In the broader context of deep learning, Multimodal Large Language Models have achieved significant breakthroughs by leveraging powerful Large Language Models as a backbone to align different modalities into the language space. A prime exemplification is the development of Video Large Language Models (Video-LLMs). While numerous advancements have been proposed to enhance the video understanding capabilities of these models, they are predominantly trained on questions generated directly from video content. However, in real-world scenarios, users often pose questions that extend beyond the informational scope of the video, highlighting the need for Video-LLMs to assess the relevance of the question. We demonstrate that even the best-performing Video-LLMs fail to reject unfit questions-not necessarily due to a lack of video understanding, but because they have not been trained to identify and refuse such questions. To address this limitation, we propose alignment for answerability, a framework that equips Video-LLMs with the ability to evaluate the relevance of a question based on the input video and appropriately decline to answer when the question exceeds the scope of the video, as well as an evaluation framework with a comprehensive set of metrics designed to measure model behavior before and after alignment. Furthermore, we present a pipeline for creating a dataset specifically tailored for alignment for answerability, leveraging existing video-description paired datasets.

Transcranial magnetic stimulation (TMS) is a non-invasive and safe brain stimulation procedure with growing applications in clinical treatments and neuroscience research. However, achieving precise stimulation over prolonged sessions poses significant challenges. By integrating advanced robotics with conventional TMS, robot-assisted TMS (Robo-TMS) has emerged as a promising solution to enhance efficacy and streamline procedures. Despite growing interest, a comprehensive review from an engineering perspective has been notably absent. This paper systematically examines four critical aspects of Robo-TMS: hardware and integration, calibration and registration, neuronavigation systems, and control systems. We review state-of-the-art technologies in each area, identify current limitations, and propose future research directions. Our findings suggest that broader clinical adoption of Robo-TMS is currently limited by unverified clinical applicability, high operational complexity, and substantial implementation costs. Emerging technologies, including marker-less tracking, non-rigid registration, learning-based electric field (E-field) modelling, individualised magnetic resonance imaging (MRI) generation, robot-assisted multi-locus TMS (Robo-mTMS), and automated calibration and registration, present promising pathways to address these challenges.

Recent years have seen rapid increases in intermittent renewable generation, requiring novel battery energy storage systems (BESS) solutions. One recent trend is the emergence of large grid-connected batteries, that can be controlled to provide multiple storage and flexibility services, using a stacked revenue model. Another emerging development is renewable energy communities (REC), in which prosumers invest in their own renewable generation capacity, but also requiring battery storage for flexibility. In this paper, we study settings in which energy communities rent battery capacity from a battery operator through a battery-as-a-service (BaaS) model. We present a methodology for determining the sizing and pricing of battery capacity that can be rented, such that it provides economic benefits to both the community and the battery operator that participates in the energy market. We examine how sizes and prices vary across a number of different scenarios for different types of tariffs (flat, dynamic) and competing energy market uses. Second, we conduct a systematic study of linear optimization models for battery control when deployed to provide flexibility to energy communities. We show that existing approaches for battery control with daily time windows have a number of important limitations in practical deployments, and we propose a number of regularization functions in the optimization to address them. Finally, we investigate the proposed method using real generation, demand, tariffs, and battery data, based on a practical case study from a large battery operator in the Netherlands. For the settings in our case study, we find that a community of 200 houses with a 330 kW wind turbine can save up to 12,874 euros per year by renting just 280 kWh of battery capacity (after subtracting battery rental costs), with the methodology applicable to a wide variety of settings and tariff types.

Large language models (LLMs) are powerful artificial intelligence (AI) tools transforming how research is conducted. However, their use in research has been met with skepticism, due to concerns about hallucinations, biases and potential harms to research. These emphasize the importance of clearly understanding the strengths and weaknesses of LLMs to ensure their effective and responsible use. Here, we present a roadmap for integrating LLMs into cross-disciplinary research, where effective communication, knowledge transfer and collaboration across diverse fields are essential but often challenging. We examine the capabilities and limitations of LLMs and provide a detailed computational biology case study (on modeling HIV rebound dynamics) demonstrating how iterative interactions with an LLM (ChatGPT) can facilitate interdisciplinary collaboration and research. We argue that LLMs are best used as augmentative tools within a human-in-the-loop framework. Looking forward, we envisage that the responsible use of LLMs will enhance innovative cross-disciplinary research and substantially accelerate scientific discoveries.

This paper systematically reviews recent advances in artificial intelligence (AI), with a particular focus on machine learning (ML), across the entire drug discovery pipeline. Due to the inherent complexity, escalating costs, prolonged timelines, and high failure rates of traditional drug discovery methods, there is a critical need to comprehensively understand how AI/ML can be effectively integrated throughout the full process. Currently available literature reviews often narrowly focus on specific phases or methodologies, neglecting the dependence between key stages such as target identification, hit screening, and lead optimization. To bridge this gap, our review provides a detailed and holistic analysis of AI/ML applications across these core phases, highlighting significant methodological advances and their impacts at each stage. We further illustrate the practical impact of these techniques through an in-depth case study focused on hyperuricemia, gout arthritis, and hyperuricemic nephropathy, highlighting real-world successes in molecular target identification and therapeutic candidate discovery. Additionally, we discuss significant challenges facing AI/ML in drug discovery and outline promising future research directions. Ultimately, this review serves as an essential orientation for researchers aiming to leverage AI/ML to overcome existing bottlenecks and accelerate drug discovery.

The recent mainstream adoption of large language model (LLM) technology is enabling novel applications in the form of chatbots and virtual assistants across many domains. With the aim of grounding LLMs in trusted domains and avoiding the problem of hallucinations, retrieval-augmented generation (RAG) has emerged as a viable solution. In order to deploy sustainable RAG systems in low-resource settings, achieving high retrieval accuracy is not only a usability requirement but also a cost-saving strategy. Through empirical evaluations on a Kinyarwanda-language dataset, we find that the most limiting factors in achieving high retrieval accuracy are limited language coverage and inadequate sub-word tokenization in pre-trained language models. We propose a new retriever model, KinyaColBERT, which integrates two key concepts: late word-level interactions between queries and documents, and a morphology-based tokenization coupled with two-tier transformer encoding. This methodology results in lexically grounded contextual embeddings that are both fine-grained and self-contained. Our evaluation results indicate that KinyaColBERT outperforms strong baselines and leading commercial text embedding APIs on a Kinyarwanda agricultural retrieval benchmark. By adopting this retrieval strategy, we believe that practitioners in other low-resource settings can not only achieve reliable RAG systems but also deploy solutions that are more cost-effective.

A recent trend in the mathematical optimization literature is to embed trained machine learning predictors into a larger optimization model. The m ost common application is for a practitioner to train a machine learning predictor as a sur rogate for a more complicated subsystem that cannot be directly embedded into an optimiza tion model, for example, because it does not have an algebraic form or because it is non -differentiable. L opez-Flores et al. (2024) provide a review of the field.

Despite advancements, Radio Access Networks (RAN) still account for over 50\% of the total power consumption in 5G networks. Existing RAN split options do not fully harness data potential, presenting an opportunity to reduce operational expenditures. This paper addresses this opportunity through a twofold approach. First, highly accurate network traffic and user predictions are achieved using the proposed Curated Collaborative Learning (CCL) framework, which selectively collaborates with relevant correlated data for traffic forecasting. CCL optimally determines whom, when, and what to collaborate with, significantly outperforming state-of-the-art approaches, including global, federated, personalized federated, and cyclic institutional incremental learnings by 43.9%, 39.1%, 40.8%, and 31.35%, respectively. Second, the Distributed Unit Pooling Scheme (DUPS) is proposed, leveraging deep reinforcement learning and prediction inferences from CCL to reduce the number of active DU servers efficiently. DUPS dynamically redirects traffic from underutilized DU servers to optimize resource use, improving energy efficiency by up to 89% over conventional strategies, translating into substantial monetary benefits for operators. By integrating CCL-driven predictions with DUPS, this paper demonstrates a transformative approach for minimizing energy consumption and operational costs in 5G RANs, significantly enhancing efficiency and cost-effectiveness.

The increasing importance of Vision-Based Navigation (VBN) algorithms in space missions raises numerous challenges in ensuring their reliability and operational robustness. Sensor faults can lead to inaccurate outputs from navigation algorithms or even complete data processing faults, potentially compromising mission objectives. Artificial Intelligence (AI) offers a powerful solution for detecting such faults, overcoming many of the limitations associated with traditional fault detection methods. However, the primary obstacle to the adoption of AI in this context is the lack of sufficient and representative datasets containing faulty image data. This study addresses these challenges by focusing on an interplanetary exploration mission scenario. A comprehensive analysis of potential fault cases in camera sensors used within the VBN pipeline is presented. The causes and effects of these faults are systematically characterized, including their impact on image quality and navigation algorithm performance, as well as commonly employed mitigation strategies. To support this analysis, a simulation framework is introduced to recreate faulty conditions in synthetically generated images, enabling a systematic and controlled reproduction of faulty data. The resulting dataset of fault-injected images provides a valuable tool for training and testing AI-based fault detection algorithms. The final link to the dataset will be added after an embargo period. For peer-reviewers, this private link is available.

The limitations of the Poisson process were more evident when modeling high-speed network traffic, particularly real-time data traffic modeling for next-generation networks. For example, Liji et al. [85] demonstrated that the Stationary Poison Increment Process can only model Short Range Dependence (SRD) but not LRD. To address this limitation, the authors proposed using second-order self-similarity models, such as fractional Gaussian noise and fractional ARIMA processes, as a more appropriate approach. In the meantime, researchers also explored modeling data center network traffic using poisson processes. To better simulate realistic traffic in data center environments, the generation of flow-level network traffic matrices based on the poisson shot-noise model is proposed in [172]. By incorporating factors such as flow arrival rates, intra-rack traffic ratios, flow sizes and durations, the poisson shot-noise process offers a more accurate representation of traffic patterns in data centers. B. Weibull distribution As discussed earlier, the limitations of Poisson processes for modeling network traffic led to exploring other distributions. One such promising model was the Weibull distribution, mainly due to its flexibility to model both heavy and non-heavy tailed distributions [11].