The need for new methods to deal with big data is a common theme in most scientific fields, although its definition tends to vary with the context. Statistical ideas are an essential part of this, and as a partial response, a thematic program on statistical inference, learning, and models in big data was held in 2015 in Canada, under the general direction of the Canadian Statistical Sciences Institute, with major funding from, and most activities located at, the Fields Institute for Research in Mathematical Sciences. This paper gives an overview of the topics covered, describing challenges and strategies that seem common to many different areas of application, and including some examples of applications to make these challenges and strategies more concrete.

The incidence of malignant melanoma continues to increase worldwide. This cancer can strike at any age; it is one of the leading causes of loss of life in young persons. Since this cancer is visible on the skin, it is potentially detectable at a very early stage when it is curable. New developments have converged to make fully automatic early melanoma detection a real possibility. First, the advent of dermoscopy has enabled a dramatic boost in clinical diagnostic ability to the point that melanoma can be detected in the clinic at the very earliest stages. The global adoption of this technology has allowed accumulation of large collections of dermoscopy images of melanomas and benign lesions validated by histopathology. The development of advanced technologies in the areas of image processing and machine learning have given us the ability to allow distinction of malignant melanoma from the many benign mimics that require no biopsy. These new technologies should allow not only earlier detection of melanoma, but also reduction of the large number of needless and costly biopsy procedures. Although some of the new systems reported for these technologies have shown promise in preliminary trials, widespread implementation must await further technical progress in accuracy and reproducibility. In this paper, we provide an overview of computerized detection of melanoma in dermoscopy images. First, we discuss the various aspects of lesion segmentation. Then, we provide a brief overview of clinical feature segmentation. Finally, we discuss the classification stage where machine learning algorithms are applied to the attributes generated from the segmented features to predict the existence of melanoma.

The bipartite record linkage task consists of merging two disparate datafiles containing information on two overlapping sets of entities. This is non-trivial in the absence of unique identifiers and it is important for a wide variety of applications given that it needs to be solved whenever we have to combine information from different sources. Most statistical techniques currently used for record linkage are derived from a seminal paper by Fellegi and Sunter (1969). These techniques usually assume independence in the matching statuses of record pairs to derive estimation procedures and optimal point estimators. We argue that this independence assumption is unreasonable and instead target a bipartite matching between the two datafiles as our parameter of interest. Bayesian implementations allow us to quantify uncertainty on the matching decisions and derive a variety of point estimators using different loss functions. We propose partial Bayes estimates that allow uncertain parts of the bipartite matching to be left unresolved. We evaluate our approach to record linkage using a variety of challenging scenarios and show that it outperforms the traditional methodology. We illustrate the advantages of our methods merging two datafiles on casualties from the civil war of El Salvador.

Sentiment analysis research has predominantly been on English texts. Thus there exist many sentiment resources for English, but less so for other languages. Approaches to improve sentiment analysis in a resource-poor focus language include: (a) translate the focus language text into a resource-rich language such as English, and apply a powerful English sentiment analysis system on the text, and (b) translate resources such as sentiment labeled corpora and sentiment lexicons from English into the focus language, and use them as additional resources in the focus-language sentiment analysis system. In this paper we systematically examine both options. We use Arabic social media posts as stand-in for the focus language text. We show that sentiment analysis of English translations of Arabic texts produces competitive results, w.r.t. Arabic sentiment analysis. We show that Arabic sentiment analysis systems benefit from the use of automatically translated English sentiment lexicons. We also conduct manual annotation studies to examine why the sentiment of a translation is different from the sentiment of the source word or text. This is especially relevant for building better automatic translation systems. In the process, we create a state-of-the-art Arabic sentiment analysis system, a new dialectal Arabic sentiment lexicon, and the first Arabic-English parallel corpus that is independently annotated for sentiment by Arabic and English speakers.

With the increasingly global nature of our everyday interactions, the need for multilin- gual technologies to support efficient and effective information access and communication cannot be overemphasized. Computational modeling of language has been the focus of Natural Language Processing, a subdiscipline of Artificial Intelligence. One of the current challenges for this discipline is to design methodologies and algorithms that are cross- language in order to create multilingual technologies rapidly. The goal of this JAIR special issue on Cross-Language Algorithms and Applications (CLAA) is to present leading re- search in this area, with emphasis on developing unifying themes that could lead to the development of the science of multi- and cross-lingualism. In this introduction, we provide the reader with the motivation for this special issue and summarize the contributions of the papers that have been included. The selected papers cover a broad range of cross-lingual technologies including machine translation, domain and language adaptation for sentiment analysis, cross-language lexical resources, dependency parsing, information retrieval and knowledge representation. We anticipate that this special issue will serve as an invaluable resource for researchers interested in topics of cross-lingual natural language processing.

Rehabilitation robots physically support and guide a patient's limb during motor therapy, but require sophisticated control algorithms and artificial intelligence to do so. This article provides an overview of the state of the art in this area. Furthermore, it describes exercise adaptation algorithms that change the overall exercise intensity based on the patient's performance or physiological responses, as well as socially assistive robots that provide only verbal and visual guidance. The article concludes with a discussion of the current challenges in rehabilitation robot software: evaluating existing control strategies in a clinical setting as well as increasing the robot's autonomy using entirely new artificial intelligence techniques.

Rehabilitation robots physically support and guide a patient's limb during motor therapy, but require sophisticated control algorithms and artificial intelligence to do so. This article provides an overview of the state of the art in this area. It begins with the dominant paradigm of assistive control, from impedance-based cooperative controller through electromyography and intention estimation. It then covers challenge-based algorithms, which provide more difficult and complex tasks for the patient to perform through resistive control and error augmentation. Furthermore, it describes exercise adaptation algorithms that change the overall exercise intensity based on the patient's performance or physiological responses, as well as socially assistive robots that provide only verbal and visual guidance. The article concludes with a discussion of the current challenges in rehabilitation robot software: evaluating existing control strategies in a clinical setting as well as increasing the robot's autonomy using entirely new artificial intelligence techniques.

We present a method for learning Bayesian networks from data sets containing thousands of variables without the need for structure constraints. Our approach is made of two parts. The first is a novel algorithm that effectively explores the space of possible parent sets of a node. It guides the exploration towards the most promising parent sets on the basis of an approximated score function that is computed in constant time. The second part is an improvement of an existing ordering-based algorithm for structure optimization. The new algorithm provably achieves a higher score compared to its original formulation. Our novel approach consistently outperforms the state of the art on very large data sets.

We introduce a novel approach to Compressed Path Databases, space efficient oracles used to very quickly identify the first edge on a shortest path. Our algorithm achieves query running times on the 100 nanosecond scale, being significantly faster than state-of-the-art first-move oracles from the literature. Space consumption is competitive, due to a compression approach that rearranges rows and columns in a first-move matrix and then performs run length encoding (RLE) on the contents of the matrix. One variant of our implemented system was, by a convincing margin, the fastest entry in the 2014 Grid-Based Path Planning Competition. We give a first tractability analysis for the compression scheme used by our algorithm. We study the complexity of computing a database of minimum size for general directed and undirected graphs. We find that in both cases the problem is NP-complete. We also show that, for graphs which can be decomposed along articulation points, the problem can be decomposed into independent parts, with a corresponding reduction in its level of difficulty. In particular, this leads to simple and tractable algorithms with linear running time which yield optimal compression results for trees.

Active learning (AL) is a learning paradigm where an active learner has to train a model (e.g., a classifier) which is in principal trained in a supervised way, but in AL it has to be done by means of a data set with initially unlabeled samples. To get labels for these samples, the active learner has to ask an oracle (e.g., a human expert) for labels. The goal is to maximize the performance of the model and to minimize the number of queries at the same time. In this article, we first briefly discuss the state of the art and own, preliminary work in the field of AL. Then, we propose the concept of collaborative active learning (CAL). With CAL, we will overcome some of the harsh limitations of current AL. In particular, we envision scenarios where an expert may be wrong for various reasons, there might be several or even many experts with different expertise, the experts may label not only samples but also knowledge at a higher level such as rules, and we consider that the labeling costs depend on many conditions. Moreover, in a CAL process human experts will profit by improving their own knowledge, too.