Overview
A Comprehensive Review of Transformer-based language models for Protein Sequence Analysis and Design
Ghosh, Nimisha, Santoni, Daniele, Nawn, Debaleena, Ottaviani, Eleonora, Felici, Giovanni
The impact of Transformer-based language models has been unprecedented in Natural Language Processing (NLP). The success of such models has also led to their adoption in other fields including bioinformatics. Taking this into account, this paper discusses recent advances in Transformer-based models for protein sequence analysis and design. In this review, we have discussed and analysed a significant number of works pertaining to such applications. These applications encompass gene ontology, functional and structural protein identification, generation of de novo proteins and binding of proteins. We attempt to shed light on the strength and weaknesses of the discussed works to provide a comprehensive insight to readers. Finally, we highlight shortcomings in existing research and explore potential avenues for future developments. We believe that this review will help researchers working in this field to have an overall idea of the state of the art in this field, and to orient their future studies.
Large Language Models in Cybersecurity: Applications, Vulnerabilities, and Defense Techniques
Jaffal, Niveen O., Alkhanafseh, Mohammed, Mohaisen, David
Large Language Models (LLMs) are transforming cybersecurity by enabling intelligent, adaptive, and automated approaches to threat detection, vulnerability assessment, and incident response. With their advanced language understanding and contextual reasoning, LLMs surpass traditional methods in tackling challenges across domains such as IoT, blockchain, and hardware security. This survey provides a comprehensive overview of LLM applications in cybersecurity, focusing on two core areas: (1) the integration of LLMs into key cybersecurity domains, and (2) the vulnerabilities of LLMs themselves, along with mitigation strategies. By synthesizing recent advancements and identifying key limitations, this work offers practical insights and strategic recommendations for leveraging LLMs to build secure, scalable, and future-ready cyber defense systems.
VerilogDB: The Largest, Highest-Quality Dataset with a Preprocessing Framework for LLM-based RTL Generation
Calzada, Paul E., Ibnat, Zahin, Rahman, Tanvir, Kandula, Kamal, Lu, Danyu, Saha, Sujan Kumar, Farahmandi, Farimah, Tehranipoor, Mark
Large Language Models (LLMs) are gaining popularity for hardware design automation, particularly through Register Transfer Level (RTL) code generation. In this work, we examine the current literature on RTL generation using LLMs and identify key requirements for training and fine-tuning datasets. We construct a robust Verilog dataset through an automated three-pronged process involving database (DB) creation and management with PostgreSQL, data collection from code hosting sites like OpenCores and GitHub, and data preprocessing to verify the codes' syntax, run logic synthesis, and extract relevant module metadata. We implement a scalable and efficient DB infrastructure to support analysis and detail our preprocessing pipeline to enforce high-quality data before DB insertion. The resulting dataset comprises 20,392 Verilog samples, 751 MB of Verilog code data, which is the largest high-quality Verilog dataset for LLM fine-tuning to our knowledge. We further evaluate the dataset, address associated challenges, and explore potential applications for future research and development in LLM-based hardware generation.
The role of large language models in UI/UX design: A systematic literature review
Ahmed, Ammar, Imran, Ali Shariq
User Interface (UI) and User Experience (UX) design are foundational components of the software development lifecycle, playing a very important role in shaping how users perceive, interact with, and derive value from digital products. UI design encompasses the visual and interactive elements of a system, including layout, typography, and on-screen components. In contrast, UX design encompasses the broader user journey, including the emotions, perceptions, and behaviors that emerge before, during, and after interaction with a product [34]. The quality of UI/UX design is a decisive factor in product success and user retention. Research consistently shows that poor UI/UX can drive users to abandon products altogether [9, 63].
Agentic Neural Networks: Self-Evolving Multi-Agent Systems via Textual Backpropagation
Ma, Xiaowen, Lin, Chenyang, Zhang, Yao, Tresp, Volker, Ma, Yunpu
Leveraging multiple Large Language Models(LLMs) has proven effective for addressing complex, high-dimensional tasks, but current approaches often rely on static, manually engineered multi-agent configurations. To overcome these constraints, we present the Agentic Neural Network(ANN), a framework that conceptualizes multi-agent collaboration as a layered neural network architecture. In this design, each agent operates as a node, and each layer forms a cooperative "team" focused on a specific subtask. Agentic Neural Network follows a two-phase optimization strategy: (1) Forward Phase-Drawing inspiration from neural network forward passes, tasks are dynamically decomposed into subtasks, and cooperative agent teams with suitable aggregation methods are constructed layer by layer. (2) Backward Phase-Mirroring backpropagation, we refine both global and local collaboration through iterative feedback, allowing agents to self-evolve their roles, prompts, and coordination. This neuro-symbolic approach enables ANN to create new or specialized agent teams post-training, delivering notable gains in accuracy and adaptability. Across four benchmark datasets, ANN surpasses leading multi-agent baselines under the same configurations, showing consistent performance improvements. Our findings indicate that ANN provides a scalable, data-driven framework for multi-agent systems, combining the collaborative capabilities of LLMs with the efficiency and flexibility of neural network principles. We plan to open-source the entire framework.
(Exhaustive) Symbolic Regression and model selection by minimum description length
Symbolic regression is the machine learning method for learning functions from data. After a brief overview of the symbolic regression landscape, I will describe the two main challenges that traditional algorithms face: they have an unknown (and likely significant) probability of failing to find any given good function, and they suffer from ambiguity and poorly-justified assumptions in their function-selection procedure. To address these I propose an exhaustive search and model selection by the minimum description length principle, which allows accuracy and complexity to be directly traded off by measuring each in units of information. I showcase the resulting publicly available Exhaustive Symbolic Regression algorithm on three open problems in astrophysics: the expansion history of the universe, the effective behaviour of gravity in galaxies and the potential of the inflaton field. In each case the algorithm identifies many functions superior to the literature standards. This general purpose methodology should find widespread utility in science and beyond.
A Comprehensive Survey of Electronic Health Record Modeling: From Deep Learning Approaches to Large Language Models
Ren, Weijieying, Zhu, Jingxi, Liu, Zehao, Zhao, Tianxiang, Honavar, Vasant
Artificial intelligence (AI) has demonstrated significant potential in transforming healthcare through the analysis and modeling of electronic health records (EHRs). However, the inherent heterogeneity, temporal irregularity, and domain-specific nature of EHR data present unique challenges that differ fundamentally from those in vision and natural language tasks. This survey offers a comprehensive overview of recent advancements at the intersection of deep learning, large language models (LLMs), and EHR modeling. We introduce a unified taxonomy that spans five key design dimensions: data-centric approaches, neural architecture design, learning-focused strategies, multimodal learning, and LLM-based modeling systems. Within each dimension, we review representative methods addressing data quality enhancement, structural and temporal representation, self-supervised learning, and integration with clinical knowledge. We further highlight emerging trends such as foundation models, LLM-driven clinical agents, and EHR-to-text translation for downstream reasoning. Finally, we discuss open challenges in benchmarking, explainability, clinical alignment, and generalization across diverse clinical settings. This survey aims to provide a structured roadmap for advancing AI-driven EHR modeling and clinical decision support. For a comprehensive list of EHR-related methods, kindly refer to https://survey-on-tabular-data.github.io/.
Transformer-based Spatial Grounding: A Comprehensive Survey
Haq, Ijazul, Saqib, Muhammad, Zhang, Yingjie
Spatial grounding, the process of associating natural language expressions with corresponding image regions, has rapidly advanced due to the introduction of transformer-based models, significantly enhancing multimodal representation and cross-modal alignment. Despite this progress, the field lacks a comprehensive synthesis of current methodologies, dataset usage, evaluation metrics, and industrial applicability. This paper presents a systematic literature review of transformer-based spatial grounding approaches from 2018 to 2025. Our analysis identifies dominant model architectures, prevalent datasets, and widely adopted evaluation metrics, alongside highlighting key methodological trends and best practices. This study provides essential insights and structured guidance for researchers and practitioners, facilitating the development of robust, reliable, and industry-ready transformer-based spatial grounding models.
Data Transformation Strategies to Remove Heterogeneity
Yoo, Sangbong, Lee, Jaeyoung, Yoon, Chanyoung, Son, Geonyeong, Hong, Hyein, Seo, Seongbum, Yim, Soobin, Jung, Chanyoung, Park, Jungsoo, Kim, Misuk, Jang, Yun
Data heterogeneity is a prevalent issue, stemming from various conflicting factors, making its utilization complex. This uncertainty, particularly resulting from disparities in data formats, frequently necessitates the involvement of experts to find resolutions. Current methodologies primarily address conflicts related to data structures and schemas, often overlooking the pivotal role played by data transformation. As the utilization of artificial intelligence (AI) continues to expand, there is a growing demand for a more streamlined data preparation process, and data transformation becomes paramount. It customizes training data to enhance AI learning efficiency and adapts input formats to suit diverse AI models. Selecting an appropriate transformation technique is paramount in preserving crucial data details. Despite the widespread integration of AI across various industries, comprehensive reviews concerning contemporary data transformation approaches are scarce. This survey explores the intricacies of data heterogeneity and its underlying sources. It systematically categorizes and presents strategies to address heterogeneity stemming from differences in data formats, shedding light on the inherent challenges associated with each strategy.
A Survey of Explainable Reinforcement Learning: Targets, Methods and Needs
The success of recent Artificial Intelligence (AI) models has been accompanied by the opacity of their internal mechanisms, due notably to the use of deep neural networks. In order to understand these internal mechanisms and explain the output of these AI models, a set of methods have been proposed, grouped under the domain of eXplainable AI (XAI). This paper focuses on a sub-domain of XAI, called eXplainable Reinforcement Learning (XRL), which aims to explain the actions of an agent that has learned by reinforcement learning. We propose an intuitive taxonomy based on two questions "What" and "How". The first question focuses on the target that the method explains, while the second relates to the way the explanation is provided. We use this taxonomy to provide a state-of-the-art review of over 250 papers. In addition, we present a set of domains close to XRL, which we believe should get attention from the community. Finally, we identify some needs for the field of XRL.