Due to the remarkable capabilities and growing impact of large language models (LLMs), they have been deeply integrated into many aspects of society. Thus, ensuring their alignment with human values and intentions has emerged as a critical challenge. This survey provides a comprehensive overview of practical alignment techniques, training protocols, and empirical findings in LLM alignment. We analyze the development of alignment methods across diverse paradigms, characterizing the fundamental trade-offs between core alignment objectives. Our analysis shows that while supervised fine-tuning enables basic instruction-following, preference-based methods offer more flexibility for aligning with nuanced human intent. We discuss state-of-the-art techniques, including Direct Preference Optimization (DPO), Constitutional AI, brain-inspired methods, and alignment uncertainty quantification (AUQ), highlighting their approaches to balancing quality and efficiency. We review existing evaluation frameworks and benchmarking datasets, emphasizing limitations such as reward misspecification, distributional robustness, and scalable oversight. We summarize strategies adopted by leading AI labs to illustrate the current state of practice. We conclude by outlining open problems in oversight, value pluralism, robustness, and continuous alignment. This survey aims to inform both researchers and practitioners navigating the evolving landscape of LLM alignment.

Classical game-theoretic models typically assume rational agents, complete information, and common knowledge of payoffs - assumptions that are often violated in real-world MAS characterized by uncertainty, misaligned perceptions, and nested beliefs. To overcome these limitations, researchers have proposed extensions that incorporate models of cognitive constraints, subjective beliefs, and heterogeneous reasoning. Among these, hypergame theory extends the classical paradigm by explicitly modeling agents' subjective perceptions of the strategic scenario, known as perceptual games, in which agents may hold divergent beliefs about the structure, payoffs, or available actions. We present a systematic review of agent-compatible applications of hypergame theory, examining how its descriptive capabilities have been adapted to dynamic and interactive MAS contexts. We analyze 44 selected studies from cybersecurity, robotics, social simulation, communications, and general game-theoretic modeling. Building on a formal introduction to hypergame theory and its two major extensions - hierarchical hypergames and HNF - we develop agent-compatibility criteria and an agent-based classification framework to assess integration patterns and practical applicability. Our analysis reveals prevailing tendencies, including the prevalence of hierarchical and graph-based models in deceptive reasoning and the simplification of extensive theoretical frameworks in practical applications. We identify structural gaps, including the limited adoption of HNF-based models, the lack of formal hypergame languages, and unexplored opportunities for modeling human-agent and agent-agent misalignment. By synthesizing trends, challenges, and open research directions, this review provides a new roadmap for applying hypergame theory to enhance the realism and effectiveness of strategic modeling in dynamic multi-agent environments.

The past decade has witnessed a transformative "cryoEM revolution" characterized by exponential growth in high - resolution structural data, driven by advances in cryogenic electron microscopy (cryoEM) and cryogenic electron t omography (cryoET). The integration of deep learning technologies into structural proteomics workflows has emerged as a pivotal force in addressing longstanding challenges, including low signal - to - noise ratios, preferred orientation artifacts, and missing - wedge problems th at have historically limited efficiency and scalability. This review article examines the application of Artificial Intelligence (AI) across the entire cryoEM pipeline, from automated particle picking using convolutional neural networks (Topaz, crYOLO, Cry oSegNet) to computational solutions for preferred orientation bias (spIsoNet, cryoPROS) and advanced denoising algorithms (Topaz - Denoise). In cryoET, tools such as IsoNet employ U - Net architectures for simultaneous missing - wedge correction and noise reduct ion, while TomoNet streamlines subtomogram averaging through AI - driven particle detection. The workflow culminates with automated atomic model building using sophisticated tools like ModelAngelo, DeepTracer, and CryoREAD that translate density maps into in terpretable biological structures. These AI - enhanced approaches have demonstrated remarkable achievements, including near - atomic resolution reconstructions with minimal manual intervention, resolution of previously intractable datasets suffering from sever e orientation bias, and successful application to diverse biological systems from HIV virus - like particles to in situ ribosomal complexes. As deep learning continues to evolve, particularly with the emergence of large language models and vision transformer s, the future promises even more sophisticated automation and accessibility in structural biology, potentially revolutionizing our understanding of macromolecular architecture and function.

The vast majority of Web pages fail to comply with established Web accessibility guidelines, excluding a range of users with diverse abilities from interacting with their content. Making Web pages accessible to all users requires dedicated expertise and additional manual efforts from Web page providers. To lower their efforts and promote inclusiveness, we aim to automatically detect and correct Web accessibility violations in HTML code. While previous work has made progress in detecting certain types of accessibility violations, the problem of automatically detecting and correcting accessibility violations remains an open challenge that we address. We introduce a novel taxonomy classifying Web accessibility violations into three key categories - Syntactic, Semantic, and Layout. This taxonomy provides a structured foundation for developing our detection and correction method and redefining evaluation metrics. We propose a novel method, AccessGuru, which combines existing accessibility testing tools and Large Language Models (LLMs) to detect violations and applies taxonomy-driven prompting strategies to correct all three categories. To evaluate these capabilities, we develop a benchmark of real-world Web accessibility violations. Our benchmark quantifies syntactic and layout compliance and judges semantic accuracy through comparative analysis with human expert corrections. Evaluation against our benchmark shows that AccessGuru achieves up to 84% average violation score decrease, significantly outperforming prior methods that achieve at most 50%.

Pre-trained Language Models (PLMs) have demonstrated impressive performance in various NLP tasks. However, traditional fine-tuning methods for leveraging PLMs for downstream tasks entail significant computational overhead. Prompt-tuning has emerged as an efficient alternative that involves prepending a limited number of parameters to the input sequence and only updating them while the PLM's parameters are frozen. However, this technique's prompts remain fixed for all inputs, reducing the model's flexibility. The Federated Learning (FL) technique has gained attention in recent years to address the growing concerns around data privacy. However, challenges such as communication and computation limitations of clients still need to be addressed. To mitigate these challenges, this paper introduces the Federated Dynamic Prompt Generator (FedDPG), which incorporates a dynamic prompt generator network to generate context-aware prompts based on the given input, ensuring flexibility and adaptability while prioritising data privacy in federated learning settings. Our experiments on three NLP benchmark datasets showcase that FedDPG outperforms the state-of-the-art parameter-efficient fine-tuning methods in terms of global model performance, and has significantly reduced the calculation time and the number of parameters to be sent through the FL network.

--Artificial intelligence (AI) and machine learning (ML) models are rapidly permeating the 5G Radio Access Network (RAN), powering beam management, channel state information (CSI) feedback, positioning, and mobility prediction. However, without a standardized life-cycle management (LCM) framework, challenges, such as model drift, vendor lock-in, and limited transparency, hinder large-scale adoption. Beginning with the Network Data Analytics Function (NWDAF) in Rel-16, subsequent releases introduced standardized interfaces for model transfer, execution, performance monitoring, and closed-loop control, culminating in Rel-20's two-sided CSI-compression Work Item and vendor-agnostic LCM profile. This article reviews the resulting five-block LCM architecture, KPI-driven monitoring mechanisms, and inter-vendor collaboration schemes, while identifying open challenges in resource-efficient monitoring, environment drift detection, intelligent decision-making, and flexible model training. These developments lay the foundation for AI-native transceivers as a key enabler for 6G. C.-H. Huang is with the Department of Electrical Engineering, National Taiwan University National Taiwan University, Taipei 10617, Taiwan, Email: chuhsianh@ntu.edu.tw. C.-K. Wen is with the Institute of Communications Engineering, National Sun Y at-sen University, Kaohsiung 80424, Taiwan, Email: chaokai.wen@mail.nsysu.edu.tw. Li is with the Department of Electrical and Electronic Engineering, Imperial College London, SW7 2AZ London, U.K., Email: geoffrey.li@imperial.ac.uk. This work has been submitted to the IEEE for possible publication. RTIFICIAL intelligence (AI) and machine learning (ML) have demonstrated significant potential in enhancing radio access network (RAN) performance, particularly for nonlinear and analytically complex tasks, such as beam management [1], channel state information (CSI) feedback [2], [3], positioning [4], and mobility prediction [5].

We present a SemiEmpirical Theory of Learning (SETOL) that explains the remarkable performance of State-Of-The-Art (SOTA) Neural Networks (NNs). We provide a formal explanation of the origin of the fundamental quantities in the phenomenological theory of Heavy-Tailed Self-Regularization (HTSR): the heavy-tailed power-law layer quality metrics, alpha and alpha-hat. In prior work, these metrics have been shown to predict trends in the test accuracies of pretrained SOTA NN models, importantly, without needing access to either testing or training data. Our SETOL uses techniques from statistical mechanics as well as advanced methods from random matrix theory and quantum chemistry. The derivation suggests new mathematical preconditions for ideal learning, including a new metric, ERG, which is equivalent to applying a single step of the Wilson Exact Renormalization Group. We test the assumptions and predictions of SETOL on a simple 3-layer multilayer perceptron (MLP), demonstrating excellent agreement with the key theoretical assumptions. For SOTA NN models, we show how to estimate the individual layer qualities of a trained NN by simply computing the empirical spectral density (ESD) of the layer weight matrices and plugging this ESD into our SETOL formulas. Notably, we examine the performance of the HTSR alpha and the SETOL ERG layer quality metrics, and find that they align remarkably well, both on our MLP and on SOTA NNs.

Hate speech targeting children on social media is a serious and growing problem, yet current NLP systems struggle to detect it effectively. This gap exists mainly because existing datasets focus on adults, lack age specific labels, miss nuanced linguistic cues, and are often too small for robust modeling. To address this, we introduce ChildGuard, the first large scale English dataset dedicated to hate speech aimed at children. It contains 351,877 annotated examples from X (formerly Twitter), Reddit, and YouTube, labeled by three age groups: younger children (under 11), pre teens (11--12), and teens (13--17). The dataset is split into two subsets for fine grained analysis: a contextual subset (157K) focusing on discourse level features, and a lexical subset (194K) emphasizing word-level sentiment and vocabulary. Benchmarking state of the art hate speech models on ChildGuard reveals notable drops in performance, highlighting the challenges of detecting child directed hate speech.

Photonic device development (PDD) has achieved remarkable success in designing and implementing new devices for controlling light across various wavelengths, scales, and applications, including telecommunications, imaging, sensing, and quantum information processing. PDD is an iterative, five-step process that consists of: i) deriving device behavior from design parameters, ii) simulating device performance, iii) finding the optimal candidate designs from simulations, iv) fabricating the optimal device, and v) measuring device performance. Classically, all these steps involve Bayesian optimization, material science, control theory, and direct physics-driven numerical methods. However, many of these techniques are computationally intractable, monetarily costly, or difficult to implement at scale. In addition, PDD suffers from large optimization landscapes, uncertainties in structural or optical characterization, and difficulties in implementing robust fabrication processes. However, the advent of machine learning over the past decade has provided novel, data-driven strategies for tackling these challenges, including surrogate estimators for speeding up computations, generative modeling for noisy measurement modeling and data augmentation, reinforcement learning for fabrication, and active learning for experimental physical discovery. In this review, we present a comprehensive perspective on these methods to enable machine-learning-assisted PDD (ML-PDD) for efficient design optimization with powerful generative models, fast simulation and characterization modeling under noisy measurements, and reinforcement learning for fabrication. This review will provide researchers from diverse backgrounds with valuable insights into this emerging topic, fostering interdisciplinary efforts to accelerate the development of complex photonic devices and systems.

Nanobodies -- single-domain antibody fragments derived from camelid heavy-chain-only antibodies -- exhibit unique advantages such as compact size, high stability, and strong binding affinity, making them valuable tools in therapeutics and diagnostics. While recent advances in pretrained protein and antibody language models (PPLMs and PALMs) have greatly enhanced biomolecular understanding, nanobody-specific modeling remains underexplored and lacks a unified benchmark. To address this gap, we introduce NbBench, the first comprehensive benchmark suite for nanobody representation learning. Spanning eight biologically meaningful tasks across nine curated datasets, NbBench encompasses structure annotation, binding prediction, and developability assessment. We systematically evaluate eleven representative models -- including general-purpose protein LMs, antibody-specific LMs, and nanobody-specific LMs -- in a frozen setting. Our analysis reveals that antibody language models excel in antigen-related tasks, while performance on regression tasks such as thermostability and affinity remains challenging across all models. Notably, no single model consistently outperforms others across all tasks. By standardizing datasets, task definitions, and evaluation protocols, NbBench offers a reproducible foundation for assessing and advancing nanobody modeling.