Figure 3: Distribution of Structural Similarity Index (SSIM), Peak Signal-to-Noise Ratio (PSNR), and Haar wavelet-based Perceptual Similarity Index (HaarPSI) scores for DeepFoqus-Accelerate reconstructions: (a-c) show results across 408 samples at 2x, 3x, and 4x acceleration, and (d-f) present distributions for the 36 image sets evaluated by reviewers. Figure 4: (A-B) Representative standard-of-care (SOC) images (first row) and DeepFoqus-Accelerate reconstructions from accelerated scans (second row), with corresponding quantitative and qualitative scores presented in the third row. Panel (B) shows two slices of the worst-case scenario in the qualitative dataset, characterized by wrap-around and motion artifacts. Discussion This evaluation of DeepFoqus-Accelerate demonstrates that this FDA-cleared k-space-based DL reconstruction software can reliably enable up to fourfold accelerated brain MRI acquisition without compromising diagnostic image quality. Both expert review and quantitative image similarity metrics confirm that AI-reconstructed images are clinically equivalent to fully sampled standards.

Image segmentation is a critical task in microscopy, essential for accurately analyzing and interpreting complex visual data. This task can be performed using custom models trained on domain-specific datasets, transfer learning from pre-trained models, or foundational models that offer broad applicability. However, foundational models often present a considerable number of non-transparent tuning parameters that require extensive manual optimization, limiting their usability for real-time streaming data analysis. Here, we introduce a reward function-based optimization to fine-tune foundational models and illustrate this approach for SAM (Segment Anything Model) framework by Meta. The reward functions can be constructed to represent the physics of the imaged system, including particle size distributions, geometries, and other criteria. By integrating a reward-driven optimization framework, we enhance SAM's adaptability and performance, leading to an optimized variant, SAM$^{*}$, that better aligns with the requirements of diverse segmentation tasks and particularly allows for real-time streaming data segmentation. We demonstrate the effectiveness of this approach in microscopy imaging, where precise segmentation is crucial for analyzing cellular structures, material interfaces, and nanoscale features.

The rapid proliferation of artificial intelligence (AI) across industry, government, and education highlights the urgent need for robust frameworks to conceptualise and guide engagement. This paper introduces the Hierarchy of Engagement with AI model, a novel maturity framework inspired by Maslow's hierarchy of needs. The model conceptualises AI adoption as a progression through eight levels, beginning with initial exposure and basic understanding and culminating in ecosystem collaboration and societal impact. Each level integrates technical, organisational, and ethical dimensions, emphasising that AI maturity is not only a matter of infrastructure and capability but also of trust, governance, and responsibility. Initial validation of the model using four diverse case studies (General Motors, the Government of Estonia, the University of Texas System, and the African Union AI Strategy) demonstrate the model's contextual flexibility across various sectors. The model provides scholars with a framework for analysing AI maturity and offers practitioners and policymakers a diagnostic and strategic planning tool to guide responsible and sustainable AI engagement. The proposed model demonstrates that AI maturity progression is multi-dimensional, requiring technological capability, ethical integrity, organisational resilience, and ecosystem collaboration.

The introduction of Artificial Intelligence (AI) into the domains of traditional art (visual arts, performing arts, and crafts) has sparked a complicated discussion about whether this might be an agent of disruption or an enhancement of our traditional art forms. This paper looks at the duality of AI, exploring the ways that recent technologies like Generative Adversarial Networks and Diffusion Models, and text-to-image generators are changing the fields of painting, sculpture, calligraphy, dance, music, and the arts of craft. Using examples and data, we illustrate the ways that AI can democratize creative expression, improve productivity, and preserve cultural heritage, while also examining the negative aspects, including: the threats to authenticity within art, ethical concerns around data, and issues including socio-economic factors such as job losses. While we argue for the context-dependence of the impact of AI (the potential for creative homogenization and the devaluation of human agency in artmaking), we also illustrate the potential for hybrid practices featuring AI in cuisine, etc. We advocate for the development of ethical guidelines, collaborative approaches, and inclusive technology development. In sum, we are articulating a vision of AI in which it amplifies our innate creativity while resisting the displacement of the cultural, nuanced, and emotional aspects of traditional art. The future will be determined by human choices about how to govern AI so that it becomes a mechanism for artistic evolution and not a substitute for the artist's soul.

The Trapped Gyro-Landau Fluid (TGLF) model provides fast, accurate predictions of turbulent transport in tokamaks, but whole device simulations requiring thousands of evaluations remain computationally expensive. Neural network (NN) surrogates offer accelerated inference with fully differentiable approximations that enable gradient-based coupling but typically require large training datasets to capture transport flux variations across plasma conditions, creating significant training burden and limiting applicability to expensive gyrokinetic simulations. We propose \textbf{TGLF-SINN (Spectra-Informed Neural Network)} with three key innovations: (1) principled feature engineering that reduces target prediction range, simplifying the learning task; (2) physics-guided regularization of transport spectra to improve generalization under sparse data; and (3) Bayesian Active Learning (BAL) to strategically select training samples based on model uncertainty, reducing data requirements while maintaining accuracy. Our approach achieves superior performance with significantly less training data. In offline settings, TGLF-SINN reduces logarithmic root mean squared error (LRMSE) by 12. 4\% compared to the current baseline \base. Using only 25\% of the complete dataset with BAL, we achieve LRMSE only 0.0165 higher than \base~and 0.0248 higher than our offline model (0.0583). In downstream flux matching applications, our NN surrogate provides 45x speedup over TGLF while maintaining comparable accuracy, demonstrating potential for training efficient surrogates for higher-fidelity models where data acquisition is costly and sparse.

This paper introduces ArGen (Auto-Regulation of Generative AI systems), a framework for aligning Large Language Models (LLMs) with complex sets of configurable, machine-readable rules spanning ethical principles, operational safety protocols, and regulatory compliance standards. Moving beyond just preference-based alignment, ArGen is designed to ensure LLMs adhere to these multifaceted policies through a novel synthesis of principle-based automated reward scoring, Group Relative Policy Optimisation (GRPO), and an Open Policy Agent (OPA) inspired governance layer. This approach provides the technical foundation for achieving and demonstrating compliance with diverse and nuanced governance requirements. To showcase the framework's capability to operationalize a deeply nuanced and culturally-specific value system, we present an in-depth case study: the development of a medical AI assistant guided by principles from Dharmic ethics (such as Ahimsa and Dharma), as derived from texts like the Bhagavad Gita. This challenging application demonstrates ArGen's adaptability, achieving a 70.9% improvement in domain-scope adherence over the baseline. Through our open-source repository, we show that ArGen's methodology offers a path to 'Governable Al' systems that are technically proficient, ethically robust, and verifiably compliant for safe deployment in diverse global contexts.

Self-supervised learning (SSL) has shown great promise in graph representation learning. However, most existing graph SSL methods are developed and evaluated under a single-dataset setting, leaving their cross-dataset transferability largely unexplored and limiting their ability to leverage knowledge transfer and large-scale pretraining, factors that are critical for developing generalized intelligence beyond fitting training data. To address this gap and advance foundation model research for graphs, we present GSTBench, the first systematic benchmark for evaluating the transferability of graph SSL methods. We conduct large-scale pretraining on ogbn-papers100M and evaluate five representative SSL methods across a diverse set of target graphs. Our standardized experimental setup decouples confounding factors such as model architecture, dataset characteristics, and adaptation protocols, enabling rigorous comparisons focused solely on pretraining objectives. Surprisingly, we observe that most graph SSL methods struggle to generalize, with some performing worse than random initialization. In contrast, GraphMAE, a masked autoencoder approach, consistently improves transfer performance. We analyze the underlying factors that drive these differences and offer insights to guide future research on transferable graph SSL, laying a solid foundation for the "pretrain-then-transfer" paradigm in graph learning. Our code is available at https://github.com/SongYYYY/GSTBench.

Rockim Prowell, 34, faces murder charges for allegedly killing two men and attempting to murder another after meeting victims through an online dating app in California.

Things to Do in L.A. Tap to enable a layout that focuses on the article. A woman in the audience wears a red hat that reads Make America Healthy Again during a Senate Homeland Security and Government Affairs Subcommittee Hearing on Capitol Hill on September 9, 2025 in Washington, DC. The hearing was titled "how the corruption of science has impacted public perception and policies regarding vaccines." Voice comes from the use of AI. Please report any issues or inconsistencies here .

What do we know about alleged Trump signature on Epstein letter? A birthday letter to Jeffrey Epstein from 2003, allegedly signed by Donald Trump, has been released by US lawmakers. The White House has said, the president did not write this letter, he did not sign this letter, but Democrats believe it is authentic. There has been a particular focus on the signature - BBC Verify's Jake Horton has been examining it, with the help of handwriting experts. The BBC's Tom Bateman spoke with Patrick Scallen who lives near the Annunciation Church and ran towards the sound of gunfire.