Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA. In addition, these methods rely on tokenizers or fixed k-mers to aggregate meaningful DNA units, losing single nucleotide resolution where subtle genetic variations can completely alter protein function via single nucleotide polymorphisms (SNPs). Recently, Hyena, a large language model based on implicit convolutions was shown to match attention in quality while allowing longer context lengths and lower time complexity. Leveraging Hyena's new long-range capabilities, we present HyenaDNA, a genomic foundation model pretrained on the human reference genome with context lengths of up to 1 million tokens at the single nucleotide-level - an up to 500x increase over previous dense attention-based models. HyenaDNA scales sub-quadratically in sequence length (training up to 160x faster than Transformer), uses single nucleotide tokens, and has full global context at each layer. We explore what longer context enables - including the first use of in-context learning in genomics. On fine-tuned benchmarks from the Nucleotide Transformer, HyenaDNA reaches state-of-the-art (SotA) on 12 of 18 datasets using a model with orders of magnitude less parameters and pretraining data. On the GenomicBenchmarks, HyenaDNA surpasses SotA on 7 of 8 datasets on average by +10 accuracy points. Code at https://github.com/HazyResearch/hyena-dna.

The rapid advancement of Large Language Models (LLMs) has sparked intense debate regarding their ability to perceive and interpret complex socio-political landscapes. In this study, we undertake an exploration of decisionmaking processes and inherent biases within Figure 1: (Undesired) Effect of Bias Treatment on Decision LLMs, exemplified by ChatGPT, specifically Process: The figure depicts how the LLM's perception contextualizing our analysis within political debates. of value A is considered during the decision We aim not to critique or validate LLMs' process while judging B and C through f(C|A) and values, but rather to discern how they interpret f(B|A). When treating the biased association of value and adjudicate "good arguments." By applying A with C (f(C|A)) by naively fine-tuning the model to Activity Dependency Networks (ADNs), align with this value of interest, other value associations we extract the LLMs' implicit criteria for such (f(B|A)), that are not actively considered. They may assessments and illustrate how normative values be changed indiscriminately, regardless of whether they influence these perceptions. We discuss were already aligned. These associations are currently the consequences of our findings for human-AI neither observable nor predictable yet changes in them alignment and bias mitigation.

Large language models (LLMs) have demonstrated remarkable open-domain capabilities. Traditionally, LLMs tailored for a domain are trained from scratch to excel at handling domain-specific tasks. In this work, we explore an alternative strategy of continual pre-training as a means to develop domain-specific LLMs. We introduce FinPythia-6.9B, developed through domain-adaptive continual pre-training on the financial domain. Continual pre-trained FinPythia showcases consistent improvements on financial tasks over the original foundational model. We further explore simple but effective data selection strategies for continual pre-training. Our data selection strategies outperforms vanilla continual pre-training's performance with just 10% of corpus size and cost, without any degradation on open-domain standard tasks. Our work proposes an alternative solution to building domain-specific LLMs from scratch in a cost-effective manner.

What will likely be the effect of the emergence of ChatGPT and other forms of artificial intelligence (AI) on the skill premium? To address this question, we develop a nested constant elasticity of substitution production function that distinguishes between industrial robots and AI. Industrial robots predominantly substitute for low-skill workers, whereas AI mainly helps to perform the tasks of high-skill workers. We show that AI reduces the skill premium as long as it is more substitutable for high-skill workers than low-skill workers are for high-skill workers.

I spent most of the summer sifting through topics, including patents, blood diamonds and police brutality. None of them really stuck. However, on September 16, 2021 I sent Dr. White this email: " In a shocking turn of events, I have found another thing I would like to research. I would like to see if Twitter "coverage" of a publicly traded stock or related phrase ("google" and "search engine") can predict the daily returns of the stock, or changes in the highs/lows/volume of trades. The theory here being that investors' valuation of a stock may be reinforced or informed based on their perception of how others think about the companies (sort of like herd behavior) or their familiarity with the firm in general. If there is an effect, I would particularly like to examine whether this effect has gotten stronger during corona times, as many journalists are claiming that now that everyone is sitting at home with their commission-free trading apps like RobinHood, there are tons of amateur investors in the scene, who may be prone to "window shopping" for hot stocks that make the news.

Artificial general intelligence (AGI) does not yet exist, but given the pace of technological development in artificial intelligence, it is projected to reach human-level intelligence within roughly the next two decades. After that, many experts expect it to far surpass human intelligence and to do so rapidly. The prospect of superintelligent AGI poses an existential risk to humans because there is no reliable method for ensuring that AGI goals stay aligned with human goals. Drawing on publicly available forecaster and opinion data, the author examines how experts and non-experts perceive risk from AGI. The findings indicate that the perceived risk of a world catastrophe or extinction from AGI is greater than for other existential risks. The increase in perceived risk over the last year is also steeper for AGI than for other existential threats (e.g., nuclear war or human-caused climate change). That AGI is a pressing existential risk is something on which experts and non-experts agree, but the basis for such agreement currently remains obscure.

Recent advancements in deep learning-based approaches have led to remarkable progress in fruit detection, enabling robust fruit identification in complex environments. However, much less progress has been made on fruit 3D localization, which is equally crucial for robotic harvesting. Complex fruit shape/orientation, fruit clustering, varying lighting conditions, and occlusions by leaves and branches have greatly restricted existing sensors from achieving accurate fruit localization in the natural orchard environment. In this paper, we report on the design of a novel localization technique, called Active Laser-Camera Scanning (ALACS), to achieve accurate and robust fruit 3D localization. The ALACS hardware setup comprises a red line laser, an RGB color camera, a linear motion slide, and an external RGB-D camera. Leveraging the principles of dynamic-targeting laser-triangulation, ALACS enables precise transformation of the projected 2D laser line from the surface of apples to the 3D positions. To facilitate laser pattern acquisitions, a Laser Line Extraction (LLE) method is proposed for robust and high-precision feature extraction on apples. Comprehensive evaluations of LLE demonstrated its ability to extract precise patterns under variable lighting and occlusion conditions. The ALACS system achieved average apple localization accuracies of 6.9 11.2 mm at distances ranging from 1.0 m to 1.6 m, compared to 21.5 mm by a commercial RealSense RGB-D camera, in an indoor experiment. Orchard evaluations demonstrated that ALACS has achieved a 95% fruit detachment rate versus a 71% rate by the RealSense camera. By overcoming the challenges of apple 3D localization, this research contributes to the advancement of robotic fruit harvesting technology.

Multilingual pre-trained language models are incredibly effective at Question Answering (QA), a core task in Natural Language Understanding, achieving high accuracies on several multilingual benchmarks. However, little is known about how well they are calibrated. In this paper, we study the calibration properties of several pre-trained multilingual large language models (LLMs) on a variety of question-answering tasks. We perform extensive experiments, spanning both extractive and generative QA model designs and diverse languages, spanning both high-resource and low-resource ones. We study different dimensions of calibration in in-distribution, out-of-distribution, and cross-lingual transfer settings, and investigate strategies to improve it, including post-hoc methods and regularized fine-tuning. We demonstrate automatically translated data augmentation as a highly effective technique to improve model calibration. We also conduct a number of ablation experiments to study the effect of model size on calibration and how multilingual models compare with their monolingual counterparts for diverse tasks and languages.

Pre-trained language models (PLMs) that achieve success in applications are susceptible to adversarial attack methods that are capable of generating adversarial examples with minor perturbations. Although recent attack methods can achieve a relatively high attack success rate (ASR), our observation shows that the generated adversarial examples have a different data distribution compared with the original examples. Specifically, these adversarial examples exhibit lower confidence levels and higher distance to the training data distribution. As a result, they are easy to detect using very simple detection methods, diminishing the actual effectiveness of these attack methods. To solve this problem, we propose a Distribution-Aware LoRA-based Adversarial Attack (DALA) method, which considers the distribution shift of adversarial examples to improve attack effectiveness under detection methods. We further design a new evaluation metric NASR combining ASR and detection for the attack task. We conduct experiments on four widely-used datasets and validate the attack effectiveness on ASR and NASR of the adversarial examples generated by DALA on the BERT-base model and the black-box LLaMA2-7b model.

We present a method for the unsupervised segmentation of electron microscopy images, which are powerful descriptors of materials and chemical systems. Images are oversegmented into overlapping chips, and similarity graphs are generated from embeddings extracted from a domain$\unicode{x2010}$pretrained convolutional neural network (CNN). The Louvain method for community detection is then applied to perform segmentation. The graph representation provides an intuitive way of presenting the relationship between chips and communities. We demonstrate our method to track irradiation$\unicode{x2010}$induced amorphous fronts in thin films used for catalysis and electronics. This method has potential for "on$\unicode{x2010}$the$\unicode{x2010}$fly" segmentation to guide emerging automated electron microscopes.