Physics-Informed Machine Learning (PIML) has successfully integrated mechanistic understanding into machine learning, particularly in domains governed by well-known physical laws. This success has motivated efforts to apply PIML to biology, a field rich in dynamical systems but shaped by different constraints. Biological modeling, however, presents unique challenges: multi-faceted and uncertain prior knowledge, heterogeneous and noisy data, partial observability, and complex, high-dimensional networks. In this position paper, we argue that these challenges should not be seen as obstacles to PIML, but as catalysts for its evolution. We propose Biology-Informed Machine Learning (BIML): a principled extension of PIML that retains its structural grounding while adapting to the practical realities of biology. Rather than replacing PIML, BIML retools its methods to operate under softer, probabilistic forms of prior knowledge. We outline four foundational pillars as a roadmap for this transition: uncertainty quantification, contextualization, constrained latent structure inference, and scalability. Foundation Models and Large Language Models will be key enablers, bridging human expertise with computational modeling. We conclude with concrete recommendations to build the BIML ecosystem and channel PIML-inspired innovation toward challenges of high scientific and societal relevance.

Long-term Time Series Forecasting (LTSF) tasks, which leverage the current data sequence as input to predict the future sequence, have become increasingly crucial in real-world applications such as weather forecasting and planning of electricity consumption. However, state-of-the-art LTSF models often fail to achieve prediction output alignment for the same timestamps across lagged input sequences.

There are about 160 datacentres operating in Australia, with another 90 proposed. There are about 160 datacentres operating in Australia, with another 90 proposed. They're a key part of the digital and AI economy, but they come at a high environmental cost and offer few operational jobs Sun 21 Jun 2026 11.00 EDTLast modified on Sun 21 Jun 2026 11.01 EDT On Mamre Road, in Sydney's outer western suburbs, there are plans to build a "hyperscale" datacentre that will be one of the biggest in the world. If approved, the 52-hectare site will include six four-storey buildings that stretch 40 metres high, alongside 936 cooling units and 852 diesel backup power generators. The Mamre Road project is part of an estimated $155bn investment pipeline over the coming decade, amid a worldwide rush to build the infrastructure enabling the artificial intelligence revolution.

Temporal graph link prediction aims to predict future interactions between nodes in a graph based on their historical interactions, which are encoded in node embeddings. We observe that heterogeneity naturally appears in temporal interactions, e.g., a few node pairs can make most interaction events, and interaction events happen at varying intervals. This leads to the problems of ineffective temporal information encoding and forgetting of past interactions for a pair of nodes that interact intermittently for their link prediction. Existing methods, however, do not consider such heterogeneity in their learning process, and thus their learned temporal node embeddings are less effective, especially when predicting the links for infrequently interacting node pairs. To cope with the heterogeneity, we propose a novel framework called TAMI, which contains two effective components, namely log time encoding function (LTE) and link history aggregation (LHA). LTE better encodes the temporal information through transforming interaction intervals into more balanced ones, and LHA prevents the historical interactions for each target node pair from being forgotten. State-of-the-art temporal graph neural networks can be seamlessly and readily integrated into TAMI to improve their effectiveness. Experiment results on 13 classic datasets and three newest temporal graph benchmark (TGB) datasets show that TAMI consistently improves the link prediction performance of the underlying models in both transductive and inductive settings.

In typical graph neural networks (GNNs), feature representation learning naturally evolves through iteratively updating node features and exchanging information based on graph topology. In this context, we conceptualize that the learning process in GNNs is a mean-field game (MFG), where each graph node is an agent, interacting with its topologically connected neighbors. However, current GNNs often employ the identical MFG strategy across different graph datasets, regardless of whether the graph exhibits homophilic or heterophilic characteristics. To address this challenge, we propose to formulate the learning mechanism into a variational framework of the MFG inverse problem, introducing an in-context selective message passing paradigm for each agent, which promotes the best overall outcome for the graph. Specifically, we seek for the application-adaptive transportation function (controlling information exchange throughout the graph) and reaction function (controlling feature representation learning on each agent), on the fly, which allows us to uncover the most suitable selective mechanism of message passing by solving an MFG variational problem through the lens of Hamiltonian flows. Taken together, our variational framework unifies existing GNN models into various mean-field games with distinct equilibrium states, each characterized by the learned in-context message passing operators. Furthermore, we present an agnostic end-to-end deep model, coined Game-of-GNN, to jointly identify the message passing mechanism and fine-tune the GNN hyper-parameters on top of the elucidated message passing operators. Game-of-GNN has achieved SOTA performance on diverse graph data, including popular benchmark datasets and human connectomes. More importantly, the mathematical insight of MFG framework provides a new window to understand the foundational principles of graph learning as an interactive dynamical system, which allows us to reshape the idea of designing next-generation GNN models.

We investigate scaling laws for stochastic momentum algorithms with small batch on the power law random features model, parameterized by data complexity, target complexity, and model size. When trained with a stochastic momentum algorithm, our analysis reveals four distinct loss curve shapes determined by varying data-target complexities. While traditional stochastic gradient descent with momentum (SGD-M) yields identical scaling law exponents to SGD, dimension-adapted Nesterov acceleration (DANA) improves these exponents by scaling momentum hyperparameters based on model size and data complexity. This outscaling phenomenon, which also improves compute-optimal scaling behavior, is achieved by DANA across a broad range of data and target complexities, while traditional methods fall short. Extensive experiments on high-dimensional synthetic quadratics validate our theoretical predictions and large-scale text experiments with LSTMs show DANA's improved loss exponents over SGD hold in a practical setting.

Unsupervised anomaly detection (AD) methods typically assume clean training data, yet real-world datasets often contain undetected or mislabeled anomalies, leading to significant performance degradation. Existing solutions require access to the training pipelines, data or prior knowledge of the proportions of anomalies in the data, limiting their real-world applicability. To address this challenge, we propose EPHAD, a simple yet effective test-time adaptation framework that updates the outputs of AD models trained on contaminated datasets using evidence gathered at test time. Our approach integrates the prior knowledge captured by the AD model trained on contaminated datasets with evidence derived from multimodal foundation models like Contrastive Language-Image Pre-training (CLIP), classical AD methods like the Local Outlier Factor or domain-specific knowledge. We illustrate the intuition behind EPHAD using a synthetic toy example and validate its effectiveness through comprehensive experiments across eight visual AD datasets, twenty-six tabular AD datasets, and a real-world industrial AD dataset. Additionally, we conduct an ablation study to analyse hyperparameter influence and robustness to varying contamination levels, demonstrating the versatility and robustness of EPHAD across diverse AD models and evidence pairs. To ensure reproducibility, our code is publicly available2.

Language-guided object recognition in remote sensing imagery is crucial for largescale mapping and automated data annotation. However, existing open-vocabulary and visual grounding methods rely on explicit category cues, limiting their ability to handle complex or implicit queries that require advanced reasoning. To address this issue, we introduce a new suite of tasks, including Instruction-Oriented Object Counting, Detection, and Segmentation (InstructCDS), covering open-vocabulary, open-ended, and open-subclass scenarios.

Pseudo-label learning is widely used in semantic segmentation, particularly in label-scarce scenarios such as unsupervised domain adaptation (UDA) and semisupervised learning (SSL). Despite its success, this paradigm can generate erroneous pseudo-labels, which are further amplified during training due to utilization of one-hot encoding. To address this issue, we propose ECOCSeg, a novel perspective for segmentation models that utilizes error-correcting output codes (ECOC) to create a fine-grained encoding for each class.

Despite recent advances in machine learning, many scientific discoveries in chemistry still rely on manually curated datasets extracted from the scientific literature. Automation of information extraction in specialized chemistry domains has the potential to scale up machine learning applications and improve the quality of predictions, enabling data-driven scientific discoveries at a faster pace. In this paper, we present ChemX, a collection of 10 benchmarking datasets across several domains of chemistry providing a reliable basis for evaluating and fine-tuning automated information extraction methods. The datasets encompassing various properties of small molecules and nanomaterials have been manually extracted from peer-reviewed publications and systematically validated by domain experts through a cross-verification procedure allowing for identification and correction of errors at sources. In order to demonstrate the utility of the resulting datasets, we evaluate the extraction performance of the state-of-the-art large language models (LLMs). Moreover, we design our own agentic approach to take full control of the document preprocessing before LLM-based information extraction.