Coordinator for Strategic Communications at the National Security Council John Kirby tells'The Story' that China, Russia, Iran and North Korea present'unique' sets of threats to the U.S. John Kirby said China, Russia, Iran and North Korea present "unique" threats and challenges to U.S. national security when asked about the "new axis of evil" Monday on FOX News. The- coordinator of strategic communications at the National Security Council reacted to Sen. Mitch McConnell, R-Ky., referring to these nations as such on "The Story." Kirby said China is a power "very much on the rise" and can challenge the "rules-based order." JOHN KIRBY: I think the president would certainly characterize multiple countries, nation-states, here who present unique and pernicious threats and challenges to our national security. Certainly, North Korea is in that group.

We demonstrate the versatility of mean-field games (MFGs) as a mathematical framework for explaining, enhancing, and designing generative models. In generative flows, a Lagrangian formulation is used where each particle (generated sample) aims to minimize a loss function over its simulated path. The loss, however, is dependent on the paths of other particles, which leads to a competition among the population of particles. The asymptotic behavior of this competition yields a mean-field game. We establish connections between MFGs and major classes of generative flows and diffusions including continuous-time normalizing flows, score-based generative models (SGM), and Wasserstein gradient flows. Furthermore, we study the mathematical properties of each generative model by studying their associated MFG's optimality condition, which is a set of coupled forward-backward nonlinear partial differential equations. The mathematical structure described by the MFG optimality conditions identifies the inductive biases of generative flows. We investigate the well-posedness and structure of normalizing flows, unravel the mathematical structure of SGMs, and derive a MFG formulation of Wasserstein gradient flows. From an algorithmic perspective, the optimality conditions yields Hamilton-Jacobi-Bellman (HJB) regularizers for enhanced training of generative models. In particular, we propose and demonstrate an HJB-regularized SGM with improved performance over standard SGMs. We present this framework as an MFG laboratory which serves as a platform for revealing new avenues of experimentation and invention of generative models.

The burgeoning capabilities of advanced large language models (LLMs) such as ChatGPT have led to an increase in synthetic content generation with implications across a variety of sectors, including media, cybersecurity, public discourse, and education. As such, the ability to detect LLMs-generated content has become of paramount importance. We aim to provide a detailed overview of existing detection strategies and benchmarks, scrutinizing their differences and identifying key challenges and prospects in the field, advocating for more adaptable and robust models to enhance detection accuracy. We also posit the necessity for a multi-faceted approach to defend against various attacks to counter the rapidly advancing capabilities of LLMs. To the best of our knowledge, this work is the first comprehensive survey on the detection in the era of LLMs. We hope it will provide a broad understanding of the current landscape of LLMs-generated content detection, offering a guiding reference for researchers and practitioners striving to uphold the integrity of digital information in an era increasingly dominated by synthetic content. The relevant papers are summarized and will be consistently updated at https://github.com/Xianjun-Yang/Awesome_papers_on_LLMs_detection.git.

Structure-based drug design (SBDD) utilizes the three-dimensional geometry of proteins to identify potential drug candidates. Traditional methods, grounded in physicochemical modeling and informed by domain expertise, are resource-intensive. Recent developments in geometric deep learning, focusing on the integration and processing of 3D geometric data, coupled with the availability of accurate protein 3D structure predictions from tools like AlphaFold, have greatly advanced the field of structure-based drug design. This paper systematically reviews the current state of geometric deep learning in SBDD. We first outline foundational tasks in SBDD, detail prevalent 3D protein representations, and highlight representative predictive and generative models. We then offer in-depth reviews of each key task, including binding site prediction, binding pose generation, \emph{de novo} molecule generation, linker design, and binding affinity prediction. We provide formal problem definitions and outline each task's representative methods, datasets, evaluation metrics, and performance benchmarks. Finally, we summarize the current challenges and future opportunities: current challenges in SBDD include oversimplified problem formulations, inadequate out-of-distribution generalization, a lack of reliable evaluation metrics and large-scale benchmarks, and the need for experimental verification and enhanced model understanding; opportunities include leveraging multimodal datasets, integrating domain knowledge, building comprehensive benchmarks, designing criteria based on clinical endpoints, and developing foundation models that broaden the range of design tasks. We also curate \url{https://github.com/zaixizhang/Awesome-SBDD}, reflecting ongoing contributions and new datasets in SBDD.

For a sequence of classification tasks that arrive over time, it is common that tasks are evolving in the sense that consecutive tasks often have a higher similarity. The incremental learning of a growing sequence of tasks holds promise to enable accurate classification even with few samples per task by leveraging information from all the tasks in the sequence (forward and backward learning). However, existing techniques developed for continual learning and concept drift adaptation are either designed for tasks with time-independent similarities or only aim to learn the last task in the sequence. This paper presents incremental minimax risk classifiers (IMRCs) that effectively exploit forward and backward learning and account for evolving tasks. In addition, we analytically characterize the performance improvement provided by forward and backward learning in terms of the tasks' expected quadratic change and the number of tasks. The experimental evaluation shows that IMRCs can result in a significant performance improvement, especially for reduced sample sizes.

In maritime traffic surveillance, detecting illegal activities, such as illegal fishing or transshipment of illicit products is a crucial task of the coastal administration. In the open sea, one has to rely on Automatic Identification System (AIS) message transmitted by on-board transponders, which are captured by surveillance satellites. However, insincere vessels often intentionally shut down their AIS transponders to hide illegal activities. In the open sea, it is very challenging to differentiate intentional AIS shutdowns from missing reception due to protocol limitations, bad weather conditions or restricting satellite positions. This paper presents a novel approach for the detection of abnormal AIS missing reception based on self-supervised deep learning techniques and transformer models. Using historical data, the trained model predicts if a message should be received in the upcoming minute or not. Afterwards, the model reports on detected anomalies by comparing the prediction with what actually happens. Our method can process AIS messages in real-time, in particular, more than 500 Millions AIS messages per month, corresponding to the trajectories of more than 60 000 ships. The method is evaluated on 1-year of real-world data coming from four Norwegian surveillance satellites. Using related research results, we validated our method by rediscovering already detected intentional AIS shutdowns.

Quantum computing (QC) is a field that has witnessed a rapid increase in interest and development over the past few decades since it was theoretically shown that quantum computers can provide an exponential speedup for certain tasks (Deutsch, Jozsa 1992; Grover 1996; Shor 1994). Translating this potential into a practically relevant quantum advantage, however, has proven to be a very challenging endeavor. Nevertheless, the emerging field is considered to have a highly disruptive potential for many domains, for example in machine learning (Schuld, Sinayskiy, Petruccione 2015), chemical simulations (Cao et al. 2019) and optimization (Li et al. 2020), the domain of this work. Due to the fact that optimization problems are of utmost importance also for industrial applications, we investigated a potential advantage of quantum and quantum-inspired technology for the so-called transport robot scheduling problem (TRSP), a real-world use-case in optimization that is derived from an industrial application of an automatized robot in a high-throughput laboratory. The optimization task is to plan a time-efficient schedule for the robot's movements as it transports chemical samples between a rack and multiple machines to conduct experiments.

Graph-based deep learning methods have become popular tools to process collections of correlated time series. Differently from traditional multivariate forecasting methods, neural graph-based predictors take advantage of pairwise relationships by conditioning forecasts on a (possibly dynamic) graph spanning the time series collection. The conditioning can take the form of an architectural inductive bias on the neural forecasting architecture, resulting in a family of deep learning models called spatiotemporal graph neural networks. Such relational inductive biases enable the training of global forecasting models on large time-series collections, while at the same time localizing predictions w.r.t. each element in the set (i.e., graph nodes) by accounting for local correlations among them (i.e., graph edges). Indeed, recent theoretical and practical advances in graph neural networks and deep learning for time series forecasting make the adoption of such processing frameworks appealing and timely. However, most of the studies in the literature focus on proposing variations of existing neural architectures by taking advantage of modern deep learning practices, while foundational and methodological aspects have not been subject to systematic investigation. To fill the gap, this paper aims to introduce a comprehensive methodological framework that formalizes the forecasting problem and provides design principles for graph-based predictive models and methods to assess their performance. At the same time, together with an overview of the field, we provide design guidelines, recommendations, and best practices, as well as an in-depth discussion of open challenges and future research directions.

Although large language models (LLMs) have apparently acquired a certain level of grammatical knowledge and the ability to make generalizations, they fail to interpret negation, a crucial step in Natural Language Processing. We try to clarify the reasons for the sub-optimal performance of LLMs understanding negation. We introduce a large semi-automatically generated dataset of circa 400,000 descriptive sentences about commonsense knowledge that can be true or false in which negation is present in about 2/3 of the corpus in different forms. We have used our dataset with the largest available open LLMs in a zero-shot approach to grasp their generalization and inference capability and we have also fine-tuned some of the models to assess whether the understanding of negation can be trained. Our findings show that, while LLMs are proficient at classifying affirmative sentences, they struggle with negative sentences and lack a deep understanding of negation, often relying on superficial cues. Although fine-tuning the models on negative sentences improves their performance, the lack of generalization in handling negation is persistent, highlighting the ongoing challenges of LLMs regarding negation understanding and generalization. The dataset and code are publicly available.

Recent developments in generative AI have shone a spotlight on high-performance synthetic text generation technologies. The now wide availability and ease of use of such models highlights the urgent need to provide equally powerful technologies capable of identifying synthetic text. With this in mind, we draw inspiration from psychological studies which suggest that people can be driven by emotion and encode emotion in the text they compose. We hypothesize that pretrained language models (PLMs) have an affective deficit because they lack such an emotional driver when generating text and consequently may generate synthetic text which has affective incoherence i.e. lacking the kind of emotional coherence present in human-authored text. We subsequently develop an emotionally aware detector by fine-tuning a PLM on emotion. Experiment results indicate that our emotionally-aware detector achieves improvements across a range of synthetic text generators, various sized models, datasets, and domains. Finally, we compare our emotionally-aware synthetic text detector to ChatGPT in the task of identification of its own output and show substantial gains, reinforcing the potential of emotion as a signal to identify synthetic text. Code, models, and datasets are available at https: //github.com/alanagiasi/emoPLMsynth