As the promise of artificial intelligence (AI) captivates biomedicine, few people are riding the wave like Priscilla Chan--because few people have her resources. Trained as a pediatrician, Chan and her husband, Facebook creator Mark Zuckerberg, co-run a philanthropy that launched in 2015 with the wildly ambitious--some would say quixotic--goal of curing, preventing, or managing every disease by the end of the century. The couple pledged nearly their entire fortune-- 45 billion then and more than 200 billion today--to the Chan Zuckerberg Initiative (CZI), which would also support their education and progressive causes. Recently, however, the foundation has wound down support for almost everything but science. And this week, CZI announced it is increasing its research spending, doubling down on AI, and vowing to meet Chan and Zuckerberg's biomedical goal even earlier--although CZI won't set a specific target.

The Federal Trade Commission reports over $2.9 billion in losses from impostor bank scams using caller ID spoofing and AI voice technology to deceive victims.

Neighbors complained about noise, security guards, and hordes of traffic. An unlicensed school named after the Zuckerbergs' pet chicken tipped them over the edge. The Crescent Park neighborhood of Palo Alto, California, has some of the best real estate in the country, with a charming hodgepodge of homes ranging in style from Tudor revival to modern farmhouse and contemporary Mediterranean. It also has a gigantic compound that is home to Mark Zuckerberg, his wife Priscilla Chan, and their daughters Maxima, August, and Aurelia. Their land has expanded to include 11 previously separate properties, five of which are connected by at least one property line. The Zuckerberg compound's expansion first became a concern for Crescent Park neighbours as early as 2016, due to fears that his purchases were driving up the market. Then, about five years later, neighbors noticed that a school appeared to be operating out of the Zuckerberg compound. This would be illegal under the area's residential zoning code without a permit.

With the continuous advancement of technology, the application of generative artificial intelligence (AI) in various fields is gradually demonstrating great potential, particularly when combined with Extended Reality (XR), creating unprecedented possibilities. This survey article systematically reviews the applications of generative AI in XR, covering as much relevant literature as possible from 2023 to 2025. The application areas of generative AI in XR and its key technology implementations are summarised through PRISMA screening and analysis of the final 26 articles. The survey highlights existing articles from the last three years related to how XR utilises generative AI, providing insights into current trends and research gaps. We also explore potential opportunities for future research to further empower XR through generative AI, providing guidance and information for future generative XR research.

Understanding temporal relationships and accurately reconstructing the event timeline is important for case law analysis, compliance monitoring, and legal summarization. However, existing benchmarks lack specialized language evaluation, leaving a gap in understanding how LLMs handle event ordering in legal contexts. We introduce LexTime, a dataset designed to evaluate LLMs' event ordering capabilities in legal language, consisting of 512 instances from U.S. Federal Complaints with annotated event pairs and their temporal relations. Our findings show that (1) LLMs are more accurate on legal event ordering than on narrative texts (up to +10.5%); (2) longer input contexts and implicit events boost accuracy, reaching 80.8% for implicit-explicit event pairs; (3) legal linguistic complexities and nested clauses remain a challenge. While performance is promising, specific features of legal texts remain a bottleneck for legal temporal event reasoning, and we propose concrete modeling directions to better address them.

Plausible, but inaccurate, tokens in model-generated text are widely believed to be pervasive and problematic for the responsible adoption of language models. Despite this concern, there is little scientific work that attempts to measure the prevalence of language model hallucination in a comprehensive way. In this paper, we argue that language models should be evaluated using repeatable, open, and domain-contextualized hallucination benchmarking. We present a taxonomy of hallucinations alongside a case study that demonstrates that when experts are absent from the early stages of data creation, the resulting hallucination metrics lack validity and practical utility.

Recent smaller language models such Phi-3.5 and Phi-4 rely on synthetic data generated using larger Language models. Questions remain about leveraging synthetic data for other use cases, such as adapting LLMs to specific domains. A key limitation of synthetic data is low diversity, which negatively impacts its downstream applicability for improving other models. To address this, we propose MetaSynth, a method for generating synthetic data that enhances diversity through meta-prompting, where a language model orchestrates multiple "expert" LLM agents to collaboratively generate data. Using only 25 million tokens of synthetic data generated with MetaSynth, we successfully adapt a well-trained LLM (Mistral-7B-v0.3) to two specialized domains-Finance and Biomedicine-without compromising the capabilities of the resulting model in general tasks. In addition, we evaluate the diversity of our synthetic data using seven automated metrics, and find that it approaches the diversity of LLM pre-training corpora. Continually pre-training Mistral-7B-v0.3 with MetaSynth notably outperforms the base LLM, showing improvements of up to 4.08% in Finance and 13.75% in Biomedicine. The same model shows degraded performance when trained on data generated using a template prompt, even when the template includes prior generations and varying In-Context exemplars of real data. Our findings suggest that a few million tokens of diverse synthetic data without mixing any real data, is sufficient for effective domain adaptation when using MetaSynth.

Large Language Models (LLMs) are increasingly deployed in sensitive domains including healthcare, legal services, and confidential communications, where privacy is paramount. This paper introduces Whisper Leak, a side-channel attack that infers user prompt topics from encrypted LLM traffic by analyzing packet size and timing patterns in streaming responses. Despite TLS encryption protecting content, these metadata patterns leak sufficient information to enable topic classification. We demonstrate the attack across 28 popular LLMs from major providers, achieving near-perfect classification (often >98% AUPRC) and high precision even at extreme class imbalance (10,000:1 noise-to-target ratio). For many models, we achieve 100% precision in identifying sensitive topics like "money laundering" while recovering 5-20% of target conversations. This industry-wide vulnerability poses significant risks for users under network surveillance by ISPs, governments, or local adversaries. We evaluate three mitigation strategies - random padding, token batching, and packet injection - finding that while each reduces attack effectiveness, none provides complete protection. Through responsible disclosure, we have collaborated with providers to implement initial countermeasures. Our findings underscore the need for LLM providers to address metadata leakage as AI systems handle increasingly sensitive information.

Zero-Shot Stance Detection (ZSSD) identifies the attitude of the post toward unseen targets. Existing research using contrastive, meta-learning, or data augmentation suffers from generalizability issues or lack of coherence between text and target. Recent works leveraging large language models (LLMs) for ZSSD focus either on improving unseen target-specific knowledge or generating explanations for stance analysis. However, most of these works are limited by their over-reliance on explicit reasoning, provide coarse explanations that lack nuance, and do not explicitly model the reasoning process, making it difficult to interpret the model's predictions. To address these issues, in our study, we develop a novel interpretable ZSSD framework, IRIS. We provide an interpretable understanding of the attitude of the input towards the target implicitly based on sequences within the text (implicit rationales) and explicitly based on linguistic measures (explicit rationales). IRIS considers stance detection as an information retrieval ranking task, understanding the relevance of implicit rationales for different stances to guide the model towards correct predictions without requiring the ground-truth of rationales, thus providing inherent interpretability. In addition, explicit rationales based on communicative features help decode the emotional and cognitive dimensions of stance, offering an interpretable understanding of the author's attitude towards the given target. Extensive experiments on the benchmark datasets of VAST, EZ-STANCE, P-Stance, and RFD using 50%, 30%, and even 10% training data prove the generalizability of our model, benefiting from the proposed architecture and interpretable design.

In this study, we explore the fine-tuning of Large Language Models (LLMs) to better support policymakers in their crucial work of understanding, analyzing, and crafting legal regulations. To equip the model with a deep understanding of legal texts, we curated a supervised dataset tailored to the specific needs of the legal domain. Additionally, we integrated the Retrieval-Augmented Generation (RAG) method, enabling the LLM to access and incorporate up-to-date legal knowledge from external sources. This combination of fine-tuning and RAG-based augmentation results in a tool that not only processes legal information but actively assists policymakers in interpreting regulations and drafting new ones that align with current needs. The results demonstrate that this approach can significantly enhance the effectiveness of legal research and regulation development, offering a valuable resource in the ever-evolving field of law.