Eli Lilly faces a congressional investigation into its China clinical trials at People's Liberation Army hospitals and Xinjiang facilities amid biotechnology competition concerns.

The pointy'trullo' is making a comeback thanks to its clever cooling attributes. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Tourists stand among the trulli of Alberobello, the whitewashed limestone houses with the typical conical roofs. Breakthroughs, discoveries, and DIY tips sent six days a week. By signing up, you confirm you are 16+, will receive newsletters and promotional content and agree to our Terms of Use and acknowledge the data practices in our Privacy Policy .

For decades, the senator has argued that concentrated wealth threatened American democracy. Now he's betting that frustration with Big Tech, billionaires, and unchecked AI is reaching a tipping point. It's hard to believe Bernie Sanders . Not because the longtime Vermont senator bears the hallmarks of a liar. Yes, he's a career politician, but the 84-year-old progressive torchbearer counts more viral memes than scandals to his name. Rather, it's hard to believe Bernie Sanders because, for decades, he's told Americans that this country can radically change, while championing ideas too far afield from the status quo to really have a chance. He wants to bring billionaires to heel, for one. And implement universal, government-run health care. If Sanders had his way, it wouldn't even exist. I believe it, and WIRED champions it. Sanders, though, is now hard at work adding one more big, improbable change to the pile: Since 2023, he's been advocating for firm and decisive regulation of the AI industry . In March of this year, Sanders and his frequent collaborator, Representative Alexandria Ocasio-Cortez, proposed legislation that would halt data center construction until a series of safeguards are implemented. In June, Sanders announced the American AI Sovereign Wealth Fund Act, which would essentially tax AI's richest companies and result in direct payments to American citizens. I wanted to talk to Sanders about those bills, and his perspective on AI more broadly. On a deeper level, though, I was curious about how Sanders sees the barriers to regulation--from tech oligarchs and deep-pocketed super PACs, to a federal administration happier to enrich itself via technology than actually govern it--and whether he thinks those seemingly intractable obstacles can be overcome. After a few months of haranguing, Sanders agreed to sit down, which is how I found myself in his modest DC campaign office watching the senator--thoughtful, genuine, vociferous as ever--grapple in real time with what he describes as "the most consequential, transformational technology in the history of humanity." Sanders and I spoke on Tuesday, June 23, as the New York Democratic primary was underway. I woke up the next day, our conversation echoing in my head, to find that a coalition of democratic socialists had swept their respective elections and sent party stalwarts into an existential tailspin. A few hours later, New Jersey representative Frank Pallone, the top Democrat on the House Energy and Commerce Committee, became the most mainstream member of the party to publicly support an AI data center moratorium .

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'There's this deep mystery of what, actually, is this thing?': the philosopher inside Google DeepMind AI Since 2017, Iason Gabriel has worked at the tech giant, trying to anticipate - and think through - the impact of AI. But as commercial and geopolitical pressures escalate, can ethicists make any difference? In 2017, a 33-year-old political philosopher named Iason Gabriel was told by a friend that he ought to apply for a job at DeepMind, the London-based subsidiary of Google where much of its AI research was concentrated. The suggestion was not an obvious one. Gabriel was a cheerful but intense junior academic with a passion for Vipassana meditation and what his brother calls "enthusiastic" rock climbing. At the University of Oxford, where he was a fellow at St John's College, Gabriel taught courses on political theory and wrote papers on the moral contortions of "yuppie ethics" and the ethical blind spots of effective altruism. When he wasn't there, he did crisis work for the United Nations Development Programme in Sudan and Lebanon. DeepMind, meanwhile, was the world's leading AI research lab. In part, this was because it had the financial and computational backing of Google, which had bought the company in 2014 for $650m. In part, it was because DeepMind had recently shown it could put those resources to stunning use. In Seoul, in 2016, a DeepMind system called AlphaGo defeated Lee Sedol, a South Korean Go champion, in a five-game match. The victory was significant not least because of Go's legendary complexity; the game has more possible configurations than there are atoms in the universe. Thanks to the fuss around AlphaGo, Gabriel was aware of DeepMind.

A growing number of techniques leverage the spatial structures that underlie many real-world datasets. Despite these advances, the complementary task of estimating spatial structures and understanding their role within these techniques has often been overlooked. In neurophysiological data analysis specifically, numerous methods exist to estimate brain connectivity, but most are not explicitly model-based, dynamic, multivariate, or directed. To address these limitations, we previously introduced noise-driven heat modelling on graphs for neurophysiological connectivity estimation. In this study, we extend this framework by relaxing earlier noise assumptions and adding regularisation to improve robustness. We also develop a simulation procedure to characterise and evaluate our technique in a controlled setting. Finally, we demonstrate that the technique is able to capture meaningful spatial structure across two experiments, each using two real-world datasets. The explicit model formulation of our connectivity estimator has the potential to improve the interpretability of graph-based techniques across a wide range of applications. The code implementing our method is available at https://github.com/sgoerttler/Heat_Connectivity.

An essential catalyst for the remarkable breakthroughs in AI that led to the modern large language models (LLMs) such as ChatGPT and Gemini has been the algorithms used to train these models on massive datasets. While the LLM architectures have gotten progressively more complex, the training algorithms have stayed relatively simple, and in fact, they have all been based on the decades-old paradigm of stochastic gradient descent (SGD). The key idea behind SGD is that in order to minimize a certain objective function (such as an LLM's error on the training data), it suffices to access only a noisy estimate of that objective at any given time (e.g., based on a small sample of the data) while making incremental progress towards the solution. This is essential for LLM training, as the datasets have become so massive one could not hope to perform computations on everything all at once. Commonly attributed to a 1951 paper by Robbins and Monro [34], SGD has seen a resurgence of interest over the last 20 years by AI researchers and computer scientists striving to understand its effectiveness, leading to numerous variants and extensions used in modern LLMs [12, 9], most notably the Adam algorithm [25]. As a result, we have gained a robust mathematical understanding of the computational complexity of SGD algorithms in a wide range of settings (e.g., see [11, 15, 5, 17]). Yet, despite this progress there is a surprising gap in the understanding of SGD: The complexity of an algorithm proposed by Stefan Kaczmarz in 1937 [24] for solving a system of linear equations - the oldest published example of an SGD algorithm, which predates Robbins and Monro's paper by over a decade - has not been settled.

Online high-dimensional regression requires algorithms that can update sequentially while preserving structural sparsity. We propose \textit{Adaptive Iterative Hard Thresholding (AIHT)}, an online sparse-regression framework that alternates stochastic subgradient updates with adaptively scheduled hard-thresholding steps. The key idea is to separate support discovery from local refinement: early in the learning process, AIHT delays thresholding so that weak but informative coordinates have time to accumulate signal, while later it increases the projection frequency to stabilize the sparse estimator and exploit local curvature. We develop the theory for high-dimensional online quantile regression, a challenging setting in which the loss is nonsmooth and the data may exhibit heterogeneity or heavy-tailed noise. Under restricted curvature and gradient-leakage conditions, AIHT remains in an inflated sparse cone, exhibits a two-phase convergence behavior, and attains logarithmic regret for the sliding-window objective. Simulations for online quantile regression, together with threshold-scheduling ablations, support the proposed mechanism and illustrate its advantage over standard online sparse-learning baselines.

Classical hypothesis testing frameworks break down in contemporary settings in which null hypotheses are increasingly abstract, the same data are used to both generate and test hypotheses, and minimal assumptions about the underlying data are made. In this work, we propose a new framework for conducting valid hypothesis tests in broad contexts. We propose to add and subtract external noise generated from a symmetric shift-family to our data, $X$, to partition it into two pieces, $X^{(1)}$ and $X^{(2)}$. We provide a generic strategy for orthogonalizing $X^{(2)}$ against $X^{(1)}$ under the null hypothesis $H_0$, then show that testing whether the orthogonalization was successful provides a valid test of $H_0$ under mild assumptions. Remarkably, this framework extends naturally to the post-selection inference setting: we simply select a hypothesis on $X^{(1)}$, then perform orthogonalization under the selected null. As our approach neither requires pre-specification of the selection mechanism, nor is restricted to a small class of data-generating distributions, it dramatically expands the settings for which valid post-selection inference can be conducted. We showcase the flexibility of our proposal in several case studies involving challenging pre-specified null hypotheses and post-selection inference scenarios.

Market microstructure has long classified trading activity by its informational role: an informed trader demands liquidity by trading in the direction of private information, while a market maker supplies liquidity by absorbing that order flow and earning the spread in compensation Kyle (1985); Glosten and Milgrom (1985). This classification is typically recovered from the data the classifier requires: signed order flow, quote revisions, or the sequential-trade structure of the market. The classification is harder to apply to an algorithmic strategy whose internal logic is unobservable. However, the signals or optimization problems generating the decisions of a typical quantitative fund are not visible, even though the trades and reported positions may be available. This paper shows that the liquidity role of such a strategy (consumer or provider) can be recovered from realized portfolio costs and trade decisions alone, without observing quotes, order flow, or any other microstructure-specific signal.