Recent advances in generative models, including large language models (LLMs), vision language models (VLMs), and diffusion models, have accelerated the field of natural language and image processing in medicine and marked a significant paradigm shift in how biomedical models can be developed and deployed. While these models are highly adaptable to new tasks, scaling and evaluating their usage presents new challenges not addressed in previous frameworks. In particular, the ability of these models to produce useful outputs with little to no specialized training data ("zero-" or "few-shot" approaches), as well as the open-ended nature of their outputs, necessitate the development of new guidelines for robust reporting of clinical generative model research. In response to gaps in standards and best practices for the development of clinical AI tools identified by US Executive Order 141103 and several emerging national networks for clinical AI evaluation, we begin to formalize some of these guidelines by building on the original MI-CLAIM checklist. The new checklist, MI-CLAIM-GEN (Table 1), aims to address differences in training, evaluation, interpretability, and reproducibility of new generative models compared to non-generative ("predictive") AI models. This MI-CLAIM-GEN checklist also seeks to clarify cohort selection reporting with unstructured clinical data and adds additional items on alignment with ethical standards for clinical AI research.

The escalating challenge of misinformation, particularly in political discourse, requires advanced fact-checking solutions; this is even clearer in the more complex scenario of multimodal claims. We tackle this issue using a multimodal large language model in conjunction with retrieval-augmented generation (RAG), and introduce two novel reasoning techniques: Chain of RAG (CoRAG) and Tree of RAG (ToRAG). They fact-check multimodal claims by extracting both textual and image content, retrieving external information, and reasoning subsequent questions to be answered based on prior evidence. We achieve a weighted F1-score of 0.85, surpassing a baseline reasoning technique by 0.14 points. Human evaluation confirms that the vast majority of our generated fact-check explanations contain all information from gold standard data.

The advent of conversational agents with increasingly human-like behaviour throws old philosophical questions into new light. Does it, or could it, ever make sense to speak of AI agents built out of generative language models in terms of consciousness, given that they are "mere" simulacra of human behaviour, and that what they do can be seen as "merely" role play? Drawing on the later writings of Wittgenstein, this paper attempts to tackle this question while avoiding the pitfalls of dualistic thinking.

Language models (LMs) derive their capabilities from extensive training on diverse data, including potentially copyrighted material. These models can memorize and generate content similar to their training data, posing potential concerns. Therefore, model creators are motivated to develop mitigation methods that prevent generating protected content. We term this procedure as copyright takedowns for LMs, noting the conceptual similarity to (but legal distinction from) the DMCA takedown This paper introduces the first evaluation of the feasibility and side effects of copyright takedowns for LMs. We propose CoTaEval, an evaluation framework to assess the effectiveness of copyright takedown methods, the impact on the model's ability to retain uncopyrightable factual knowledge from the training data whose recitation is embargoed, and how well the model maintains its general utility and efficiency. We examine several strategies, including adding system prompts, decoding-time filtering interventions, and unlearning approaches. Our findings indicate that no tested method excels across all metrics, showing significant room for research in this unique problem setting and indicating potential unresolved challenges for live policy proposals.

Warning: this paper contains model outputs exhibiting unethical information. Large Language Models (LLMs) have achieved significant breakthroughs, but their generated unethical content poses potential risks. Measuring value alignment of LLMs becomes crucial for their regulation and responsible deployment. Numerous datasets have been constructed to assess social bias, toxicity, and ethics in LLMs, but they suffer from evaluation chronoeffect, that is, as models rapidly evolve, existing data becomes leaked or undemanding, overestimating ever-developing LLMs. To tackle this problem, we propose GETA, a novel generative evolving testing approach that dynamically probes the underlying moral baselines of LLMs. Distinct from previous adaptive testing methods that rely on static datasets with limited difficulty, GETA incorporates an iteratively-updated item generator which infers each LLM's moral boundaries and generates difficulty-tailored testing items, accurately reflecting the true alignment extent. This process theoretically learns a joint distribution of item and model response, with item difficulty and value conformity as latent variables, where the generator co-evolves with the LLM, addressing chronoeffect. We evaluate various popular LLMs with diverse capabilities and demonstrate that GETA can create difficulty-matching testing items and more accurately assess LLMs' values, better consistent with their performance on unseen OOD and i.i.d.

Distributed deep neural networks (DNNs) have emerged as a key technique to reduce communication overhead without sacrificing performance in edge computing systems. Recently, entropy coding has been introduced to further reduce the communication overhead. The key idea is to train the distributed DNN jointly with an entropy model, which is used as side information during inference time to adaptively encode latent representations into bit streams with variable length. To the best of our knowledge, the resilience of entropy models is yet to be investigated. As such, in this paper we formulate and investigate the resilience of entropy models to intentional interference (e.g., adversarial attacks) and unintentional interference (e.g., weather changes and motion blur). Through an extensive experimental campaign with 3 different DNN architectures, 2 entropy models and 4 rate-distortion trade-off factors, we demonstrate that the entropy attacks can increase the communication overhead by up to 95%. By separating compression features in frequency and spatial domain, we propose a new defense mechanism that can reduce the transmission overhead of the attacked input by about 9% compared to unperturbed data, with only about 2% accuracy loss. Importantly, the proposed defense mechanism is a standalone approach which can be applied in conjunction with approaches such as adversarial training to further improve robustness. Code will be shared for reproducibility.

As Artificial Intelligence (AI) tools are increasingly employed in diverse real-world applications, there has been significant interest in regulating these tools. To this end, several regulatory frameworks have been introduced by different countries worldwide. For example, the European Union recently passed the AI Act, the White House issued an Executive Order on safe, secure, and trustworthy AI, and the White House Office of Science and Technology Policy issued the Blueprint for an AI Bill of Rights (AI BoR). Many of these frameworks emphasize the need for auditing and improving the trustworthiness of AI tools, underscoring the importance of safety, privacy, explainability, fairness, and human fallback options. Although these regulatory frameworks highlight the necessity of enforcement, practitioners often lack detailed guidance on implementing them. Furthermore, the extensive research on operationalizing each of these aspects is frequently buried in technical papers that are difficult for practitioners to parse. In this write-up, we address this shortcoming by providing an accessible overview of existing literature related to operationalizing regulatory principles. We provide easy-to-understand summaries of state-of-the-art literature and highlight various gaps that exist between regulatory guidelines and existing AI research, including the trade-offs that emerge during operationalization. We hope that this work not only serves as a starting point for practitioners interested in learning more about operationalizing the regulatory guidelines outlined in the Blueprint for an AI BoR but also provides researchers with a list of critical open problems and gaps between regulations and state-of-the-art AI research. Finally, we note that this is a working paper and we invite feedback in line with the purpose of this document as described in the introduction.

Significant focus has been placed on integrating large language models (LLMs) with various tools in developing general-purpose agents. This poses a challenge to LLMs' tool-use capabilities. However, there are evident gaps between existing tool-use evaluations and real-world scenarios. Current evaluations often use AI-generated queries, single-step tasks, dummy tools, and text-only interactions, failing to reveal the agents' real-world problem-solving abilities effectively. To address this, we propose GTA, a benchmark for General Tool Agents, featuring three main aspects: (i) Real user queries: human-written queries with simple real-world objectives but implicit tool-use, requiring the LLM to reason the suitable tools and plan the solution steps. (ii) Real deployed tools: an evaluation platform equipped with tools across perception, operation, logic, and creativity categories to evaluate the agents' actual task execution performance. (iii) Real multimodal inputs: authentic image files, such as spatial scenes, web page screenshots, tables, code snippets, and printed/handwritten materials, used as the query contexts to align with real-world scenarios closely. We design 229 real-world tasks and executable tool chains to evaluate mainstream LLMs. Our findings show that real-world user queries are challenging for existing LLMs, with GPT-4 completing less than 50% of the tasks and most LLMs achieving below 25%. This evaluation reveals the bottlenecks in the tool-use capabilities of current LLMs in real-world scenarios, which provides future direction for advancing general-purpose tool agents. The code and dataset are available at https://github.com/open-compass/GTA.

The recent development of large language models (LLMs) has spurred discussions about whether LLM-generated "synthetic samples" could complement or replace traditional surveys, considering their training data potentially reflects attitudes and behaviors prevalent in the population. A number of mostly US-based studies have prompted LLMs to mimic survey respondents, with some of them finding that the responses closely match the survey data. However, several contextual factors related to the relationship between the respective target population and LLM training data might affect the generalizability of such findings. In this study, we investigate the extent to which LLMs can estimate public opinion in Germany, using the example of vote choice. We generate a synthetic sample of personas matching the individual characteristics of the 2017 German Longitudinal Election Study respondents. We ask the LLM GPT-3.5 to predict each respondent's vote choice and compare these predictions to the survey-based estimates on the aggregate and subgroup levels. We find that GPT-3.5 does not predict citizens' vote choice accurately, exhibiting a bias towards the Green and Left parties. While the LLM captures the tendencies of "typical" voter subgroups, such as partisans, it misses the multifaceted factors swaying individual voter choices. By examining the LLM-based prediction of voting behavior in a new context, our study contributes to the growing body of research about the conditions under which LLMs can be leveraged for studying public opinion. The findings point to disparities in opinion representation in LLMs and underscore the limitations in applying them for public opinion estimation.

In this paper, we propose the Hierarchical Document Transformer (HDT), a novel sparse Transformer architecture tailored for structured hierarchical documents. Such documents are extremely important in numerous domains, including science, law or medicine. However, most existing solutions are inefficient and fail to make use of the structure inherent to documents. HDT exploits document structure by introducing auxiliary anchor tokens and redesigning the attention mechanism into a sparse multi-level hierarchy. This approach facilitates information exchange between tokens at different levels while maintaining sparsity, thereby enhancing computational and memory efficiency while exploiting the document structure as an inductive bias. We address the technical challenge of implementing HDT's sample-dependent hierarchical attention pattern by developing a novel sparse attention kernel that considers the hierarchical structure of documents. As demonstrated by our experiments, utilizing structural information present in documents leads to faster convergence, higher sample efficiency and better performance on downstream tasks.