A machine-learning algorithm has the capability to identify hospitalized patients at risk for severe sepsis and septic shock using data from electronic health records (EHRs), according to a study presented at the 2017 American Thoracic Society International Conference. Sepsis is an extreme systemic response to infection, which can be life-threatening in its advanced stages of severe sepsis and septic shock, if left untreated. "We have developed and validated the first machine-learning algorithm to predict severe sepsis and septic shock in a large academic multi-hospital healthcare system," said lead author Heather Giannini, MD, of the Hospital of the University of Pennsylvania. "This is a breakthrough in the use of machine learning technology, and could change the paradigm in early intervention in sepsis." Machine learning is a type of artificial intelligence that provides computers with the ability to learn complex patterns in data without being explicitly programmed, unlike simpler rule-based systems.

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Objectives: Discussions of fairness in criminal justice risk assessments typically lack conceptual precision. Rhetoric too often substitutes for careful analysis. In this paper, we seek to clarify the tradeoffs between different kinds of fairness and between fairness and accuracy. Methods: We draw on the existing literatures in criminology, computer science and statistics to provide an integrated examination of fairness and accuracy in criminal justice risk assessments. We also provide an empirical illustration using data from arraignments. Results: We show that there are at least six kinds of fairness, some of which are incompatible with one another and with accuracy. Conclusions: Except in trivial cases, it is impossible to maximize accuracy and fairness at the same time, and impossible simultaneously to satisfy all kinds of fairness. In practice, a major complication is different base rates across different legally protected groups. There is a need to consider challenging tradeoffs.

Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale can be quite high, a pragmatic approach has been to partition the follow-up into coarser intervals of pre-specified length. Current guidelines suggest employing a 'small' interval, but the feasibility and practical impact of this recommendation has not been evaluated and no formal methodology to inform this choice has been developed. We start filling these gaps by leveraging large-scale EHR data from a diabetes study to develop and illustrate a fast and scalable targeted learning approach that allows to follow the current recommendation and study its practical impact on inference. More specifically, we map daily EHR data into four analytic datasets using 90, 30, 15 and 5-day intervals. We apply a semi-parametric and doubly robust estimation approach, the longitudinal TMLE, to estimate the causal effects of four dynamic treatment rules with each dataset, and compare the resulting inferences. To overcome the computational challenges presented by the size of these data, we propose a novel TMLE implementation, the 'long-format TMLE', and rely on the latest advances in scalable data-adaptive machine-learning software, xgboost and h2o, for estimation of the TMLE nuisance parameters.

Often in machine learning, data are collected as a combination of multiple conditions, e.g., the voice recordings of multiple persons, each labeled with an ID. How could we build a model that captures the latent information related to these conditions and generalize to a new one with few data? We present a new model called Latent Variable Multiple Output Gaussian Processes (LVMOGP) and that allows to jointly model multiple conditions for regression and generalize to a new condition with a few data points at test time. LVMOGP infers the posteriors of Gaussian processes together with a latent space representing the information about different conditions. We derive an efficient variational inference method for LVMOGP, of which the computational complexity is as low as sparse Gaussian processes. We show that LVMOGP significantly outperforms related Gaussian process methods on various tasks with both synthetic and real data.

Deep learning applies hierarchical layers of hidden variables to construct nonlinear high dimensional predictors. Our goal is to develop and train deep learning architectures for spatio-temporal modeling. Training a deep architecture is achieved by stochastic gradient descent (SGD) and drop-out (DO) for parameter regularization with a goal of minimizing out-of-sample predictive mean squared error. To illustrate our methodology, we predict the sharp discontinuities in traffic flow data, and secondly, we develop a classification rule to predict short-term futures market prices as a function of the order book depth. Finally, we conclude with directions for future research.

Many robotic planning applications involve continuous actions with highly non-linear constraints, which cannot be modeled using modern planners that construct a propositional representation. We introduce STRIPStream: an extension of the STRIPS language which can model these domains by supporting the specification of blackbox generators to handle complex constraints. The outputs of these generators interact with actions through possibly infinite streams of objects and static predicates. We provide two algorithms which both reduce STRIPStream problems to a sequence of finite-domain planning problems. The representation and algorithms are entirely domain independent. We demonstrate our framework on simple illustrative domains, and then on a high-dimensional, continuous robotic task and motion planning domain.

We consider an online version of the robust Principle Component Analysis (PCA), which arises naturally in time-varying source separations such as video foreground-background separation. This paper proposes a compressive online robust PCA with prior information for recursively separating a sequences of frames into sparse and low-rank components from a small set of measurements. In contrast to conventional batch-based PCA, which processes all the frames directly, the proposed method processes measurements taken from each frame. Moreover, this method can efficiently incorporate multiple prior information, namely previous reconstructed frames, to improve the separation and thereafter, update the prior information for the next frame. We utilize multiple prior information by solving $n\text{-}\ell_{1}$ minimization for incorporating the previous sparse components and using incremental singular value decomposition ($\mathrm{SVD}$) for exploiting the previous low-rank components. We also establish theoretical bounds on the number of measurements required to guarantee successful separation under assumptions of static or slowly-changing low-rank components. Using numerical experiments, we evaluate our bounds and the performance of the proposed algorithm. In addition, we apply the proposed algorithm to online video foreground and background separation from compressive measurements. Experimental results show that the proposed method outperforms the existing methods.

One of the most challenging problems in kernel online learning is to bound the model size and to promote the model sparsity. Sparse models not only improve computation and memory usage, but also enhance the generalization capacity, a principle that concurs with the law of parsimony. However, inappropriate sparsity modeling may also significantly degrade the performance. In this paper, we propose Approximation Vector Machine (AVM), a model that can simultaneously encourage the sparsity and safeguard its risk in compromising the performance. When an incoming instance arrives, we approximate this instance by one of its neighbors whose distance to it is less than a predefined threshold. Our key intuition is that since the newly seen instance is expressed by its nearby neighbor the optimal performance can be analytically formulated and maintained. We develop theoretical foundations to support this intuition and further establish an analysis to characterize the gap between the approximation and optimal solutions. This gap crucially depends on the frequency of approximation and the predefined threshold. We perform the convergence analysis for a wide spectrum of loss functions including Hinge, smooth Hinge, and Logistic for classification task, and $l_1$, $l_2$, and $\epsilon$-insensitive for regression task. We conducted extensive experiments for classification task in batch and online modes, and regression task in online mode over several benchmark datasets. The results show that our proposed AVM achieved a comparable predictive performance with current state-of-the-art methods while simultaneously achieving significant computational speed-up due to the ability of the proposed AVM in maintaining the model size.

With the temptation of social media and no professor around to scold you, it can be easy to get distracted while taking an online class. Now, one school in Paris is making efforts to keep remote students on track with their tasks – an AI will monitor their every move. Starting in September, two online classes from the ESG business school will be using a facial recognition program called Nestor to measure students' engagement, and it will even give them warnings when they start to slack off. A business school in Paris is making efforts to keep remote students on track with their tasks – an AI will monitor their every move. Nestor, a software from LCA Learning, tracks eye movements and facial expressions using the computer's webcam Nestor, a software from LCA Learning, tracks eye movements and facial expressions.