The world's fourth industrial revolution is ushering in big shifts in the workplace. Professor Steven Dhondt has a reassurance of sorts for people in the EU worried about losing their jobs to automation: relax. Dhondt, an expert in work and organisational change at the Catholic University Leuven in Belgium, has studied the impact of technology on jobs for the past four decades. Fresh from leading an EU research project on the issue, he stresses opportunities rather than threats. 'We need to develop new business practices and welfare support but, with the right vision, we shouldn't see technology as a threat,' Dhondt said.

While machine learning (ML) has made significant contributions to the biopharmaceutical field, its applications are still in the early stages in terms of providing direct support for quality-by-design based development and manufacturing of biopharmaceuticals, hindering the enormous potential for bioprocesses automation from their development to manufacturing. However, the adoption of ML-based models instead of conventional multivariate data analysis methods is significantly increasing due to the accumulation of large-scale production data. This trend is primarily driven by the real-time monitoring of process variables and quality attributes of biopharmaceutical products through the implementation of advanced process analytical technologies. Given the complexity and multidimensionality of a bioproduct design, bioprocess development, and product manufacturing data, ML-based approaches are increasingly being employed to achieve accurate, flexible, and high-performing predictive models to address the problems of analytics, monitoring, and control within the biopharma field. This paper aims to provide a comprehensive review of the current applications of ML solutions in a bioproduct design, monitoring, control, and optimisation of upstream, downstream, and product formulation processes. Finally, this paper thoroughly discusses the main challenges related to the bioprocesses themselves, process data, and the use of machine learning models in biopharmaceutical process development and manufacturing. Moreover, it offers further insights into the adoption of innovative machine learning methods and novel trends in the development of new digital biopharma solutions.

The last decades have been characterized by unprecedented technological advances, many of them powered by modern technologies such as Artificial Intelligence (AI) and Machine Learning (ML). The world has become more digitally connected than ever, but we face major challenges. One of the most significant is cybercrime, which has emerged as a global threat to governments, businesses, and civil societies. The pervasiveness of digital technologies combined with a constantly shifting technological foundation has created a complex and powerful playground for cybercriminals, which triggered a surge in demand for intelligent threat detection systems based on machine and deep learning. This paper investigates AI-based cyber threat detection to protect our modern digital ecosystems. The primary focus is on evaluating ML-based classifiers and ensembles for anomaly-based malware detection and network intrusion detection and how to integrate those models in the context of network security, mobile security, and IoT security. The discussion highlights the challenges when deploying and integrating AI-enabled cybersecurity solutions into existing enterprise systems and IT infrastructures, including options to overcome those challenges. Finally, the paper provides future research directions to further increase the security and resilience of our modern digital industries, infrastructures, and ecosystems.

This study enhances stance detection on social media by incorporating deeper psychological attributes, specifically individuals' moral foundations. These theoretically-derived dimensions aim to provide a comprehensive profile of an individual's moral concerns which, in recent work, has been linked to behaviour in a range of domains, including society, politics, health, and the environment. In this paper, we investigate how moral foundation dimensions can contribute to predicting an individual's stance on a given target. Specifically we incorporate moral foundation features extracted from text, along with message semantic features, to classify stances at both message- and user-levels across a range of targets and models. Our preliminary results suggest that encoding moral foundations can enhance the performance of stance detection tasks and help illuminate the associations between specific moral foundations and online stances on target topics. The results highlight the importance of considering deeper psychological attributes in stance analysis and underscores the role of moral foundations in guiding online social behavior.

The principal goal of data science is to derive meaningful information from data. To do this, data scientists develop a space of analytic possibilities and from it reach their information goals by using their knowledge of the domain, the available data, the operations that can be performed on those data, the algorithms/models that are fed the data, and how all of these facets interweave. In this work, we take the first steps towards automating a key aspect of the data science pipeline: data analysis. We present an extensible taxonomy of data analytic operations that scopes across domains and data, as well as a method for codifying domain-specific knowledge that links this analytics taxonomy to actual data. We validate the functionality of our analytics taxonomy by implementing a system that leverages it, alongside domain labelings for 8 distinct domains, to automatically generate a space of answerable questions and associated analytic plans. In this way, we produce information spaces over data that enable complex analyses and search over this data and pave the way for fully automated data analysis.

Language models have become the backbone of today's AI systems. However, their predominant left-to-right generation limits the use of bidirectional context, which is essential for tasks that involve filling text in the middle. We propose the Fill-in Language Model (FiLM), a new language modeling approach that allows for flexible generation at any position without adhering to a specific generation order. Its training extends the masked language modeling objective by adopting varying mask probabilities sampled from the Beta distribution to enhance the generative capabilities of FiLM. During inference, FiLM can seamlessly insert missing phrases, sentences, or paragraphs, ensuring that the outputs are fluent and are coherent with the surrounding context. In both automatic and human evaluations, FiLM outperforms existing infilling methods that rely on left-to-right language models trained on rearranged text segments. FiLM is easy to implement and can be either trained from scratch or fine-tuned from a left-to-right language model. Notably, as the model size grows, FiLM's perplexity approaches that of strong left-to-right language models of similar sizes, indicating FiLM's scalability and potential as a large language model.

There is no doubt that the Moon has become the center of interest for commercial and international actors. Over the past decade, the number of planned long-term missions has increased dramatically. This makes the establishment of cislunar space networks (CSNs) crucial to orchestrate uninterrupted communications between the Moon and Earth. However, there are numerous challenges, unknowns, and uncertainties associated with cislunar communications that may pose various risks to lunar missions. In this study, we aim to address these challenges for cislunar communications by proposing a machine learning-based cislunar space domain awareness (SDA) capability that enables robust and secure communications. To this end, we first propose a detailed channel model for selected cislunar scenarios. Secondly, we propose two types of interference that could model anomalies that occur in cislunar space and are so far known only to a limited extent. Finally, we discuss our cislunar SDA to work in conjunction with the spacecraft communication system. Our proposed cislunar SDA, involving heuristic learning capabilities with machine learning algorithms, detects interference models with over 96% accuracy. The results demonstrate the promising performance of our cislunar SDA approach for secure and robust cislunar communication.

Advance Persistent Threats (APTs), adopted by most delicate attackers, are becoming increasing common and pose great threat to various enterprises and institutions. Data provenance analysis on provenance graphs has emerged as a common approach in APT detection. However, previous works have exhibited several shortcomings: (1) requiring attack-containing data and a priori knowledge of APTs, (2) failing in extracting the rich contextual information buried within provenance graphs and (3) becoming impracticable due to their prohibitive computation overhead and memory consumption. In this paper, we introduce MAGIC, a novel and flexible self-supervised APT detection approach capable of performing multi-granularity detection under different level of supervision. MAGIC leverages masked graph representation learning to model benign system entities and behaviors, performing efficient deep feature extraction and structure abstraction on provenance graphs. By ferreting out anomalous system behaviors via outlier detection methods, MAGIC is able to perform both system entity level and batched log level APT detection. MAGIC is specially designed to handle concept drift with a model adaption mechanism and successfully applies to universal conditions and detection scenarios. We evaluate MAGIC on three widely-used datasets, including both real-world and simulated attacks. Evaluation results indicate that MAGIC achieves promising detection results in all scenarios and shows enormous advantage over state-of-the-art APT detection approaches in performance overhead.

Most legal text in the Indian judiciary is written in complex English due to historical reasons. However, only about 10% of the Indian population is comfortable in reading English. Hence legal text needs to be made available in various Indian languages, possibly by translating the available legal text from English. Though there has been a lot of research on translation to and between Indian languages, to our knowledge, there has not been much prior work on such translation in the legal domain. In this work, we construct the first high-quality legal parallel corpus containing aligned text units in English and nine Indian languages, that includes several low-resource languages. We also benchmark the performance of a wide variety of Machine Translation (MT) systems over this corpus, including commercial MT systems, open-source MT systems and Large Language Models. Through a comprehensive survey by Law practitioners, we check how satisfied they are with the translations by some of these MT systems, and how well automatic MT evaluation metrics agree with the opinions of Law practitioners.

We introduce a univariate signal deconvolution method based on the principles of an approach to Artificial General Intelligence in order to build a general-purpose model of models independent of any arbitrarily assumed prior probability distribution. We investigate how non-random data may encode information about the physical properties, such as dimensions and length scales of the space in which a signal or message may have been originally encoded, embedded, or generated. Our multidimensional space reconstruction method is based on information theory and algorithmic probability, so that it is proven to be agnostic vis-a-vis the arbitrarily chosen encoding-decoding scheme, computable or semi-computable method of approximation to algorithmic complexity, and computational model. The results presented in this paper are useful for applications in coding theory, particularly in zero-knowledge one-way communication channels, such as in deciphering messages from unknown generating sources about which no prior knowledge is available and to which no return message can be sent. We argue that this method has the potential to be of great value in cryptography, signal processing, causal deconvolution, life and technosignature detection.