Postoperative atrial fibrillation (PAF) occurs in 10% to 65% of the patients undergoing cardiothoracic surgery. It is associated with increased post-surgical mortality and morbidity, and results in longer and more expensive hospital stays. Accurately stratifying patients for PAF allows for selective use of prophylactic therapies (e.g., amiodarone). Unfortunately, existing tools to stratify patients for PAF fail to provide clinically adequate discrimination. Our research addresses this situation through the development of novel electrocardiographic(ECG) markers to identify patients at risk of PAF. As a first step, we explore an eigen-decomposition approach that partitions ECG signals into atrial and ventricular components by exploiting knowledge of the underlying cardiac cycle. We then quantify electrical instability in the myocardium manifesting as probabilistic variations in atrial ECG morphology to assess therisk of PAF. When evaluated on 385 patients undergoing cardiac surgery, this approach of stratifying patients for PAF through an analysis of morphologic variability within decoupled atrial ECG demonstrated substantial promise and improved net reclassification by over 53% relative to the use of baseline clinical characteristics.

Explosive growth of multimedia data has brought challenge of how to efficiently browse, retrieve and organize these data. Under this circumstance, different approaches have been proposed to facilitate multimedia analysis. Several semi-supervised feature selection algorithms have been proposed to exploit both labeled and unlabeled data. However, they are implemented based on graphs, such that they cannot handle large-scale datasets. How to conduct semi-supervised feature selection on large-scale datasets has become a challenging research problem. Moreover, existing multi-label feature selection algorithms rely on eigen-decomposition with heavy computational burden, which further prevent current feature selection algorithms from being applied for big data. In this paper, we propose a novel convex semi-supervised multi-label feature selection algorithm, which can be applied to large-scale datasets. We evaluate performance of the proposed algorithm over five benchmark datasets and compare the results with state-of-the-art supervised and semi-supervised feature selection algorithms as well as baseline using all features. The experimental results demonstrate that our proposed algorithm consistently achieve superiors performances.

This paper introduces a novel framework for performing machine learning onlongitudinal neuroimaging datasets. These datasets are characterized by theirsize, particularly their width (millions of features per data input). Specifically, we address the problem of detecting subtle, short-term changes inneural structure that are indicative of cognitive change and correlate withrisk factors for Alzheimer's disease. We introduce a new spatially-sensitivekernel that allows us to reason about individuals, as opposed to populations. In doing so, this paper presents the first evidence demonstrating that verysmall changes in white matter structure over a two year period can predictchange in cognitive function in healthy adults.

Generalized CP-nets (GCP-nets) allow a succinct representation of preferences over multi-attribute domains. As a consequence of their succinct representation, many GCP-net related tasks are computationally hard. Even finding the more preferable of two outcomes is PSPACE-complete. In this work, we employ the framework of parameterized complexity to achieve two goals: First, we want to gain a deeper understanding of the complexity of GCP-nets. Second, we search for efficient fixed-parameter tractable algorithms.

We study the problem of rewriting a disjunctive datalog program into plain datalog. We show that a disjunctive program is rewritable if and only if it is equivalent to a linear disjunctive program, thus providing a novel characterisation of datalog rewritability. Motivated by this result, we propose weakly linear disjunctive datalog -- a novel rule-based KR language that extends both datalog and linear disjunctive datalog and for which reasoning is tractable in data complexity. We then explore applications of weakly linear programs to ontology reasoning and propose a tractable extension of OWL 2 RL with disjunctive axioms. Our empirical results suggest that many non-Horn ontologies can be reduced to weakly linear programs and that query answering over such ontologies using a datalog engine is feasible in practice.

Recent work introduced Generalized First Order Decision Diagrams (GFODD) as a knowledge representation that is useful in mechanizing decision theoretic planning in relational domains. GFODDs generalize function-free first order logic and include numerical values and numerical generalizations of existential and universal quantification. Previous work presented heuristic inference algorithms for GFODDs. In this paper, we study the complexity of the evaluation problem, the satiability problem, and the equivalence problem for GFODDs under the assumption that the size of the intended model is given with the problem, a restriction that guarantees decidability. Our results provide a complete characterization. The same characterization applies to the corresponding restriction of problems in first order logic, giving an interesting new avenue for efficient inference when the number of objects is bounded. Our results show that for Σk formulas, and for corresponding GFODDs, evaluation and satisfiability are Σkp complete, and equivalence is Πk+1p complete. For Πk formulas evaluation is Πkp complete, satisfiability is one level higher and is Σk+1p complete, and equivalence is Πk+1p complete.

Valued decision diagrams (VDDs) are data structures that represent functions mapping variable-value assignments to non-negative real numbers. They prove useful to compile cost functions, utility functions, or probability distributions. While the complexity of some queries (notably optimization) and transformations (notably conditioning) on VDD languages has been known for some time, there remain many significant queries and transformations, such as the various kinds of cuts, marginalizations, and combinations, the complexity of which has not been identified so far. This paper contributes to filling this gap and completing previous results about the time and space efficiency of VDD languages, thus leading to a knowledge compilation map for real-valued functions. Our results show that many tasks that are hard on valued CSPs are actually tractable on VDDs.

Answer set programs (ASP) with external evaluations are a declarative means to capture advanced applications. However, their evaluation can be expensive due to external source accesses. In this paper we consider HEX-programs that provide external atoms as a bidirectional interface to external sources and present a novel evaluation method based on support sets, which informally are portions of the input to an external atom that will determine its output for any completion of the partial input. Support sets allow one to shortcut the external source access, which can be completely eliminated. This is particularly attractive if a compact representation of suitable support sets is efficiently constructible. We discuss some applications with this property, among them description logic programs over DL-Lite ontologies, and present experimental results showing that support sets can significantly improve efficiency.

ABox abduction is an important reasoning mechanism for description logic ontologies. It computes all minimal explanations (sets of ABox assertions) whose appending to a consistent ontology enforces the entailment of an observation while keeps the ontology consistent. We focus on practical computation for a general problem of ABox abduction, called the query abduction problem, where an observation is a Boolean conjunctive query and the explanations may contain fresh individuals neither in the ontology nor in the observation. However, in this problem there can be infinitely many minimal explanations. Hence we first identify a class of TBoxes called first-order rewritable TBoxes. It guarantees the existence of finitely many minimal explanations and is sufficient for many ontology applications. To reduce the number of explanations that need to be computed, we introduce a special kind of minimal explanations called representative explanations from which all minimal explanations can be retrieved. We develop a tractable method (in data complexity) for computing all representative explanations in a consistent ontology. xperimental results demonstrate that the method is efficient and scalable for ontologies with large ABoxes.

Recently several inconsistency-tolerant semantics have been introduced for querying inconsistent description logic knowledge bases. Most of these semantics rely on the notion of a repair, defined as an inclusion-maximal subset of the facts (ABox) which is consistent with the ontology (TBox). In this paper, we study variants of two popular inconsistency-tolerant semantics obtained by replacing classical repairs by various types of preferred repair. We analyze the complexity of query answering under the resulting semantics, focusing on the lightweight logic DL-Lite_R. Unsurprisingly, query answering is intractable in all cases, but we nonetheless identify one notion of preferred repair, based upon priority levels, whose data complexity is "only" coNP-complete. This leads us to propose an approach combining incomplete tractable methods with calls to a SAT solver. An experimental evaluation of the approach shows good scalability on realistic cases.