The Hamlyn Centre for Robotic Surgery, Imperial College London, UK 2. Institute of Medical Robotics, Shanghai Jiao Tong University, ChinaAbstract Artificial Intelligence (AI) is gradually changing the practice of surgery with the advanced technological development of imaging, navigation and robotic intervention. In this article, the recent successful and influential applications of AI in surgery are reviewed from preoperative planning and intra-operative guidance to the integration of surgical robots. We end with summarizing the current state, emerging trends and major challenges in the future development of AI in surgery. Keywords: Artificial intelligence, Surgical autonomy, Medical robotics, Deep learning 1. Introduction Advances in surgery have made a significant impact on the management of both acute and chronic diseases, prolonging life and continuously extending the boundary of survival. These advances are underpinned by continuing technological developments in diagnosis, imaging, and surgical instrumentation. Complex surgical navigation and planning are made possible through the use of both pre-and intra-operative imaging techniques such as ultrasound, Computed Tomography (CT), and Magnetic Resonance Imaging Preprint submitted to Frontiers of Medicine January 6, 2020 arXiv:2001.00627v1 Many terminal illnesses have been transformed into clinically manageable chronic lifelong conditions and increasing surgery is focused on the systematic level impact on patients, avoiding isolated surgical treatment or anatomical alteration, with careful consideration of metabolic, haemodynamic and neurohormonal consequences that can influence the quality of life. For recent advances in medicine, AI has played an important role in clinical decision support since the early years of developing the MYCIN system [5]. AI is now increasingly used for risk stratification, genomics, imaging and diagnosis, precision medicine, and drug discovery. The introduction of AI in surgery is more recent and it has a strong root in imaging and navigation, with early techniques focused on feature detection and computer assisted intervention for both preoperative planning and intra-operative guidance. Over the years, supervised algorithms such as active shape models, atlas based methods and statistical classifiers have been developed [1]. With recent successes of AlexNet [6], deep learning methods, especially Deep Con-volutional Neural Network (DCNN) where multiple convolutional layers are cascaded, have enabled automatically learned data-driven descriptors, rather than ad hoc handcrafted features, to be used for image understanding with improved robustness and generalizability.

Designing a controller for autonomous vehicles capable of providing adequate performance in all driving scenarios is challenging due to the highly complex environment and inability to test the system in the wide variety of scenarios which it may encounter after deployment. However, deep learning methods have shown great promise in not only providing excellent performance for complex and non-linear control problems, but also in generalising previously learned rules to new scenarios. For these reasons, the use of deep learning for vehicle control is becoming increasingly popular. Although important advancements have been achieved in this field, these works have not been fully summarised. This paper surveys a wide range of research works reported in the literature which aim to control a vehicle through deep learning methods. Although there exists overlap between control and perception, the focus of this paper is on vehicle control, rather than the wider perception problem which includes tasks such as semantic segmentation and object detection. The paper identifies the strengths and limitations of available deep learning methods through comparative analysis and discusses the research challenges in terms of computation, architecture selection, goal specification, generalisation, verification and validation, as well as safety. Overall, this survey brings timely and topical information to a rapidly evolving field relevant to intelligent transportation systems.

Predictive process analytics has recently gained significant attention, and yet its successful adoption in organisations relies on how well users can trust the predictions of the underlying machine learning algorithms that are often applied and recognised as a `black-box'. Without understanding the rationale of the black-box machinery, there will be a lack of trust in the predictions, a reluctance to use the predictions, and in the worse case, consequences of an incorrect decision based on the prediction. In this paper, we emphasise the importance of interpreting the predictive models in addition to the evaluation using conventional metrics, such as accuracy, in the context of predictive process monitoring. We review existing studies on business process monitoring benchmarks for predicting process outcomes and remaining time. We derive explanations that present the behaviour of the entire predictive model as well as explanations describing a particular prediction. These explanations are used to reveal data leakages, assess the interpretability of features used by the model, and the degree of the use of process knowledge in the existing benchmark models. Findings from this exploratory study motivate the need to incorporate interpretability in predictive process analytics.

Consider a Bayesian inference problem where a variable of interest does not take values in a Euclidean space. These "non-standard" data structures are in reality fairly common. They are frequently used in problems involving latent discrete factor models, networks, and domain specific problems such as sequence alignments and reconstructions, pedigrees, and phylogenies. In principle, Bayesian inference should be particularly well-suited in such scenarios, as the Bayesian paradigm provides a principled way to obtain confidence assessment for random variables of any type. However, much of the recent work on making Bayesian analysis more accessible and computationally efficient has focused on inference in Euclidean spaces. In this paper, we introduce Blang, a domain specific language (DSL) and library aimed at bridging this gap. Blang allows users to perform Bayesian analysis on arbitrary data types while using a declarative syntax similar to BUGS. Blang is augmented with intuitive language additions to invent data types of the user's choosing. To perform inference at scale on such arbitrary state spaces, Blang leverages recent advances in parallelizable, non-reversible Markov chain Monte Carlo methods.

Systems powered by artificial intelligence are being developed to be more user-friendly by communicating with users in a progressively human-like conversational way. Chatbots, also known as dialogue systems, interactive conversational agents, or virtual agents are an example of such systems used in a wide variety of applications ranging from customer support in the business domain to companionship in the healthcare sector. It is becoming increasingly important to develop chatbots that can best respond to the personalized needs of their users so that they can be as helpful to the user as possible in a real human way. This paper investigates and compares three popular existing chatbots API offerings and then propose and develop a voice interactive and multilingual chatbot that can effectively respond to users mood, tone, and language using IBM Watson Assistant, Tone Analyzer, and Language Translator. The chatbot was evaluated using a use case that was targeted at responding to users needs regarding exam stress based on university students survey data generated using Google Forms. The results of measuring the chatbot effectiveness at analyzing responses regarding exam stress indicate that the chatbot responding appropriately to the user queries regarding how they are feeling about exams 76.5%. The chatbot could also be adapted for use in other application areas such as student info-centers, government kiosks, and mental health support systems.

The demand for artificial intelligence has grown significantly over the last decade and this growth has been fueled by advances in machine learning techniques and the ability to leverage hardware acceleration. However, in order to increase the quality of predictions and render machine learning solutions feasible for more complex applications, a substantial amount of training data is required. Although small machine learning models can be trained with modest amounts of data, the input for training larger models such as neural networks grows exponentially with the number of parameters. Since the demand for processing training data has outpaced the increase in computation power of computing machinery, there is a need for distributing the machine learning workload across multiple machines, and turning the centralized into a distributed system. These distributed systems present new challenges, first and foremost the efficient parallelization of the training process and the creation of a coherent model. This article provides an extensive overview of the current state-of-the-art in the field by outlining the challenges and opportunities of distributed machine learning over conventional (centralized) machine learning, discussing the techniques used for distributed machine learning, and providing an overview of the systems that are available.

Autonomous vehicles rely on machine learning to solve challenging tasks in perception and motion planning. However, automotive software safety standards have not fully evolved to address the challenges of machine learning safety such as interpretability, verification, and performance limitations. In this paper, we review and organize practical machine learning safety techniques that can complement engineering safety for machine learning based software in autonomous vehicles. Our organization maps safety strategies to state-of-the-art machine learning techniques in order to enhance dependability and safety of machine learning algorithms. We also discuss security limitations and user experience aspects of machine learning components in autonomous vehicles.

The thesis contributes in several important ways to the research area of 3D object category learning and recognition. To cope with the mentioned limitations, we look at human cognition, in particular at the fact that human beings learn to recognize object categories ceaselessly over time. This ability to refine knowledge from the set of accumulated experiences facilitates the adaptation to new environments. Inspired by this capability, we seek to create a cognitive object perception and perceptual learning architecture that can learn 3D object categories in an open-ended fashion. In this context, ``open-ended'' implies that the set of categories to be learned is not known in advance, and the training instances are extracted from actual experiences of a robot, and thus become gradually available, rather than being available since the beginning of the learning process. In particular, this architecture provides perception capabilities that will allow robots to incrementally learn object categories from the set of accumulated experiences and reason about how to perform complex tasks. This framework integrates detection, tracking, teaching, learning, and recognition of objects. An extensive set of systematic experiments, in multiple experimental settings, was carried out to thoroughly evaluate the described learning approaches. Experimental results show that the proposed system is able to interact with human users, learn new object categories over time, as well as perform complex tasks. The contributions presented in this thesis have been fully implemented and evaluated on different standard object and scene datasets and empirically evaluated on different robotic platforms.

The simultaneous control of multiple coordinated robotic agents represents an elaborate problem. If solved, however, the interaction between the agents can lead to solutions to sophisticated problems. The concept of swarming, inspired by nature, can be described as the emergence of complex system-level behaviors from the interactions of relatively elementary agents. Due to the effectiveness of solutions found in nature, bio-inspired swarming-based control techniques are receiving a lot of attention in robotics. One method, known as swarm shepherding, is founded on the sheep herding behavior exhibited by sheepdogs, where a swarm of relatively simple agents are governed by a shepherd (or shepherds) which is responsible for high-level guidance and planning. Many studies have been conducted on shepherding as a control technique, ranging from the replication of sheep herding via simulation, to the control of uninhabited vehicles and robots for a variety of applications. We present a comprehensive review of the literature on swarm shepherding to reveal the advantages and potential of the approach to be applied to a plethora of robotic systems in the future.

When and why can a neural network be successfully trained? This article provides an overview of optimization algorithms and theory for training neural networks. First, we discuss the issue of gradient explosion/vanishing and the more general issue of undesirable spectrum, and then discuss practical solutions including careful initialization and normalization methods. Second, we review generic optimization methods used in training neural networks, such as SGD, adaptive gradient methods and distributed methods, and theoretical results for these algorithms. Third, we review existing research on the global issues of neural network training, including results on bad local minima, mode connectivity, lottery ticket hypothesis and infinite-width analysis.