Large Language Models (LLMs) are intensively used to assist security analysts in counteracting the rapid exploitation of cyber threats, wherein LLMs offer cyber threat intelligence (CTI) to support vulnerability assessment and incident response. While recent work has shown that LLMs can support a wide range of CTI tasks such as threat analysis, vulnerability detection, and intrusion defense, significant performance gaps persist in practical deployments. In this paper, we investigate the intrinsic vulnerabilities of LLMs in CTI, focusing on challenges that arise from the nature of the threat landscape itself rather than the model architecture. Using large-scale evaluations across multiple CTI benchmarks and real-world threat reports, we introduce a novel categorization methodology that integrates stratification, autoregressive refinement, and human-in-the-loop supervision to reliably analyze failure instances. Through extensive experiments and human inspections, we reveal three fundamental vulnerabilities: spurious correlations, contradictory knowledge, and constrained generalization, that limit LLMs in effectively supporting CTI. Subsequently, we provide actionable insights for designing more robust LLM-powered CTI systems to facilitate future research.

The safe use of pharmaceuticals in food-producing animals is vital to protect animal welfare and human food safety. Adverse events (AEs) may signal unexpected pharmacokinetic or toxicokinetic effects, increasing the risk of violative residues in the food chain. This study introduces a predictive framework for classifying outcomes (Death vs. Recovery) using ~1.28 million reports (1987-2025 Q1) from the U.S. FDA's OpenFDA Center for Veterinary Medicine. A preprocessing pipeline merged relational tables and standardized AEs through VeDDRA ontologies. Data were normalized, missing values imputed, and high-cardinality features reduced; physicochemical drug properties were integrated to capture chemical-residue links. We evaluated supervised models, including Random Forest, CatBoost, XGBoost, ExcelFormer, and large language models (Gemma 3-27B, Phi 3-12B). Class imbalance was addressed, such as undersampling and oversampling, with a focus on prioritizing recall for fatal outcomes. Ensemble methods(Voting, Stacking) and CatBoost performed best, achieving precision, recall, and F1-scores of 0.95. Incorporating Average Uncertainty Margin (AUM)-based pseudo-labeling of uncertain cases improved minority-class detection, particularly in ExcelFormer and XGBoost. Interpretability via SHAP identified biologically plausible predictors, including lung, heart, and bronchial disorders, animal demographics, and drug physicochemical properties. These features were strongly linked to fatal outcomes. Overall, the framework shows that combining rigorous data engineering, advanced machine learning, and explainable AI enables accurate, interpretable predictions of veterinary safety outcomes. The approach supports FARAD's mission by enabling early detection of high-risk drug-event profiles, strengthening residue risk assessment, and informing regulatory and clinical decision-making.

The integration of artificial intelligence (AI) in early-stage drug discovery offers unprecedented opportunities for exploring chemical space and accelerating hit-to-lead optimization. However, using docking as a reward function during generative model training is computationally expensive and may yield inaccurate results. Here, we present a novel generative framework that balances pharma-cophore similarity to reference compounds with structural diversity from active molecules. The framework allows users to provide custom reference sets, including FDA-approved drugs or clinical candidates, and guides the de novo generation of potential therapeutics. We demonstrate its applicability through a case study targeting alpha estrogen receptor modulators and antagonists for breast cancer. The generated compounds maintain high pharmacophoric fidelity to known active molecules while introducing substantial structural novelty, suggesting strong potential for functional innovation and patentability. Comprehensive evaluation of the generated molecules against common drug-like properties confirms the robustness and pharmaceutical relevance of the approach.

This matching requires researchers to know the exact wording that other researchers previously used, creating a challenging process that could lead to missing relevant data. Large Language Models (LLMs) could enhance data discovery by removing this requirement and allowing researchers to ask questions with natural language. However, we do not currently know if researchers would accept LLMs for data discovery. Using a human-centered artificial intelligence (HCAI) focus, we ran focus groups (N = 27) to understand researchers' perspectives towards LLMs for data discovery. Our conceptual model shows that the potential benefits are not enough for researchers to use LLMs instead of current technology. Barriers prevent researchers from fully accepting LLMs, but features around transparency could overcome them. Using our model will allow developers to incorporate features that result in an increased acceptance of LLMs for data discovery.

Data from online job postings are difficult to access and are not built in a standard or transparent manner. Data included in the standard taxonomy and occupational information database (O*NET) are updated infrequently and based on small survey samples. We adopt O*NET as a framework for building natural language processing tools that extract structured information from job postings. We publish the Job Ad Analysis Toolkit (JAAT), a collection of open-source tools built for this purpose, and demonstrate its reliability and accuracy in out-of-sample and LLM-as-a-Judge testing. We extract more than 10 billion data points from more than 155 million online job ads provided by the National Labor Exchange (NLx) Research Hub, including O*NET tasks, occupation codes, tools, and technologies, as well as wages, skills, industry, and more features. We describe the construction of a dataset of occupation, state, and industry level features aggregated by monthly active jobs from 2015 - 2025. We illustrate the potential for research and future uses in education and workforce development.

This paper investigates the impact of the adoption of generative AI on financial stability. We conduct laboratory-style experiments using large language models to replicate classic studies on herd behavior in trading decisions. Our results show that AI agents make more rational decisions than humans, relying predominantly on private information over market trends. Increased reliance on AI-powered trading advice could therefore potentially lead to fewer asset price bubbles arising from animal spirits that trade by following the herd. However, exploring variations in the experimental settings reveals that AI agents can be induced to herd optimally when explicitly guided to make profit-maximizing decisions. While optimal herding improves market discipline, this behavior still carries potential implications for financial stability. In other experimental variations, we show that AI agents are not purely algorithmic, but have inherited some elements of human conditioning and bias.

System logs represent a valuable source of Cyber Threat Intelligence (CTI), capturing attacker behaviors, exploited vulnerabilities, and traces of malicious activity. Yet their utility is often limited by lack of structure, semantic inconsistency, and fragmentation across devices and sessions. Extracting actionable CTI from logs therefore requires approaches that can reconcile noisy, heterogeneous data into coherent and interoperable representations. We introduce OntoLogX, an autonomous Artificial Intelligence (AI) agent that leverages Large Language Models (LLMs) to transform raw logs into ontology-grounded Knowledge Graphs (KGs). OntoLogX integrates a lightweight log ontology with Retrieval Augmented Generation (RAG) and iterative correction steps, ensuring that generated KGs are syntactically and semantically valid. Beyond event-level analysis, the system aggregates KGs into sessions and employs a LLM to predict MITRE ATT&CK tactics, linking low-level log evidence to higher-level adversarial objectives. We evaluate OntoLogX on both logs from a public benchmark and a real-world honeypot dataset, demonstrating robust KG generation across multiple KGs backends and accurate mapping of adversarial activity to ATT&CK tactics. Results highlight the benefits of retrieval and correction for precision and recall, the effectiveness of code-oriented models in structured log analysis, and the value of ontology-grounded representations for actionable CTI extraction.

Large language models (LLMs) excel at general language tasks but often struggle with event-based questions-especially those requiring causal or temporal reasoning. We introduce TAG-EQA (Text-And-Graph for Event Question Answering), a prompting framework that injects causal event graphs into LLM inputs by converting structured relations into natural-language statements. TAG-EQA spans nine prompting configurations, combining three strategies (zero-shot, few-shot, chain-of-thought) with three input modalities (text-only, graph-only, text+graph), enabling a systematic analysis of when and how structured knowledge aids inference. On the TORQUESTRA benchmark, TAG-EQA improves accuracy by 5% on average over text-only baselines, with gains up to 12% in zero-shot settings and 18% when graph-augmented CoT prompting is effective. While performance varies by model and configuration, our findings show that causal graphs can enhance event reasoning in LLMs without fine-tuning, offering a flexible way to encode structure in prompt-based QA.

We introduce Small PDE U-Net Solver (SPUS), a compact and efficient foundation model (FM) designed as a unified neural operator for solving a wide range of partial differential equations (PDEs). Unlike existing state-of-the-art PDE FMs-primarily based on large complex transformer architectures with high computational and parameter overhead-SPUS leverages a lightweight residual U-Net-based architecture that has been largely underexplored as a foundation model architecture in this domain. To enable effective learning in this minimalist framework, we utilize a simple yet powerful auto-regressive pretraining strategy which closely replicates the behavior of numerical solvers to learn the underlying physics. SPUS is pretrained on a diverse set of fluid dynamics PDEs and evaluated across 6 challenging unseen downstream PDEs spanning various physical systems. Experimental results demonstrate that SPUS using residual U-Net based architecture achieves state-of-the-art generalization on these downstream tasks while requiring significantly fewer parameters and minimal fine-tuning data, highlighting its potential as a highly parameter-efficient FM for solving diverse PDE systems.

Reliable long-range flight of unmanned aerial vehicles (UAVs) in GNSS-denied environments is challenging: integrating odometry leads to drift, loop closures are unavailable in previously unseen areas and embedded platforms provide limited computational power. We present a fully onboard UAV system developed for the SPRIN-D Funke Fully Autonomous Flight Challenge, which required 9 km long-range waypoint navigation below 25 m AGL (Above Ground Level) without GNSS or prior dense mapping. The system integrates perception, mapping, planning, and control with a lightweight drift-correction method that matches LiDAR-derived local heightmaps to a prior geo-data heightmap via gradient-template matching and fuses the evidence with odometry in a clustered particle filter. Deployed during the competition, the system executed kilometer-scale flights across urban, forest, and open-field terrain and reduced drift substantially relative to raw odometry, while running in real time on CPU-only hardware. We describe the system architecture, the localization pipeline, and the competition evaluation, and we report practical insights from field deployment that inform the design of GNSS-denied UAV autonomy.