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The Next Alzheimer's Breakthrough Will Take More Than Just Science

WIRED

The Next Alzheimer's Breakthrough Will Take More Than Just Science At WIRED Health, pioneering Alzheimer's researcher John Hardy outlined the stakes--and next steps--of where treatment is headed next. Alzheimer's research is entering a new phase, as treatments that have taken decades to develop begin to reach patients . But getting those advances to people will depend on more than scientific progress alone, according to pioneering Alzheimer's researcher John Hardy . Speaking at WIRED Health in April, Hardy, chair of the Molecular Biology of Neurological Disease at University College London, said that alongside more effective drugs, better diagnosis and political will were still needed to improve treatment of Alzheimer's disease. "We've got to get better," he said.


How time travel could work: Scientists have uncovered a way to send messages into the PAST

Daily Mail - Science & tech

TPUSA issues blistering response to Hollywood nepo baby who called Erika Kirk a'sociopath' and urged Trump to'kill' organization Who's The Boss? star Judith Light, 77, has fans concerned with strange poses on red carpet Shock as Home Depot rival closes all 15 of its stores and declares bankruptcy thanks to consumers' reluctance to spend ROBERT HARDMAN: What Trump told me about the King and William. Men everywhere secretly have the same complaint about their sex lives. It's NOT about looks or frequency... Spirit Airlines prepares to shut down as Trump's rescue deal falls apart I'm the REAL Emily from Devil Wears Prada: Anna Wintour's assistant played by Emily Blunt reveals herself... and cutthroat behind-scenes details that the movie did NOT include The Devil Wears Prada 2 review: Searingly silly, ridiculous sequel is a complete disgrace to fashion... and guilty of the biggest sin of all: JANE TIPPETT The ultimate Ozempic survival kit: Experts reveal cheap drugstore remedies and one miracle food every GLP-1 user needs to ease side effects... meaning you can take a HIGHER dose and lose MORE weight Mom stunned to discover she is pregnant with twins just WEEKS after giving birth: 'I was in denial' Alleged JPMorgan sex slave unmasked as crisis sparks drama at America's biggest bank: 'Everyone's wondering what Jamie thinks' Time machines may seem better suited to science fiction than the physics lab, but experts say this futuristic technology could become a reality. Researchers have revealed how time travel could really work by using the laws of quantum physics. While their method won't let you hop back to the time of the dinosaurs, scientists say it could be possible to send messages into the past.


A brain implant to treat depression gets FDA greenlight to start trials

Popular Science

In theory, Motif Neurotech's berry-sized device would work like a continuous glucose monitor. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Patients receiving the experimental new implant would not need to undergo a complicated surgery. Breakthroughs, discoveries, and DIY tips sent six days a week. Earlier this week, the United States Food and Drug Administration (FDA) approved a human trial for a blueberry-sized brain implant intended to target treatment-resistant depression.


Do not open until July 4, 2276: U.S. buries a 'zombie-proof' time capsule

Popular Science

Do not open until July 4, 2276: U.S. buries a'zombie-proof' time capsule The durable stainless steel container will be buried in Philadelphia for the country's 250th birthday. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. The time capsule will include items from all 50 states and six territories. Breakthroughs, discoveries, and DIY tips sent six days a week. It's been 250 years since the United States decided it was no longer interested in being part of Great Britain.


Your guide to the California state controller race: Democrat Malia Cohen faces challengers

Los Angeles Times

Things to Do in L.A. From left, Meghann Adams, Malia Cohen and Herb Morgan are running for state controller in the California primary election. California voters will choose who oversees the state's finances as incumbent Malia Cohen faces Republican Herb Morgan, a finance executive, and Meghann Adams, a school bus driver and Peace and Freedom Party member. Morgan proposes using blockchain and AI technology for real-time spending transparency, while Adams advocates corporate audits and redirecting billions toward education, housing and healthcare for working-class Californians. Cohen improved financial report timeliness but fell short on promised audits of homelessness programs, the DMV and Employment Development Department. The state's fiscal watchdog oversees the intake and outtake of public funds and audits departments across the state.


This Indigenous Language Survived Russian Occupation. Can It Survive YouTube?

WIRED

This Indigenous Language Survived Russian Occupation. YouTube's search and recommendation algorithms are driving children to Russian-language content even when they seek out videos in Kyrgyz, creating a cultural shift that concerns some parents. When anthropology researcher Ashley McDermott was doing fieldwork in Kyrgyzstan a few years ago, she says many people voiced the same concern: Children were losing touch with their indigenous language. The Central Asian country of 7 million people was under Russian control for a century until 1991, but Kyrgyz (pronounced kur-giz) survived and remains widely spoken among adults. McDermott, a doctoral student at the University of Michigan, says she also heard that some kids in rural villages where Kyrgyz dominated had spontaneously learned to speak Russian.


Hardware Resilience Properties of Text-Guided Image Classifiers

Neural Information Processing Systems

This paper presents a novel method to enhance the reliability of image classification models during deployment in the face of transient hardware errors. By utilizing enriched text embeddings derived from GPT-3 with question prompts per class and CLIP pretrained text encoder, we investigate their impact as an initialization for the classification layer. Our approach achieves a remarkable 5.5 average increase in hardware reliability (and up to 14) across various architectures in the most critical layer, with minimal accuracy drop (0.3% on average) compared to baseline PyTorch models. Furthermore, our method seamlessly integrates with any image classification backbone, showcases results across various network architectures, decreases parameter and FLOPs overhead, and follows a consistent training recipe. This research offers a practical and efficient solution to bolster the robustness of image classification models against hardware failures, with potential implications for future studies in this domain.


Pruning Randomly Initialized Neural Networks with Iterative Randomization

Neural Information Processing Systems

Pruning the weights of randomly initialized neural networks plays an important role in the context of lottery ticket hypothesis. Ramanujan et al. [23] empirically showed that only pruning the weights can achieve remarkable performance instead of optimizing the weight values. However, to achieve the same level of performance as the weight optimization, the pruning approach requires more parameters in the networks before pruning and thus more memory space. To overcome this parameter inefficiency, we introduce a novel framework to prune randomly initialized neural networks with iteratively randomizing weight values (IteRand). Theoretically, we prove an approximation theorem in our framework, which indicates that the randomizing operations are provably effective to reduce the required number of the parameters. We also empirically demonstrate the parameter efficiency in multiple experiments on CIFAR-10 and ImageNet.



Batched Gaussian Process Bandit Optimization via Determinantal Point Processes

Neural Information Processing Systems

Gaussian Process bandit optimization has emerged as a powerful tool for optimizing noisy black box functions. One example in machine learning is hyper-parameter optimization where each evaluation of the target function may require training a model which may involve days or even weeks of computation. Most methods for this so-called "Bayesian optimization" only allow sequential exploration of the parameter space. However, it is often desirable to propose batches or sets of parameter values to explore simultaneously, especially when there are large parallel processing facilities at our disposal. Batch methods require modeling the interaction between the different evaluations in the batch, which can be expensive in complex scenarios. In this paper, we propose a new approach for parallelizing Bayesian optimization by modeling the diversity of a batch via Determinantal point processes (DPPs) whose kernels are learned automatically. This allows us to generalize a previous result as well as prove better regret bounds based on DPP sampling. Our experiments on a variety of synthetic and real-world robotics and hyper-parameter optimization tasks indicate that our DPP-based methods, especially those based on DPP sampling, outperform state-of-the-art methods.