India faces a significant cancer burden, with an incidence - to - mortality ratio indicating that nearly three out of five individuals diagnosed with cancer succumb to the disease. While the limitations of physical healthcare infrastructure are widely acknowledged as a primary challenge, concerted efforts by government and healthcare agencies are underway to mitigate these constraints. However, given the country's vast geography and high population density, it is imperative to explore alternative soft infrastructure solutions to complement existing frameworks . Artificial Intelligence agents are increasingly transforming problem - solving approaches across various domains, with their application in medicine proving particularly transformative. In this perspective, we examine the potential role of AI agents in advancing nuclear medicine fo r cancer research, diagnosis, and management in India. We begin with a brief overview of AI agents and their capabilities, followed by a proposed agent - based ecosystem that can address prevailing sustainability challenges in India's nuclear medicine. Keywords: AI Agents; cancer; nuclear medicine ecosystem; sustainability challenges 1. Introduction India's with population of 1.4 billion faces a significant cancer burden, with ~1.5 million new cases and ~850,000 deaths annually [1] [2] . With an i ncidence - to - m ortality p ercentage of approximately 64.8%, nearly three out of five individuals diagnosed with cancer are expected to succumb to the disease [2] . Projections indicate that mortality rates will rise significantly, increasing from 64.7% to 109.6% between 2022 and 2050, largely due to demographic shifts as the reproductive - age population transitions into middle and old age. This growing cancer burden will place even more pressure on the already overburdened healthcare system, making it essential to address the gaps in both infrastructure and indigenous research and innovations to ensure timely and effective patient treatment [3] . This trend underscores the urgent need for a resilient, patient - centred framework that integrates medical advancements, early detection through diagnostics, timely therapeutic interventions, and equitable access to care. Nuclear medicine uses a small amount of targeted radioactive material to diagnose and treat cancer [4] .

Generic text rewriting is a prevalent large language model (LLM) application that covers diverse real-world tasks, such as style transfer, fact correction, and email editing. These tasks vary in rewriting objectives (e.g., factual consistency vs. semantic preservation), making it challenging to develop a unified model that excels across all dimensions. Existing methods often specialize in either a single task or a specific objective, limiting their generalizability. In this work, we introduce a generic model proficient in factuality, stylistic, and conversational rewriting tasks. To simulate real-world user rewrite requests, we construct a conversational rewrite dataset, ChatRewrite, that presents ``natural''-sounding instructions, from raw emails using LLMs. Combined with other popular rewrite datasets, including LongFact for the factuality rewrite task and RewriteLM for the stylistic rewrite task, this forms a broad benchmark for training and evaluating generic rewrite models. To align with task-specific objectives, we propose Dr Genre, a Decoupled-reward learning framework for Generic rewriting, that utilizes objective-oriented reward models with a task-specific weighting. Evaluation shows that \approach delivers higher-quality rewrites across all targeted tasks, improving objectives including instruction following (agreement), internal consistency (coherence), and minimal unnecessary edits (conciseness).

A warrior is in a prison cell. His guard approaches and shows him the wooden sword that he will receive once he has earned his freedom. The warrior grabs it, uses his unlocked cell door to knock the guard down, and places the sword's tip on the guard's throat. He drives it in as one might hammer a post, a coarse and grisly death. Then, for some reason, swaying back and forth, the warrior yells down at the corpse, "Wood or steel, a point is still a point!"

Designing safety-critical controllers for acceleration-controlled unicycle robots is challenging, as control inputs may not appear in the constraints of control Lyapunov functions(CLFs) and control barrier functions (CBFs), leading to invalid controllers. Existing methods often rely on state-feedback-based CLFs and high-order CBFs (HOCBFs), which are computationally expensive to construct and fail to maintain effectiveness in dynamic environments with fast-moving, nearby obstacles. To address these challenges, we propose constructing velocity obstacle-based CBFs (VOCBFs) in the velocity space to enhance dynamic collision avoidance capabilities, instead of relying on distance-based CBFs that require the introduction of HOCBFs. Additionally, by extending VOCBFs using variants of VO, we enable reactive collision avoidance between robots. We formulate a safety-critical controller for acceleration-controlled unicycle robots as a mixed-integer quadratic programming (MIQP), integrating state-feedback-based CLFs for navigation and VOCBFs for collision avoidance. To enhance the efficiency of solving the MIQP, we split the MIQP into multiple sub-optimization problems and employ a decision network to reduce computational costs. Numerical simulations demonstrate that our approach effectively guides the robot to its target while avoiding collisions. Compared to HOCBFs, VOCBFs exhibit significantly improved dynamic obstacle avoidance performance, especially when obstacles are fast-moving and close to the robot. Furthermore, we extend our method to distributed multi-robot systems.

Blind and Low Vision (BLV) people have adopted AI-powered visual interpretation applications to address their daily needs. While these applications have been helpful, prior work has found that users remain unsatisfied by their frequent errors. Recently, multimodal large language models (MLLMs) have been integrated into visual interpretation applications, and they show promise for more descriptive visual interpretations. However, it is still unknown how this advancement has changed people's use of these applications. To address this gap, we conducted a two-week diary study in which 20 BLV people used an MLLM-enabled visual interpretation application we developed, and we collected 553 entries. In this paper, we report a preliminary analysis of 60 diary entries from 6 participants. We found that participants considered the application's visual interpretations trustworthy (mean 3.75 out of 5) and satisfying (mean 4.15 out of 5). Moreover, participants trusted our application in high-stakes scenarios, such as receiving medical dosage advice. We discuss our plan to complete our analysis to inform the design of future MLLM-enabled visual interpretation systems.

The Association for Computing Machinery, has named Andrew Barto and Richard Sutton as the recipients of the 2024 ACM A.M. Turing Award. The pair have received the honour for "developing the conceptual and algorithmic foundations of reinforcement learning". In a series of papers beginning in the 1980s, Barto and Sutton introduced the main ideas, constructed the mathematical foundations, and developed important algorithms for reinforcement learning. The Turing Award comes with a 1 million prize, to be split between the recipients. Since its inception in 1966, the award has honoured computer scientists and engineers on a yearly basis.

Multi-entity question answering (MEQA) poses significant challenges for large language models (LLMs), which often struggle to consolidate scattered information across multiple documents. An example question might be "What is the distribution of IEEE Fellows among various fields of study?", which requires retrieving information from diverse sources e.g., Wikipedia pages. The effectiveness of current retrieval-augmented generation (RAG) methods is limited by the LLMs' capacity to aggregate insights from numerous pages. To address this gap, this paper introduces a structured RAG (SRAG) framework that systematically organizes extracted entities into relational tables (e.g., tabulating entities with schema columns like "name" and "field of study") and then apply table-based reasoning techniques. Our approach decouples retrieval and reasoning, enabling LLMs to focus on structured data analysis rather than raw text aggregation. Extensive experiments on Wikipedia-based multi-entity QA tasks demonstrate that SRAG significantly outperforms state-of-the-art long-context LLMs and RAG solutions, achieving a 29.6% improvement in accuracy. The results underscore the efficacy of structuring unstructured data to enhance LLMs' reasoning capabilities.

Large language models (LLMs) like OpenAI ChatGPT, Google Gemini, and GitHub Copilot are rapidly gaining traction in the software industry, but their full impact on software engineering remains insufficiently explored. Despite their growing adoption, there is a notable lack of formal, qualitative assessments of how LLMs are applied in real-world software development contexts. To fill this gap, we conducted semi-structured interviews with sixteen early-adopter professional developers to explore their use of LLMs throughout various stages of the software development life cycle. Our investigation examines four dimensions: people - how LLMs affect individual developers and teams; process - how LLMs alter software engineering workflows; product - LLM impact on software quality and innovation; and society - the broader socioeconomic and ethical implications of LLM adoption. Thematic analysis of our data reveals that while LLMs have not fundamentally revolutionized the development process, they have substantially enhanced routine coding tasks, including code generation, refactoring, and debugging. Developers reported the most effective outcomes when providing LLMs with clear, well-defined problem statements, indicating that LLMs excel with decomposed problems and specific requirements. Furthermore, these early-adopters identified that LLMs offer significant value for personal and professional development, aiding in learning new languages and concepts. Early-adopters, highly skilled in software engineering and how LLMs work, identified early and persisting challenges for software engineering, such as inaccuracies in generated content and the need for careful manual review before integrating LLM outputs into production environments. Our study provides a nuanced understanding of how LLMs are shaping the landscape of software development, with their benefits, limitations, and ongoing implications.

The study of representation universality in AI models reveals growing convergence across domains, modalities, and architectures. However, the practical applications of representation universality remain largely unexplored. We bridge this gap by demonstrating that safety interventions can be transferred between models through learned mappings of their shared activation spaces. We demonstrate this approach on two well-established AI safety tasks: backdoor removal and refusal of harmful prompts, showing successful transfer of steering vectors that alter the models' outputs in a predictable way. Additionally, we propose a new task, \textit{corrupted capabilities}, where models are fine-tuned to embed knowledge tied to a backdoor. This tests their ability to separate useful skills from backdoors, reflecting real-world challenges. Extensive experiments across Llama, Qwen and Gemma model families show that our method enables using smaller models to efficiently align larger ones. Furthermore, we demonstrate that autoencoder mappings between base and fine-tuned models can serve as reliable ``lightweight safety switches", allowing dynamic toggling between model behaviors.

This paper presents a game master AI for single-player role-playing games. The AI is designed to deliver interactive text-based narratives and experiences typically associated with multiplayer tabletop games like Dungeons & Dragons. We report on the design process and the series of experiments to improve the functionality and experience design, resulting in two functional versions of the system. While v1 of our system uses simplified prompt engineering, v2 leverages a multi-agent architecture and the ReAct framework to include reasoning and action. A comparative evaluation demonstrates that v2 as an agentic system maintains play while significantly improving modularity and game experience, including immersion and curiosity. Our findings contribute to the evolution of AI-driven interactive fiction, highlighting new avenues for enhancing solo role-playing experiences.