Quasi-experimental evaluations are central for generating real-world causal evidence and complementing insights from randomized trials. The regression discontinuity design (RDD) is a quasi-experimental design that can be used to estimate the causal effect of treatments that are assigned based on a running variable crossing a threshold. Such threshold-based rules are ubiquitous in healthcare, where predictive and prognostic biomarkers frequently guide treatment decisions. However, standard RD estimators rely on complete outcome data, an assumption often violated in time-to-event analyses where censoring arises from loss to follow-up. To address this issue, we propose a nonparametric approach that leverages doubly robust censoring corrections and can be paired with existing RD estimators. Our approach can handle multiple survival endpoints, long follow-up times, and covariate-dependent variation in survival and censoring. We discuss the relevance of our approach across multiple areas of applications and demonstrate its usefulness through simulations and the prostate component of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial where our new approach offers several advantages, including higher efficiency and robustness to misspecification. We have also developed an open-source software package, $\texttt{rdsurvival}$, for the $\texttt{R}$ language.

We study high-dimensional mediation analysis in which exposures, mediators, and outcomes are all multivariate, and both exposures and mediators may be high-dimensional. We formalize this as a many (exposures)-to-many (mediators)-to-many (outcomes) (MMM) mediation analysis problem. Methodologically, MMM mediation analysis simultaneously performs variable selection for high-dimensional exposures and mediators, estimates the indirect effect matrix (i.e., the coefficient matrices linking exposure-to-mediator and mediator-to-outcome pathways), and enables prediction of multivariate outcomes. Theoretically, we show that the estimated indirect effect matrices are consistent and element-wise asymptotically normal, and we derive error bounds for the estimators. To evaluate the efficacy of the MMM mediation framework, we first investigate its finite-sample performance, including convergence properties, the behavior of the asymptotic approximations, and robustness to noise, via simulation studies. We then apply MMM mediation analysis to data from the Alzheimer's Disease Neuroimaging Initiative to study how cortical thickness of 202 brain regions may mediate the effects of 688 genome-wide significant single nucleotide polymorphisms (SNPs) (selected from approximately 1.5 million SNPs) on eleven cognitive-behavioral and diagnostic outcomes. The MMM mediation framework identifies biologically interpretable, many-to-many-to-many genetic-neural-cognitive pathways and improves downstream out-of-sample classification and prediction performance. Taken together, our results demonstrate the potential of MMM mediation analysis and highlight the value of statistical methodology for investigating complex, high-dimensional multi-layer pathways in science. The MMM package is available at https://github.com/THELabTop/MMM-Mediation.

Cross-validation (CV) is commonly used to estimate predictive risk when independent test data are unavailable. Its validity depends on the assumption that validation tasks are sampled from the same distribution as prediction tasks encountered during deployment. In spatial prediction and other settings with structured data, this assumption is frequently violated, leading to biased estimates of deployment risk. We propose Target-Weighted CV (TWCV), an estimator of deployment risk that accounts for discrepancies between validation and deployment task distributions, thus accounting for (1) covariate shift and (2) task-difficulty shift. We characterize prediction tasks by descriptors such as covariates and spatial configuration. TWCV assigns weights to validation losses such that the weighted empirical distribution of validation tasks matches the corresponding distribution over a target domain. The weights are obtained via calibration weighting, yielding an importance-weighted estimator that targets deployment risk. Since TWCV requires adequate coverage of the deployment distribution's support, we combine it with spatially buffered resampling that diversifies the task difficulty distribution. In a simulation study, conventional as well as spatial estimators exhibit substantial bias depending on sampling, whereas buffered TWCV remains approximately unbiased across scenarios. A case study in environmental pollution mapping further confirms that discrepancies between validation and deployment task distributions can affect performance assessment, and that buffered TWCV better reflects the prediction task over the target domain. These results establish task distribution mismatch as a primary source of CV bias in spatial prediction and show that calibration weighting combined with a suitable validation task generator provides a viable approach to estimating predictive risk under dataset shift.

Aligning human-interpretable concepts with the internal representations learned by modern machine learning systems remains a central challenge for interpretable AI. We introduce a geometric framework for comparing supervised human concepts with unsupervised intermediate representations extracted from foundation model embeddings. Motivated by the role of conceptual leaps in scientific discovery, we formalise the notion of concept frustration: a contradiction that arises when an unobserved concept induces relationships between known concepts that cannot be made consistent within an existing ontology. We develop task-aligned similarity measures that detect concept frustration between supervised concept-based models and unsupervised representations derived from foundation models, and show that the phenomenon is detectable in task-aligned geometry while conventional Euclidean comparisons fail. Under a linear-Gaussian generative model we derive a closed-form expression for Bayes-optimal concept-based classifier accuracy, decomposing predictive signal into known-known, known-unknown and unknown-unknown contributions and identifying analytically where frustration affects performance. Experiments on synthetic data and real language and vision tasks demonstrate that frustration can be detected in foundation model representations and that incorporating a frustrating concept into an interpretable model reorganises the geometry of learned concept representations, to better align human and machine reasoning. These results suggest a principled framework for diagnosing incomplete concept ontologies and aligning human and machine conceptual reasoning, with implications for the development and validation of safe interpretable AI for high-risk applications.

Optimizing survival outcomes, such as patient survival or customer retention, is a critical objective in data-driven decision-making. Off-Policy Evaluation~(OPE) provides a powerful framework for assessing such decision-making policies using logged data alone, without the need for costly or risky online experiments in high-stakes applications. However, typical estimators are not designed to handle right-censored survival outcomes, as they ignore unobserved survival times beyond the censoring time, leading to systematic underestimation of the true policy performance. To address this issue, we propose a novel framework for OPE and Off-Policy Learning~(OPL) tailored for survival outcomes under censoring. Specifically, we introduce IPCW-IPS and IPCW-DR, which employ the Inverse Probability of Censoring Weighting technique to explicitly deal with censoring bias. We theoretically establish that our estimators are unbiased and that IPCW-DR achieves double robustness, ensuring consistency if either the propensity score or the outcome model is correct. Furthermore, we extend this framework to constrained OPL to optimize policy value under budget constraints. We demonstrate the effectiveness of our proposed methods through simulation studies and illustrate their practical impacts using public real-world data for both evaluation and learning tasks.

Panel data methods are widely used in empirical analysis to address unobserved heterogeneity, but causal inference remains challenging when treatments are endogenous and confounding variables high-dimensional and potentially nonlinear. Standard instrumental variables (IV) estimators, such as two-stage least squares (2SLS), become unreliable when instrument validity requires flexibly conditioning on many covariates with potentially non-linear effects. This paper develops a Double Machine Learning estimator for static panel models with endogenous treatments (panel IV DML), and introduces weak-identification diagnostics for it. We revisit three influential migration studies that use shift-share instruments. In these settings, instrument validity depends on a rich covariate adjustment. In one application, panel IV DML strengthens the predictive power of the instrument and broadly confirms 2SLS results. In the other cases, flexible adjustment makes the instruments weak, leading to substantially more cautious causal inference than conventional 2SLS. Monte Carlo evidence supports these findings, showing that panel IV DML improves estimation accuracy under strong instruments and delivers more reliable inference under weak identification.

We introduce Generalized Discrete Diffusion from Snapshots (GDDS), a unified framework for discrete diffusion modeling that supports arbitrary noising processes over large discrete state spaces. Our formulation encompasses all existing discrete diffusion approaches, while allowing significantly greater flexibility in the choice of corruption dynamics. The forward noising process relies on uniformization and enables fast arbitrary corruption. For the reverse process, we derive a simple evidence lower bound (ELBO) based on snapshot latents, instead of the entire noising path, that allows efficient training of standard generative modeling architectures with clear probabilistic interpretation. Our experiments on large-vocabulary discrete generation tasks suggest that the proposed framework outperforms existing discrete diffusion methods in terms of training efficiency and generation quality, and beats autoregressive models for the first time at this scale. We provide the code along with a blog post on the project page : \href{https://oussamazekri.fr/gdds}{https://oussamazekri.fr/gdds}.

Existing machine learning frameworks for compliance monitoring -- Markov Logic Networks, Probabilistic Soft Logic, supervised models -- share a fundamental paradigm: they treat observed data as ground truth and attempt to approximate rules from it. This assumption breaks down in rule-governed domains such as taxation or regulatory compliance, where authoritative rules are known a priori and the true challenge is to infer the latent state of rule activation, compliance, and parametric drift from partial and noisy observations. We propose Rule-State Inference (RSI), a Bayesian framework that inverts this paradigm by encoding regulatory rules as structured priors and casting compliance monitoring as posterior inference over a latent rule-state space S = {(a_i, c_i, delta_i)}, where a_i captures rule activation, c_i models the compliance rate, and delta_i quantifies parametric drift. We prove three theoretical guarantees: (T1) RSI absorbs regulatory changes in O(1) time via a prior ratio correction, independently of dataset size; (T2) the posterior is Bernstein-von Mises consistent, converging to the true rule state as observations accumulate; (T3) mean-field variational inference monotonically maximizes the Evidence Lower BOund (ELBO). We instantiate RSI on the Togolese fiscal system and introduce RSI-Togo-Fiscal-Synthetic v1.0, a benchmark of 2,000 synthetic enterprises grounded in real OTR regulatory rules (2022-2025). Without any labeled training data, RSI achieves F1=0.519 and AUC=0.599, while absorbing regulatory changes in under 1ms versus 683-1082ms for full model retraining -- at least a 600x speedup.

Due to health and energy concerns, the California Legislature is considering bills to prohibit data centers from being exempted from the state's stringent environmental law and impose new tariffs on new major energy users that strain power supplies.

In a place denied access to basic forensic technology--and where people disappear into Israeli detention--the fate of thousands remains unknown. One of them is an autistic teenager. In the early morning dark, Abeer Skaik turned to her husband, Ali Al-Qatta, and said that today would be the day they would find their son. Ali nodded in silence, and she handed him the stack of flyers. Each bore a photograph of 16-year-old Hassan smiling widely, his shoulders loose, wearing a plain red T-shirt. He is looking directly at the camera, unguarded. On top of the page, in large letters, Abeer had written a single word in bold red ink: --an appeal. Abeer watched as Ali stepped into a car with a few close friends and drove away. They started the 30-kilometer trip south, from al-Tuffah, east of Gaza City, to the European Hospital in Khan Younis. They had heard that a group of people detained by Israel, including children, would be released there. The gate was already crowded. Families stood shoulder to shoulder, wrapped in blankets against the cold, clutching photographs and ID cards. Ali distributed the flyers among his friends. When the buses of released detainees arrived, he and the others moved slowly through the narrow gaps between clusters of people. Some of those who had just been released were being pulled into embraces. Ali waited at the edge of each reunion. "Have you seen my son?" he asked. One after another, people shook their heads.