Recent advances in computational pathology have led to the emergence of numerous foundation models. These models typically rely on general-purpose encoders with multi-instance learning for whole slide image (WSI) classification or apply multimodal approaches to generate reports directly from images. However, these models cannot emulate the diagnostic approach of pathologists, who systematically examine slides at low magnification to obtain an overview before progressively zooming in on suspicious regions to formulate comprehensive diagnoses.

Crossmodal matching in single-cell omics is essential for explaining biological regulatory mechanisms and enhancing downstream analyses. However, current single-cell crossmodal models often suffer from three limitations: sparse modality signals, underutilization of biological attributes, and insufficient modeling of regulatory interactions. These challenges hinder generalization in data-scarce settings and restrict the ability to uncover fine-grained biologically meaningful crossmodal relationships. Here, we present a novel framework which reformulates crossmodal matching as a graph classification task on Attributed Bipartite Graphs (ABGs). It models single-cell ATAC-RNA data as an ABG, where each expressed ATAC and RNA is treated as a distinct node with unique IDs and biological features. To model crossmodal interaction patterns on the constructed ABG, we propose Bi2Former, a biologically-driven bipartite graph transformer that learns interpretable attention over ATAC-RNA pairs. This design enables the model to effectively learn and explain biological regulatory relationships between ATAC and RNA modalities. Extensive experiments demonstrate that Bi2Former achieves state-of-the-art performance in crossmodal matching across diverse datasets, remains robust under sparse training data, generalizes to unseen cell types and datasets, and reveals biologically meaningful regulatory patterns.

Discrete Flow-based Models (DFMs) are powerful generative models for highquality discrete data but typically suffer from slow sampling speeds due to their reliance on iterative decoding processes. This reliance on a multi-step process originates from the factorization approximation of DFMs, which is necessary for handling high-dimensional data. In this paper, we analyze the factorization approximation error using Conditional Total Correlation (TC), and reveal its dependence on the coupling. To address the challenge of efficient few-step generation, we propose Rectified Discrete Flow (ReDi), a novel iterative method that reduces the underlying factorization error (measured as Conditional TC) by rectifying the coupling between source and target distributions. We theoretically prove that each ReDi step guarantees a monotonic decreasing Conditional TC, ensuring its convergence. Empirically, ReDi significantly reduces Conditional TC and enables few-step generation. Moreover, we demonstrate that the rectified couplings are well-suited for training efficient one-step models on image generation. ReDi offers a simple and theoretically grounded approach for tackling the few-step challenge, providing a new perspective on efficient discrete data synthesis.

Existing distribution compression methods, like Kernel Herding (KH), were originally developed for unlabelled data.

As major progress in LLM-based long-form text generation enables paradigms such as retrieval-augmented generation (RAG) and inference-time scaling, safely incorporating private information into the generation remains a critical open question.

Simplicial complexes provide a powerful framework for modeling higher-order interactions in structured data, making them particularly suitable for applications such as trajectory prediction and mesh processing. However, existing simplicial neural networks (SNNs), whether convolutional or attention-based, rely primarily on discrete filtering techniques, which can be restrictive. In contrast, partial differential equations (PDEs) on simplicial complexes offer a principled approach to capture continuous dynamics in such structures. In this work, we introduce continuous simplicial neural network (COSIMO), a novel SNN architecture derived from PDEs on simplicial complexes. We provide theoretical and experimental justifications of COSIMO's stability under simplicial perturbations. Furthermore, we investigate the over-smoothing phenomenon--a common issue in geometric deep learning--demonstrating that COSIMO offers better control over this effect than discrete SNNs. Our experiments on real-world datasets demonstrate that COSIMO achieves competitive performance compared to state-of-the-art SNNs in complex and noisy environments.

Ensembles of generative large language models (LLMs) are a promising way to compensate for individual model limitations, integrating the strengths of different LLMs. Existing LLM ensemble methods, however, face limitations such as first-token delay and challenges in long-range semantic collaboration between models, Moreover, they typically assume equal voting weights for all models during ensemble, ignoring task-specific performance differences among models. In this work, we propose SpecEM, a training-free, plug-and-play LLM ensemble framework that dynamically adjusts each model's model contribution in real time based on task performance. Inspired by speculative decoding, SpecEM iteratively performs drafting and verification, allowing models to collaborate semantically at the segment level for integrated output. Furthermore, we introduce an online feedback mechanism with multiplicative weight updates, where each model's voting weight is adjusted on-the-fly according to how often it outperforms others during verification stage, ensuring that stronger models exert greater influence during ensembling. Experimental results on five LLM families (ranging from 7B to 72B parameters) and six benchmark datasets, spanning open-domain instruction following, reasoning, commonsense, demonstrate consistent performance improvements compared to state-of-the-art LLM ensemble methods.

Recent advances in artificial intelligence have significantly impacted image retrieval tasks, yet Patent-Product Image Retrieval (PPIR) has received limited attention. PPIR, which retrieves patent images based on product images to identify potential infringements, presents unique challenges: (1) both product and patent images often contain numerous categories of artificial objects, but models pre-trained on standard datasets exhibit limited discriminative power to recognize some of those unseen objects; and (2) the significant domain gap between binary patent line drawings and colorful RGB product images further complicates similarity comparisons for product-patent pairs. To address these challenges, we formulate it as an open-set image retrieval task and introduce a comprehensive Patent-Product Image Retrieval Dataset (PPIRD) including a test set with 439 product-patent pairs, a retrieval pool of 727,921 patents, and an unlabeled pre-training set of 3,799,695 images. We further propose a novel Intermediate Domain Alignment and Morphology Analogy (IDAMA) strategy. IDAMA maps both image types to an intermediate sketch domain using edge detection to minimize the domain discrepancy, and employs a Morphology Analogy Filter to select discriminative patent images based on visual features via analogical reasoning. Extensive experiments on PPIRD demonstrate that IDAMA significantly outperforms baseline methods (+7.58 mAR) and offers valuable insights into domain mapping and representation learning for PPIR.

We study contextual online pricing with biased offline data. For the scalar price elasticity case, we identify the instance-dependent quantity δ2 that measures how far the offline data lies from the (unknown) online optimum. We show that the time length T, bias bound V, size N and dispersion λmin(ˆΣ) of the offline data, and δ2 jointly determine the statistical complexity.

Large Vision-Language Models (LVLMs) have exhibited remarkable progress. However, deficiencies remain compared to human intelligence, such as hallucination and shallow pattern matching. In this work, we aim to evaluate a fundamental yet underexplored intelligence: association, a cornerstone of human cognition for creative thinking and knowledge integration. Current benchmarks, often limited to closed-ended tasks, fail to capture the complexity of open-ended association reasoning vital for real-world applications. To address this, we present MMOPERA, a systematic benchmark with 11,497 instances across two open-ended tasks: Remote-Item Association (RIA) and In-Context Association (ICA), aligning association intelligence evaluation with human psychometric principles. It challenges LVLMs to resemble the spirit of divergent thinking and convergent associative reasoning through free-form responses and explicit reasoning paths. We deploy tailored LLM-as-a-Judge strategies to evaluate open-ended outputs, applying process-reward-informed judgment to dissect reasoning with precision. Extensive empirical studies on state-of-the-art LVLMs, including sensitivity analysis of task instances, validity analysis of LLM-as-a-Judge strategies, and diversity analysis across abilities, domains, languages, cultures, etc., provide a comprehensive and nuanced understanding of the limitations of current LVLMs in associative reasoning, paving the way for more human-like and general-purpose AI.