson's ratios and stresses for strains up to 15\%, respectively. Both models achieved $R^2$ scores exceeding 0.995, which indicates highly reliable predictions. Building on this, we developed a neural network-based design model capable of tailoring patch designs to achieve specific mechanical properties. This model demonstrated superior performance when compared to traditional optimization methods, such as genetic algorithms, by providing more efficient and precise design solutions. The proposed framework represents a significant advancement in the design of bio-inspired metastructures for medical applications, paving the way for future innovations in tissue engineering and regenerative medicine.

Deep learning (DL) models have gained prominence in domains such as computer vision and natural language processing but remain underutilized for regression tasks involving tabular data. In these cases, traditional machine learning (ML) models often outperform DL models. In this study, we propose and evaluate various data augmentation (DA) techniques to improve the performance of DL models for tabular data regression tasks. We compare the performance gain of Neural Networks by different DA strategies ranging from a naive method of duplicating existing observations and adding noise to a more sophisticated DA strategy that preserves the underlying statistical relationship in the data. Our analysis demonstrates that the advanced DA method significantly improves DL model performance across multiple datasets and regression tasks, resulting in an average performance increase of over 10\% compared to baseline models without augmentation. The efficacy of these DA strategies was rigorously validated across 30 distinct datasets, with multiple iterations and evaluations using three different automated deep learning (AutoDL) frameworks: AutoKeras, H2O, and AutoGluon. This study demonstrates that by leveraging advanced DA techniques, DL models can realize their full potential in regression tasks, thereby contributing to broader adoption and enhanced performance in practical applications.

Recent self-supervised learning (SSL) models trained on human-like egocentric visual inputs substantially underperform on image recognition tasks compared to humans. These models train on raw, uniform visual inputs collected from head-mounted cameras. This is different from humans, as the anatomical structure of the retina and visual cortex relatively amplifies the central visual information, i.e. around humans' gaze location. This selective amplification in humans likely aids in forming object-centered visual representations. Here, we investigate whether focusing on central visual information boosts egocentric visual object learning. We simulate 5-months of egocentric visual experience using the large-scale Ego4D dataset and generate gaze locations with a human gaze prediction model. To account for the importance of central vision in humans, we crop the visual area around the gaze location. Finally, we train a time-based SSL model on these modified inputs. Our experiments demonstrate that focusing on central vision leads to better object-centered representations. Our analysis shows that the SSL model leverages the temporal dynamics of the gaze movements to build stronger visual representations. Overall, our work marks a significant step toward bio-inspired learning of visual representations.

The alignment of large language models (LLMs) with human values is critical as these models become increasingly integrated into various societal and decision-making processes. Traditional methods, such as reinforcement learning from human feedback (RLHF), achieve alignment by fine-tuning model parameters, but these approaches are often computationally expensive and impractical when models are frozen or inaccessible for parameter modification. In contrast, prompt optimization is a viable alternative to RLHF for LLM alignment. While the existing literature has shown empirical promise of prompt optimization, its theoretical underpinning remains under-explored. We address this gap by formulating prompt optimization as an optimization problem and try to provide theoretical insights into the optimality of such a framework. To analyze the performance of the prompt optimization, we study theoretical suboptimality bounds and provide insights in terms of how prompt optimization depends upon the given prompter and target model. We also provide empirical validation through experiments on various datasets, demonstrating that prompt optimization can effectively align LLMs, even when parameter fine-tuning is not feasible.

A very crucial part of Bangladeshi people's employment, GDP contribution, and mainly livelihood is agriculture. It plays a vital role in decreasing poverty and ensuring food security. Plant diseases are a serious stumbling block in agricultural production in Bangladesh. At times, humans can't detect the disease from an infected leaf with the naked eye. Using inorganic chemicals or pesticides in plants when it's too late leads in vain most of the time, deposing all the previous labor. The deep-learning technique of leaf-based image classification, which has shown impressive results, can make the work of recognizing and classifying all diseases trouble-less and more precise. In this paper, we've mainly proposed a better model for the detection of leaf diseases. Our proposed paper includes the collection of data on three different kinds of crops: bell peppers, tomatoes, and potatoes. For training and testing the proposed CNN model, the plant leaf disease dataset collected from Kaggle is used, which has 17,430 images. The images are labeled with 14 separate classes of damage. The developed CNN model performs efficiently and could successfully detect and classify the tested diseases. The proposed CNN model may have great potency in crop disease management.

There's no doubt Great Britain lays claim to some of the greatest scientific discoveries and inventions that have changed the face of modern society. Now, MailOnline's interactive map reveals the birthplace of 30 of these famous British marvels, from stainless steel to the jet engine and the electric motor. Who can forget Alan Turing's Bombe machine, used to break Enigma-enciphered messages about enemy military operations during WWII? Turing developed the Bombe in 1939 at Bletchley Park in Buckinghamshire and hundreds were built, marking a crucial contribution to the war effort. Also on the map is the hovercraft invented by Christopher Cockerell in 1955 and first launched four years later on the the Isle of Wight.

In this paper, we present the design and benchmark of an innovative sensor, ViTacTip, which fulfills the demand for advanced multi-modal sensing in a compact design. A notable feature of ViTacTip is its transparent skin, which incorporates a `see-through-skin' mechanism. This mechanism aims at capturing detailed object features upon contact, significantly improving both vision-based and proximity perception capabilities. In parallel, the biomimetic tips embedded in the sensor's skin are designed to amplify contact details, thus substantially augmenting tactile and derived force perception abilities. To demonstrate the multi-modal capabilities of ViTacTip, we developed a multi-task learning model that enables simultaneous recognition of hardness, material, and textures. To assess the functionality and validate the versatility of ViTacTip, we conducted extensive benchmarking experiments, including object recognition, contact point detection, pose regression, and grating identification. To facilitate seamless switching between various sensing modalities, we employed a Generative Adversarial Network (GAN)-based approach. This method enhances the applicability of the ViTacTip sensor across diverse environments by enabling cross-modality interpretation.

The advancement of machine learning and the availability of large-scale reaction datasets have accelerated the development of data-driven models for computer-aided synthesis planning (CASP) in the past decade. Here, we detail the newest version of ASKCOS, an open source software suite for synthesis planning that makes available several research advances in a freely available, practical tool. Four one-step retrosynthesis models form the basis of both interactive planning and automatic planning modes. Retrosynthetic planning is complemented by other modules for feasibility assessment and pathway evaluation, including reaction condition recommendation, reaction outcome prediction, and auxiliary capabilities such as solubility prediction and quantum mechanical descriptor prediction. ASKCOS has assisted hundreds of medicinal, synthetic, and process chemists in their day-to-day tasks, complementing expert decision making. It is our belief that CASP tools like ASKCOS are an important part of modern chemistry research, and that they offer ever-increasing utility and accessibility.

Generative artificial intelligence offers a promising avenue for materials discovery, yet its advantages over traditional methods remain unclear. In this work, we introduce and benchmark two baseline approaches - random enumeration of charge-balanced prototypes and data-driven ion exchange of known compounds - against three generative models: a variational autoencoder, a large language model, and a diffusion model. Our results show that established methods such as ion exchange perform comparably well in generating stable materials, although many of these materials tend to closely resemble known compounds. In contrast, generative models excel at proposing novel structural frameworks and, when sufficient training data is available, can more effectively target properties such as electronic band gap and bulk modulus while maintaining a high stability rate. To enhance the performance of both the baseline and generative approaches, we implement a post-generation screening step in which all proposed structures are passed through stability and property filters from pre-trained machine learning models including universal interatomic potentials. This low-cost filtering step leads to substantial improvement in the success rates of all methods, remains computationally efficient, and ultimately provides a practical pathway toward more effective generative strategies for materials discovery.

Accurate prediction of protein-ligand binding affinities is crucial in drug discovery, particularly during hit-to-lead and lead optimization phases, however, limitations in ligand force fields continue to impact prediction accuracy. In this work, we validate relative binding free energy (RBFE) accuracy using neural network potentials (NNPs) for the ligands. We utilize a novel NNP model, AceForce 1.0, based on the TensorNet architecture for small molecules that broadens the applicability to diverse drug-like compounds, including all important chemical elements and supporting charged molecules. Using established benchmarks, we show overall improved accuracy and correlation in binding affinity predictions compared with GAFF2 for molecular mechanics and ANI2-x for NNPs. Slightly less accuracy but comparable correlations with OPLS4. We also show that we can run the NNP simulations at 2 fs timestep, at least two times larger than previous NNP models, providing significant speed gains. The results show promise for further evolutions of free energy calculations using NNPs while demonstrating its practical use already with the current generation. The code and NNP model are publicly available for research use.