Age-related macular degeneration (AMD) is a major cause of blindness in older adults, severely affecting vision and quality of life. Despite advances in understanding AMD, the molecular factors driving the severity of subretinal scarring (fibrosis) remain elusive, hampering the development of effective therapies. This study introduces a machine learning-based framework to predict key genes that are strongly correlated with lesion severity and to identify potential therapeutic targets to prevent subretinal fibrosis in AMD. Using an original RNA sequencing (RNA-seq) dataset from the diseased retinas of JR5558 mice, we developed a novel and specific feature engineering technique, including pathway-based dimensionality reduction and gene-based feature expansion, to enhance prediction accuracy. Two iterative experiments were conducted by leveraging Ridge and ElasticNet regression models to assess biological relevance and gene impact. The results highlight the biological significance of several key genes and demonstrate the framework's effectiveness in identifying novel therapeutic targets. The key findings provide valuable insights for advancing drug discovery efforts and improving treatment strategies for AMD, with the potential to enhance patient outcomes by targeting the underlying genetic mechanisms of subretinal lesion development.

Large Language Models (LLMs) have rapidly increased in size and apparent capabilities in the last three years, but their training data is largely English text. There is growing interest in multilingual LLMs, and various efforts are striving for models to accommodate languages of communities outside of the Global North, which include many languages that have been historically underrepresented in digital realms. These languages have been coined as "low resource languages" or "long-tail languages", and LLMs performance on these languages is generally poor. While expanding the use of LLMs to more languages may bring many potential benefits, such as assisting cross-community communication and language preservation, great care must be taken to ensure that data collection on these languages is not extractive and that it does not reproduce exploitative practices of the past. Collecting data from languages spoken by previously colonized people, indigenous people, and non-Western languages raises many complex sociopolitical and ethical questions, e.g., around consent, cultural safety, and data sovereignty. Furthermore, linguistic complexity and cultural nuances are often lost in LLMs. This position paper builds on recent scholarship, and our own work, and outlines several relevant social, cultural, and ethical considerations and potential ways to mitigate them through qualitative research, community partnerships, and participatory design approaches. We provide twelve recommendations for consideration when collecting language data on underrepresented language communities outside of the Global North.

Language model alignment research often attempts to ensure that models are not only helpful and harmless, but also truthful and unbiased. However, optimizing these objectives simultaneously can obscure how improving one aspect might impact the others. In this work, we focus on analyzing the relationship between two concepts essential in both language model alignment and political science: \textit{truthfulness} and \textit{political bias}. We train reward models on various popular truthfulness datasets and subsequently evaluate their political bias. Our findings reveal that optimizing reward models for truthfulness on these datasets tends to result in a left-leaning political bias. We also find that existing open-source reward models (i.e. those trained on standard human preference datasets) already show a similar bias and that the bias is larger for larger models. These results raise important questions about both the datasets used to represent truthfulness and what language models capture about the relationship between truth and politics.

This paper presents an adaptive visual servoing framework for robotic on-orbit servicing (OOS), specifically designed for capturing tumbling satellites. The vision-guided robotic system is capable of selecting optimal control actions in the event of partial or complete vision system failure, particularly in the short term. The autonomous system accounts for physical and operational constraints, executing visual servoing tasks to minimize a cost function. A hierarchical control architecture is developed, integrating a variant of the Iterative Closest Point (ICP) algorithm for image registration, a constrained noise-adaptive Kalman filter, fault detection and recovery logic, and a constrained optimal path planner. The dynamic estimator provides real-time estimates of unknown states and uncertain parameters essential for motion prediction, while ensuring consistency through a set of inequality constraints. It also adjusts the Kalman filter parameters adaptively in response to unexpected vision errors. In the event of vision system faults, a recovery strategy is activated, guided by fault detection logic that monitors the visual feedback via the metric fit error of image registration. The estimated/predicted pose and parameters are subsequently fed into an optimal path planner, which directs the robot's end-effector to the target's grasping point. This process is subject to multiple constraints, including acceleration limits, smooth capture, and line-of-sight maintenance with the target. Experimental results demonstrate that the proposed visual servoing system successfully captured a free-floating object, despite complete occlusion of the vision system.

The integration of Large Language Models (LLMs) like GPT-4o into robotic systems represents a significant advancement in embodied artificial intelligence. These models can process multi-modal prompts, enabling them to generate more context-aware responses. However, this integration is not without challenges. One of the primary concerns is the potential security risks associated with using LLMs in robotic navigation tasks. These tasks require precise and reliable responses to ensure safe and effective operation. Multi-modal prompts, while enhancing the robot's understanding, also introduce complexities that can be exploited maliciously. For instance, adversarial inputs designed to mislead the model can lead to incorrect or dangerous navigational decisions. This study investigates the impact of prompt injections on mobile robot performance in LLM-integrated systems and explores secure prompt strategies to mitigate these risks. Our findings demonstrate a substantial overall improvement of approximately 30.8% in both attack detection and system performance with the implementation of robust defence mechanisms, highlighting their critical role in enhancing security and reliability in mission-oriented tasks.

With the great advancements in large language models (LLMs), adversarial attacks against LLMs have recently attracted increasing attention. We found that pre-existing adversarial attack methodologies exhibit limited transferability and are notably inefficient, particularly when applied to LLMs. In this paper, we analyze the core mechanisms of previous predominant adversarial attack methods, revealing that 1) the distributions of importance score differ markedly among victim models, restricting the transferability; 2) the sequential attack processes induces substantial time overheads. Based on the above two insights, we introduce a new scheme, named TF-Attack, for Transferable and Fast adversarial attacks on LLMs. TF-Attack employs an external LLM as a third-party overseer rather than the victim model to identify critical units within sentences. Moreover, TF-Attack introduces the concept of Importance Level, which allows for parallel substitutions of attacks. We conduct extensive experiments on 6 widely adopted benchmarks, evaluating the proposed method through both automatic and human metrics. Results show that our method consistently surpasses previous methods in transferability and delivers significant speed improvements, up to 20 times faster than earlier attack strategies.

This paper presents a novel Collaborative Cyberattack Detection (CCD) system aimed at enhancing the security of blockchain-based data-sharing networks by addressing the complex challenges associated with noise addition in federated learning models. Leveraging the theoretical principles of differential privacy, our approach strategically integrates noise into trained sub-models before reconstructing the global model through transmission. We systematically explore the effects of various noise types, i.e., Gaussian, Laplace, and Moment Accountant, on key performance metrics, including attack detection accuracy, deep learning model convergence time, and the overall runtime of global model generation. Our findings reveal the intricate trade-offs between ensuring data privacy and maintaining system performance, offering valuable insights into optimizing these parameters for diverse CCD environments. Through extensive simulations, we provide actionable recommendations for achieving an optimal balance between data protection and system efficiency, contributing to the advancement of secure and reliable blockchain networks.

Information Extraction (IE) and Text Classification (CLS) serve as the fundamental pillars of NLU, with both disciplines relying on analyzing input sequences to categorize outputs into pre-established schemas. However, there is no existing encoder-based model that can unify IE and CLS tasks from this perspective. To fully explore the foundation shared within NLU tasks, we have proposed a Recursive Method with Explicit Schema Instructor for Universal NLU. Specifically, we firstly redefine the true universal information extraction (UIE) with a formal formulation that covers almost all extraction schemas, including quadruples and quintuples which remain unsolved for previous UIE models. Then, we expands the formulation to all CLS and multi-modal NLU tasks. Based on that, we introduce RexUniNLU, an universal NLU solution that employs explicit schema constraints for IE and CLS, which encompasses all IE and CLS tasks and prevent incorrect connections between schema and input sequence. To avoid interference between different schemas, we reset the position ids and attention mask matrices. Extensive experiments are conducted on IE, CLS in both English and Chinese, and multi-modality, revealing the effectiveness and superiority. Our codes are publicly released.

Large Language Models (LLMs) have been profusely evaluated on their ability to answer questions on many topics and their performance on different natural language understanding tasks. Those tests are usually conducted in English, but most LLM users are not native English speakers. Therefore, it is of interest to analyze how LLMs understand other languages at different levels: from paragraphs to morphems. In this paper, we evaluate the performance of state-of-the-art LLMs in TELEIA, a recently released benchmark with similar questions to those of Spanish exams for foreign students, covering topics such as reading comprehension, word formation, meaning and compositional semantics, and grammar. The results show that LLMs perform well at understanding Spanish but are still far from achieving the level of a native speaker in terms of grammatical competence.

The Ukrainian Air Force said it repelled a massive air attack by Russia across the country, shooting down 58 of 67 long-range drones that were launched overnight. Debris from a downed drone was also found next to Ukraine's parliament building in the capital, Kyiv, the Verkhovna Rada said in a statement on the Telegram messaging app on Saturday. Air defence units were scrambled into action in 11 regions across Ukraine, the air force said in a statement on Telegram. It also said the Shahed drones were launched from two border regions in Russia as well as from the Russian-occupied peninsula of Crimea. There were no immediate reports on casualties from the attacks.