This study quantifies the association between non-adherence to antipsychotic medications and adverse outcomes in individuals with schizophrenia. We frame the problem using survival analysis, focusing on the time to the earliest of several adverse events (early death, involuntary hospitalization, jail booking). We extend standard causal inference methods (T-learner, S-learner, nearest neighbor matching) to utilize various survival models to estimate individual and average treatment effects, where treatment corresponds to medication non-adherence. Analyses are repeated using different amounts of longitudinal information (3, 6, 9, and 12 months). Using data from Allegheny County in western Pennsylvania, we find strong evidence that non-adherence advances adverse outcomes by approximately 1 to 4 months. Ablation studies confirm that county-provided risk scores adjust for key confounders, as their removal amplifies the estimated effects. Subgroup analyses by medication formulation (injectable vs. oral) and medication type consistently show that non-adherence is associated with earlier adverse events. These findings highlight the clinical importance of adherence in delaying psychiatric crises and show that integrating survival analysis with causal inference tools can yield policy-relevant insights. We caution that although we apply causal inference, we only make associative claims and discuss assumptions needed for causal interpretation.

This work describes the participation of the MLLP-VRAIN research group in the shared task of the IWSLT 2025 Simultaneous Speech Translation track. Our submission addresses the unique challenges of real-time translation of long-form speech by developing a modular cascade system that adapts strong pre-trained models to streaming scenarios. We combine Whisper Large-V3-Turbo for ASR with the multilingual NLLB-3.3B model for MT, implementing lightweight adaptation techniques rather than training new end-to-end models from scratch. Our approach employs document-level adaptation with prefix training to enhance the MT model's ability to handle incomplete inputs, while incorporating adaptive emission policies including a wait-$k$ strategy and RALCP for managing the translation stream. Specialized buffer management techniques and segmentation strategies ensure coherent translations across long audio sequences. Experimental results on the ACL60/60 dataset demonstrate that our system achieves a favorable balance between translation quality and latency, with a BLEU score of 31.96 and non-computational-aware StreamLAAL latency of 2.94 seconds. Our final model achieves a preliminary score on the official test set (IWSLT25Instruct) of 29.8 BLEU. Our work demonstrates that carefully adapted pre-trained components can create effective simultaneous translation systems for long-form content without requiring extensive in-domain parallel data or specialized end-to-end training.

Detecting when public discourse shifts in response to major events is crucial for understanding societal dynamics. Real-world data is high-dimensional, sparse, and noisy, making changepoint detection in this domain a challenging endeavor. In this paper, we leverage neural networks for changepoint detection in news data, introducing a method based on the so-called learning-by-confusion scheme, which was originally developed for detecting phase transitions in physical systems. We train classifiers to distinguish between articles from different time periods. The resulting classification accuracy is used to estimate the total variation distance between underlying content distributions, where significant distances highlight changepoints. We demonstrate the effectiveness of this method on both synthetic datasets and real-world data from The Guardian newspaper, successfully identifying major historical events including 9/11, the COVID-19 pandemic, and presidential elections. Our approach requires minimal domain knowledge, can autonomously discover significant shifts in public discourse, and yields a quantitative measure of change in content, making it valuable for journalism, policy analysis, and crisis monitoring.

Ensuring diversity and inclusion (D&I) in artificial intelligence (AI) is crucial for mitigating biases and promoting equitable decision-making. However, existing AI risk assessment frameworks often overlook inclusivity, lacking standardized tools to measure an AI system's alignment with D&I principles. This paper introduces a structured AI inclusivity question bank, a comprehensive set of 253 questions designed to evaluate AI inclusivity across five pillars: Humans, Data, Process, System, and Governance. The development of the question bank involved an iterative, multi-source approach, incorporating insights from literature reviews, D&I guidelines, Responsible AI frameworks, and a simulated user study. The simulated evaluation, conducted with 70 AI-generated personas related to different AI jobs, assessed the question bank's relevance and effectiveness for AI inclusivity across diverse roles and application domains. The findings highlight the importance of integrating D&I principles into AI development workflows and governance structures. The question bank provides an actionable tool for researchers, practitioners, and policymakers to systematically assess and enhance the inclusivity of AI systems, paving the way for more equitable and responsible AI technologies.

Cellular automata (CA) provide a minimal formalism for investigating how simple local interactions generate rich spatiotemporal behavior in domains as diverse as traffic flow, ecology, tissue morphogenesis and crystal growth. However, automatically discovering the local update rules for a given phenomenon and using them for quantitative prediction remains challenging. Here we present AutomataGPT, a decoder-only transformer pretrained on around 1 million simulated trajectories that span 100 distinct two-dimensional binary deterministic CA rules on toroidal grids. When evaluated on previously unseen rules drawn from the same CA family, AutomataGPT attains 98.5% perfect one-step forecasts and reconstructs the governing update rule with up to 96% functional (application) accuracy and 82% exact rule-matrix match. These results demonstrate that large-scale pretraining over wider regions of rule space yields substantial generalization in both the forward (state forecasting) and inverse (rule inference) problems, without hand-crafted priors. By showing that transformer models can faithfully infer and execute CA dynamics from data alone, our work lays the groundwork for abstracting real-world dynamical phenomena into data-efficient CA surrogates, opening avenues in biology, tissue engineering, physics and AI-driven scientific discovery.

Healthcare 5.0 integrates Artificial Intelligence (AI), the Internet of Things (IoT), real-time monitoring, and human-centered design toward personalized medicine and predictive diagnostics. However, the increasing reliance on interconnected medical technologies exposes them to cyber threats. Meanwhile, current AI-driven cybersecurity models often neglect biomedical data, limiting their effectiveness and interpretability. This study addresses this gap by applying eXplainable AI (XAI) to a Healthcare 5.0 dataset that integrates network traffic and biomedical sensor data. Classification outputs indicate that XGBoost achieved 99% F1-score for benign and data alteration, and 81% for spoofing. Explainability findings reveal that network data play a dominant role in intrusion detection whereas biomedical features contributed to spoofing detection, with temperature reaching a Shapley values magnitude of 0.37.

Fine-scale soil mapping in Alaska, traditionally relying on fieldwork and localized simulations, remains a critical yet underdeveloped task, despite the region's ecological importance and extensive permafrost coverage. As permafrost thaw accelerates due to climate change, it threatens infrastructure stability and key ecosystem services, such as soil carbon storage. High-resolution soil maps are essential for characterizing permafrost distribution, identifying vulnerable areas, and informing adaptation strategies. We present MISO, a vision-based machine learning (ML) model to produce statewide fine-scale soil maps for near-surface permafrost and soil taxonomy. The model integrates a geospatial foundation model for visual feature extraction, implicit neural representations for continuous spatial prediction, and contrastive learning for multimodal alignment and geo-location awareness. We compare MISO with Random Forest (RF), a traditional ML model that has been widely used in soil mapping applications. Spatial cross-validation and regional analysis across Permafrost Zones and Major Land Resource Areas (MLRAs) show that MISO generalizes better to remote, unseen locations and achieves higher recall than RF, which is critical for monitoring permafrost thaw and related environmental processes. These findings demonstrate the potential of advanced ML approaches for fine-scale soil mapping and provide practical guidance for future soil sampling and infrastructure planning in permafrost-affected landscapes. The project will be released at https://github.com/knowledge-computing/Peatland-permafrost.

System prompts in Large Language Models (LLMs) are predefined directives that guide model behaviour, taking precedence over user inputs in text processing and generation. LLM deployers increasingly use them to ensure consistent responses across contexts. While model providers set a foundation of system prompts, deployers and third-party developers can append additional prompts without visibility into others' additions, while this layered implementation remains entirely hidden from end-users. As system prompts become more complex, they can directly or indirectly introduce unaccounted for side effects. This lack of transparency raises fundamental questions about how the position of information in different directives shapes model outputs. As such, this work examines how the placement of information affects model behaviour. To this end, we compare how models process demographic information in system versus user prompts across six commercially available LLMs and 50 demographic groups. Our analysis reveals significant biases, manifesting in differences in user representation and decision-making scenarios. Since these variations stem from inaccessible and opaque system-level configurations, they risk representational, allocative and potential other biases and downstream harms beyond the user's ability to detect or correct. Our findings draw attention to these critical issues, which have the potential to perpetuate harms if left unexamined. Further, we argue that system prompt analysis must be incorporated into AI auditing processes, particularly as customisable system prompts become increasingly prevalent in commercial AI deployments.

By effectively merging these two retrieval paradigms, the system would be capable of assembling a more comprehensive evidence base, thereby reducing the likelihood of missing pertinent details. Additionally, incorporating incremental graph update techniques would enable TrumorGPT to seamlessly integrate new medical studies and real-time health news without the need for extensive re-indexing or system downtime. This continuous update process is particularly crucial in the dynamic field of health, where the rapid emergence of new data can significantly impact the accuracy of fact-checking outcomes. In addition to efficient updating, implementing a dual-level retrieval strategy can further enhance contextual reasoning. Under this strategy, an initial coarse-grained retrieval would rapidly identify broad thematic and relational contexts, while a subsequent fine-grained search would extract specific factual details. This layered retrieval approach not only ensures that both high-level and granular information is captured but also supports more robust multi-hop reasoning by effectively bridging the gap between abstract concepts and concrete facts. Thus, these enhancements would bolster the fact-checking framework of TrumorGPT, striking an optimal balance between precision, efficiency, and comprehensive reasoning.

We introduce a new dataset and algorithm for fast and efficient coastal distance calculations from Anywhere on Earth (AoE). Existing global coastal datasets are only available at coarse resolution (e.g. 1-4 km) which limits their utility. Publicly available satellite imagery combined with computer vision enable much higher precision. We provide a global coastline dataset at 10 meter resolution, a 100+ fold improvement in precision over existing data. To handle the computational challenge of querying at such an increased scale, we introduce a new library: Layered Iterative Geospatial Hierarchical Terrain-Oriented Unified Search Engine (Lighthouse). Lighthouse is both exceptionally fast and resource-efficient, requiring only 1 CPU and 2 GB of RAM to achieve millisecond online inference, making it well suited for real-time applications in resource-constrained environments.