Nephrology


Amplifying intelligent drug design

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'The idea of understanding a disease from an evolutionary viewpoint to inform drug design still resonates today in how Exscientia is approaching the design of anticancer agents. 'I spent a season at the GlaxoWellcome labs in Stevenage making the compounds I'd designed, and vividly remember the excitement of discovering the first molecule we'd made was active.' These included topics such as the druggable genome, ligand efficiency and network pharmacology – all of which are familiar topics to drug discovery chemists today. An early success involved feeding historical data for the project that discovered erectile dysfunction drug tadalafil (Cialis) into the evolutionary drug design model.


Google could soon get access to genetic patient data

Daily Mail

By building a neural network, Google's algorithms can interpret huge amounts of genetic, health, and environmental data to predict a persons health status, such as their level of risk of heart attack (stock image) It was created after Google bought University College London spinout, DeepMind, for £400 million in 2014. By building a neural network, these algorithms can interpret huge amounts of genetic, health, and environmental data to predict a persons health status, such as their level of risk of heart attack. Google announced the first of its NHS collaborations in February 2016, saying it was building an app to help hospital staff monitor patients with kidney disease. ', With personalisation as their ultimate'goal', Google intend to use the machine learning algorithms which track our digital footprint and target users with personalised advertising based on their preferences.


DeepMind's kidney disease-fighting Streams app is coming to a new hospital

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Google's DeepMind, the British artificial intelligence firm behind the human-besting AlphaGo software, launched a healthcare platform in partnership with the U.K.'s Moorfields Eye Hospital and Royal Free London in 2015. Starting this month, doctors and nurses at Musgrove Park will get DeepMind's Streams app for iPhone, which helps spot early signs of acute kidney injury. "This is all about early detection of seriously unwell patients so that we can immediately escalate care, ensure a very rapid response, and make sure they are treated quickly by the right specialist doctor," Luke Gompels, a consultant in medicine at Musgrove Park Hospital, told the BBC. Last year, it acquired Hark, a task management app optimized for hospital environments that was co-developed by students from Imperial College London and the National Institute for Health Research.


BioData Mining

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Most biological network inference methods focus on the definition of gene regulatory networks, in which edges represent direct regulatory interactions between genes [2–4]. Two approaches to functional network inference: one based on the expression profile similarity and the other based on the extraction of knowledge from machine learning models. The specific focus of this paper is the network inference from rule-based machine learning models, these have been successfully applied before to extract knowledge from genetic data [17] and identify disease risk factors in a bladder cancer study [18]. To address these questions, we propose in this article a new network inference protocol, called FuNeL (Functional Network Learning).


Why Google wants your medical records - BBC News

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Projects include a tie-up with London Moorfields eye hospital, which will see it using one million eye scans to train its artificial intelligence system to diagnose potential sight issues, and development of an app to help doctors spot kidney disease. In May it was revealed that Google's DeepMind, had been given access to the healthcare data of up to 1.6 million patients from three hospitals run by London's Royal Free Trust in order to develop an app, called Streams, that would notify doctors should someone be at risk of developing acute kidney injury (AKI). Some were also bemused when it became apparent that the deal with Google's AI firm would not actually involve any artificial intelligence. In the case of the Royal Free, the BBC understands that 148 people have withdrawn their consent, a tiny fraction of the patients involved.


Google's DeepMind tried to justify why it has access to millions of NHS patient records

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The AI research lab, acquired by Google in 2014 for around 400 million, signed a data-sharing agreement with the Royal Free London NHS Foundation Trust on 29 September 2015. Streams -- used by Royal Free clinicians in three separate trials since December 2015 -- is designed to detect acute kidney injury (AKI), a condition that kills more than 1,000 people a month. In this case, the sharing of information is both necessary and proportionate to the purposes: failure to share a historical data set effectively would carry risk of avoidable harm if a patient presented to the Royal Free London and information could not be effectively presented to a clinician. Google DeepMindThe Streams app has been developed by Google DeepMind, the NHS, and design studio ustwo.


Artificial Intelligence News: Artificial Intelligence News Issue 36

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The sports world today is getting tech savvy by combining natural, athletic talent with advanced analytics and even artificial intelligence (AI) to produce the best possible outcomes on the playing field. The White House Office of Science and Technology on Tuesday announced four public workshops to discuss the fast growing artificial intelligence field, or AI, in which computers learn to handle tasks from writing news stories to performing surgery. Google agrees new data share deal with Royal Free NHS Trust in London Internet giant is developing new app to help care for kidney patients But Google can access complete medical records - not just kidney data Campaigners unhappy Google will have free access to all patient records Up to 1.6 million patients have had their private medical files passed on to Google without their permission, it was revealed today The internet giant was given the data by one of the largest NHS trusts to develop an app to monitor possible kidney failure. In 2016, the leading contender has to be Artificial Intelligence (AI).


Revealed: Google AI has access to huge haul of NHS patient data

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The document – a data-sharing agreement between Google-owned artificial intelligence company DeepMind and the Royal Free NHS Trust – gives the clearest picture yet of what the company is doing and what sensitive data it now has access to. "The data-sharing agreement gives Google access to information on millions of NHS patients" DeepMind announced in February that it was working with the NHS, saying it was building an app called Streams to help hospital staff monitor patients with kidney disease. This is the first we've heard of DeepMind getting access to historical medical records, says Sam Smith, who runs health data privacy group MedConfidential. The document also reveals that DeepMind is developing a platform called Patient Rescue, which will provide data analytics services to NHS hospital trusts.


Revealed: Google AI has access to huge haul of NHS patient data

New Scientist

The document – a data-sharing agreement between Google-owned artificial intelligence company DeepMind and the Royal Free NHS Trust – gives the clearest picture yet of what the company is doing and what sensitive data it now has access to. "The data-sharing agreement gives Google access to information on millions of NHS patients" DeepMind announced in February that it was working with the NHS, saying it was building an app called Streams to help hospital staff monitor patients with kidney disease. This is the first we've heard of DeepMind getting access to historical medical records, says Sam Smith, who runs health data privacy group MedConfidential. The document also reveals that DeepMind is developing a platform called Patient Rescue, which will provide data analytics services to NHS hospital trusts.