Fox News' Bret Baier has the latest on concerns over the retirement of the International Space Station on'Special Report.' Before the International Space Station was launched into orbit in 1998, the U.S. signed a document with several other countries to agree to the peaceful use of the orbital laboratory. The agreement included Russia, Japan, Canada and 11 European countries. China was left out of the plan. Nearly a decade later, China expressed interest in joining those on board the space station.

Peptide therapeutics, a major class of medicines, have achieved remarkable success across diseases such as diabetes and cancer, with landmark examples such as GLP-1 receptor agonists revolutionizing the treatment of type-2 diabetes and obesity. Despite their success, designing peptides that satisfy multiple conflicting objectives, such as target binding affinity, solubility, and membrane permeability, remains a major challenge. Classical drug development and structure-based design are ineffective for such tasks, as they fail to optimize global functional properties critical for therapeutic efficacy. Existing generative frameworks are largely limited to continuous spaces, unconditioned outputs, or single-objective guidance, making them unsuitable for discrete sequence optimization across multiple properties. To address this, we present PepTune, a multi-objective discrete diffusion model for the simultaneous generation and optimization of therapeutic peptide SMILES. Built on the Masked Discrete Language Model (MDLM) framework, PepTune ensures valid peptide structures with state-dependent masking schedules and penalty-based objectives. To guide the diffusion process, we propose a Monte Carlo Tree Search (MCTS)-based strategy that balances exploration and exploitation to iteratively refine Pareto-optimal sequences. MCTS integrates classifier-based rewards with search-tree expansion, overcoming gradient estimation challenges and data sparsity inherent to discrete spaces. Using PepTune, we generate diverse, chemically-modified peptides optimized for multiple therapeutic properties, including target binding affinity, membrane permeability, solubility, hemolysis, and non-fouling characteristics on various disease-relevant targets. In total, our results demonstrate that MCTS-guided discrete diffusion is a powerful and modular approach for multi-objective sequence design in discrete state spaces.

This paper explores the application of Hidden Markov Models (HMM) and Long Short-Term Memory (LSTM) neural networks for economic forecasting, focusing on predicting CPI inflation rates. The study explores a new approach that integrates HMM-derived hidden states and means as additional features for LSTM modeling, aiming to enhance the interpretability and predictive performance of the models. The research begins with data collection and preprocessing, followed by the implementation of the HMM to identify hidden states representing distinct economic conditions. Subsequently, LSTM models are trained using the original and augmented data sets, allowing for comparative analysis and evaluation. The results demonstrate that incorporating HMM-derived data improves the predictive accuracy of LSTM models, particularly in capturing complex temporal patterns and mitigating the impact of volatile economic conditions. Additionally, the paper discusses the implementation of Integrated Gradients for model interpretability and provides insights into the economic dynamics reflected in the forecasting outcomes.

Simultaneous generation models write generation results while reading streaming inputs, necessitating a policy-maker to determine the appropriate output timing. Existing simultaneous generation methods generally adopt the traditional encoder-decoder architecture and learn the generation and policy-making capabilities through complex dynamic programming techniques. Although LLMs excel at text generation, they face challenges in taking on the role of policy-makers through traditional training methods, limiting their exploration in simultaneous generation. To overcome these limitations, we propose a novel LLM-driven Simultaneous Generation (LSG) framework, which allows the off-the-shelf LLM to decide the generation timing and produce output concurrently. Specifically, LSG selects the generation policy that minimizes latency as the baseline policy. Referring to the baseline policy, LSG enables the LLM to devise an improved generation policy that better balances latency and generation quality, and writes generation results accordingly. Experiments on simultaneous translation and streaming automatic speech recognition tasks show that our method can achieve state-of-the-art performance utilizing the open-source LLMs and demonstrate practicality in real-world scenarios.

The increasing use of AI technologies has led to increasing AI incidents, posing risks and causing harm to individuals, organizations, and society. This study recognizes and addresses the lack of standardized protocols for reliably and comprehensively gathering such incident data crucial for preventing future incidents and developing mitigating strategies. Specifically, this study analyses existing open-access AI-incident databases through a systematic methodology and identifies nine gaps in current AI incident reporting practices. Further, it proposes nine actionable recommendations to enhance standardization efforts to address these gaps. Ensuring the trustworthiness of enabling technologies such as AI is necessary for sustainable digital transformation. Our research promotes the development of standards to prevent future AI incidents and promote trustworthy AI, thus facilitating achieving the UN sustainable development goals. Through international cooperation, stakeholders can unlock the transformative potential of AI, enabling a sustainable and inclusive future for all.

The application of machine learning to the study of coronal mass ejections (CMEs) and their impacts on Earth has seen significant growth recently. Understanding and forecasting CME geoeffectiveness is crucial for protecting infrastructure in space and ensuring the resilience of technological systems on Earth. Here we present GeoCME, a deep-learning framework designed to predict, deterministically or probabilistically, whether a CME event that arrives at Earth will cause a geomagnetic storm. A geomagnetic storm is defined as a disturbance of the Earth's magnetosphere during which the minimum Dst index value is less than -50 nT. GeoCME is trained on observations from the instruments including LASCO C2, EIT and MDI on board the Solar and Heliospheric Observatory (SOHO), focusing on a dataset that includes 136 halo/partial halo CMEs in Solar Cycle 23. Using ensemble and transfer learning techniques, GeoCME is capable of extracting features hidden in the SOHO observations and making predictions based on the learned features. Our experimental results demonstrate the good performance of GeoCME, achieving a Matthew's correlation coefficient of 0.807 and a true skill statistics score of 0.714 when the tool is used as a deterministic prediction model. When the tool is used as a probabilistic forecasting model, it achieves a Brier score of 0.094 and a Brier skill score of 0.493. These results are promising, showing that the proposed GeoCME can help enhance our understanding of CME-triggered solar-terrestrial interactions.

Data is essential for secondary use, but ensuring its privacy while allowing such use is a critical challenge. Various techniques have been proposed to address privacy concerns in data sharing and publishing. However, these methods often degrade data utility, impacting the performance of machine learning (ML) models. Our research identifies key limitations in existing optimization models for privacy preservation, particularly in handling categorical variables, assessing data utility, and evaluating effectiveness across diverse datasets. We propose a novel multi-objective optimization model that simultaneously minimizes information loss and maximizes protection against attacks. This model is empirically validated using diverse datasets and compared with two existing algorithms. We assess information loss, the number of individuals subject to linkage or homogeneity attacks, and ML performance after anonymization. The results indicate that our model achieves lower information loss and more effectively mitigates the risk of attacks, reducing the number of individuals susceptible to these attacks compared to alternative algorithms in some cases. Additionally, our model maintains comparative ML performance relative to the original data or data anonymized by other methods. Our findings highlight significant improvements in privacy protection and ML model performance, offering a comprehensive framework for balancing privacy and utility in data sharing.

This work introduces Transformer-based Successive Convexification (T-SCvx), an extension of Transformer-based Powered Descent Guidance (T-PDG), generalizable for efficient six-degree-of-freedom (DoF) fuel-optimal powered descent trajectory generation. Our approach significantly enhances the sample efficiency and solution quality for nonconvex-powered descent guidance by employing a rotation invariant transformation of the sampled dataset. T-PDG was previously applied to the 3-DoF minimum fuel powered descent guidance problem, improving solution times by up to an order of magnitude compared to lossless convexification (LCvx). By learning to predict the set of tight or active constraints at the optimal control problem's solution, Transformer-based Successive Convexification (T-SCvx) creates the minimal reduced-size problem initialized with only the tight constraints, then uses the solution of this reduced problem to warm-start the direct optimization solver. 6-DoF powered descent guidance is known to be challenging to solve quickly and reliably due to the nonlinear and non-convex nature of the problem, the discretization scheme heavily influencing solution validity, and reference trajectory initialization determining algorithm convergence or divergence. Our contributions in this work address these challenges by extending T-PDG to learn the set of tight constraints for the successive convexification (SCvx) formulation of the 6-DoF powered descent guidance problem. In addition to reducing the problem size, feasible and locally optimal reference trajectories are also learned to facilitate convergence from the initial guess. T-SCvx enables onboard computation of real-time guidance trajectories, demonstrated by a 6-DoF Mars powered landing application problem.

The Segment Anything Model (SAM) is a cornerstone of image segmentation, demonstrating exceptional performance across various applications, particularly in autonomous driving and medical imaging, where precise segmentation is crucial. However, SAM is vulnerable to adversarial attacks that can significantly impair its functionality through minor input perturbations. Traditional techniques, such as FGSM and PGD, are often ineffective in segmentation tasks due to their reliance on global perturbations that overlook spatial nuances. Recent methods like Attack-SAM-K and UAD have begun to address these challenges, but they frequently depend on external cues and do not fully leverage the structural interdependencies within segmentation processes. This limitation underscores the need for a novel adversarial strategy that exploits the unique characteristics of segmentation tasks. In response, we introduce the Region-Guided Attack (RGA), designed specifically for SAM. RGA utilizes a Region-Guided Map (RGM) to manipulate segmented regions, enabling targeted perturbations that fragment large segments and expand smaller ones, resulting in erroneous outputs from SAM. Our experiments demonstrate that RGA achieves high success rates in both white-box and black-box scenarios, emphasizing the need for robust defenses against such sophisticated attacks. RGA not only reveals SAM's vulnerabilities but also lays the groundwork for developing more resilient defenses against adversarial threats in image segmentation.

Large language models are increasingly being integrated into applications that shape the production and discovery of societal knowledge such as search, online education, and travel planning. As a result, language models will shape how people learn about, perceive and interact with global cultures making it important to consider whose knowledge systems and perspectives are represented in models. Recognizing this importance, increasingly work in Machine Learning and NLP has focused on evaluating gaps in global cultural representational distribution within outputs. However, more work is needed on developing benchmarks for cross-cultural impacts of language models that stem from a nuanced sociologically-aware conceptualization of cultural impact or harm. We join this line of work arguing for the need of metricizable evaluations of language technologies that interrogate and account for historical power inequities and differential impacts of representation on global cultures, particularly for cultures already under-represented in the digital corpora. We look at two concepts of erasure: omission: where cultures are not represented at all and simplification i.e. when cultural complexity is erased by presenting one-dimensional views of a rich culture. The former focuses on whether something is represented, and the latter on how it is represented. We focus our analysis on two task contexts with the potential to influence global cultural production. First, we probe representations that a language model produces about different places around the world when asked to describe these contexts. Second, we analyze the cultures represented in the travel recommendations produced by a set of language model applications. Our study shows ways in which the NLP community and application developers can begin to operationalize complex socio-cultural considerations into standard evaluations and benchmarks.