We explore the role of ontologies in enhancing hybrid modeling and simulation through improved semantic rigor, model reusability, and interoperability across systems, disciplines, and tools. By distinguishing between methodological and referential ontologies, we demonstrate how these complementary approaches address interoperability challenges along three axes: Human-Human, Human-Machine, and Machine-Machine. Techniques such as competency questions, ontology design patterns, and layered strategies are highlighted for promoting shared understanding and formal precision. Integrating ontologies with Semantic Web Technologies, we showcase their dual role as descriptive domain representations and prescriptive guides for simulation construction. Four application cases - sea-level rise analysis, Industry 4.0 modeling, artificial societies for policy support, and cyber threat evaluation - illustrate the practical benefits of ontology-driven hybrid simulation workflows. We conclude by discussing challenges and opportunities in ontology-based hybrid M&S, including tool integration, semantic alignment, and support for explainable AI.

This paper explores the use of large language models (LLMs) as research tools in the history, philosophy, and sociology of science (HPSS). LLMs are remarkably effective at processing unstructured text and inferring meaning from context, offering new affordances that challenge long-standing divides between computational and interpretive methods. This raises both opportunities and challenges for HPSS, which emphasizes interpretive methodologies and understands meaning as context-dependent, ambiguous, and historically situated. We argue that HPSS is uniquely positioned not only to benefit from LLMs' capabilities but also to interrogate their epistemic assumptions and infrastructural implications. To this end, we first offer a concise primer on LLM architectures and training paradigms tailored to non-technical readers. We frame LLMs not as neutral tools but as epistemic infrastructures that encode assumptions about meaning, context, and similarity, conditioned by their training data, architecture, and patterns of use. We then examine how computational techniques enhanced by LLMs, such as structuring data, detecting patterns, and modeling dynamic processes, can be applied to support interpretive research in HPSS. Our analysis compares full-context and generative models, outlines strategies for domain and task adaptation (e.g., continued pretraining, fine-tuning, and retrieval-augmented generation), and evaluates their respective strengths and limitations for interpretive inquiry in HPSS. We conclude with four lessons for integrating LLMs into HPSS: (1) model selection involves interpretive trade-offs; (2) LLM literacy is foundational; (3) HPSS must define its own benchmarks and corpora; and (4) LLMs should enhance, not replace, interpretive methods.

A beginning is made at mapping four neural theories of consciousness onto the Common Model of Cognition. This highlights how the four jointly depend on recurrent local modules plus a cognitive cycle operating on a global working memory with complex states, and reveals how an existing integrative view of consciousness from a neural perspective aligns with the Com-mon Model.

Quantum communication is poised to become a foundational element of next-generation networking, offering transformative capabilities in security, entanglement-based connectivity, and computational offloading. However, the classical OSI model-designed for deterministic and error-tolerant systems-cannot support quantum-specific phenomena such as coherence fragility, probabilistic entanglement, and the no-cloning theorem. This paper provides a comprehensive survey and proposes an architectural redesign of the OSI model for quantum networks in the context of 7G. We introduce a Quantum-Converged OSI stack by extending the classical model with Layer 0 (Quantum Substrate) and Layer 8 (Cognitive Intent), supporting entanglement, teleportation, and semantic orchestration via LLMs and QML. Each layer is redefined to incorporate quantum mechanisms such as enhanced MAC protocols, fidelity-aware routing, and twin-based applications. This survey consolidates over 150 research works from IEEE, ACM, MDPI, arXiv, and Web of Science (2018-2025), classifying them by OSI layer, enabling technologies such as QKD, QEC, PQC, and RIS, and use cases such as satellite QKD, UAV swarms, and quantum IoT. A taxonomy of cross-layer enablers-such as hybrid quantum-classical control, metadata-driven orchestration, and blockchain-integrated quantum trust-is provided, along with simulation tools including NetSquid, QuNetSim, and QuISP. We present several domain-specific applications, including quantum healthcare telemetry, entangled vehicular networks, and satellite mesh overlays. An evaluation framework is proposed based on entropy throughput, coherence latency, and entanglement fidelity. Key future directions include programmable quantum stacks, digital twins, and AI-defined QNet agents, laying the groundwork for a scalable, intelligent, and quantum-compliant OSI framework for 7G and beyond.

The era of Large Language Models (LLMs) presents a new opportunity for interpretability--agentic interpretability: a multi-turn conversation with an LLM wherein the LLM proactively assists human understanding by developing and leveraging a mental model of the user, which in turn enables humans to develop better mental models of the LLM. Such conversation is a new capability that traditional `inspective' interpretability methods (opening the black-box) do not use. Having a language model that aims to teach and explain--beyond just knowing how to talk--is similar to a teacher whose goal is to teach well, understanding that their success will be measured by the student's comprehension. While agentic interpretability may trade off completeness for interactivity, making it less suitable for high-stakes safety situations with potentially deceptive models, it leverages a cooperative model to discover potentially superhuman concepts that can improve humans' mental model of machines. Agentic interpretability introduces challenges, particularly in evaluation, due to what we call `human-entangled-in-the-loop' nature (humans responses are integral part of the algorithm), making the design and evaluation difficult. We discuss possible solutions and proxy goals. As LLMs approach human parity in many tasks, agentic interpretability's promise is to help humans learn the potentially superhuman concepts of the LLMs, rather than see us fall increasingly far from understanding them.

Tariff exemptions are fundamental to attracting Foreign Direct Investment (FDI) into the manufacturing sector, though the associated administrative processes present areas for optimization for both investing entities and the national tax authority. This paper proposes a conceptual framework to empower tax administration by leveraging a synergistic integration of Optical Character Recognition (OCR) and Large Language Model (LLM) technologies. The proposed system is designed to first utilize OCR for intelligent digitization, precisely extracting data from diverse application documents and key regulatory texts such as tariff orders. Subsequently, the LLM would enhance the capabilities of administrative officers by automating the critical and time-intensive task of verifying submitted HS Tariff Codes for machinery, equipment, and raw materials against official exemption lists. By enhancing the speed and precision of these initial assessments, this AI-driven approach systematically reduces potential for non-alignment and non-optimized exemption utilization, thereby streamlining the investment journey for FDI companies. For the national administration, the benefits include a significant boost in operational capacity, reduced administrative load, and a strengthened control environment, ultimately improving the ease of doing business and solidifying the nation's appeal as a premier destination for high-value manufacturing FDI.

Cybersecurity organizations are adapting to GenAI integration through modified frameworks and hybrid operational processes, with success influenced by existing security maturity, regulatory requirements, and investments in human capital and infrastructure. This qualitative research employs systematic document analysis and comparative case study methodology to examine how cybersecurity organizations adapt their threat modeling frameworks and operational processes to address generative artificial intelligence integration. Through examination of 25 studies from 2022 to 2025, the research documents substantial transformation in organizational approaches to threat modeling, moving from traditional signature-based systems toward frameworks incorporating artificial intelligence capabilities. The research identifies three primary adaptation patterns: Large Language Model integration for security applications, GenAI frameworks for risk detection and response automation, and AI/ML integration for threat hunting. Organizations with mature security infrastructures, particularly in finance and critical infrastructure sectors, demonstrate higher readiness through structured governance approaches, dedicated AI teams, and robust incident response processes. Organizations achieve successful GenAI integration when they maintain appropriate human oversight of automated systems, address data quality concerns and explainability requirements, and establish governance frameworks tailored to their specific sectors. Organizations encounter ongoing difficulties with privacy protection, bias reduction, personnel training, and defending against adversarial attacks. This work advances understanding of how organizations adopt innovative technologies in high-stakes environments and offers actionable insights for cybersecurity professionals implementing GenAI systems.

Scholar Inbox is a new open-access platform designed to address the challenges researchers face in staying current with the rapidly expanding volume of scientific literature. We provide personalized recommendations, continuous updates from open-access archives (arXiv, bioRxiv, etc.), visual paper summaries, semantic search, and a range of tools to streamline research workflows and promote open research access. The platform's personalized recommendation system is trained on user ratings, ensuring that recommendations are tailored to individual researchers' interests. To further enhance the user experience, Scholar Inbox also offers a map of science that provides an overview of research across domains, enabling users to easily explore specific topics. We use this map to address the cold start problem common in recommender systems, as well as an active learning strategy that iteratively prompts users to rate a selection of papers, allowing the system to learn user preferences quickly. We evaluate the quality of our recommendation system on a novel dataset of 800k user ratings, which we make publicly available, as well as via an extensive user study. https://www.scholar-inbox.com/

In cancer therapeutics, protein-metal binding mechanisms critically govern the pharmacokinetics and targeting efficacy of drugs, thereby fundamentally shaping the rational design of anticancer metallodrugs. While conventional laboratory methods used to study such mechanisms are often costly, low throughput, and limited in capturing dynamic biological processes, machine learning (ML) has emerged as a promising alternative. Despite increasing efforts to develop protein-metal binding datasets and ML algorithms, the application of ML in tumor protein-metal binding remains limited. Key challenges include a shortage of high-quality, tumor-specific datasets, insufficient consideration of multiple data modalities, and the complexity of interpreting results due to the ''black box'' nature of complex ML models. This paper summarizes recent progress and ongoing challenges in using ML to predict tumor protein-metal binding, focusing on data, modeling, and interpretability. We present multimodal protein-metal binding datasets and outline strategies for acquiring, curating, and preprocessing them for training ML models. Moreover, we explore the complementary value provided by different data modalities and examine methods for their integration. We also review approaches for improving model interpretability to support more trustworthy decisions in cancer research. Finally, we offer our perspective on research opportunities and propose strategies to address the scarcity of tumor protein data and the limited number of predictive models for tumor protein-metal binding. We also highlight two promising directions for effective metal-based drug design: integrating protein-protein interaction data to provide structural insights into metal-binding events and predicting structural changes in tumor proteins after metal binding.

We propose Polyra Swarms, a novel machine-learning approach that approximates shapes instead of functions. Our method enables general-purpose learning with very low bias. In particular, we show that depending on the task, Polyra Swarms can be preferable compared to neural networks, especially for tasks like anomaly detection. We further introduce an automated abstraction mechanism that simplifies the complexity of a Polyra Swarm significantly, enhancing both their generalization and transparency. Since Polyra Swarms operate on fundamentally different principles than neural networks, they open up new research directions with distinct strengths and limitations.