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MS2Query: reliable and scalable MS2 mass spectra-based analogue search

#artificialintelligence

Metabolomics-driven discoveries of biological samples remain hampered by the grand challenge of metabolite annotation and identification. Only few metabolites have an annotated spectrum in spectral libraries; hence, searching only for exact library matches generally returns a few hits. An attractive alternative is searching for so-called analogues as a starting point for structural annotations; analogues are library molecules which are not exact matches but display a high chemical similarity. However, current analogue search implementations are not yet very reliable and relatively slow. Here, we present MS2Query, a machine learning-based tool that integrates mass spectral embedding-based chemical similarity predictors (Spec2Vec and MS2Deepscore) as well as detected precursor masses to rank potential analogues and exact matches. Benchmarking MS2Query on reference mass spectra and experimental case studies demonstrate improved reliability and scalability. Thereby, MS2Query offers exciting opportunities to further increase the annotation rate of metabolomics profiles of complex metabolite mixtures and to discover new biology. The authors develop a machine learning approach to find structurally related chemicals in mass spectral libraries. Their method boosts the annotation rate and aids in assessing novelty in metabolomics datasets.


AI imagines how historical figures such as Napoleon would look if they'd taken smartphone portraits

Daily Mail - Science & tech

No living human can imagine what it was like to sit at The Last Supper or stand in Cleopatra's court, but AI has provided us with a look at these epic events - and from a first-person perspective. A freelance film editor recently shared a gallery of realistic images showing historical figures snapping selfies, which he spent months working out a formula of prompts, language and photographic elements. Duncan Thomsen, 53, used the software Midjourney, which generates images from natural language descriptions, also shows smiling soldiers at the Battle of Waterloo and the Battle of Agincourt, along with a grinning Napoleon. 'The results are hilarious, and everyone I've shared my work with can't believe how real the pictures really look,' said Thomsen. 'I've done Cleopatra, Queen Elizabeth I, Henry VIII, Jesus and many more.' AI is making waves in the image industry, letting anyone create realistic content just by telling the system what they want.


Drew Carey made a radio show with AI. Fans weren't pleased.

Engadget

Instead, The Price is Right host and longtime improv comedian is embracing the technology. During a recent episode of his SiriusXM radio show, "Friday Night Freakout," Carey used an artificially generated version of his voice to handle most of his DJ work, reading a script written by ChatGPT. His AI voice kicked off the show, introduced upcoming songs and recapped what listeners were hearing. As an experiment to see just how far AI could go on the radio, the episode was mostly a success. "I violated a rule from Radio 101," Carey told me.


Discovering Chemically Novel, High-Temperature Superconductors

#artificialintelligence

One of the biggest unsolved problems in condensed matter physics is what mechanism causes high-temperature superconductivity and if there is a material that can exhibit superconductivity at both room temperature and atmospheric pressure. Among the many important properties of a superconductor, the critical temperature (Tc) or transition temperature is the point at which a material transitions into a superconductive state. In this implementation, machine learning is used to predict the critical temperatures of chemically unique compounds in an attempt to identify new chemically novel, high-temperature superconductors. The training data set (SuperCon) consists of known superconductors and their critical temperatures, and the testing data set (NOMAD) consists of around 700,000 novel chemical formulae. The chemical formulae in these data sets are first passed through a collection of rapid screening tools, SMACT, to check for chemical validity.


Do you find AI a mystery? - CUInsight

#artificialintelligence

Artificial intelligence (AI) is becoming increasingly ubiquitous in our daily lives, from the recommendations we receive on social media to the autonomous vehicles being tested on our roads. Yet, for many people, AI remains shrouded in mystery, and the thought of interacting with it can be intimidating. However, there are several steps you can take to familiarize yourself with AI and gain a better understanding. First and foremost, it's essential to understand what AI is and how it works. At its core, AI is the use of computer algorithms to perform tasks that typically require humans, such as recognizing patterns, making decisions, and learning from experience.


Student slapped with a £60 parking fine uses ChatGPT to write appeal - and gets penalty REVOKED

Daily Mail - Science & tech

Elon Musk wants to push technology to its absolute limit, from space travel to self-driving cars -- but he draws the line at artificial intelligence. The billionaire first shared his distaste for AI in 2014, calling it humanity's'biggest existential threat' and comparing it to'summoning the demon.' At the time, Musk also revealed he was investing in AI companies not to make money but to keep an eye on the technology in case it gets out of hand. His main fear is that in the wrong hands, if AI becomes advanced, it could overtake humans and spell the end of mankind, which is known as singularity. That concern is shared among many brilliant minds, including the late Stephen Hawking, who told BBC in 2014: 'The development of full artificial intelligence could spell the end of the human race.


Could YOU make $335,000 using ChatGPT?

Daily Mail - Science & tech

Mark Standen, who runs the staffing business for artificial intelligence, machine learning and automation at Hays in the UK, told Bloomberg the prompt engineer market was the'fastest-moving for 25 years'. He added that although salaries start at £40,000 ($49,000), expert prompt engineers'can name their price' and charge up to £200,000 ($247,000) or £300,000 ($371,000) per year. Sam Altman, the CEO of OpenAI which created ChatGPT, has previously spoken about a need for prompt engineers. Last month he tweeted how'writing a really great prompt for a chatbot persona is an amazingly high-leverage skill'. OpenAI, a private company backed by Microsoft Corp, made ChatGPT available to the public for free in late November.


The Morning After: Midjourney shutters free trials of its AI image generator due to 'extraordinary' abuse

Engadget

In the last 24 hours alone, we've had hoaxes, FTC complaints and… ads. We'll get into how Microsoft is bringing ads to its Bing chatbot – bound to happen – while OpenAI may have to halt ChatGPT releases in the face of FTC complaints. The nonprofit research organization, Center for AI and Digital Policy (CAIDP), says OpenAI's models are "biased, deceptive" and threaten privacy and public safety. The CAIDP says OpenAI also fails to meet Commission guidelines calling for AI to be transparent, fair and easy to explain. There's no guarantee the FTC will act on the complaint.


SpotLyf - Apps on Google Play

#artificialintelligence

Spotlyf is an AI-powered social media platform that works on content authenticity & appreciates its user to share valuable posts. Spotlyf acknowledge the true power of Social Media by embracing authentic, original & genuine content. SpotLyf welcomes everyone to create a positive social impact on each other lives for their Digital well-being. We aim to connect valued lives across the globe. With its advanced core A.I. Technology SpotLyf helps you to discover meaningful content & pull out misleading social activities.


The case for how and why AI might kill us all

#artificialintelligence

Forget the collapse of employment, forget the spam and misinformation, forget human obsolescence and the upending of society. Some believe AI is flat-out going to wipe out all of biological life at its earliest opportunity. Here's how and why.